Article
Biotechnology & Applied Microbiology
Juan Yu, Chaoqun Xu, Chuanwei Lu, Qian Liu, Jifu Wang, Fuxiang Chu
Summary: The sustainable polymeric micelles synthesized from rosin and vegetable oils via ATRP demonstrate great promise for efficient doxorubicin delivery and potential industrial applications.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2021)
Article
Medicine, Research & Experimental
Carolina Henriques Cavalcante, Renata Salgado Fernandes, Juliana de Oliveira Silva, Caroline Mari Ramos Oda, Elaine Amaral Leite, Geovanni Dantas Cassali, Ives Charlie-Silva, Bianca Helena Ventura Fernandes, Lucas Antonio Miranda Ferreira, Andre Luis Branco de Barros
Summary: The developed pH-sensitive micelles encapsulating DOX showed promising results with small diameter, high stability, low toxicity, and significantly better inhibition of tumor growth compared to other forms of DOX.
BIOMEDICINE & PHARMACOTHERAPY
(2021)
Review
Pharmacology & Pharmacy
Zuha Imtiyaz, Jiaxi He, Qixin Leng, Atul K. Agrawal, A. James Mixson
Summary: Researchers are exploring various nanoparticle methods to deliver chemotherapeutic agents to tumors with higher accumulation. pH-dependent histidine-based nanoparticles show promising potential for treatment, but challenges remain in clinical trials.
Article
Biophysics
Yamini Bobde, Tarun Patel, Milan Paul, Swati Biswas, Balaram Ghosh
Summary: Polymeric micelles composed of mPEG-b-HPMA copolymer were studied for delivering DOX effectively. The optimized micelle P6-M1 showed small particle size, high drug loading, and promising anticancer effects in breast cancer cell lines. This study demonstrated the potential of mPEG-b-HPMA micelles as a nanomedicine for breast cancer treatment.
COLLOIDS AND SURFACES B-BIOINTERFACES
(2021)
Article
Pharmacology & Pharmacy
Yang Yang, Fuwei Yang, Xiaotian Shan, Jiamin Xu, Wenjie Fang, Juan Zhou, Lipeng Qiu, Jinghua Chen
Summary: The pH/reduction dual sensitive PCT polymers have been synthesized to promote rapid release of drug-loaded micelles at tumor site, showing strong cytotoxicity against tumor cells and better inhibitory effect on tumor growth compared to control micelles. The PCT micelles can be depolymerized in intracellular acidic and reductive environment to release drugs rapidly, indicating great potential for intercellular delivery of antitumor drugs.
Article
Pharmacology & Pharmacy
Jafrin Jobayer Sonju, Achyut Dahal, Sitanshu S. Singh, Xin Gu, William D. Johnson, Chandra Mohan Reddy Muthumula, Sharon A. Meyer, Seetharama D. Jois
Summary: This research focuses on the use of a pH-sensitive liposomal formulation and a targeting ligand conjugated cytotoxic drug to achieve targeted delivery of chemotherapy. The results showed promising in vitro and in vivo studies, indicating improved anticancer treatment.
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2022)
Article
Environmental Sciences
Muhammad Usman Akram, Naseem Abbas, Muhammad Farman, Suryyia Manzoor, Muhammad Imran Khan, Sameh M. Osman, Rafael Luque, Abdallah Shanableh
Summary: A therapeutic system is designed to release drugs at specific target tissues without damaging healthy cells, by using chitosan-based polymeric nanoparticles containing N-isopropyl acrylamide and 2-(di -isopropyl amino) ethyl methacrylate.
Article
Biochemistry & Molecular Biology
Yang Han, Jieyi Pan, Na Liang, Xianfeng Gong, Shaoping Sun
Summary: The study synthesized an amphiphilic conjugate based on mPEG and cholesterol-modified chitosan with hydrazone bonds, which was used to prepare PTX-loaded micelles. These micelles exhibited promising therapeutic efficacy of PTX and reduced side effects, indicating potential as pH-sensitive nanocarriers for drug delivery.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Biochemistry & Molecular Biology
Mohamed Alaa Mohamed, Ajay Singh, Paras N. Prasad, Chong Cheng
Summary: Delivery of chemotherapeutics to cancer cells using polymeric micelles is a promising strategy for cancer treatment. However, the limited stability of micelles, premature drug release, and off-target effect hinder their utilization as effective drug delivery systems. In this study, pH-sensitive crosslinked polymeric micelles were designed to address these challenges and showed remarkable promise as smart drug delivery systems for cancer therapy.
Article
Biophysics
Hongyan Zhang, Ji Li, Rong Yuan, Yufen Li, Yue Zhang, Xiaoyun Hu, Jiqiang Qu, Yu Chen, Zheran Wang, Mingyu Xia, Dongkai Wang
Summary: A valid strategy for delivering natural drug Hol has been proposed, using a non-toxic degradable pH-sensitive polymer and Folate-DSPE-PEG2000 outer layer to efficiently inhibit the migration and invasion of breast cancer cells while targeting tumor sites. This drug delivery system demonstrated marked anti-tumor and lung metastasis suppression effects in mice models, with elevated apoptosis levels and repression of metalloproteinase expression.
COLLOIDS AND SURFACES B-BIOINTERFACES
(2021)
Article
Biochemistry & Molecular Biology
Xiaotao Wang, Yebin Yang, Gaowen Zhang, Chak-Yin Tang, Wing-Cheung Law, Cong Yu, Xuanqi Wu, Shuai Li, Yonggui Liao
Summary: Responsive drug release and low toxicity of drug carriers are crucial for controlled release systems. In this study, poly o-nitrobenzyl@UCNP nanocapsules were synthesized using a double functional diffractive o-nitrobenzyl as a crosslinker and methacrylic acid (MAA) as a monomer. These nanocapsules exhibited near-infrared (NIR) light-/pH-responsive properties, allowing efficient drug release upon NIR irradiation. The research also included the study of photodegradation kinetics and the loading of the anticancer drug doxorubicin hydrochloride (DOX). Cytotoxicity studies demonstrated that the release of DOX could be triggered by NIR to effectively kill cancer cells.
Article
Polymer Science
Xiaolei Hu, Arman Moini Jazani, Jung Kwon Oh
Summary: This review summarizes recent advances in the design and synthesis of imine-bearing block copolymers and their nanoassemblies, focusing on their disassembly mechanism and enhanced drug release in acidic tumor environments.
Article
Chemistry, Multidisciplinary
Jiapeng Deng, Su Liu, Guoqing Li, Yien Zheng, Weifei Zhang, Jianjing Lin, Fei Yu, Jian Weng, Peng Liu, Hui Zeng
Summary: Chemotherapy is not highly effective in treating osteosarcoma due to its low targeting, low bioavailability, and high toxicity. Nanoparticles can improve drug delivery to tumor sites and enhance the therapeutic efficacy. This study developed a pH-sensitive charge-conversion polymeric micelle for targeted delivery of cinnamaldehyde to osteosarcoma, which showed promising results in vitro.
FRONTIERS IN CHEMISTRY
(2023)
Article
Pharmacology & Pharmacy
Zhangjie Wang, Xiaowen Ye, Yuting Fang, Hui Cheng, Yan Xu, Xiaoqin Wang
Summary: This study successfully synthesized a pH-sensitive and aptamer-modified drug-loading polymer micelles, demonstrating superior tumor targeting and pH-sensitive drug release abilities. In vitro experiments showed significant inhibitory effects and clear targeting of AP-(NAR@ZIF-8)/PMs on human lung cancer and breast cancer cells.
JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY
(2021)
Article
Pharmacology & Pharmacy
Min Jeong Jo, Hee Ji Shin, Moon Sup Yoon, Seo Yeon Kim, Chae Eun Jin, Chun-Woong Park, Jin-Seok Kim, Dae Hwan Shin
Summary: We used pH-sensitive polymeric micelles to effectively control drug release and improve water solubility, treating gastric cancer. The combination of PTX, ETP, and RAPA showed a synergistic effect and high combination index values. PTX/ETP/RAPA-loaded mPEG-pH-PCL micelles exhibited different drug release behaviors depending on the tumor and normal tissues' pH, with increased bioavailability and circulation time in the blood, making them advantageous for gastric cancer treatment.