Article
Biochemistry & Molecular Biology
Wenyu Wang, Huan Sheng, Daihong Cao, Fenglian Zhang, Weifen Zhang, Fang Yan, Dejun Ding, Ni Cheng
Summary: This study developed a multifunctional wound dressing by connecting endogenous NO donor to nanoparticles. The dressing achieved NO release and photothermal therapy through photothermal conversion, enhancing antimicrobial efficacy and wound healing activities. In addition, the dressing exhibited good biocompatibility.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2022)
Article
Engineering, Biomedical
Kavoos Razmjooee, Fereshteh Oustadi, Alireza Golaghaei, Ehsan Nassireslami
Summary: Despite progress in developing diabetic wound dressing, an ideal one that promotes angiogenesis and has antibacterial properties is still lacking. This study used nitric oxide as an angiogenic agent and loaded it into a composite film. The in-vivo test showed that this wound dressing was more effective in diabetic wound healing compared to other dressings.
BIOMEDICAL MATERIALS
(2022)
Article
Materials Science, Biomaterials
Jianhua Zhang, Junfei Hu, Baoshu Chen, Tianbao Zhao, Zhipeng Gu
Summary: The PAA/PEA hybrid hydrogel dressing exhibits good antioxidant properties which can promote wound healing, support cell proliferation, and angiogenesis. Experimental results on mouse skin wounds demonstrate that the hybrid hydrogel scaffolds significantly accelerate the wound healing process, showing superior healing effects.
REGENERATIVE BIOMATERIALS
(2021)
Article
Materials Science, Biomaterials
Jie Dou, Rong Yang, Xingxing Jin, Pengfei Li, Xiao Han, Lijuan Wang, Bo Chi, Jian Shen, Jiang Yuan
Summary: Nitric oxide plays a crucial role in wound healing, and the PU/KSNO biocomposite mats show excellent cytocompatibility and antibacterial properties, promoting the wound healing process.
REGENERATIVE BIOMATERIALS
(2022)
Article
Chemistry, Multidisciplinary
Zijie Luo, Yingzhu Zhou, Tao Yang, Yuan Gao, Priyank Kumar, Rona Chandrawati
Summary: Ceria nanoparticles can induce the generation of nitric oxide in addition to scavenging it. This study demonstrates that ceria nanoparticles catalytically decompose S-nitrosoglutathione to produce nitric oxide, with a high release recovery rate and maintained crystalline structure. The newly discovered capability of ceria nanoparticles to generate nitric oxide from GSNO overturns the conventional concept of their role solely as NO-scavenging agents, and shows potential therapeutic effects in cancer cell suppression.
Article
Chemistry, Multidisciplinary
Lin Teng, Yingying Song, Lingli Hu, Qian Bai, Xueliang Zhang, Chang-Ming Dong
Summary: A novel NO-releasing poly(L-glutamic acid) based graphene oxide hybrid hydrogel was constructed to inhibit inflammation and bacterial infection in diabetic wounds, showing good biocompatibility and the ability to control pulsatile NO release. The hydrogel exhibited excellent antibacterial activity through a combination of photothermia and NO release, and achieved effective hemostasis and diabetic wound healing in vivo.
CHINESE JOURNAL OF CHEMISTRY
(2023)
Article
Chemistry, Multidisciplinary
Pengpeng Jia, Yu Zou, Jiang Jiang
Summary: This study proposes a hydrogel dressing co-loaded with CuS nanoparticles and NO donors, which exhibits excellent antibacterial and repair-promoting activity for the treatment of infected wounds. Compared to dressings with single active agent, this hydrogel dressing shows better therapeutic effects both in vitro and in vivo.
Article
Environmental Sciences
Esmaeel Sharifi, Rezvan Jamaledin, Fatemeh Familsattarian, Fereshteh Nejaddehbashi, Mitra Bagheri, Mohammad Chehelgerdi, Ehsan Nazarzadeh Zare, Omid Akhavan
Summary: This research evaluated the potential of bioactive chitosan@poly (ethylene oxide)@CuFe2O4 (CS@PEO@CF) nanofibers in wound healing. The nanoparticles showed antibacterial and antioxidant properties and did not adversely affect fibroblast cell viability. The nanofibrous mats promoted cell migration and growth at the wound edge, leading to enhanced wound healing and regeneration of sebaceous glands and hair follicles within the skin.
ENVIRONMENTAL RESEARCH
(2023)
Article
Engineering, Multidisciplinary
Jiahui He, Zhenlong Li, Jiaxin Wang, Tongyang Li, Jueying Chen, Xianglong Duan, Baolin Guo
Summary: This study developed a multifunctional hydrogel with antibacterial, antioxidant, self-healing, and conductive properties. The hydrogel is capable of releasing nitric oxide (NO) under near-infrared (NIR) laser irradiation, which promotes the healing of diabetic wounds.
COMPOSITES PART B-ENGINEERING
(2023)
Article
Polymer Science
Jingying Zhang, Guannan Zhang, Yong Wang, Xiujun Qin, Ying Lu, Zhifang Wu, Chuxin Zhang, Li Xu, Jiali Han, Shuai Yang, Jianbo Song, Sijin Li
Summary: In this study, a hydrogel containing L-arginine-modified carboxymethyl cellulose and chitosan was developed, which exhibited antibacterial and nitric oxide-release properties and accelerated wound healing by promoting vascular reconstruction. The hydrogel showed good degradability and biocompatibility, as well as excellent inhibitory effects against Staphylococcus aureus. Furthermore, the hydrogel released nitric oxide, which benefited angiogenesis and promoted wound healing. This safe, antibacterial, and collaborative system has great potential for application in skin tissue engineering.
EUROPEAN POLYMER JOURNAL
(2023)
Article
Chemistry, Inorganic & Nuclear
Anna Wadolek, Maria Oszajca, Wiktoria Pecak, Malgorzata Brindell, Grazyna Stochel
Summary: S-Nitrosothiols act as a reservoir of releasable nitric oxide in vivo, and exposure to PM can affect their stability. Copper ions play a dominant role in inducing NO release from S-nitrosoalbumin, with the potential participation of other water-soluble PM components. Ascorbic acid enhances the effectiveness of NO release by PM extracts by promoting the reduction of Cu2+ to Cu+.
DALTON TRANSACTIONS
(2021)
Article
Medicine, Research & Experimental
Kaan Kaltalioglu
Summary: This study found that sinapic acid, a phytochemical, has the potential to promote wound healing in individuals with diabetes. By using sinapic acid-loaded gels, the researchers observed improved re-epithelialization and angiogenesis, increased collagen content, and decreased oxidative damage in diabetic wounds. These findings suggest that topical application of sinapic acid can be an effective approach for promoting diabetic wound healing, especially at low doses.
BIOMEDICINE & PHARMACOTHERAPY
(2023)
Article
Chemistry, Multidisciplinary
Shun Yao, Yuetong Wang, Junjie Chi, Yunru Yu, Yuanjin Zhao, Yuan Luo, Yongan Wang
Summary: A novel porous metal-organic framework (MOF) microneedle (MN) patch enabling photothermal-responsive nitric oxide (NO) delivery for promoting diabetic wound healing is presented. The NO-loadable copper-benzene-1,3,5-tricarboxylate (HKUST-1) MOF encapsulated with graphene oxide (GO) facilitates controlled release of NO molecules, resulting in accelerated vascularization, tissue regeneration, and collagen deposition in diabetic wound healing.
Review
Pharmacology & Pharmacy
Gina Tavares, Patricia Alves, Pedro Simoes
Summary: This article discusses the application of nitric oxide in wound healing, with hydrogels being studied as carriers for storing and delivering NO, showing promising results in improving wound healing, controlling and sustaining NO release, and bactericidal properties.
Article
Chemistry, Applied
Xiaozhao Wang, Jixuan Cao, Jin Qiao, Jing Pan, Song Zhang, Qingqing Li, Qingguo Wang, Biao Gong, Jingying Shi
Summary: This study found that treating cherry tomatoes with GABA can enhance their disease resistance by regulating GSNOR to maintain endogenous NO balance.
Article
Polymer Science
Giorgio Marques Milani, Isabela Trindade Coutinho, Felipe Nogueira Ambrosio, Monica Helena Monteiro do Nascimento, Christiane Bertachini Lombello, Everaldo Carlos Venancio, Mathilde Champeau
Summary: The combination of conducting polymers and hydrogels in a conductive interpenetrated polymer network (CIPN) has the potential to mimic muscles and create bending actuators. This study synthesized and characterized PAA/PPy CIPNs with different compositions, and found promising materials with good mechanical response and reversibility.
JOURNAL OF APPLIED POLYMER SCIENCE
(2022)
Article
Multidisciplinary Sciences
Li Han, Carlos P. Jara, Ou Wang, Yu Shi, Xinran Wu, Sandra Thibivilliers, Rafal K. Woycicki, Mark A. Carlson, William H. Velander, Eliana P. Araujo, Marc Libault, Chi Zhang, Yuguo Lei
Summary: This study presents a robust method for isolating and cryopreserving pig skin single cells for scRNA-seq, allowing researchers to identify major skin cell types in pigs.
Article
Polymer Science
Laura C. E. da Silva, Maria do Carmo Goncalves, Marcelo G. de Oliveira
Summary: In this study, cellulose nanocrystals (CNC)-based foams with a supramolecular structure were prepared by in situ condensation. The foams showed excellent thermal stability, structural stability, and compressive strength, as well as the ability to release nitric oxide (NO) locally.
MACROMOLECULAR RAPID COMMUNICATIONS
(2022)
Correction
Multidisciplinary Sciences
Sara Abalde-Cela, Patricia Taladriz-Blanco, Marcelo Ganzarolli de Oliveira, Chris Abell
SCIENTIFIC REPORTS
(2022)
Article
Spectroscopy
Andre M. Batista, Leticia Foiani, Mathilde Champeau, Herculano Martinho
Summary: This article primarily introduces the applications of techniques such as Raman, atomic force microscopy, and tip-enhanced Raman scattering in the study of cells and tissues, as well as the detailed physical, chemical, biophysical, and physiological property analysis they can provide. It also discusses the limitations, drawbacks, and future prospects of these technologies.
JOURNAL OF RAMAN SPECTROSCOPY
(2022)
Article
Cardiac & Cardiovascular Systems
Rafael L. Camargo, Bruna Bombassaro, Milena Monfort-Pires, Eli Mansour, Andre C. Palma, Luciana C. Ribeiro, Raisa G. Ulaf, Ana Flavia Bernardes, Thyago A. Nunes, Marcus V. Agrela, Rachel P. Dertkigil, Sergio S. Dertkigil, Eliana P. Araujo, Wilson Nadruz, Maria Luiza Moretti, Licio A. Velloso, Andrei C. Sposito
Summary: This study investigated the blood levels of ACE, ACE2, angiotensin-II, angiotensin (1-7), and angiotensin (1-9) in patients with COVID-19 and found that elevated levels of angiotensin-II were associated with a higher risk of developing critical symptoms. Early measurement of angiotensin-II could serve as a useful biomarker for identifying patients at higher risk of severe progression of the disease.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2022)
Article
Endocrinology & Metabolism
Robert Haddad Tovolli, Joseane Morari, Roberta Barbizan, Vanessa C. Bobbo, Rodrigo S. Carraro, Carina Solon, Nathalia R. Dragano, Marcio A. Torsoni, Eliana P. Araujo, Licio A. Velloso
Summary: Maternal obesity is a significant risk factor for obesity, cardiovascular, and metabolic diseases in offspring. It leads to inflammation in the hypothalamus of the offspring, affecting the function of neurons that regulate food intake and energy expenditure. Maternal obesity-induced structural and functional damage to the offspring's hypothalamic BBB, but breastfeeding by lean mothers can partially reverse these effects.
AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM
(2023)
Article
Nursing
Thais P. Prado, Carlos P. Jara, Vanessa C. Dias Bobbo, Rodrigo S. Carraro, Davi Sidarta-Oliveira, Guilherme R. A. de Mendonca, Licio A. Velloso, Eliana P. Araujo
Summary: The aim of this study was to evaluate the effects of topical GW9508 on wound healing in mice. The results showed that GW9508 accelerated wound healing, decreased the expression of IL-10 and metalloproteinase 9 genes, increased the quantity of Collagen I, and improved the organization of collagen fibres. Therefore, GW9508 could be an attractive drug treatment for wounded skin.
BIOLOGICAL RESEARCH FOR NURSING
(2023)
Article
Biology
T. P. Prado, J. Morari, E. P. Araujo
Summary: Diabetes increases the risk of skin infections and foot ulcers. The effects of diabetes on uninjured skin are less studied. However, it is known that diabetes can cause increased oxidative stress and lipid peroxidation. In this study, hyperglycemia in mice induced a decrease in Il-6 and an increase in Tnf-a, Il-10, F4/80, Tgf-b, and Igf-1. It also led to lower cellular density, delayed collagen fiber maturation, decreased neuron number, and decreased Bdnf expression in the skin.
BRAZILIAN JOURNAL OF MEDICAL AND BIOLOGICAL RESEARCH
(2023)
Article
Biochemistry & Molecular Biology
Matheus F. de Oliveira, Laura C. E. da Silva, Daniele M. Catori, Marcos Lorevice, Karen E. A. Galvao, Ana L. G. Millas, Marcelo G. de Oliveira
Summary: This study reports the fabrication of a novel elastomeric, bioabsorbable, and photocurable copolyester for the design of bioresorbable vascular stents capable of releasing nitric oxide (NO). The release rate of NO can be modulated by varying the composition of the copolyester and the strut geometry of the stents.
MACROMOLECULAR BIOSCIENCE
(2023)
Article
Virology
Bruna Rafaela Santos Silva, Carlos Poblete Jara, Davi Sidarta-Oliveira, Licio A. Velloso, William H. Velander, Eliana P. Araujo
Summary: This study found changes in the expression of the protein C signaling network in patients with COVID-19, including downregulation of protein C and its downstream cascade components. Transcripts encoding proteins at the interface between coagulation and the immune system were upregulated in the liver and peripheral blood cells, while ciliated cells in the nasal epithelium expressed transcripts encoding both ACE2 and proteins related to the coagulation and immune system interface.
Proceedings Paper
Polymer Science
Daniele M. Catori, Marcos Lorevice, Laura C. E. da Silva, Geovany Candido, Ana L. C. Millas, Marcelo C. de Oliveira
Summary: This study successfully utilized the Freeform Reversible Embedding of Suspended Hydrogels (FRESH) extrusion-based technique to fabricate self-supported 3D constructs from low-viscosity polysaccharide inks, providing new possibilities for soft tissue repair or substitution.
MACROMOLECULAR SYMPOSIA
(2022)
Proceedings Paper
Polymer Science
Herllan V. de Almeida, Daniele M. Catori, Laura C. E. da Silva, Marcelo G. de Oliveira
Summary: This study functionalizes chitosan to produce S-nitroso derivatives that exhibit enhanced thermal stability in the dark and can release nitric oxide upon light-triggered activation. These CS-based biomaterials have potential biomedical applications.
MACROMOLECULAR SYMPOSIA
(2022)
Article
Chemistry, Multidisciplinary
Daniel J. da Silva, Guilherme B. Gramcianinov, Pamela Z. Jorge, Vanessa B. Malaquias, Augusto A. Mori, Mario H. Hirata, Sergio A. M. Lopes, Luciano A. Bueno, Mathilde Champeau, Danilo J. Carastan
Summary: In order to prevent biofouling and combat the COVID-19 virus, PVC nanocomposites with silver nanoparticles (AgNPs) were prepared. The PVC/AgNP nanocomposites exhibit virucidal activity against SARS-CoV-2 when the AgNP content is at least 0.3 wt%, making them suitable for manufacturing furniture and medical equipment with self-disinfectant capacity to prevent secondary routes of COVID-19 transmission.
FRONTIERS IN CHEMISTRY
(2023)
Article
Nanoscience & Nanotechnology
Daniele M. Catori, Laura C. E. da Silva, Matheus F. de Oliveira, Grace H. Nguyen, Joseph C. Moses, Elizabeth J. Brisbois, Hitesh Handa, Marcelo G. de Oliveira
Summary: Studies have shown that local release of nitric oxide (NO) from hydrogels stimulates tissue regeneration. In this study, a hydrogel composed of methacrylated hyaluronic acid (HAGMA) and thiolated gelatin (GELSH) was engineered for in situ photo-cross-linking and localized NO release. The hydrogel loaded with PLGA-GSNO nanoparticles demonstrated sustained NO release and showed biocompatibility, promoting fibroblast adhesion and proliferation. This study provides a promising avenue for achieving localized and sustained NO delivery in tissue regeneration applications.
ACS APPLIED MATERIALS & INTERFACES
(2023)