期刊
ACS APPLIED MATERIALS & INTERFACES
卷 10, 期 29, 页码 24344-24348出版社
AMER CHEMICAL SOC
DOI: 10.1021/acsami.8b09222
关键词
DNA origami; self-assembly; nanotechnology; structural DNA nanotechnology; molecular biology
资金
- National Key Research and Development Program of China [2016YFA0502600]
- National Natural Science Foundation of China [21603100, 21708018]
- Fundamental Research Funds for the Central Universities
As a milestone in DNA self-assembly, DNA origami has demonstrated powerful applications in many fields. However, the scarce availability of long single-stranded DNA (ssDNA) limits the size and sequences of DNA origami nanostructures, which in turn impedes the further development. In this study, we present a robust strategy to produce long circular ssDNA scaffold strands with custom-tailored lengths and sequences. These ssDNA products were then used as scaffolds for constructing various DNA origami nanostructures. This scalable method produces ssDNA at low cost with high purity and high yield, which can enable production of custom-designed DNA origami for various applications.
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