Article
Computer Science, Interdisciplinary Applications
Ivan Aranzales, Ho Fai Chan, Benno Torgler
Summary: Understanding the role of emotions in academia is challenging, but studying Nobel Prize winners can provide insights. We hypothesize that Nobel laureates who have waited longer for the award will experience stronger positive emotions upon receiving it. Analyzing banquet speeches, we find a robust positive correlation between waiting time and positive emotions.
Book Review
Multidisciplinary Sciences
Alison Abbott
Summary: The neuroscientist, who has won a Nobel Prize, has been studying connections on a larger scale.
Article
Humanities, Multidisciplinary
Pandelis Mitsis
Summary: This study aims to examine the time gap between pioneering work and Nobel recognition in different disciplines. The analysis suggests that factors such as accolades, citation indices, and sharing of the award may explain this variation to some extent. Additionally, the longer waiting period for the Nobel Prize in economics may be attributed to factors such as the age of laureates.
HUMANITIES & SOCIAL SCIENCES COMMUNICATIONS
(2022)
News Item
Multidisciplinary Sciences
Davide Castelvecchi, Katharine Sanderson
Summary: Pierre Agostini, Ferenc Krausz, and Anne L'Huillier have been awarded for their research on ultra-short pulses of light, which has made it possible to study electrons in detail.
Editorial Material
Medicine, Research & Experimental
Katherine E. Uyhazi, Jean Bennett
Summary: The 2020 Nobel Prize in Chemistry was awarded to Emmanuelle Charpentier and Jennifer Doudna for their groundbreaking discovery of the CRISPR/Cas9 genetic scissors, revolutionizing genome editing methods.
JOURNAL OF CLINICAL INVESTIGATION
(2021)
Review
Chemistry, Multidisciplinary
Jeffrey I. Seeman, Guillermo Restrepo
Summary: The solicitation of nominations has been the first step in the selection process of the Nobel Prizes in Chemistry since its inception in 1901. However, analysis of data from the Nobel Prize Nomination Archives reveals that nominations have not been the decisive factor in selecting the recipients of the award. Instead, nominations have served as a source of information for the committee, guiding future contenders and possibly influencing the selection through personal biases.
CHEMISTRY-A EUROPEAN JOURNAL
(2023)
Article
Multidisciplinary Sciences
Yakub Sebastian, Chaomei Chen
Summary: The study applies the SVA model to investigate Nobel Prize winning papers, finding that they exhibit remarkable boundary-spanning traits and exert significant structural variations on existing intellectual space. SVA not only provides leading indicators for future Nobel Prize winning papers, but also broadens our understanding of prize-winning properties in academic publications.
Review
Medicine, Research & Experimental
Miroslaw Janowski, Anna Andrzejewska
Summary: Advances in mRNA engineering have played a crucial role in healthcare, particularly in vaccine research and supplementation of missing proteins. Furthermore, mRNA is expected to have applications in ex vivo cell engineering and genome editing.
MOLECULAR THERAPY-NUCLEIC ACIDS
(2022)
Article
Endocrinology & Metabolism
Lars Ryden, Jan Lindsten
Summary: The discovery of insulin, celebrated on its 100th anniversary in 2021, was a result of a long and interesting history in the field of medicine. From the earliest known mentions of diabetes-like diseases in 1550 BCE to the first successful isolation and use of insulin in 1922, various medical professionals contributed to this breakthrough. The Nobel Prize in Physiology or Medicine was awarded to Banting and MacLeod in 1923 for their significant role in the discovery and development of insulin.
DIABETES RESEARCH AND CLINICAL PRACTICE
(2021)
Review
Endocrinology & Metabolism
Jeffrey S. Flier, C. Ronald Kahn
Summary: The discovery of insulin has had a profound impact on diabetes treatment and biomedical research, serving as a catalyst for scientific research across different fields. This impact, both direct and indirect, has significantly shaped modern bioscience.
MOLECULAR METABOLISM
(2021)
Review
Biochemistry & Molecular Biology
Lolita Piersimoni, Marina Abd el Malek, Twinkle Bhatia, Julian Bender, Christin Brankatschk, Jaime Calvo Sanchez, Guy W. Dayhoff, Alessio Di Ianni, Jhonny Oscar Figueroa Parra, Dailen Garcia-Martinez, Julia Hesselbarth, Janett Koeppen, Luca M. Lauth, Laurin Lippik, Lisa Machner, Shubhra Sachan, Lisa Schmidt, Robin Selle, Ioannis Skalidis, Oleksandr Sorokin, Daniele Ubbiali, Bruno Voigt, Alice Wedler, Alan An Jung Wei, Peter Zorn, Alan Keith Dunker, Marcel Koehn, Andrea Sinz, Vladimir N. Uversky
Summary: Intrinsically disordered proteins and regions (IDPs and IDRs) are increasingly recognized in biology, and their importance is demonstrated by their involvement in Nobel Prize-winning discoveries. While the specific molecular functions of IDPs and IDRs are still being determined, their presence in various biological processes highlights their significance in biology.
CELLULAR AND MOLECULAR LIFE SCIENCES
(2022)
Article
Computer Science, Information Systems
Chunli Wei, Jiang Li, Dongbo Shi
Summary: To quantify revolutionary discoveries, a two-dimensional metric combining the consolidation-or-destabilization (CD) index with citation count is proposed. Through multivariate linear regression analysis on 164 Nobel prize-winning papers and 9,034 counterparts, significant differences were found between the two groups, with the Nobel prize-winning papers receiving approximately 880 more citations and having an average CD index 0.07 higher than the counterparts. The proposed metric proves to be reliable in measuring revolutionary science.
INFORMATION PROCESSING & MANAGEMENT
(2023)
Article
Biochemical Research Methods
Joseph Zaia
Summary: The 2022 Nobel Prize in Chemistry was awarded for the development of biorthogonal chemical ligation reactions, also known as click chemistry, in biomedicine. This concept has significantly advanced sensing and diagnosis, chemical biology, materials chemistry, and drug discovery and delivery. In the field of proteomics, the incorporation of click tags into proteins has revolutionized the selective enrichment of protein complexes and the study of protein networks, as well as the enrichment of protein post-translational modifications. This feature article summarizes the impact of biorthogonal click chemistry on proteomics.
ANALYTICAL AND BIOANALYTICAL CHEMISTRY
(2023)
Editorial Material
Computer Science, Interdisciplinary Applications
[Anonymous]
Summary: This month's Focus issue highlights the contributions of the computational science community to Nobel Prizes in chemistry and physics.
NATURE COMPUTATIONAL SCIENCE
(2022)
Article
Computer Science, Interdisciplinary Applications
Guoqiang Liang, Ying Lou, Haiyan Hou
Summary: In this study, the performance of the disruptive index (DI) in reference is analyzed, and it is found that Nobel Prize-winning articles are not necessarily more disruptive than benchmark articles. The results based on DI depend on the length of the citation time window and the discipline and time factors also play a role in measuring the innovativeness of scientific work using DI.
Review
Physiology
Charna Dibner
Review
Biochemistry & Molecular Biology
Flore Sinturel, Volodymyr Petrenko, Charna Dibner
JOURNAL OF MOLECULAR BIOLOGY
(2020)
Article
Multidisciplinary Sciences
Volodymyr Petrenko, Nikhil R. Gandasi, Daniel Sage, Anders Tengholm, Sebastian Barg, Charna Dibner
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2020)
Article
Physiology
J. Thomas Hannich, Ursula Loizides-Mangold, Flore Sinturel, Takeshi Harayama, Bart Vandereycken, Camille Saini, Pauline Gosselin, Marie-Claude Brulhart-Meynet, Maud Robert, Stephanie Chanon, Christine Durand, Jonathan Paz Montoya, Fabrice P. A. David, Idris Guessous, Zoltan Pataky, Alain Golay, Francois R. Jornayvaz, Jacques Philippe, Emmanouil T. Dermitzakis, Steven A. Brown, Etienne Lefai, Howard Riezman, Charna Dibner
Summary: This study analyzed the lipid profile of lean and obese individuals with T2D and non-T2D, revealing significant alterations in lipid homeostasis in a disease- and tissue-specific manner. These lipid changes, including sphingolipids, will aid in identifying T2D patient subgroups and advancing personalized medicine in diabetes.
Article
Biochemistry & Molecular Biology
Phillip Alexander Keller Andersen, Volodymyr Petrenko, Peter Horskjaer Rose, Melissa Koomen, Nico Fischer, Seyed Mojtaba Ghiasi, Tina Dahlby, Charna Dibner, Thomas Mandrup-Poulsen
Summary: The combination of proinflammatory cytokines IL-1 beta and interferon-gamma disrupted the intrinsic clocks in mouse and human pancreatic islets, leading to uncoordinated clock gene expression in INS-1 cells. This effect was associated with nitric oxide (NO), lysine deacetylase HDAC3, and immunoproteasome activity.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Immunology
Stephan J. Holtkamp, Louise M. Ince, Coline Barnoud, Madeleine T. Schmitt, Flore Sinturel, Violetta Pilorz, Robert Pick, Stephane Jemelin, Michael Muehlstaedt, Wolf-Henning Boehncke, Jasmin Weber, David Laubender, Julia Philippou-Massier, Chien-Sin Chen, Leonie Holtermann, Dietmar Vestweber, Markus Sperandio, Barbara U. Schraml, Cornelia Halin, Charna Dibner, Henrik Oster, Joerg Renkawitz, Christoph Scheiermann
Summary: The study demonstrates that circadian clocks regulate the infiltration of dendritic cells into skin lymphatics, which is crucial for adaptive immune responses. The migration pattern of dendritic cells is influenced by rhythmic gradients in the expression of chemokines and adhesion molecules in both mice and humans. Targeting the circadian oscillations in skin lymphatic endothelial cells and dendritic cells disrupts the circadian trafficking of dendritic cells.
Review
Nutrition & Dietetics
Alexandra Hemmer, Julie Mareschal, Charna Dibner, Jacques A. Pralong, Victor Dorribo, Stephen Perrig, Laurence Genton, Claude Pichard, Tinh-Hai Collet
Summary: Energy metabolism is closely connected to circadian rhythms and external factors like shift work can disrupt these rhythms, impacting physiological markers and potentially leading to cardio-metabolic disorders. Research on shift work and its effects on health outcomes have shown inconsistent results due to variations in study designs, highlighting the need for novel approaches to better understand the relationship between shift work and metabolic disorders.
Review
Biochemistry & Molecular Biology
Flore Sinturel, Weronika Spaleniak, Charna Dibner
Summary: Lipid metabolism is crucial for maintaining metabolic health, and the circadian clock system plays an important role in regulating lipid metabolism. Perturbation of circadian regulation has been found to contribute to the development of metabolic disorders such as obesity and type 2 diabetes.
BIOCHEMICAL SOCIETY TRANSACTIONS
(2022)
Article
Endocrinology & Metabolism
Cecilia Jimenez-Sanchez, Teresa Mezza, Flore Sinturel, Lingzi Li, Gianfranco Di Giuseppe, Giuseppe Quero, Francois R. Jornayvaz, Idris Guessous, Charna Dibner, Patrick Schrauwen, Sergio Alfieri, Andrea Giaccari, Pierre Maechler
Summary: The plasma concentration of 1,5-anhydroglucitol is closely related to the mass of β cells, and its noninvasive monitoring can serve as an indicator of β cell loss in individuals at risk for diabetes.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2022)
Article
Biochemistry & Molecular Biology
Volodymyr Petrenko, Flore Sinturel, Ursula Loizides-Mangold, Jonathan Paz Montoya, Simona Chera, Howard Riezman, Charna Dibner
Summary: Recent evidence suggests that circadian clocks play a role in regulating lipid metabolism in human pancreatic islets and perturbation of temporal regulation of lipid metabolism in islets upon type 2 diabetes leads to altered insulin secretion and membrane fluidity. These findings provide important insights into the pathophysiology of metabolic diseases and the role of circadian rhythms in pancreatic function.
Article
Endocrinology & Metabolism
Mohamed Asrih, Flore Sinturel, Richard Dubos, Idris Guessous, Zoltan Pataky, Charna Dibner, Francois R. Jornayvaz, Karim Gariani
Summary: The study found that GDF15 levels may be dependent on sex in diabetes and/or obesity groups, with decreased levels in women who have obesity alone or in combination with diabetes.
ENDOCRINE CONNECTIONS
(2022)
Article
Multidisciplinary Sciences
Louise Madeleine Ince, Coline Barnoud, Lydia Kay Lutes, Robert Pick, Chen Wang, Flore Sinturel, Chien-Sin Chen, Alba de Juan, Jasmin Weber, Stephan J. Holtkamp, Sophia Martina Hergenhan, Jennifer Geddes-McAlister, Stefan Ebner, Paola Fontannaz, Benjamin Meyer, Maria Vono, Stephane Jemelin, Charna Dibner, Claire-Anne Siegrist, Felix Meissner, Frederik Graw, Christoph Scheiermann
Summary: The study shows that circadian rhythms affect immune responses, including responses to vaccines. Dendritic cells migrate in a time-of-day-dependent manner, altering interactions with T cells and influencing vaccine responses. The findings provide a mechanistic understanding of the development and maintenance of an adaptive immune response under circadian control, offering a strategy for optimizing vaccination regimes based on time-of-day.
NATURE COMMUNICATIONS
(2023)
Biographical-Item
Biology
Ueli Schibler, Charna Dibner, Jurgen Ripperger
JOURNAL OF BIOLOGICAL RHYTHMS
(2023)
Article
Cell Biology
Chantal Alkhoury, Nathaniel F. Henneman, Volodymyr Petrenko, Yui Shibayama, Arianna Segaloni, Alexis Gadault, Ivan Nemazanyy, Edouard Le Guillou, Amare Desalegn Wolide, Konstantina Antoniadou, Xin Tong, Teruya Tamaru, Takeaki Ozawa, Muriel Girard, Karim Hnia, Dominik Lutter, Charna Dibner, Ganna Panasyuk
Summary: The class 3 phosphatidylinositol-3-kinase Vps15 subunit plays a crucial role in transcriptional gene regulation and metabolic rhythmicity. It interacts with RNA polymerase II and co-localizes with active transcription sites. Loss of Vps15 leads to decreased transcriptional activity of Bmal1-Clock, indicating its non-redundancy with the Vps34 subunit. Additionally, Vps15 is required for metabolic rhythmicity in liver and promotes pro-anabolic de novo purine synthesis.
NATURE CELL BIOLOGY
(2023)
Review
Biochemistry & Molecular Biology
Volodymyr Petrenko, Flore Sinturel, Howard Riezman, Charna Dibner
Summary: Lipids have important roles in energy metabolism and various biological functions. Disruption of lipid metabolism can lead to metabolic disorders such as metabolic syndrome, obesity, and type 2 diabetes. Circadian rhythms play a key role in regulating lipid metabolism, and recent studies have revealed the mechanistic links between molecular clocks, lipid homeostasis, and metabolic diseases. Manipulating circadian oscillators could be a promising approach for preventing and managing metabolic disorders in humans.
PROGRESS IN LIPID RESEARCH
(2023)
Review
Physiology
Minyu Zhang, Biyang Xiao, Xiaoqi Chen, Bingming Ou, Songtao Wang
Summary: Non-alcoholic fatty liver disease (NAFLD) is closely related to bile acid and gut microbiota disorders. Exercise plays an important role in maintaining the homeostasis of the enterohepatic circulation and the health of the host gut microbiota by regulating the composition and function of the bile acid pool in the enterohepatic axis. Exercise has been recommended as a first-line intervention for NAFLD, and regulating bile acids through exercise may be a promising treatment strategy.
