Article
Chemistry, Applied
Tao Zhang, Guoqing Sun, Ming Shuai, Jingyu Ye, Jian Huang, Xiaodong Yao, Chengxin Sun, Xun Min
Summary: This study isolated five fractions from modified citrus pectin (MCP) and studied their structures, ability to inhibit galectin-3, and antiproliferation activities on MCF-7 and A549 cell lines. One of the fractions, EMCP-3p, showed strong inhibition of galectin-3 and significant cytotoxicity against MCF-7 and A549 cell lines. These results offer new insights into the structure-function relationships of polysaccharides derived from MCP.
Article
Engineering, Biomedical
Yiyun Zhang, Danning Su, Yimeng Wang, Ziqiang Wang, Ying Ren, Rui Liu, Bo Du, Ruiping Duan, Yanping Shi, Lingrong Liu, Xuemin Li, Qiqing Zhang
Summary: A collagen membrane-based modified citrus pectin (MCP) delivery system (MCP-C) was developed in this study to simultaneously modulate regenerative and inflammatory responses by targeting galectin-3 (Gal-3), enhancing the repair of articular cartilage (AC) defects.
Article
Cardiac & Cardiovascular Systems
Emily S. Lau, Elizabeth Liu, Samantha M. Paniagua, Amy A. Sarma, Giovanna Zampierollo, Begona Lopez, Javier Diez, Thomas J. Wang, Jennifer E. Ho
Summary: In this trial, higher Gal-3 levels were associated with female sex, diabetes, and reduced glomerular filtration rate in cross-sectional analyses, but treatment with modified citrus pectin did not change collagen markers. Further investigation is needed for the effect of Gal-3 inhibition among individuals with heart failure.
JACC-BASIC TO TRANSLATIONAL SCIENCE
(2021)
Article
Acoustics
Wenjun Wang, Yiming Feng, Weijun Chen, Kyle Adie, Donghong Liu, Yun Yin
Summary: The modified pectin treated with a combination of microfluidization and moderate ultrasonication (MUB) showed the lowest hydrodynamic diameter, molecular weight, and polydispersity, with relatively low apparent viscosity and significantly higher DPPH radical scavenging capacity. MUB also exhibited improved emulsifying and encapsulation properties compared to the original and ultrasonication treated pectin.
ULTRASONICS SONOCHEMISTRY
(2021)
Article
Medicine, Research & Experimental
Jaudah Ahmed Al-Maghrabi, Mohamad Nidal Khabaz
Summary: This study aimed to explore the clinical significance of galectin-3 in the development of bladder cancer by examining its expression in urothelial carcinomas and normal tissues, and its correlation with clinicopathological factors. The results showed that galectin-3 was downregulated in bladder cancer and was not a useful marker for diagnosing or predicting the prognosis of bladder cancer.
JOURNAL OF INTERNATIONAL MEDICAL RESEARCH
(2023)
Article
Medicine, Research & Experimental
Diego D. Santos, Gisela R. S. Sasso, Nycole M. Belote, Rafael Andre da Silva, Izabella Lice, Rebeca D. Correia-Silva, Fernanda T. Borges, Adriana A. F. Carbonel, Cristiane D. Gil
Summary: The role of galectin-3 in liver was evaluated using an acute model of cisplatin-induced toxicity. Treatment with modified citrus pectin (MCP) was used to inhibit galectin-3. The study showed that reducing the levels of galectin-3 in hepatocytes promotes cell death and increases oxidative stress.
Review
Biochemistry & Molecular Biology
Lucas de Freitas Pedrosa, Avraham Raz, Joao Paulo Fabi
Summary: The review focuses on revealing the structure/function relationship of pectins, their fragments, and their biological effects. The discussion highlights different effects described within in vitro and in vivo experimental models, with interesting and sometimes contradictory results, especially regarding galectin-3 interaction.
Article
Biochemistry & Molecular Biology
Fei Fei, Mingfeng Zhang, Somayeh S. Tarighat, Eun Ji Joo, Lu Yang, Nora Heisterkamp
Summary: Galectin-1 and Galectin-3 have a complicated joint contribution to BCP-ALL survival, with stromal Galectin-3 playing an important role in maintaining BCP-ALL fitness during chemotherapy exposure, while stromal Galectin-1 does not significantly contribute to drug resistance.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Chemistry, Applied
Shaoyi Cen, Zhihua Li, Ziang Guo, Jiyong Shi, Xiaowei Huang, Xiaobo Zou, Melvin Holmes
Summary: In this study, citrus pectins modified with beta-cyclodextrin were used to stabilize Pickering emulsions for 3D printing. The modification of pectin improved the stability of the complex particles, and the addition of beta-CD enhanced the wettability and zeta-potential of the complexes. The rheological properties, texture properties, and stability of the emulsions were influenced by the ratio of pectin/beta-CD.
CARBOHYDRATE POLYMERS
(2023)
Article
Engineering, Multidisciplinary
Gustavo Murilo Alves, Jose Luiz da Silva, Nelson Ramos Stradiotto
Summary: This paper presents the development and application of a citrus pectin-modified carbon paste electrode for the electrochemical detection of copper in biofuel. The sensor showed enhanced current response and excellent performance characteristics, making it a reliable tool for quality control in commercial bioethanol production.
Article
Immunology
Camilo G. Sotomayor, Charlotte A. Te Velde-Keyzer, Arjan Diepstra, Marco van Londen, Robert A. Pol, Adrian Post, Rijk O. B. Gans, Ilja M. Nolte, Riemer H. J. A. Slart, Martin H. de Borst, Stefan P. Berger, Ramon Rodrigo, Gerjan J. Navis, Rudolf A. de Boer, Stephan J. L. Bakker
Summary: Elevated serum galectin-3 levels are independently associated with an increased risk of late graft failure in kidney transplant recipients, especially in those with high systolic blood pressure or a history of smoking. Patients with high galectin-3 levels are consistently at higher risk of graft failure.
Article
Cell Biology
Hemn Mohammadpour, Takemasa Tsuji, Cameron R. MacDonald, Joseph L. Sarow, Hanna Rosenheck, Saeed Daneshmandi, Jingxin Qiu, Jee Eun Choi, Junko Matsuzaki, Agnieszka K. Witkiewicz, Kristopher Attwood, Bruce R. Blazar, Kunle Odunsi, Elizabeth A. Repasky, Philip L. McCarthy
Summary: Activated donor T cells express galectin-3 (Gal-3) after allo-HCT, which suppresses T cell activation and effector cytokine secretion, leading to decreased inflammation in murine aGvHD. Gal-3 overexpression in human T cells also suppresses cytotoxic T cells and prevents severe disease in xenogeneic aGvHD models.
Article
Nutrition & Dietetics
Daniel Keizman, Moshe Frenkel, Avivit Peer, Eli Rosenbaum, David Sarid, Ilan Leibovitch, Roy Mano, Ofer Yossepowitch, Ido Wolf, Ravit Geva, David Margel, Keren Rouvinov, Anat Stern, Hadas Dresler, Igal Kushnir, Isaac Eliaz
Summary: The study shows that P-MCP may have long-term durable efficacy and is safe for patients with non-metastatic biochemically relapsed prostate cancer (BRPC-M0). This provides hope for the treatment of BRPC-M0 patients.
Article
Chemistry, Applied
Zhongcan Peng, Shurong Tian, Hailing Li, Longping Zhu, Zhimin Zhao, Guodong Zheng, Qiyin Wen, Hongru Tian, Depo Yang
Summary: The cell wall polysaccharides of Citrus reticulata cv. Chachiensis were extracted and characterized in terms of composition, structure, thermal, rheological, and antioxidant properties. The pectin fractions exhibited high methoxy pectin characteristics and high thermal stability. The water-soluble pectin showed the highest radical scavenging activity.
FOOD HYDROCOLLOIDS
(2023)
Article
Medicine, Research & Experimental
Carolin Pozder geb Gehlken, A. Rogier van der Velde, Wouter C. Meijers, Herman H. W. Sillje, Pieter Muntendam, Martin M. Dokter, Wiek H. van Gilst, Henk A. Schols, Rudolf A. de Boer
Summary: The study aimed to find a therapy for cardiac fibrosis and identified rhubarb pectin as a potent inhibitor of galectin-3. The effectiveness of rhubarb pectin was validated in a mouse model of myocardial fibrosis, showing significant reduction of fibrosis and preserved cardiac function.
CURRENT RESEARCH IN TRANSLATIONAL MEDICINE
(2022)
Article
Oncology
Yi-lin Yan, Zheng-nan Huang, Zhen Zhu, Yang-yan Cui, Mei-qian Li, Rui-min Huang, Jun Yan, Bing Shen
FRONTIERS IN ONCOLOGY
(2020)
Article
Integrative & Complementary Medicine
Tian Fang, Ze-sheng Xue, Jia-xuan Li, Jia-kuan Liu, Di Wu, Mei-qian Li, Yu-ting Song, Shi-feng Yun, Jun Yan
Summary: The extract of Rauwolfia vomitoria significantly reduced prostate weight and proliferation markers in BPH rats, while also decreasing the expression levels of androgen receptor and its associated proteins. Compared to the reference drug, R. vomitoria extract did not significantly affect sperm count, suggesting it may be a promising therapeutic agent for BPH with milder side effects.
JOURNAL OF INTEGRATIVE MEDICINE-JIM
(2021)
Article
Oncology
Lin Yang, Jingya Sun, Meiqian Li, Yiming Long, Dianzheng Zhang, Hongqian Guo, Ruimin Huang, Jun Yan
Summary: The study highlights the association between hypercholesterolemia-induced oxidized ldL and urinary bladder cancer, with CD36/JAK2/STAT3 signaling axis being potential therapeutic targets. ox-LDL could serve as a biomarker for aggressive UBC.
Article
Cell Biology
Zhengnan Huang, Yilin Yan, Zhen Zhu, Jiakuan Liu, Xiao He, Sumiya Dalangood, Meiqian Li, Mingyue Tan, Jinming Cai, Pengfei Tang, Ruimin Huang, Bing Shen, Jun Yan
Summary: CBX7 is frequently downregulated in urinary bladder cancer due to promoter hypermethylation, leading to poor prognosis. Its ectopic expression suppresses UBC cell aggressiveness and tumor development by downregulating AKR1B10 and inactivating ERK signaling, providing a potential therapeutic target against UBC.
CELL DEATH & DISEASE
(2021)
Article
Cell Biology
Zhengnan Huang, Jiakuan Liu, Jiale Yang, Yilin Yan, Chenkai Yang, Xiao He, Ruimin Huang, Mingyue Tan, Denglong Wu, Jun Yan, Bing Shen
Summary: The study identified PDE4B as a potential therapeutic target in urinary bladder cancer, showing that its upregulation promoted cancer cell migration and invasion through the beta-catenin/EMT pathway. Furthermore, PDE4B expression was correlated with aggressive clinicopathological characteristics and unfavorable prognosis in UBC.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Review
Chemistry, Multidisciplinary
Wen-sheng Yang, Jing-lin Wang, Wei Wu, Guang-fei Wang, Jun Yan, Qing Liu, Xiao-yan Wu, Qing-tong Zhou, De-hua Yang, Ming-Wei Wang, Zhi-ping Li
Summary: Inflammatory bowel disease (IBD) is a global health burden, and the current treatment mainly relies on anti-inflammatory drugs. However, their clinical efficacy and adverse reactions are still unacceptable. Resolution, as an active and orchestrated phase of inflammation, involves specialized pro-resolving mediators (SPMs), neutrophils, and phagocyte efferocytosis. The formyl peptide receptor 2 (FPR2/ALX), a human G protein-coupled receptor, can bind SPMs and participate in the resolution process.
ACTA PHARMACOLOGICA SINICA
(2023)
Article
Chemistry, Analytical
Wenyong Wu, Jinjun Hou, Zijia Zhang, Feifei Li, Rong Zhang, Lei Gao, Hui Ni, Tengqian Zhang, Huali Long, Min Lei, Bing Shen, Jun Yan, Ruimin Huang, Zhongda Zeng, Wanying Wu
Summary: This study presents a novel method for objectively evaluating the image quality of hyperspectral images. The method is validated by analyzing data from human prostate cancer and mouse brain tissue, demonstrating its applicability. The method utilizes information entropy and contrast to assess image quality and reduces high-dimensional data to three-dimensional embeddings for evaluation, resulting in satisfactory visualization results.
ANALYTICAL CHEMISTRY
(2022)
Article
Immunology
Jiakuan Liu, Meiqian Li, Jiajun Wu, Qi Qi, Yang Li, Simei Wang, Shengjie Liang, Yuqing Zhang, Zhitao Zhu, Ruimin Huang, Jun Yan, Rujian Zhu
Summary: It has been found that ST3GAL5 is overexpressed in clear cell renal cell carcinoma (ccRCC) and is associated with its pathological features and prognosis. ST3GAL5 is also involved in tumor immunoregulation and is associated with the infiltration and exhaustion of CD8(+) T cells.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Cell Biology
Jiaxuan Li, Yiming Long, Jingya Sun, Jiajun Wu, Xiao He, Simei Wang, Xiongbiao Wang, Xiayi Miao, Ruimin Huang, Jun Yan
Summary: The downregulation of ST3GAL6 in lung adenocarcinoma (LUAD) is associated with advanced stage and poor clinical outcomes. Its deficiency promotes invasiveness of LUAD cells through the activation of EGFR/MAPK signaling pathway.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Yangyan Cui, Hanyi Feng, Jiakuan Liu, Jiajun Wu, Rujian Zhu, Ruimin Huang, Jun Yan
Summary: The hexosamine biosynthesis pathway (HBP) has been identified as a promising prognostic biomarker in urinary bladder cancer (UBC) patients and is strongly associated with immune infiltration.
FRONTIERS IN MOLECULAR BIOSCIENCES
(2022)
Article
Oncology
Junlong Zhuang, Lan Shen, Meiqian Li, Jingya Sun, Jiange Hao, Jiaxuan Li, Zhen Zhu, Shuning Ge, Dianzheng Zhang, Hongqian Guo, Ruimin Huang, Jun Yan
Summary: Cancer-associated fibroblasts (CAF) promote cancer stemness and chemoresistance in urothelial bladder cancer (UBC) by overexpressing miR-146a-5p. MiR-146a-5p also enhances UBC stemness and chemoresistance by targeting ARID1A and PRKAA2 mRNA in UBC cells. Elevated levels of exosomal miR-146a-5p in UBC patients' serum are associated with tumor stage and relapse risk.
Editorial Material
Biochemistry & Molecular Biology
Yali Lu, Yan Lin, Xiaoyang Zhang, Jun Yan, Zhe Kong, Lu Zhang, Chenji Wang, Yan Huang, Shimin Zhao, Yao Li
Article
Integrative & Complementary Medicine
Guifang Huang, Xiao He, Zesheng Xue, Yiming Long, Jiakuan Liu, Jinming Cai, Pengfei Tang, Bangmin Han, Bing Shen, Ruimin Huang, Jun Yan
Summary: This study demonstrates that RWF extract induces apoptosis in BPH epithelial cells and BPH myofibroblasts by upregulating endoplasmic reticulum stress and autophagy, suggesting that RWF extract could be a potential alternative therapeutic approach for BPH.
BMC COMPLEMENTARY MEDICINE AND THERAPIES
(2022)
Article
Integrative & Complementary Medicine
Yu Dong, Jiakuan Liu, Zesheng Xue, Jingya Sun, Zhengnan Huang, Yifeng Jing, Bangmin Han, Bing Shen, Jun Yan, Ruimin Huang
BMC COMPLEMENTARY MEDICINE AND THERAPIES
(2020)
Article
Medicine, Research & Experimental
Sumiya Dalangood, Zhen Zhu, Zhihui Ma, Jiaxuan Li, Qinghe Zeng, Yilin Yan, Bing Shen, Jun Yan, Ruimin Huang