Article
Cell Biology
Jun Yan, Te Liu, Yang Li, Jun Zhang, Bo Shi, Fuqiang Zhang, Xuejia Hou, Xiaowen Zhang, Wanxing Cui, Jing Li, Hua Yao, Xiuying Li, Yufei Gao, Jinlan Jiang
Summary: This study presents a magnetic targeting technique for the transplantation of a large number of cells into the affected brain area, which can be used as a potential therapy for cerebral infarction.
Article
Engineering, Biomedical
Na Liang, Na Ren, Zhichao Feng, Zhaoyang Sun, Mengwei Dong, Wenhan Wang, Feng Liu, Chunhui Sun, Weijia Zhou, Zhiqing Xing, Jingang Wang, Chao Liu, Hong Liu
Summary: In this study, a biomimetic nanoplatform was developed using stem cell membrane-wrapped dexamethasone-loaded zeolitic imidazolate framework-8. The nanoplatform achieved efficient drug delivery and enhanced bone repair through its high loading capacity, sustained release, and specific uptake by mesenchymal stem cells. The nanoplatform showed high cytocompatibility, greatly enhanced osteogenic differentiation, and activated the PI3K-Akt signaling pathways involved in accelerated osteogenesis. In a bone defect model, the nanoplatform exhibited excellent biocompatibility and effectively promoted bone regeneration. This research provides a new and valid strategy for treating tissue injuries.
ADVANCED HEALTHCARE MATERIALS
(2022)
Article
Nanoscience & Nanotechnology
Mei Tian, Yunfei Lian, Jing Gao, Fengxiang Yu, Ge Song, Jin Cao, Juan Li, Aftab Ullah, Xueyong Qi
Summary: In this study, magnetic drug-loaded nanoparticles were constructed and precisely delivered to tumor sites by umbilical cord mesenchymal stem cells. In vitro experiments showed that stem cells could transport magnetic drug-loaded nanoparticles to induce robust apoptosis in tumor cells.
SCIENCE OF ADVANCED MATERIALS
(2022)
Article
Biotechnology & Applied Microbiology
Jinxiu Cao, Junyang Qi, Xun Lin, Yue Xiong, Fumei He, Wenbin Deng, Gan Liu
Summary: By utilizing a biomimetic strategy to combine BP NSs with DACHPt and camouflage them with MSC-derived membranes, this study achieved in vivo tumor-targeted delivery with enhanced antitumor effects.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2021)
Article
Engineering, Biomedical
Zixuan Zhou, Jingnan Xun, Chenghao Wu, Chao Ji, Shizhao Ji, Futing Shu, Yuxiang Wang, Hao Chen, Yongjun Zheng, Shichu Xiao
Summary: This study demonstrates that micronized amniotic membrane (mAM) can be used as a microcarrier to improve the proliferation efficiency of umbilical cord-derived mesenchymal stem cells (UC-MSC) in vitro and accelerate burn wound healing when used in combination with UC-MSC (mAM-MSC). Transcriptome sequencing revealed upregulation of genes related to growth factors, angiogenesis, and wound healing in mAM-MSC compared to traditional 2D-cultured MSC, which was confirmed by RT-qPCR. Gene ontology analysis showed enrichment of terms related to cell proliferation, angiogenesis, cytokine activity, and wound healing in mAM-MSC. In a burn wound model, topical application of mAM-MSC promoted faster wound healing, increased MSC survival, and enhanced neovascularization.
MATERIALS TODAY BIO
(2023)
Review
Biochemistry & Molecular Biology
Na-Hyun Lee, Sumin You, Ali Taghizadeh, Mohsen Taghizadeh, Hye Sung Kim
Summary: The cell membrane cloaking technique, which utilizes natural design cues, is a promising bioinspired nanotechnology for surface modification of nanoparticles. This technique can replicate complex physicochemical properties and biomimetic functions, thereby enhancing nanotherapeutic platforms. However, there are challenges to be addressed for clinical translation and further research is needed.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Daiany de Souza Dobuchak, Priscila Elias Ferreira Stricker, Nathalia Barth de Oliveira, Bassam Felipe Mogharbel, Nadia Nascimento da Rosa, Dilcele Silva Moreira Dziedzic, Ana Carolina Irioda, Katherine Athayde Teixeira de Carvalho
Summary: MSC, particularly UC-MSC, show promise for regenerative medicine due to their differentiation potential; The use of NFBX membrane can drive UC-MSC differentiation into neural precursors, showcasing potential application in neurodegenerative disease research.
Article
Chemistry, Multidisciplinary
Yong Xie, Yi Sun, Yudong Liu, Jinyun Zhao, Quanbo Liu, Jiaqi Xu, Yiming Qin, Rundong He, Feifei Yuan, Tianding Wu, Chunyue Duan, Liyuan Jiang, Hongbin Lu, Jianzhong Hu
Summary: This study explores a specific targeted treatment approach for spinal cord injury by identifying stable subpopulations of exosomes that can improve blood-spinal cord barrier integrity and promote neural function recovery.
Article
Medicine, Research & Experimental
Yi Wang, Kang Zhang, Tianhan Li, Ali Maruf, Xian Qin, Li Luo, Yuan Zhong, Juhui Qiu, Sean McGinty, Giuseppe Pontrelli, Xiaoling Liao, Wei Wu, Guixue Wang
Summary: This study aimed to develop an ideal biomimetic nanoparticle for targeted atherosclerosis (AS) therapy. The results showed that the advanced MM/RAPNPs demonstrated good biocompatibility, effectively inhibited the progression of AS, and displayed favorable safety performance in AS mouse models. These biomimetic nanoparticles may be potential drug delivery systems for safe and effective anti-AS applications.
Review
Medicine, Research & Experimental
Jianghong Huang, Qisong Liu, Jiang Xia, Xi Chen, Jianyi Xiong, Lei Yang, Yujie Liang
Summary: This article comprehensively reviews the homing effect of stem cells in joints and highlights progress towards the targeted modification of MSCs.
JOURNAL OF TRANSLATIONAL MEDICINE
(2022)
Article
Biophysics
Yue Li, Junfang Ke, Hongxin Jia, Jungang Ren, Li Wang, Zhiqiang Zhang, Chen Wang
Summary: Based on the immune escape and homologous adhesion ability of cancer cells, a biomimetic drug delivery system was developed by coating cancer cell membrane (CCM) on poly lactic acid-glycolic acid (PLGA) nanoparticles. The CCM-coated PLGA nanoparticles (CCMNPs) showed superior cellular affinity and had the abilities of immune escape and homologous targeting, which was confirmed by cellular uptake and in vivo distribution tests. Furthermore, CCMNPs achieved improved therapeutic effect of tumor and accurately targeted therapy, as evidenced by the higher tumor inhibition rate compared to PLGANPs and PTX injection.
COLLOIDS AND SURFACES B-BIOINTERFACES
(2023)
Review
Cell Biology
Yuelong Zhang, Huangming Zhuang, Xunshan Ren, Fuze Jiang, Panghu Zhou
Summary: Osteoarthritis is a common and disabling disease, and surgical treatment is the main approach. Human umbilical cord mesenchymal stem cells (hUC-MSCs) are self-regenerative pluripotent cells that promote cartilage regeneration through the secretion of various trophic factors. The combination of hUC-MSCs with other substances also shows a significant synergistic effect on osteoarthritis treatment. Some scholars have suggested transplanting stem cells into damaged cartilage to slow down the progression of osteoarthritis.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2023)
Review
Chemistry, Multidisciplinary
Riccardo Rampado, Paolo Caliceti, Marco Agostini
Summary: In recent years, biomimetic materials have emerged as an alternative design approach for the development of innovative nanovectors. These materials use cell-derived components and coatings to endow nanomaterials with biological properties and functions.
Article
Reproductive Biology
Meriem Baouche, Agnieszka Krawczenko, Maria Paprocka, Aleksandra Klimczak, Pascal Mermillod, Yann Locatelli, Malgorzata Ochota, Wojciech Nizanski
Summary: This study investigates whether cells derived from the feline umbilical cord exhibit mesenchymal stromal/stem cells (MSCs) characteristics. The results show that MSCs derived from Wharton's jelly have the best proliferation ability, pluripotency gene expressions, and differentiation potential, making them the most valuable for feline regenerative medicine.
Article
Materials Science, Biomaterials
Dan Tang, Yi Wang, Andy Wijaya, Boyan Liu, Ali Maruf, Jinxuan Wang, Jianxiong Xu, Xiaoling Liao, Wei Wu, Guixue Wang
Summary: The development of nanomedicines provides new opportunities for the treatment of atherosclerosis, but still facing challenges such as short circulation life, lack of specific targeting, and poor drug release controllability. Combining biomimetic strategy with smart nanoagents may be a promising solution.
REGENERATIVE BIOMATERIALS
(2021)
Article
Biochemical Research Methods
Marzieh Geranpayehvaghei, Quanwei Shi, Baochang Zhao, Suping Li, Junchao Xu, Mohammad Taleb, Hao Qin, Yinlong Zhang, Khosro Khajeh, Guangjun Nie
BIOCONJUGATE CHEMISTRY
(2019)
Article
Engineering, Biomedical
Mohammad Taleb, Yanping Ding, Bin Wang, Na Yang, Xuexiang Han, Chong Du, Yingqiu Qi, Yinlong Zhang, Zeinab Farhadi Sabet, Hamideh Rezvani Alanagh, Ayeesha Mujeeb, Khosro Khajeh, Guangjun Nie
ADVANCED HEALTHCARE MATERIALS
(2019)
Review
Chemistry, Analytical
Xiaomeng Yu, Lingjun Sha, Langjian Dong, Ya Cao, Jing Zhao
Summary: Exosomes play a crucial role in intercellular transport and communication, and have the potential to serve as biomarkers for early detection and real-time monitoring of tumors. This review provides a summary of the recent advances in tumor exosome detection and their potential applications.
CRITICAL REVIEWS IN ANALYTICAL CHEMISTRY
(2022)
Article
Chemistry, Analytical
Ying Wang, Langjian Dong, Jing Zhao, Mohammed Jalalah, M. S. Al-Assiri, Farid A. Harraz, Ya Cao
Summary: The developed dual-functional probe sensing method can specifically identify CD44 even in serum samples and breast cancer cells with broad detection range and high sensitivity. The method can monitor changes in CD44 expression, providing a new approach to study stem-like properties in breast cancer.
SENSORS AND ACTUATORS B-CHEMICAL
(2021)
Review
Nanoscience & Nanotechnology
Marzieh Geranpayehvaghei, Bahareh Dabirmanesh, Mohammad Khaledi, Mona Atabakhshi-Kashi, Chao Gao, Mohammad Taleb, Yinlong Zhang, Khosro Khajeh, Guangjun Nie
Summary: Platelets play a crucial role in hemostasis and thrombosis activities, as well as in cancer progression by promoting tumor growth and metastasis through releasing various cytokines and chemokines. Blocking platelet-cancer cell interaction could be an attractive strategy for cancer treatment, but systemic inhibition of platelets may lead to severe bleeding complications. Nanomedicines targeting cancer-associated platelets and coated with platelet membrane show potential for targeted cancer therapy.
WILEY INTERDISCIPLINARY REVIEWS-NANOMEDICINE AND NANOBIOTECHNOLOGY
(2021)
Article
Chemistry, Multidisciplinary
Ya Cao, Xiaomeng Yu, Bing Han, Langjian Dong, Jingjing Xu, Yuhao Dai, Genxi Li, Jing Zhao
Summary: The electrochemical phenotyping method provides a low-cost and robust way to characterize stemlike phenotype in breast cancer, offering sensitivity, accuracy, and reliability. It can monitor phenotypic transition of cancer cells, drug effects, and determine stemlike phenotype, potentially supporting precise management of breast tumors.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
(2021)
Article
Chemistry, Analytical
Lingjun Sha, Bing Bo, Fan Yang, Jiayu Li, Ya Cao, Jing Zhao
Summary: A programmable DNA-fueled electrochemical analysis strategy was designed for the determination of an emerging biomarker in lung cancer, PD-L1-expressing exosomes. The method showed high sensitivity and specificity and could be applied to clinical samples, providing new insights into immunotherapy for lung cancer.
ANALYTICAL CHEMISTRY
(2022)
Article
Chemistry, Multidisciplinary
Ya Cao, Xiaomeng Yu, Tianyu Zeng, Ziyi Fu, Yingyan Zhao, Beibei Nie, Jing Zhao, Yongmei Yin, Genxi Li
Summary: The study developed biomimetic vesicles for molecular classification of breast cancer exosomes. These vesicles specifically recognized and fused with breast cancer exosomes, amplifying electrochemical signaling using DNA machinery. Application to clinical samples demonstrated the feasibility and reliability of this method for diagnosis and treatment of breast cancer patients.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
(2022)
Review
Chemistry, Analytical
Huiru Mao, Longmei Yu, Ming Tu, Shuning Wang, Jing Zhao, Haiyun Zhang, Ya Cao
Summary: Sensitive and selective detection of cancer biomarkers is crucial for early diagnosis and treatment of cancer. Metal-organic frameworks (MOFs) have emerged as promising materials for the detection of cancer biomarkers.
CRITICAL REVIEWS IN ANALYTICAL CHEMISTRY
(2022)
Article
Nanoscience & Nanotechnology
Yingyan Zhao, Qi Liu, Yujia Qin, Yue Cao, Jing Zhao, Kai Zhang, Ya Cao
Summary: In this work, an electrochemical aptasensor was designed for the high-accuracy assay of AFP-L3 ratio. The aptasensor demonstrated the ability to accurately measure the AFP-L3 ratio in a linear range of 0.0008-40 ng mL-1, with satisfactory specificity and good recoveries in complex serum samples. This aptasensor may serve as a valuable tool for the measurement of AFP-L3 ratio and have great potential for early warning of hepatocellular carcinoma in clinical application.
ACS APPLIED MATERIALS & INTERFACES
(2023)
Review
Chemistry, Multidisciplinary
Yue Cao, Liang Zhou, Zhikai Fang, Zihan Zou, Jing Zhao, Xiaolei Zuo, Genxi Li
Summary: Early screening and diagnosis are crucial for cancer prevention, and various biosensing strategies have been developed to detect cancer biomarkers rapidly and effectively. Functional peptides have gained attention in cancer-related biosensing due to their advantageous features. They can serve as recognition ligands, enzyme substrates, and interfacial materials to improve biosensing performances. This review focuses on the recent advances in functional peptide-based biosensing using electrochemical and optical techniques, and discusses the challenges and prospects in clinical diagnosis.
CHEMICAL COMMUNICATIONS
(2023)
Article
Chemistry, Multidisciplinary
Huiru Mao, Ya Cao, Zihan Zou, Jianan Xia, Jing Zhao
Summary: Breast cancer is the most common malignancy worldwide, and early diagnosis and accurate classification of subtype-specific features are essential. A new enzyme-powered microRNA discriminator was developed to selectively distinguish breast cancer cells and further identify subtype-specific features. The experimental results showed high sensitivity in detecting miR-21 and miR-210, allowing for the quantification of different subtypes and the identification of triple-negative subtype.
Article
Engineering, Biomedical
Qi Liu, Jianhua Yao, Zichen Huang, Shuning Wang, Jizong Jiang, Ya Cao, Yihua Bei, Jing Zhao
Summary: A phosphatidylserine-targeting peptide-facilitated design is proposed for versatile analysis of circulating extracellular vesicles, which can meet different requirements. DNA probes are inserted into the EV membrane to release methylene blue molecules and amplify the electrochemical signal. The indiscriminative DNA probe shows high sensitivity for quantification of EVs from different cell sources, and can also identify specific EV biomarkers for accurate classification of cell-specific features and potential diagnosis of cardiovascular diseases.
ADVANCED HEALTHCARE MATERIALS
(2023)
Article
Chemistry, Analytical
Xiaomeng Yu, Ya Cao, Yingyan Zhao, Jianan Xia, Jie Yang, Yuanyuan Xu, Jing Zhao
Summary: This study presents a universal method for accurate and sensitive analysis of tumor-associated glycoprotein biomarkers. The method utilizes dual recognition of carbohydrates and proteins to achieve amplified electrochemical responses for glycoprotein analysis. The results show high accuracy, specificity, and versatility in complex serum samples, making this method a valuable tool for the analysis of glycoprotein biomarkers.
ANALYTICAL CHEMISTRY
(2023)
Article
Chemistry, Multidisciplinary
Lin Wang, Haojie Xie, Xinyi Zhou, Yuxin Lin, Yujia Qin, Jie Yang, Jing Zhao, Genxi Li
Summary: Identifying the phenotype of aggressive breast cancer cells is crucial and a proposed electrochemical biosensor can achieve sensitive and specific detection of HER-2 and MMP-2. The biosensor can distinguish HER-2(+) breast cancer cells and evaluate invasion capability, providing a method for the accurate identification of tumor features in breast cancer subtypes.
CHEMICAL COMMUNICATIONS
(2023)