Discovery and development of NA-1 for the treatment of acute ischemic stroke

Delayed Administration of Tat-HA-NR2B9c Promotes Recovery After Stroke in Rats

(2015) H.-H. Zhou et al.   STROKE

Stroke Incidence and Mortality Trends in US Communities, 1987 to 2011

(2014) Silvia Koton et al.   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Involvement and interplay of Parkin, PINK1, and DJ1 in neurodegenerative and neuroinflammatory disorders

(2012) Micha M.M. Wilhelmus et al.   FREE RADICAL BIOLOGY AND MEDICINE

The Two Pathophysiologies of Focal Brain Ischemia: Implications for Translational Stroke Research

(2012) Konstantin-Alexander Hossmann   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

G-Protein-Coupled Receptor 30 Mediates Rapid Neuroprotective Effects of Estrogen via Depression of NR2B-Containing NMDA Receptors

(2012) S.-b. Liu et al.   JOURNAL OF NEUROSCIENCE

Safety and efficacy of NA-1 in patients with iatrogenic stroke after endovascular aneurysm repair (ENACT): a phase 2, randomised, double-blind, placebo-controlled trial

(2012) Michael D Hill et al.   LANCET NEUROLOGY

Treatment of stroke with a PSD-95 inhibitor in the gyrencephalic primate brain

(2012) Douglas J. Cook et al.   NATURE

A high-affinity, dimeric inhibitor of PSD-95 bivalently interacts with PDZ1-2 and protects against ischemic brain damage

(2012) A. Bach et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Pathophysiology, treatment, and animal and cellular models of human ischemic stroke

(2011) Trent M Woodruff et al.   Molecular Neurodegeneration

Stroke research at a crossroad: asking the brain for directions

(2011) Costantino Iadecola et al.   NATURE NEUROSCIENCE

Emerging mechanisms of disrupted cellular signaling in brain ischemia

(2011) Michael Tymianski   NATURE NEUROSCIENCE

The transient receptor potential family of ion channels

(2011) Bernd Nilius et al.   GENOME BIOLOGY

Dendritic Function of Tau Mediates Amyloid-β Toxicity in Alzheimer's Disease Mouse Models

(2010) Lars M. Ittner et al.   CELL

DAPK1 Interaction with NMDA Receptor NR2B Subunits Mediates Brain Damage in Stroke

(2010) Weihong Tu et al.   CELL

Inhibiting pro-death NMDA receptor signaling dependent on the NR2 PDZ ligand may not affect synaptic function or synaptic NMDA receptor signaling to gene expression

(2010) Marc-Andre Martel et al.   Channels

Memantine Preferentially Blocks Extrasynaptic over Synaptic NMDA Receptor Currents in Hippocampal Autapses

(2010) P. Xia et al.   JOURNAL OF NEUROSCIENCE

Treatment of cerebral ischemia by disrupting ischemia-induced interaction of nNOS with PSD-95

(2010) Li Zhou et al.   NATURE MEDICINE

Synaptic versus extrasynaptic NMDA receptor signalling: implications for neurodegenerative disorders

(2010) Giles E. Hardingham et al.   NATURE REVIEWS NEUROSCIENCE

The Science of Stroke: Mechanisms in Search of Treatments

(2010) Michael A. Moskowitz et al.   NEURON

Neuroprotective strategies targeting apoptotic and necrotic cell death for stroke

(2009) Junying Yuan   APOPTOSIS

Disruption of nNOS-PSD95 protein-protein interaction inhibits acute thermal hyperalgesia and chronic mechanical allodynia in rodents

(2009) SK Florio et al.   BRITISH JOURNAL OF PHARMACOLOGY

Regulation of PINK1 by NR2B-containing NMDA receptors in ischemic neuronal injury

(2009) Yuexin Shan et al.   JOURNAL OF NEUROCHEMISTRY

Neuroprotection After Status Epilepticus by Targeting Protein Interactions With Postsynaptic Density Protein 95

(2009) Crystal M. Dykstra et al.   JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY

Reverse glial glutamate uptake triggers neuronal cell death through extrasynaptic NMDA receptor activation

(2009) E. Gouix et al.   MOLECULAR AND CELLULAR NEUROSCIENCE

Role of NMDA receptor–dependent activation of SREBP1 in excitotoxic and ischemic neuronal injuries

(2009) Changiz Taghibiglou et al.   NATURE MEDICINE

Suppression of hippocampal TRPM7 protein prevents delayed neuronal death in brain ischemia

(2009) Hong-Shuo Sun et al.   NATURE NEUROSCIENCE

Organization and dynamics of PDZ-domain-related supramodules in the postsynaptic density

(2009) Wei Feng et al.   NATURE REVIEWS NEUROSCIENCE

Update of the Stroke Therapy Academic Industry Roundtable Preclinical Recommendations

(2009) Marc Fisher et al.   STROKE

Stroke Therapy Academic Industry Roundtable (STAIR) Recommendations for Extended Window Acute Stroke Therapy Trials

(2009) Jeffrey L. Saver et al.   STROKE

Evolution of NMDA receptor cytoplasmic interaction domains: implications for organisation of synaptic signalling complexes

(2008) Tomás J Ryan et al.   BMC NEUROSCIENCE

Specific Targeting of Pro-Death NMDA Receptor Signals with Differing Reliance on the NR2B PDZ Ligand

(2008) F. X. Soriano et al.   JOURNAL OF NEUROSCIENCE

Surface trafficking of N-methyl-d-aspartate receptors: Physiological and pathological perspectives

(2008) L. Groc et al.   NEUROSCIENCE

Differential Roles of NMDA Receptor Subtypes in Ischemic Neuronal Cell Death and Ischemic Tolerance

(2008) Min Chen et al.   STROKE

Effectiveness of PSD95 Inhibitors in Permanent and Transient Focal Ischemia in the Rat

(2008) Hong-Shuo Sun et al.   STROKE