Article
Chemistry, Analytical
Ya-Xi Ye, Jing Guan, Xin-Yue Chen, Ya-Wen Yu, Zhu-Min Xu, Shang-Ming-Zhu Zeng, Zhong-Chang Wang, Bao-Zhong Wang, Qing-Cai Jiao, Hai-Liang Zhu
Summary: A new fluorescently labeled bisphosphonate for bone metastasis detection of breast cancer was reported in the study, showing promising potential for clinical application.
Article
Engineering, Biomedical
Rui Zhao, Tieliang Shang, Bo Yuan, Xiangdong Zhu, Xingdong Zhang, Xiao Yang
Summary: This study developed a new type of bioceramic for osteoporotic bone repair. The bioceramic was shown to promote the proliferation and differentiation of osteoblasts, and in in vivo experiments, it significantly enhanced bone regeneration and delayed adjacent bone loss. The study also discovered two different types of osteogenesis within the bioceramic pores, which is of importance for osteoporotic bone formation.
BIOACTIVE MATERIALS
(2022)
Article
Chemistry, Medicinal
Vignesh Krishnamoorthi Kaliannagounder, Mohammad Amjad Hossain, Jong-Hoon Kim, Muthukumar Thangavelu, Aravinthan Adithan
Summary: Progressive aging causes damage to bone tissue structure and function, necessitating effective therapies for permanent tissue regeneration. Advances in tissue engineering have led to the use of biomimetic nanoparticles, particularly hydroxyapatite (HAP), for regenerative medicine. Magnetic nanoparticles (MNPs) have also shown multifunctional potential, including hyperthermia, drug delivery, and cell differentiation. This study synthesized HAP-decorated MNPs (MHAP NPs) and evaluated their effects on MC3T3-E1 cells. The results showed that MHAP NPs up to a concentration of 10 μg/mL were non-toxic and promoted cell proliferation, apoptosis and ROS generation. Cells cocultured with MHAP NPs at 5 μg/mL showed significant osteogenic differentiation potential. Therefore, MHAP NPs synthesized through wet chemistry could be used in bone regenerative therapy.
Article
Medicine, General & Internal
Hong Jin Kim, Ha Kyun Chang, Dong-Gune Chang, JiYun Ha, Byeong-Rak Keum, Gun-Hwa Kim
Summary: This study aimed to analyze the incidence of bisphosphonate treatment failure, associated radiological factors, and effect of fracture healing in postmenopausal women with osteoporotic vertebral fractures. The non-response group had significantly lower initial BMD values than the response group, and the initial BMD value of the spine and the FRAX hip were identified as radiological factors influencing bisphosphonate non-response. These findings provide insights into the possible mechanisms and factors influencing bisphosphonate treatment failure in osteoporosis.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Nanoscience & Nanotechnology
Cheng Hu, Mei Zhang, Jin Wu, Xing Cao, Luxian Chen, Jiayin Yan, Gaolin Liang, Jiali Tan
Summary: A novel biomaterial was synthesized to promote periodontal tissue regeneration by inhibiting osteoclast overactivation. It displayed outstanding mechanical properties and 3D structure, and could inhibit the proliferation of macrophages and differentiation of osteoclasts. This study provides a new strategy for tissue regeneration engineering.
ACS APPLIED MATERIALS & INTERFACES
(2023)
Article
Chemistry, Physical
Raluca-Stefania Danila, Ioan Dumitru, Maria Ignat, Aurel Pui
Summary: A CoFe2O4@HaP nanocomposite was synthesized and used for the adsorption of Congo Red dye from aqueous solutions. Characterization techniques confirmed the structure and properties of the nanocomposite. The nanocomposite exhibited high adsorption capacity and good fitting to a pseudo-second-order kinetic model.
Article
Chemistry, Physical
Atilla Topcu, Zekai Halici, Elif Cadirci, Emre Karakus, Aysegul Dogan, Feray Bakan, Yapincak Goncu, Nuran Ay, Fikrettin Sahin
Summary: This study investigated the effects of incorporating different concentrations of boron nitride and/or hydroxyapatite into poly-(lactide-co-glycolide) (PLGA) scaffolds on bone defects in osteoporotic rats. Results showed that bone defects were healed in the groups treated with PLGA scaffolds containing boron nitride and/or hydroxyapatite, with the 2.5% boron nitride + 10% hydroxyapatite group showing the best healing.
JOURNAL OF MOLECULAR STRUCTURE
(2024)
Article
Orthopedics
Junjie Xu, Wei Su, Jiebo Chen, Zipeng Ye, Chenliang Wu, Jia Jiang, Xiaoyu Yan, Jiangyu Cai, Jinzhong Zhao
Summary: The study found that in osteoporotic rats, there was a high osteoclast density at the repaired interface during the early healing stage after rotator cuff repair surgery, which affected the healing process. The use of risedronate helped reduce osteoclast density and promote rotator cuff healing in osteoporotic rats, although the effect was not as significant as in nonosteoporotic rats.
AMERICAN JOURNAL OF SPORTS MEDICINE
(2021)
Article
Chemistry, Inorganic & Nuclear
Luqmon Azeez, Segun A. Adebisi, Ayoade L. Adejumo, Hassan K. Busari, Harun K. Aremu, Olalekan A. Olabode, Oluwadamilare Awolola
Summary: This study investigated the characterization and adsorption performance of silver nanoparticles functionalized periwinkle shelled-hydroxyapatite (HAP) for dye wastewater remediation, and found that it exhibited superior adsorption capacity and effectiveness compared to previously reported adsorbents.
INORGANIC CHEMISTRY COMMUNICATIONS
(2022)
Article
Chemistry, Physical
N. Nunez, M. Raineri, H. E. Troiani, D. Tobia, R. D. Zysler, E. Lima, E. L. Winkler
Summary: We developed a bifunctional magnetic composite that can induce magnetic hyperthermia and exhibit stable paramagnetic defects after X-ray irradiation. The composite consists of Zn0.16Fe2.84O4 nanoparticles embedded in a carbonated hydroxyapatite matrix. The magnetic properties of the nanoparticles can be adjusted to induce local heating by magnetic losses in the presence of an AC magnetic field. The composite also acts as a sensor of ionizing radiation. This composite has potential applications in nanomedicine for oncological treatments.
JOURNAL OF ALLOYS AND COMPOUNDS
(2022)
Article
Biochemistry & Molecular Biology
Domenico Franco, Giovanna Calabrese, Salvatore Petralia, Giulia Neri, Carmelo Corsaro, Lucia Forte, Stefano Squarzoni, Salvatore Guglielmino, Francesco Traina, Enza Fazio, Sabrina Conoci
Summary: The study involved functionalizing a MgHA scaffold with gold nanorods, which significantly improved its antibacterial properties with 100% bacterial reduction after 24 hours. However, long-term toxicity study showed a 4.38-fold decrease in cell number after 24 days. Further optimization on nano-functionalization process is needed for reducing cytotoxicity.
Article
Nanoscience & Nanotechnology
Xiaocong Pu, Lei Tong, Xinyue Wang, Quanying Liu, Manyu Chen, Xing Li, Gonggong Lu, Wanling Lan, Qi Li, Jie Liang, Yong Sun, Yujiang Fang, Xingdong Zhang
Summary: This study developed a biologically inspired bony implant by preparing a 3DP methacrylic anhydride-modified gelatin/hydroxyapatite scaffold with high solid content and anchoring it with a functionalized polyphenol hydrogel. The implant showed improved water retention, delayed degradation, and mechanical stability compared to a simple 3DP scaffold. It also promoted migration, proliferation, and osteogenic differentiation of bone marrow stem cells in vitro, as well as direction migration, early osteogenesis, and angiogenesis in vivo.
ACS APPLIED MATERIALS & INTERFACES
(2022)
Article
Chemistry, Multidisciplinary
Lorenzo Cursi, Silvia Vercellino, Mura M. McCafferty, Emily Sheridan, Vanya Petseva, Laurent Adumeau, Kenneth A. Dawson
Summary: Magnetic nanoparticles are valuable tools for studying complex intracellular bio-nano interactions. By synthesizing biocompatible multifunctional nanoparticles with fluorescent properties, intracellular tracking of nanoparticles can be achieved, providing a promising approach for studying bio-nano interactions.
Article
Green & Sustainable Science & Technology
J. Kalita, A. Das, L. Bharali, D. Chakraborty, S. S. Dhar, P. Pandey
Summary: In this study, we fabricated a nanocomposite with antibacterial and photocatalytic properties using modified hydroxyapatite. This material exhibited potent antimicrobial activity against various bacteria and showed excellent degradation performance under solar light.
MATERIALS TODAY SUSTAINABILITY
(2023)
Article
Chemistry, Physical
Leonardo Francisco Goncalves Dias, Milena Yumi Kasama Nakata, Gabriel Junior Cavalcante Pimentel, Erika Soares Bronze-Uhle, Valmor Roberto Mastelaro, Paulo Noronha Lisboa-Filho
Summary: This study explores the adsorption behavior of bisphosphonates (BPs) on TiO2, hydroxyapatite (HA), and TiO2+HA composite surfaces. The impact of UV irradiation on BP adsorption was investigated through adsorption curves, revealing an increase in adsorbed BP content due to enhanced deprotonation and hydroxyl group formation. X-ray photoelectron spectroscopy (XPS) analysis indicates that BPs adsorb through condensation reactions with TiO2, while phosphate and Ca2+ ions coordinate with HA. Functionalized films exhibit a water contact angle of zero, and atomic force microscopy (AFM) measurements suggest that BP adsorption has a smaller impact on titania topography compared to HA.
SURFACES AND INTERFACES
(2023)
Article
Cell Biology
Chuan Liu, Zhen Cao, Yun Bai, Ce Dou, Xiaoshan Gong, Mengmeng Liang, Rui Dong, Hongyu Quan, Jianmei Li, Jingjin Dai, Fei Kang, Chunrong Zhao, Shiwu Dong
JOURNAL OF CELLULAR PHYSIOLOGY
(2019)
Article
Biochemistry & Molecular Biology
Chunrong Zhao, Ying Miao, Zhen Cao, Jian Shi, Jianmei Li, Fei Kang, Ce Dou, Zhao Xie, Qiang Xiang, Shiwu Dong
JOURNAL OF CELLULAR BIOCHEMISTRY
(2019)
Review
Cell Biology
Qinyu Ma, Zaisong Ma, Mengmeng Liang, Fei Luo, Jianzhong Xu, Ce Dou, Shiwu Dong
JOURNAL OF CELLULAR PHYSIOLOGY
(2019)
Article
Cell Biology
Ning Ding, Yuxing Wang, Ce Dou, Feila Liu, Ge Guan, Keyu Wei, Jingyuan Yang, Mingcan Yang, Ju Tan, Wen Zeng, Chuhong Zhu
JOURNAL OF CELLULAR PHYSIOLOGY
(2019)
Article
Engineering, Biomedical
Keyu Luo, Xiaoliang Gao, Yuan Gao, Yan Li, Moyuan Deng, Jiulin Tan, Jing Gou, Chuan Liu, Ce Dou, Zhilin Li, Zehua Zhang, Jianzhong Xu, Fei Luo
ACTA BIOMATERIALIA
(2019)
Review
Biochemistry & Molecular Biology
Yun Bai, Xiaoshan Gong, Ce Dou, Zhen Cao, Shiwu Dong
FREE RADICAL BIOLOGY AND MEDICINE
(2019)
Article
Cell Biology
Mengmeng Liang, Qinyu Ma, Ning Ding, Fei Luo, Yun Bai, Fei Kang, Xiaoshan Gong, Rui Dong, Jingjin Dai, Qijie Dai, Ce Dou, Shiwu Dong
CELL DEATH & DISEASE
(2019)
Article
Materials Science, Biomaterials
Chuanchuan Lin, Ye He, Kun Xu, Qian Feng, Xuan Li, Songyue Zhang, Ke Li, Ruqing Bai, Hong Jiang, Kaiyong Cai
Summary: The increased matrix stiffness was found to promote the proliferation-related signaling of mesenchymal stem cells (MSCs), and this process depended on the increased cortex tension caused by the activation of RAS and myosin II.
ACS BIOMATERIALS SCIENCE & ENGINEERING
(2021)
Article
Engineering, Biomedical
Ce Dou, Jianmei Li, Jian He, Fei Luo, Tao Yu, Qijie Dai, Yueqi Chen, Jianzhong Xu, Xiaochao Yang, Shiwu Dong
Summary: A novel bone-targeted nanomaterial was designed for selectively eliminating mature osteoclasts while preserving beneficial preosteoclasts, showing better protective effects in treating osteoporosis with improved bone formation and vascularization. This study provides a new anabolic therapeutic strategy for bone disorders with excessive bone resorption.
BIOACTIVE MATERIALS
(2021)
Article
Nanoscience & Nanotechnology
Yuwei He, Hongyu Quan, Ping Long, Haibin Ding, Yulu Yang, Weihu Yang, Shiwu Dong, Hong Jiang
Summary: The study introduces an electrospinning device with auxiliary electrodes to control the alignment of nanofibers, resulting in enhanced mechanical properties and biological stabilities of the scaffolds. Different oblique angles of electrospun nanofibers are assembled into osteon-like structures, showing potential for vascularized bone regeneration without the need for additional biological factors.
ACS APPLIED NANO MATERIALS
(2022)
Article
Cell Biology
Yutong Wu, Hongbo Ai, Yuhang Xi, Pengbin Yin, Ying Qu, Jianzhong Xu, Ce Dou, Fei Luo
Summary: Osteoporosis is related to excessive activity of osteoclasts. Most osteoclasts undergo apoptosis after bone resorption and produce a large number of apoptotic bodies. However, the biological function of osteoclast-derived apoptotic bodies in the progression of osteoporosis is still unknown.
CELL DEATH DISCOVERY
(2023)
Review
Engineering, Biomedical
Hongyu Quan, Chencan Ren, Yuwei He, Fuyou Wang, Shiwu Dong, Hong Jiang
Summary: Osteonecrosis of the femoral head (ONFH) is a progressive pathological process caused by multiple etiologies, with no complete cure at present. Biomaterials have gained extensive attention in the treatment of early ONFH, aiming to sustain normal morphology and function, and slow disease progression.
ACTA BIOMATERIALIA
(2023)
Article
Cell Biology
Yutong Wu, Hongbo Ai, Yuhang Xi, Jiulin Tan, Ying Qu, Jianzhong Xu, Fei Luo, Ce Dou
Summary: The bone microenvironment plays a role in promoting cancer cell proliferation and dissemination through apoptotic bodies (ABs) produced by osteoclasts. In this study, it was discovered that AB-null mice showed resistance to breast cancer cell implantation, with increased CD8+ T cell infiltrations and higher survival rate. The researchers found that membranous Siglec15 on osteoclast-derived ABs binds with sialylated Toll-like receptor 2 (TLR2) and inhibits activation of naive CD8+ T cells. Furthermore, treatment with Siglec15 neutralizing antibodies decreased secondary metastases and improved the survival rate in mice with advanced breast cancer bone metastasis. These findings reveal the immunosuppressive function of osteoclast-derived ABs in the bone-tumor niche and highlight the potential of Siglec15 as a target for anti-resorption and immunotherapy.
CELL REPORTS MEDICINE
(2023)
Article
Cell & Tissue Engineering
Ce Dou, Gehua Zhen, Yang Dan, Mei Wan, Nathachit Limjunyawong, Xu Cao
Summary: The process of cell recognition mediated by Siglec15-TLR2 binding is essential for osteoclast formation and occurs before cell fusion in RANKL-mediated osteoclastogenesis. The binding of sialylated TLR2 to Siglec15 initiates cell fusion, and the expression of Siglec15 is activated by M-CSF while ST3Gal1 expression is induced by RANKL. Deletion of Siglec15 or inhibition of sialylation abrogates cell recognition and reduces osteoclast formation.
Article
Cell & Tissue Engineering
Qinyu Ma, Mengmeng Liang, Yutong Wu, Fei Luo, Zaisong Ma, Shiwu Dong, Jianzhong Xu, Ce Dou
Summary: The study identified the molecular profile of apoptotic bodies (ABs) derived from osteoclasts at different differentiation stages, showing marked differences in protein cargo and high similarity to parental cells. Functionally, pOC-ABs promoted endothelial progenitor cell differentiation and endothelial cell formation, while mOC-ABs induced osteogenic differentiation of mesenchymal stem cells and facilitated osteogenesis via RANKL reverse signaling, highlighting the important biological roles of ABs in coupling bone formation with resorption during bone remodeling.
