Article
Multidisciplinary Sciences
Nissim Arish, Gabriel Izbicki, Ariel Rokach, Amir Jarjou'i, George Kalak, Shmuel Goldberg
Summary: Patients with both COVID-19 and obstructive sleep apnoea (OSA) have worse outcomes. This study found that high OSA risk was associated with severe COVID-19 and longer hospitalization. The Berlin and ESS questionnaires should be completed for every COVID-19-infected patient, especially those with comorbidities.
Review
Biochemistry & Molecular Biology
Maria Carmina Pau, Arduino Aleksander Mangoni, Elisabetta Zinellu, Gianfranco Pintus, Ciriaco Carru, Alessandro Giuseppe Fois, Pietro Pirina, Angelo Zinellu
Summary: The study found that whole blood SOD concentrations were significantly lower in patients with obstructive sleep apnoea, while serum/plasma SOD concentrations did not show a significant difference. This suggests an impaired antioxidant defence in OSA patients.
Article
Respiratory System
Thomas Gaisl, Protazy Rejmer, Maurice Roeder, Patrick Baumgartner, Noriane A. Sievi, Sandra Siegfried, Simon F. Staempfli, Robert Thurnheer, John R. Stradling, Felix C. Tanner, Malcolm Kohler
Summary: This study found that OSA may be a modest but independent risk factor for faster TAA expansion, potentially contributing to life-threatening complications in aortic disease. There was no association between OSA severity and aortic events in the participants.
EUROPEAN RESPIRATORY JOURNAL
(2021)
Article
Respiratory System
Xavier Waltz, Andrew E. Beaudin, Elise Belaidi, Jill Raneri, Jean-Louis Pepin, Vincent Pialoux, Patrick J. Hanly, Samuel Verges, Marc J. Poulin
Summary: Studies on rats and human patients have shown that intermittent hypoxia and obstructive sleep apnoea do not directly cause alterations in hemorheology. Despite the presence of oxidative stress or increased sensitivity to reactive oxygen species, no significant changes in hemorheological properties were observed.
EUROPEAN RESPIRATORY JOURNAL
(2021)
Review
Cardiac & Cardiovascular Systems
Susan Redline, Ali Azarbarzin, Yuksel Peker
Summary: In this Review, the authors summarize the shared risk factors and causal links between obstructive sleep apnoea (OSA) and cardiovascular disease (CVD), as well as the emerging knowledge on the heterogeneity of OSA. They also explore the potential role of new biomarkers for cardiovascular risk stratification in patients with OSA.
NATURE REVIEWS CARDIOLOGY
(2023)
Article
Chemistry, Multidisciplinary
Nicoleta Anton, Catalin Lisa, Bogdan Doroftei, Silvia Curteanu, Camelia Margareta Bogdanici, Dorin Chiselita, Daniel Constantin Branisteanu, Ionela Nechita-Dumitriu, Ovidiu-Dumitru Ilie, Roxana Elena Ciuntu
Summary: This study aimed to construct neural models to predict the progression of glaucoma in patients with sleep apnea. The results showed excellent outcomes during the validation stage, further supporting the connection between sleep apnea syndrome and glaucoma changes.
APPLIED SCIENCES-BASEL
(2022)
Review
Ophthalmology
Alex Jia Yang Cheong, Sean Kang Xuan Wang, Chang Yi Woon, Ki Han Yap, Kevin Joo Yang Ng, Flora Wen Xin Xu, Uri Alkan, Adele Chin Wei Ng, Anna See, Shaun Ray Han Loh, Tin Aung, Song Tar Toh
Summary: In this meta-analysis, OSA was found to be associated with a higher risk of glaucoma. After adjusting for confounding factors, patients with OSA had a 40% higher odds of developing glaucoma.
Article
Respiratory System
Rene Cortese, Taylor S. Adams, Kylie H. Cataldo, Justin Hummel, Naftali Kaminski, Leila Kheirandish-Gozal, David Gozal
Summary: Obstructive sleep apnoea (OSA) is a prevalent disease that affects neurocognitive, behavioural, metabolic, and cardiovascular function. This study used single-cell transcriptomics analysis to show the impact of OSA on the composition of immune cells in peripheral blood mononuclear cells (PBMCs), and identified severity-dependent differences in cell lineages. A molecular signature consisting of 32 genes was also identified, which could accurately distinguish OSA patients from controls.
EUROPEAN RESPIRATORY JOURNAL
(2023)
Article
Obstetrics & Gynecology
Peter G. Middleton
Summary: This review provides a summary of the interactions between pregnancy and breathing during sleep, and highlights the changes in respiratory function that can increase the incidence and severity of sleep-disordered breathing. The increased risk of snoring and obstructive sleep apnea hypopnea syndrome during pregnancy is discussed, and the potential impact of increasing obesity rates on sleep-disordered breathing in pregnant women is considered.
BEST PRACTICE & RESEARCH CLINICAL OBSTETRICS & GYNAECOLOGY
(2022)
Review
Respiratory System
Margaret Gleeson, Walter T. McNicholas
Summary: Obstructive sleep apnoea (OSA) is often associated with various comorbidities, including metabolic, cardiovascular, renal, pulmonary, and neuropsychiatric conditions. There is evidence to suggest a bidirectional relationship between OSA and comorbidity, with some comorbidities possibly predisposing to the development of OSA. The impact of therapy in bidirectional relationships is also reviewed, emphasizing the importance of accurate diagnosis.
EUROPEAN RESPIRATORY REVIEW
(2022)
Article
Respiratory System
Elena Diaz-Garcia, David Sanz-Rubio, Sara Garcia-Tovar, Enrique Alfaro, Pablo Cubero, Ana Gil, Jose M. Marin, Carolin Cubillos-Zapta, Francisco Garcia-Rio
Summary: This study found that OSA patients, especially those with eSA, have high levels of oxLDL, as well as an overexpression of NLRP3 cascade components and TF. In addition, oxLDL and plasma from OSA patients synergistically activate NLRP3 and enhance the inflammatory response, pyroptosis, and TF release. Therefore, there is a pathway mediated by oxLDL that contributes to the interaction between OSA and the development of atherosclerosis.
EUROPEAN RESPIRATORY JOURNAL
(2023)
Review
Cardiac & Cardiovascular Systems
John E. Sanderson, Fang Fang, Mi Lu, Chen Yao Ma, Yong Xiang Wei
Summary: OSA is recognized as a significant risk factor for HFpEF due to similar pathological effects and shared pathophysiological consequences, including activation of the sympathetic nervous system, renin-angiotensin-aldosterone system, systemic inflammatory state, and ultimately leading to myocardial fibrosis and structural changes that cause myocardial stiffening. Further trials of preventive treatment for OSA as a risk factor for HFpEF should be considered.
Article
Biochemistry & Molecular Biology
Yuki Kitamura, Shinji Oikawa, Jie Chang, Yurie Mori, Gaku Ichihara, Sahoko Ichihara
Summary: This study used 2D-Oxyblot and 2D-DIGE techniques to analyze carbonylated proteins induced by oxidative stress in a metabolic syndrome animal model, as well as changes in protein expression levels in adipose tissue at different stages of the syndrome. The results showed that up-regulated proteins at the pre-symptomatic stage were mainly involved in ATP production and redox reactions, while down-regulated proteins at the symptomatic stage were associated with antioxidant activity and the TCA cycle. Increased levels of carbonylated proteins, including gelsolin, may contribute to the oxidative stress state and progression of metabolic syndrome.
Review
Clinical Neurology
Ya-Nan Lv, Yu Cui, Bo Zhang, Shu-Ming Huang
Summary: Sleep deficiency is associated with an increased risk for Alzheimer's disease, potentially through its effects on oxidative stress, protein deposition, neuroinflammation, and synaptic loss.
FRONTIERS IN NEUROLOGY
(2022)
Article
Respiratory System
Jean-Benoit Martinot, Nhat-Nam Le-Dong, Atul Malhotra, Jean-Louis Pepin
Summary: Respiratory effort is a main feature of obstructive sleep apnoea (OSA), and is associated with sympathetic overactivity. This study found that the percentage of total sleep time spent with increased respiratory effort (REMOV,%TST), measured by mandibular jaw movements, can predict the prevalence of hypertension in adults with OSA.
EUROPEAN RESPIRATORY JOURNAL
(2023)
Letter
Ophthalmology
Naoko Aizawa, Hiroshi Kunikata, Toru Nakazawa
CLINICAL AND EXPERIMENTAL OPHTHALMOLOGY
(2019)
Article
Ophthalmology
Kohei Ichinohasama, Hiroshi Kunikata, Azusa Ito, Masayuki Yasuda, Shojiro Sawada, Keiichi Kondo, Chihiro Satake, Hideki Katagiri, Toru Nakazawa
JOURNAL OF OPHTHALMOLOGY
(2019)
Article
Multidisciplinary Sciences
Junko Ouchi, Hiroshi Kunikata, Kazuko Omodaka, Haruka Sato, Hiroyuki Sato, Azusa Ito, Naoko Aizawa, Yoshiki Tanaka, Kazuo Ichikawa, Toru Nakazawa
Article
Multidisciplinary Sciences
Risa Sato, Hiroshi Kunikata, Toshifumi Asano, Naoko Aizawa, Naoki Kiyota, Yukihiro Shiga, Koji M. Nishiguchi, Keiichi Kato, Toru Nakazawa
SCIENTIFIC REPORTS
(2019)
Article
Ophthalmology
Naoki Kiyota, Yukihiro Shiga, Masayuki Yasuda, Naoko Aizawa, Kazuko Omodaka, Satoru Tsuda, Kyongsun Pak, Hiroshi Kunikata, Toru Nakazawa
ACTA OPHTHALMOLOGICA
(2020)
Article
Ophthalmology
Taimu Sato, Koji M. Nishiguchi, Kosuke Fujita, Fuyuki Miya, Takashi Inoue, Erika Sasaki, Toshifumi Asano, Satoru Tsuda, Yukihiro Shiga, Hiroshi Kunikata, Mitsuru Nakazawa, Toru Nakazawa
ACTA OPHTHALMOLOGICA
(2020)
Article
Ophthalmology
Koji M. Nishiguchi, Hiroshi Kunikata, Kosuke Fujita, Kazuki Hashimoto, Yoshito Koyanagi, Masato Akiyama, Yasuhiro Ikeda, Yukihide Momozawa, Koh-Hei Sonoda, Akira Murakami, Yuko Wada, Toru Nakazawa
CLINICAL AND EXPERIMENTAL OPHTHALMOLOGY
(2020)
Article
Ophthalmology
Masaald Yoshida, Hiroshi Kunikata, Shiho Kunimatsu-Sanuki, Toru Nakazawa
JOURNAL OF OPHTHALMOLOGY
(2019)
Article
Ophthalmology
Urara Osada, Hiroshi Kunikata, Masayuki Yasuda, Kazuki Hashimoto, Koji M. Nishiguchi, Toru Nakazawa
GRAEFES ARCHIVE FOR CLINICAL AND EXPERIMENTAL OPHTHALMOLOGY
(2020)
Letter
Ophthalmology
Hiroshi Kunikata, Urara Osada, Toshiaki Abe, Toru Nakazawa
GRAEFES ARCHIVE FOR CLINICAL AND EXPERIMENTAL OPHTHALMOLOGY
(2021)
Article
Ophthalmology
Ninomiya Takahiro, Hiroshi Kunikata, Ishikawa Makoto, Toru Nakazawa
GRAEFES ARCHIVE FOR CLINICAL AND EXPERIMENTAL OPHTHALMOLOGY
(2023)
Article
Ophthalmology
Tatsu Okabe, Hiroshi Kunikata, Masayuki Yasuda, Shinjiro Kodama, Yuta Maeda, Joe Nakano, Dan Takeno, Nobuo Fuse, Toru Nakazawa
Summary: Non-invasive measurements of the nailfold capillaries were associated with the presence and severity of diabetic retinopathy in patients with type 2 diabetes. Systemic characteristics such as age, sex, blood pressure, and medical history can help predict the presence of DR and PDR. Adding nailfold capillary length to systemic findings can improve the discriminative power of diabetic retinopathy.
GRAEFES ARCHIVE FOR CLINICAL AND EXPERIMENTAL OPHTHALMOLOGY
(2023)
Article
Ophthalmology
Naoki Kiyota, Yukihiro Shiga, Nana Takahashi, Masayuki Yasuda, Kazuko Omodaka, Satoru Tsuda, Hiroshi Kunikata, Toru Nakazawa
OPHTHALMOLOGY GLAUCOMA
(2020)
Letter
Ophthalmology
Hiroshi Kunikata, Kosuke Fujita, Koji M. Nishiguchi, Toru Nakazawa
CLINICAL AND EXPERIMENTAL OPHTHALMOLOGY
(2018)
Article
Ophthalmology
Naoki Kiyota, Hiroshi Kunikata, Seri Takahashi, Yukihiro Shiga, Kazuko Omodaka, Toru Nakazawa
ACTA OPHTHALMOLOGICA
(2018)