期刊
ACTA BIOCHIMICA ET BIOPHYSICA SINICA
卷 50, 期 10, 页码 941-949出版社
OXFORD UNIV PRESS
DOI: 10.1093/abbs/gmy092
关键词
TGF-beta; cancer; EMT; immune; cancer treatment
资金
- National Natural Science Foundation of China [31771546, 91540205, 31730057, 31571447]
- Zhejiang Provincial Natural Science Foundation [LY17C07002]
- Fundamental Research Funds for the Central Universities
Signals from the transforming growth factor-beta (TGF-beta) superfamily mediate a broad spectrum of cellular processes and are deregulated in many diseases, including cancer. TGF-beta signaling has dual roles in tumorigenesis. In the early phase of tumorigenesis, TGF-beta has tumor suppressive functions, primarily through cell cycle arrest and apoptosis. However, in the late stage of cancer, TGF-beta acts as a driver of tumor progression and metastasis by increasing tumor cell invasiveness and migration and promoting chemo-resistance. Here, we briefly review the mechanisms and functions of TGF-beta signaling during tumor progression and discuss the therapeutic potentials of targeting the TGF-beta pathway in cancer.
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