Article
Nanoscience & Nanotechnology
Seounghun Kang, Gyeonghye Yim, Se-Youl Chae, Subean Kim, Yeong-Gyu Gil, Young-Kwan Kim, Dal-Hee Min, Hongje Jang
Summary: This study designed a method for synthesizing highly crystalline Rh nanocrystal-decorated Rh-Te nanorods and demonstrated their excellent performance in heat dissipation and photocatalysis. In vitro and in vivo experiments confirmed the selective physical death of cancer cells using RhTeNRs in phototherapy.
ACS APPLIED MATERIALS & INTERFACES
(2022)
Article
Engineering, Biomedical
Zhenhu Guo, Jingsong Lu, Dan Wang, Wensheng Xie, Yongjie Chi, Jianzhong Xu, Nonaka Takuya, Junxin Zhang, Wanling Xu, Fei Gao, Hong Wu, Lingyun Zhao
Summary: In this study, litchi-shaped heterogeneous gallium indium-gold nanoparticles were successfully prepared and utilized as effective radiosensitizers and photothermal agents for radio-photothermal cancer therapy, showing promising therapeutic effects.
BIOACTIVE MATERIALS
(2021)
Article
Chemistry, Multidisciplinary
Hongda Lu, Shi-Yang Tang, Jiayuan Zhu, Xumin Huang, Helen Forgham, Xiangke Li, Ao Shen, Guolin Yun, Jinming Hu, Shiwu Zhang, Thomas P. Davis, Weihua Li, Ruirui Qiao
Summary: By nanoengineering liquid metal nanoparticles and using galvanic replacement, diverse core-shell nanostructures including LM@Au, Au@Ga oxide, and hollow Ga oxide nanoparticles are successfully fabricated. LM@Au exhibits exceptional photothermal performance with a conversion efficiency of 65.9%, which is five times that of gold nanoparticles. The high photothermal conversion efficiency and biocompatibility of LM@Au show promising applications in hyperthermia cancer therapy.
ADVANCED FUNCTIONAL MATERIALS
(2023)
Article
Materials Science, Multidisciplinary
Jinling Zhao, Guozhi Jia, Yang Li, Lingxia Li
Summary: A convenient method for large-scale synthesis of Cu2O-Ag nanocomposites is reported through a spontaneous galvanic replacement reaction. The structural properties and chemical states of Cu2O-Ag are characterized by XRD and XPS techniques, respectively. The morphology and microstructure of Cu2O-Ag are further examined using TEM and HRTEM, revealing the formation of Ag clusters on the surfaces of Cu2O. The enhanced photothermal conversion characteristics of Cu2O-Ag nanocomposites may be attributed to the enhancement of infrared absorption of Cu2O by thin silver clusters.
APPLIED PHYSICS A-MATERIALS SCIENCE & PROCESSING
(2023)
Review
Materials Science, Multidisciplinary
Mingming Fu, Yifeng Shen, Hao Zhou, Xiaojia Liu, Wenjun Chen, Xing Ma
Summary: Gallium-based liquid metals have unique properties that have attracted significant interest in the biomedical field. Photothermal therapy has shown great development in antitumor treatment and the photothermal capability of gallium-based liquid metals provides unparalleled advantages. This review presents the major preparation methods of liquid metal micro/nanoparticles, the mechanism of liquid metal photothermal conversion, and discusses the factors affecting the photothermal properties of liquid metals. The biological applications, challenges, and opportunities for the clinical translation of liquid metals in biomedical applications are also discussed.
JOURNAL OF MATERIALS SCIENCE & TECHNOLOGY
(2023)
Article
Biophysics
Bao Jiang, Liping Wang, Gang Wu, Lin Zhou, Shaohua Wei
Summary: Researchers have successfully synthesized a core-shell CDT drug FeCNB, which achieves high-efficiency CDT under physiological pH conditions through the galvanic cell structure formed in physiological electrolyte solution. FeCNB not only has T2-magnetic resonance imaging function and photothermal conversion ability, but also improves the CDT effect through tumor heating to achieve a satisfactory synergistic photothermal therapy (PTT)/CDT outcome.
COLLOIDS AND SURFACES B-BIOINTERFACES
(2022)
Article
Chemistry, Applied
Bingyu Xu, Zhao Wang, Weimin Zhao
Summary: A novel photosensitizer aggregate has been designed and constructed, showing high photothermal conversion efficiency and good hydrophilia, suitable for both photodynamic therapy and photothermal therapy, resulting in superior antitumor performance. Additionally, the aggregate exhibits excellent biocompatibility and safety for biomedical applications.
Article
Chemistry, Multidisciplinary
Gyeonghye Yim, Seounghun Kang, Subean Kim, Hongje Jang
Summary: Due to their unique physicochemical properties, hybrid nanoparticles with different elemental compositions can be widely used for various applications. In this study, iridium-tellurium nanorods (IrTeNRs) were synthesized by galvanic replacement to combine the sacrificial template properties of tellurium nanorods with the presence of iridium. The resulting IrTeNRs exhibited peroxidase-like activity, photoconversion, and exceptional colloidal stability in complete media. Based on these properties, IrTeNRs were applied for cancer therapy, enabling enzymatic therapy through reactive oxygen species generation and cancer cell apoptosis through photothermal and photodynamic therapy under laser irradiation.
Article
Chemistry, Physical
Nishakavya Saravanan, Prasanna Ganesh, Sudhagar Pitchaimuthu, Anandhakumar Sundaramurthy
Summary: The fabrication of nanomaterials with the ability to mimic biological enzymes (nanozymes) is gaining popularity in biomedical applications, particularly in cancer photothermal therapy. This study focuses on the synthesis of MoS2 nanoflowers (NFs) decorated with CeO2 nanoparticles (NPs) using linker molecules of cysteine and polyethylenimine. The resulting nanozymes demonstrated promising photo-thermal heat generation and anti-cancer activity, with potential for use in cancer photothermal therapy.
SURFACES AND INTERFACES
(2023)
Article
Nanoscience & Nanotechnology
Seounghun Kang, Yeong-Gyu Gil, Gyeonghye Yim, Dal-Hee Min, Hongje Jang
Summary: Os-Te nanorods with superior photothermal conversion and photocatalytic activity were synthesized and utilized for a pentamodal treatment for hepatocellular carcinoma, demonstrating effectiveness in alleviating hypoxia and reducing unintended drug accumulation in organs.
ACS APPLIED MATERIALS & INTERFACES
(2021)
Article
Biochemistry & Molecular Biology
Xiao-Zhen Yang, Lin-Feng Wen, Gan Xu, Hao-Hua Lin, Shuai Wang, Jian-Yong Liu
Summary: This study developed two organic photothermal agents based on aza-BODIPY, which showed improved optical properties and demonstrated efficacy in tumor inhibition and metastasis prevention when encapsulated into nanoparticles.
BIOORGANIC CHEMISTRY
(2023)
Article
Medicine, Research & Experimental
Cui Wei, Pengfei Wang, Zhenpeng Huang, Dahua He, Wanye Zhu, Huan Liu, Zhihao Chen, Wanting Wang, Yusheng Li, Juan Shen, Linghao Qin
Summary: A nanocarrier delivery system was developed for targeted cancer therapy using polydopamine-coated nanoparticles loaded with doxorubicin, combining chemotherapy and photothermal therapy. The system demonstrated excellent stability, photothermal conversion, and controlled drug release with pH, NIR irradiation, and redox level dependency. In vivo studies showed improved antitumor efficacy and reduced cardiotoxicity compared to free doxorubicin, highlighting the potential of this system for effective and precise cancer treatment.
MOLECULAR PHARMACEUTICS
(2021)
Article
Engineering, Environmental
Hongyan Shen, Binbin Wu, Qin Zhang, Jiahao Ni, Manshan Liang, Yanlong Liu, Xu-Feng Zang, Shihua Wang, Yun-Yun Quan, Xiaoxia Ye, Zu-Sheng Huang
Summary: In this study, a strong photothermal agent TPTQ is developed through rational design, which involves planarizing acceptor and pi-bridge and rotating donor. The TPTQ nanoparticles achieve high photothermal conversion efficiency and can be used for NIR-II fluorescence imaging and photothermal therapy in tumor treatment. This study provides a new approach to developing effective NIR-II photothermal therapeutic agents.
CHEMICAL ENGINEERING JOURNAL
(2023)
Article
Chemistry, Physical
Astrini Pradyasti, Jae Hwan Jeong, Sang Heon Kim, Mun Ho Kim
Summary: A facile method for preparing porous triangular Au-Ag-Ag2S bimetal-semiconductor hybrid nanostructures was developed by selectively etching Ag and controlled deposition of Au. These hybrid nanostructures exhibited enhanced catalytic performance and high photothermal conversion properties.
JOURNAL OF ALLOYS AND COMPOUNDS
(2021)
Article
Engineering, Biomedical
Yong Kang, Na Kong, Meitong Ou, Ying Wang, Qicai Xiao, Lin Mei, Bing Liu, Liqun Chen, Xiaobin Zeng, Xiaoyuan Ji
Summary: This study developed a thermoelectric therapy (TET) based on thermoelectric materials that utilizes light-thermal-electricity-chemical energy conversion to induce apoptosis in cancer cells without damaging the surrounding tissues. The formation of electric fields in the heterojunction structure was found to improve charge separation and transfer.
BIOACTIVE MATERIALS
(2023)
Article
Nanoscience & Nanotechnology
Gyeonghye Yim, Seounghun Kang, Se-Youl Chae, Euisuk Chung, Tai-Kyong Song, Ji Hun Park, Changhan Yoon, Dal-Hee Min, Hongje Jang
Summary: This study synthesized Mo-Te nanoparticles with different shapes through specific chemical reactions, among which Mo-Te nanorice is considered to have potential anti-cancer therapeutic effects due to its excellent photothermal conversion, low toxicity, and high colloidal stability. The excellent therapeutic efficacy and clearance of Mo-Te nanorice were confirmed in vitro and in vivo.
ACS APPLIED MATERIALS & INTERFACES
(2022)
Article
Engineering, Biomedical
Jun Kim, Seounghun Kang, Kyoung Won Kim, Myeong-Gang Heo, Dae-In Park, Joon-Hyung Lee, Nam Ju Lim, Dal-Hee Min, Cheolhee Won
Summary: Local injection of BALLkine-2 can significantly reduce systemic side effects, enhance intratumoral lymphocyte infiltration, and more effectively synergize with PD-1 blockade, making it a potential highly effective anti-tumor treatment option.
Article
Thermodynamics
Sanghyuk Cho, Gyeonghye Yim, Jung Tae Park, Hongje Jang
Summary: A novel inter-cation redox reaction was used to synthesize nanostar structures without toxic surfactants. The nanostars were then coated with TiO2 shells and applied in photoelectrochemical applications, enhancing the performance of water-splitting devices. This study provides a simplified and reproducible method for the fabrication of nanostructures.
ENERGY CONVERSION AND MANAGEMENT
(2022)
Article
Chemistry, Multidisciplinary
Seounghun Kang, Namgook Kwon, Kyunglee Kang, Hojung Ahn, Sunbum Kwon, Dal-Hee Min, Hongje Jang
Summary: In advanced galvanic replacement, the choice of solvent plays a crucial role in the formation of nanostructures, as the polarity index and hydrogen bonding type of the solvent can affect the surface polymeric environment of the nanoplate.
Article
Chemistry, Multidisciplinary
Se-Youl Chae, Euihwan Jeong, Seounghun Kang, Yeajee Yim, Jin-Soo Kim, Dal-Hee Min
Summary: Researchers have developed a porous nanoparticle called BALL for efficient delivery of CRISPR/Cas9 endonuclease. The BALL-mediated delivery of Cas9 RNP showed high efficiency in gene knockout both in vitro and in vivo, and successfully treated muscular dystrophy in animal models.
JOURNAL OF CONTROLLED RELEASE
(2022)
Article
Engineering, Biomedical
Jungho Ahn, Da-Hyun Kim, Dong-Jun Koo, Jungeun Lim, Tae-Eun Park, Jungseub Lee, Jihoon Ko, Seongchan Kim, Minjae Kim, Kyung-Sun Kang, Dal-Hee Min, Sung-Yon Kim, YongTae Kim, Noo Li Jeon
Summary: This study established a vascularized tumor spheroid (VTS) model to recapitulate the pathological features of solid tumors. The tumor-EC hybrid spheroids with self-assembled intratumoral vessels showed improved uniformity and peritumoral angiogenic capacity compared to spheroids composed only of cancer cells. The blood vessels sprouting around the hybrid spheroids on the VTS chip displayed the distinctive characteristics of leaky tumor vessels. The study validated the suppressive effects of axitinib on tumor growth and angiogenesis in the VTS model.
ACTA BIOMATERIALIA
(2023)
Article
Engineering, Biomedical
Seongchan Kim, You Kyeong Jeong, Chang Sik Cho, SeokHoon Lee, Chang Ho Sohn, Jeong Hun Kim, Youngdo Jeong, Dong Hyun Jo, Sangsu Bae, Hyojin Lee
Summary: A robust RNP delivery platform based on a biocompatible silica nanoconstruct has been designed, which can safely and effectively deliver therapeutic RNPs into cells. Compared with commercialized materials, this platform achieves higher gene deletion and base substitution efficiency without significant impact on cellular function.
ADVANCED HEALTHCARE MATERIALS
(2023)
Article
Engineering, Environmental
Seongchan Kim, Ji-Seon Lee, Hyojin Lee
Summary: In this study, a dual-therapeutic platform using engineered graphene oxide (GO) as a multi-functional co-delivery carrier was developed. It successfully delivered two therapeutic reagents as a single vehicle, targeting multiple organelles in cells. The combination therapy showed enhanced efficacy in suppressing tumor growth and had a two-fold therapeutic efficiency compared to single-drug treatment.
CHEMICAL ENGINEERING JOURNAL
(2023)
Article
Engineering, Biomedical
Kyung Su Kim, Woo-Youl Maeng, Seongchan Kim, Gyubok Lee, Minki Hong, Ga-been Kim, Jaewon Kim, Sungeun Kim, Seunghun Han, Jaeyoung Yoo, Hyojin Lee, Kangwon Lee, Jahyun Koo
Summary: This study develops a highly conductive, naturally resorbable paste that addresses the issues of bioresorbable interconnections in bioresorbable electronic devices. The paste, composed of beeswax, submicron tungsten particles, and glycofurol, exhibits enhanced electrical conductivity and mechanical stability. It serves as isotropic conductive paths for three-dimensional interconnects and functions as antennas, sensors, and contact pads in bioresorbable electronic systems. The paste demonstrates stability in aqueous solutions and retains electrical conductance (-7 kS/m) and structural form over the dissolution period. In vitro and in vivo biocompatibility tests confirm the safety of the paste as an implantable material.
MATERIALS TODAY BIO
(2023)
Article
Chemistry, Multidisciplinary
Seunghwan Kim, Yong Suk Oh, Kwanghyoung Lee, Seongchan Kim, Woo-Youl Maeng, Kyung Su Kim, Ga-Been Kim, Seokjoo Cho, Hyeonseok Han, Hyunwoo Park, Mengqiu Wang, Raudel Avila, Zhaoqian Xie, Kabseok Ko, Jungrak Choi, Minkyu Je, Hyojin Lee, Sungho Lee, Jahyun Koo, Inkyu Park
Summary: A battery-free, wireless, cuff-type, implantable, multimodal physical sensing platform is introduced for continuous in vivo monitoring of temperature and strain from peripheral nerve injuries. The system enables power harvesting and data communication to multiple implanted devices wrapped around the nerve.
Article
Chemistry, Multidisciplinary
Gyeonghye Yim, Seounghun Kang, Subean Kim, Hongje Jang
Summary: Due to their unique physicochemical properties, hybrid nanoparticles with different elemental compositions can be widely used for various applications. In this study, iridium-tellurium nanorods (IrTeNRs) were synthesized by galvanic replacement to combine the sacrificial template properties of tellurium nanorods with the presence of iridium. The resulting IrTeNRs exhibited peroxidase-like activity, photoconversion, and exceptional colloidal stability in complete media. Based on these properties, IrTeNRs were applied for cancer therapy, enabling enzymatic therapy through reactive oxygen species generation and cancer cell apoptosis through photothermal and photodynamic therapy under laser irradiation.
Article
Chemistry, Physical
Jaeeun Yoon, Seongchan Kim, Ki Hong Park, Seungjun Lee, Seon Joon Kim, Hyojin Lee, Taegon Oh, Chong Min Koo
Summary: Surface chemistry of MXene nanomaterials plays a crucial role in their physicochemical properties, safety, and applications. This study successfully synthesized well-delaminated halogen-free Ti3C2Tx flakes using a NaOH-based etching solution, which showed a red-shifted surface plasmon mode and a different density of state compared to conventional HF-based etched fluorinated Ti3C2Tx MXene. The halogen-free Ti3C2Tx MXene exhibited higher biocompatibility, lower water contact angle, and lower work function than the fluorinated counterpart, making it a promising candidate for biomedical applications.
Article
Chemistry, Multidisciplinary
S. Cho, G. Yim, J. Koh, H. Jang, J. T. Park
Summary: To enhance the stability of noble-metal nanomaterials, core-shell Pt@TiO2 nanoparticles were synthesized, which can be widely used as catalysts for water splitting. This synthetic strategy is environmentally friendly and doesn't require additional reductants, surfactants, or organic compounds. Pt@TiO2 core-shell nanoparticles exhibited comparable HER activity to Pt/C control in both acidic and alkaline media, and they were also more durable. The TiO2 shell increased the hydrophilicity of the Pt@TiO2 surface, ensuring sufficient active sites for HER performance.
MATERIALS TODAY CHEMISTRY
(2023)
Article
Materials Science, Biomaterials
Hojung Ahn, Seounghun Kang, Kyungtae Kang, Do Nam Lee, Dal-Hee Min, Hongje Jang
Summary: This study presents the solvothermal galvanic replacement method to synthesize highly stable and biocompatible Ag-Te nanoparticles (AgTeNPs) through the replacement of a Te nanorod template with a Ag precursor. These AgTeNPs composed of Ag2Te-Ag4.53Te3 demonstrated selective toxicity through metabolic degradation in breast cancer cells, making them potential nanotherapeutic agents. Combinatorial treatment with hyperthermic cancer-cell ablation through photothermal conversion showed effective cancer treatment both in vitro and in vivo.
JOURNAL OF MATERIALS CHEMISTRY B
(2023)