Article
Biochemistry & Molecular Biology
Ruimin Liu, Yan Sun, Shuai Chen, Yun Hong, Zhongxian Lu
Summary: This study identifies a mutual inhibition between the tumor suppressor Foxd3 and the tumor enhancer Gab2 in hepatocellular carcinoma. Foxd3 inhibits the expression of Gab2 and its associated cell proliferation and migration, providing a potential therapeutic target for liver cancer.
Article
Pharmacology & Pharmacy
Fang Liu, Xin-Ting Zhu, Yi Li, Chen-jing Wang, Jia-li Fu, Jing Hui, Yi Xiao, Liu Liu, Rong Yan, Xiao-Fei Li, Yun Liu
Summary: The study demonstrated that Magnesium demethylcantharidate (MDC) has inhibitory effects on the invasion and metastasis of hepatocellular carcinoma (HCC) cells, through activating the transcription factor FOXO1. The combination of MDC and sorafenib showed significant enhancement in inhibiting HCC cell invasion and metastasis compared to single drug treatment, indicating that MDC could be a potential therapeutic candidate against the invasion and metastasis of HCC.
EUROPEAN JOURNAL OF PHARMACOLOGY
(2021)
Article
Cell Biology
Bowen Liu, Jinling Cao, Biting Wu, Kaixuan Hao, Xiangyun Wang, Xin Chen, Zhifa Shen
Summary: This study reveals that METTL3 and STAT3 are both highly expressed in high-metastatic HCC cells and tissues, with a positive correlation between their expression in HCC tissues. Mechanistically, METTL3 induces m6A modification of STAT3 mRNA, promoting its translation, while STAT3 promotes nuclear localization and methyltransferase function of METTL3. METTL3 and STAT3 form a positive feedback loop to accelerate HCC metastasis. These findings provide insights into the mechanisms of HCC metastasis and suggest the METTL3-STAT3 feedback signaling as a potential target for anti-metastatic treatment of HCC.
CELL COMMUNICATION AND SIGNALING
(2023)
Article
Pharmacology & Pharmacy
Jiamei Le, Yi Fu, Qiuqin Han, Yujie Ma, Houlin Ji, Xindong Wei, Yifan Chen, Yongning Sun, Yueqiu Gao, Hailong Wu
Summary: This study revealed that SA has significant inhibitory effects on the migration and invasion of HCC, and identified differentially expressed genes through transcriptome analysis. The findings provide new insights into the inhibitory effects and potential targets of SA on HCC metastasis.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Gastroenterology & Hepatology
Keren Li, Yi Niu, Kai Li, Chengrui Zhong, Zhiyu Qiu, Yichuan Yuan, Yunxing Shi, Zhu Lin, Zhenkun Huang, Dinglan Zuo, Yunfei Yuan, Binkui Li
Summary: The study revealed the crucial role of PLOD2 in HCC metastasis, which was mediated by promoting BIRC3. Additionally, the high expression of PLOD2 was associated with poor survival in HCC patients, indicating its potential as a valuable prognostic biomarker for HCC treatment.
JOURNAL OF CLINICAL AND TRANSLATIONAL HEPATOLOGY
(2023)
Article
Gastroenterology & Hepatology
Zhen-Jie Li, Jin-Ping Zhang, Dong-Ying Li, Hui-Yu Yang, Bing-Rong Liu
Summary: The study reveals that ATF2 promotes cell proliferation, migration, invasion and metastasis in HCC by regulating the miR-548p/TUFT1 axis. This finding provides new insights into the pathogenesis of HCC and the development of novel medications.
HEPATOLOGY RESEARCH
(2022)
Article
Cell Biology
Qun Zhang, Ping Feng, Xun-Hua Zhu, Shi-Qing Zhou, Ming-Liang Ye, Xiao-Jing Yang, Sha Gong, Sheng-Yan Huang, Xi-Rong Tan, Shi-Wei He, Ying-Qing Li
Summary: DNAJA4 is hypermethylated and downregulated in nasopharyngeal carcinoma (NPC). Overexpression of DNAJA4 inhibits NPC cell migration, invasion, and EMT by promoting MYH9 protein degradation. Low level of DNAJA4 is associated with poor prognosis and increased probability of distant metastasis in NPC patients.
CELL DEATH & DISEASE
(2023)
Article
Cell Biology
Qipeng Wu, Le Li, Chunmeng Miao, Muhammad Hasnat, Lixin Sun, Zhenzhou Jiang, Luyong Zhang
Summary: This study demonstrates that osteopontin (OPN) promotes hepatocellular carcinoma (HCC) progression by increasing reactive oxygen species (ROS) production through upregulating the expression of NADPH oxidase 1 (NOX1) and activating the JAK2/STAT3 signaling pathway. Disruption of the OPN/NOX1 axis might be a promising therapeutic strategy for HCC.
CELL DEATH & DISEASE
(2022)
Article
Medicine, Research & Experimental
Yijie Hao, Qingxia Yang, Qiye He, Huanjing Hu, Zongpeng Weng, Zhixi Su, Shuling Chen, Sui Peng, Ming Kuang, Zhihang Chen, Lixia Xu
Summary: In this study, we developed and established a preoperative predictive model for microvascular invasion (MVI) status in patients with hepatocellular carcinoma (HCC) based on DNA methylation markers. The model showed high accuracy and is important for surgical strategy determination in HCC patients.
EUROPEAN JOURNAL OF MEDICAL RESEARCH
(2022)
Article
Biotechnology & Applied Microbiology
Xiaoming Jiang, Zhe Chu, Yang Cao, Ying Tang, Ying Shi, Xu Shi
Summary: Hepatocellular carcinoma (HCC) is a common and deadly malignancy worldwide. This study found that the downregulation of PDLIM2 in HCC is associated with poor prognosis, and overexpressed PDLIM2 can inhibit HCC cell proliferation, migration, invasion, and EMT by regulating beta-catenin, suggesting PDLIM2 as a promising therapeutic target for HCC.
CANCER GENE THERAPY
(2021)
Article
Biochemistry & Molecular Biology
Guang-Ang Tian, Wen-Ting Xu, Xue-Li Zhang, Yao-Qi Zhou, Yue Sun, Li-Peng Hu, Shu-Heng Jiang, Hui-Zhen Nie, Zhi-Gang Zhang, Lei Zhu, Jun Li, Xiao-Mei Yang, Lin -Li Yao
Summary: This study found that the extracellular matrix-related protein CCBE1 promotes mitochondrial fusion in hepatocellular carcinoma (HCC) and inhibits mitochondrial fission by preventing the localization of DRP1 on mitochondria through inhibiting its phosphorylation at Ser616 by directly binding with TGF3R2 to inhibit TGF3 signaling activity. Increased CCBE1 expression or treatment with recombinant CCBE1 protein significantly inhibited HCC cell proliferation, migration, and invasion in vitro and in vivo, suggesting CCBE1 as a potential therapeutic strategy for HCC.
Article
Oncology
Yao Lu, Deng Huang, Baolin Wang, Bowen Zheng, Jialong Liu, Juxian Song, Shuguo Zheng
Summary: This study found that FAM21C binds to CAPZA1 and inhibits its capping ability, thus promoting the invasion and migration of hepatocellular carcinoma cells.
FRONTIERS IN ONCOLOGY
(2022)
Article
Gastroenterology & Hepatology
Shizhong Yang, Yanfeng Liu, Xiaobin Feng, Xiaojuan Wang, Meilong Wu, Lei Gong, Bin Shu, Qian Lu, Jiahong Dong
Summary: The study showed that HBx is highly expressed in HCC tissues and promotes migration and invasion of HCC cells, both in vitro and in vivo. HBx can serve as a novel therapeutic target for HCC.
DIGESTIVE AND LIVER DISEASE
(2021)
Article
Multidisciplinary Sciences
Zirui Jia, Jiacheng Gao, Yuhang Wang, Tingting Zhou, Xiangwen Zhang, Guo Zu
Summary: Through meta-analysis and bioinformatics analysis, the study investigated the relationship between LOX expression and methylation level with clinicopathological parameters and prognosis in GC patients. Results showed that LOX expression was related to lymph node metastasis, tumor distant metastasis, and poor prognosis, while low methylation levels were associated with advanced tumor stage and poor prognosis.
SCIENTIFIC REPORTS
(2022)
Article
Biochemistry & Molecular Biology
Zichang Dai, Qiyuan Huang, Xueran Huang, Chuiyu Zhu, Kashif Rafiq Zahid, Tiancai Liu, Qiuyan Li, Chunmei Wu, Minghui Peng, Xiangyan Xiao, Umar Raza, Nan Yu, Tao Zeng
Summary: The expression of KIN17 is significantly increased in HCC and is associated with tumor progression and metastasis. KIN17 promotes migration and invasion of HCC cells by stimulating the TGF-beta/Smad2 pathway. It could serve as a potential therapeutic target and prognostic biomarker in HCC.
MOLECULAR CARCINOGENESIS
(2023)
