Article
Biotechnology & Applied Microbiology
Jinze Lan, Lianxin Shi, Wuyi Xiao, Xiaobin Zhang, Yuzhe Wang, Shutao Wang
Summary: Excessive exudates from burn wounds hinder healing, causing adhesion, inflammation, and infection. Conventional dressings cannot effectively remove exudates. To address this, a enhanced self-pumping dressing was developed using hollow glass microspheres in a hydrogel precursor, which continuously drains water at a high speed and promotes burn wound healing. This study provides insights for designing efficient and continuous-draining dressings for clinical applications.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2023)
Article
Nanoscience & Nanotechnology
Jinfeng Cao, Ping Wu, Qianqian Cheng, Chen He, Yun Chen, Jinping Zhou
Summary: A new type of injectable CMCh hydrogel wound dressing with self-healing properties is constructed using coordination bonds and alkali/urea aqueous solutions. The hydrogel exhibits self-healing, self-adaption, and thermoresponsive ability, significantly accelerating skin tissue regeneration and wound closure. It has great potential in tissue engineering applications.
ACS APPLIED MATERIALS & INTERFACES
(2021)
Article
Nanoscience & Nanotechnology
Xia Qiu, Jiamin Zhang, Lilong Cao, Qin Jiao, Junhao Zhou, Lijun Yang, Hong Zhang, Yuping Wei
Summary: Dextran-based hydrogels with zwitterionic structures showed faster wound healing rates compared to natural dextran hydrogel and commercial dressings, attributed to their protein resistance and ability to scavenge free radicals. These hydrogels also demonstrated excellent cytocompatibility and antibacterial properties, along with self-healing capabilities for irregular wounds, providing a new pathway for multifunctional polysaccharide hydrogels in wound treatment and pain relief during dressing changes.
ACS APPLIED MATERIALS & INTERFACES
(2021)
Article
Chemistry, Multidisciplinary
Xiaoya Ding, Gao Li, Peng Zhang, E. Jin, Chunsheng Xiao, Xuesi Chen
Summary: An injectable self-healing hydrogel with rapid gelation and cysteine-specific on-demand dissolution was designed for wound dressings, showing excellent injectability, self-healing ability, and rapid cysteine-triggered dissolution. The hydrogel displayed favorable biocompatibility, achieved rapid wound closure in seconds, and fast on-demand dissolution for dressing changes, highlighting its potential for wound healing applications.
ADVANCED FUNCTIONAL MATERIALS
(2021)
Article
Nanoscience & Nanotechnology
Ye Wang, Changyuan He, Chong Chen, Wentao Dong, Xuekun Yang, Ye Wu, Qingquan Kong, Bin Yan
Summary: In this study, an injectable zwitterionic hydrogel with excellent self-healing property, good cytocompatibility, and antibacterial adhesion was developed. The hydrogel showed a distinct thermal-induced sol-gel transition and could be easily applied to complex wounds. It possessed rapid self-healing ability and low cytotoxicity, and effectively prevented bacterial adhesion, promoting wound healing.
ACS APPLIED MATERIALS & INTERFACES
(2022)
Review
Polymer Science
Pavel Yudaev, Yaroslav Mezhuev, Evgeniy Chistyakov
Summary: This review examines the use of dressings containing nanoparticles for wound repair and evaluates their antimicrobial effects and healing actions. The analysis of 31 sources published between 2021 and 2022 demonstrates a trend towards the development of modern antibacterial wound-healing nanomaterials.
Article
Multidisciplinary Sciences
Mingtao Chen, Yue Wu, Baohong Chen, Alexander M. Tucker, Anand Jagota, Shu Yang
Summary: Fast and reversible adhesive consisting of dynamic boronic ester covalent bonds between poly(vinyl alcohol) (PVA) and boric acid (BA) shows high strength and tunable mechanical properties, making it a potential candidate for wound dressing adhesive.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2022)
Article
Engineering, Biomedical
Lipeng Qiao, Yongping Liang, Jueying Chen, Ying Huang, Saeed A. Alsareii, Abdulrahman Manaa Alamri, Farid A. Harraz, Baolin Guo
Summary: In this study, adhesive self-healing conductive antibacterial hydrogel dressings were prepared for the repair of infected wounds. The hydrogel exhibited self-healing properties, good conductivity, photothermal anti-bacterial properties, and improved wound healing in the infected skin wound repair test. These hydrogels have potential as promising candidates for wound healing dressings for the treatment of infected skin wounds.
BIOACTIVE MATERIALS
(2023)
Article
Chemistry, Applied
Chuang Li, Tao Jiang, Cong Zhou, Ankang Jiang, Cuifen Lu, Guichun Yang, Junqi Nie, Feiyi Wang, Xiaofan Yang, Zhenbing Chen
Summary: Promoting the healing of diabetic wounds is a major challenge, but Chitosan-based POSS-PEG hybrid hydrogels show excellent healing properties with strong mechanical strength, self-healing efficiency, cytocompatibility, and antibacterial properties.
CARBOHYDRATE POLYMERS
(2023)
Article
Engineering, Environmental
Yao Wu, Zhaoyu Yang, Xuexuan Li, Teng Li, Jun Zheng, Mingrui Hu, Zhe Yu, Weikang Luo, Wei Zhang, Fei Zheng, Tao Tang, Yang Wang
Summary: This study successfully develops a self-assembled hydrogel that integrates easy absorption, satisfactory injectability, rapid self-healing property, and multiple therapeutic effects. The hydrogel exhibits good adhesion and easy peeling off from tissues, allowing for percutaneous absorption within a short time. It shows broad-spectrum antibacterial activities without cytotoxicity and promotes wound healing through various effects. Additionally, it can induce anti-inflammatory macrophages. This research provides an environmentally friendly and efficient design for complicated wound treatment.
CHEMICAL ENGINEERING JOURNAL
(2023)
Article
Materials Science, Multidisciplinary
Weijie Xu, Xin Gao, Huaping Tan, Shengke Li, Tianle Zhou, Jianliang Li, Yong Chen
Summary: This study aims to develop a polysaccharide-based hydrogel dressing with self-healing ability and sustained antibacterial function for wound healing. The dressing shows good elasticity and sustained release performance, and it also supports the survival and proliferation of stem cells.
MATERIALS TODAY COMMUNICATIONS
(2022)
Article
Chemistry, Multidisciplinary
Chukwuma O. Agubata, Cynthia C. Mbaoji, Ifeanyi T. Nzekwe, Cesar Saldias, David Diaz Diaz
Summary: This study evaluated a biohydrogel based on alginate and dynamic covalent B-O bonds for wound healing applications. The hydrogels showed low interfacial tension, high moisture loss, self-healing ability, and compatibility with collagen, leading to improved wound healing.
APPLIED SCIENCES-BASEL
(2021)
Article
Chemistry, Multidisciplinary
Rui Yu, Zhenlong Li, Guoying Pan, Baolin Guo
Summary: Wounds on stretchable parts of the human body cause prolonged suffering and involve more severe healing processes than wounds on stationary parts. However, they have received insufficient attention compared with other types of chronic wounds. In this study, a novel supramolecular gelatin (GT) hydrogel composed of GT-graft-aniline tetramer and quaternized chitosan was presented. The hydrogel exhibited flexibility, self-healing, and tissue adhesiveness and well adapted to motion wounds. Moreover, it showed bioactive properties such as conductivity, antioxidant, hemostatic, antibacterial, and photothermal effects. In MRSA-infected motional wound healing experiment, this hydrogel demonstrated significantly enhanced wound healing efficacy with fast wound closure, mild inflammatory response, high collagen deposition, and enhanced re-epithelialization. The hydrogel has great potential in wound healing and skin tissue engineering, serving as an inspiration for the design of supramolecular biomaterials.
SCIENCE CHINA-CHEMISTRY
(2022)
Article
Pharmacology & Pharmacy
Qida Zong, Shiya Zhou, Jing Ye, Xinxuan Peng, Huiying Wu, Mohan Li, Xuanjiayi Ye, Naixin Tian, Wei Sun, Yinglei Zhai
Summary: A hydrogel matrix (MTC-Ban-b-PEG6k-b-MTC-Ban, MBP) was prepared by ring opening polymerization using aldehyde modified aliphatic cyclic carbonate monomer (MTC-Ba) and polyethylene glycol (PEG) as the initiator. The resulting self-healing hydrogel (SH-Gel) was covalently linked with adipic acid dihydrazide (ADH) through dynamic hydrazide bond. Curcumin was also loaded into the hydrogel as a functional model drug. The hydrogel exhibited porosity, injectability, appropriate swelling rate, friendly cell compatibility, and safe degradability. In vivo wound healing evaluation, histological evaluation, and immunofluorescence staining confirmed the effectiveness of the hydrogel in promoting wound closure, re-epithelium, and collagen regeneration.
JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY
(2023)
Article
Chemistry, Multidisciplinary
Jinze Lan, Lianxin Shi, Wuyi Xiao, Xiaobin Zhang, Shutao Wang
Summary: A self-pumping organohydrogel dressing with hydrophilic fractal microchannels is developed, which can rapidly drain excessive exudates and promote burn wound healing. This dressing significantly reduces dermal cavity, accelerates blood vessel and hair follicle regeneration compared with commercial dressings.
ADVANCED MATERIALS
(2023)
Article
Biochemistry & Molecular Biology
Lilong Sun, Zhijia Liu, Houkuan Tian, Zhicheng Le, Lixin Liu, Kam W. Leong, Hai-Quan Mao, Yongming Chen
Article
Chemistry, Physical
Boyuan Chen, Zhitao Hu, Haoqi Li, Zhiyong Li, Qiong Li, Yongming Chen
COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS
(2019)
Review
Oncology
Run-Cong Nie, Fo-Ping Chen, Shu-Qiang Yuan, Ying-Shan Luo, Shi Chen, Yong-Ming Chen, Xiao-Jiang Chen, Ying-Bo Chen, Yuan-Fang Li, Zhi-Wei Zhou
EUROPEAN JOURNAL OF CANCER
(2019)
Article
Polymer Science
Jing Wang, Yan Lu, Yongming Chen
Article
Oncology
Shao-Bo Liang, Ning Zhang, Dan-Ming Chen, Xing-Li Yang, Bin-Hong Chen, Hai Zhao, Rui-Liang Lu, Yong Chen, Li-Wu Fu
RADIOTHERAPY AND ONCOLOGY
(2019)
Article
Engineering, Biomedical
Zhipeng Zeng, Cong Dong, Pengfei Zhao, Zhijia Liu, Lixin Liu, Hai-Quan Mao, Kam W. Leong, Xiaohu Gao, Yongming Chen
ADVANCED HEALTHCARE MATERIALS
(2019)
Article
Oncology
Ruiwan Chen, Yu Zhou, Yujie Yuan, Qun Zhang, Shasha He, Yong Chen, Yufeng Ren
FRONTIERS IN ONCOLOGY
(2019)
Article
Engineering, Biomedical
Ziyi Li, Lixin Liu, Yongming Chen
ACTA BIOMATERIALIA
(2020)
Article
Chemistry, Physical
Qunfeng Liu, Zhijie Geng, Dating Pei, Ziyi Li, Shan Yu
CHEMICAL PHYSICS LETTERS
(2020)
Article
Dermatology
Jingling Zhao, Shuai Yang, Bin Shu, Lei Chen, Ronghua Yang, Yingbin Xu, Julin Xie, Xusheng Liu, Shaohai Qi
Summary: The study found that transient hyperglycemia had long-lasting effects on wound healing in diabetic mice, causing persistent damage to the vascular endothelium and leading to reduced angiogenesis. The upregulation of DNMT1 by transient hyperglycemia resulted in hypermethylation of Ang-1, leading to decreased expression of Ang-1 and subsequent endothelial dysfunction. Targeting DNMT1 was shown to promote angiogenesis and accelerate diabetic wound healing.
JOURNAL OF INVESTIGATIVE DERMATOLOGY
(2021)
Article
Oncology
Fei Zhou, Lijun Zhang, Lei Chen, Yingbin Xu, Yanan Chen, Zilun Li, Xusheng Liu, Jun Wu, Shaohai Qi
AMERICAN JOURNAL OF TRANSLATIONAL RESEARCH
(2019)
Article
Polymer Science
Yongwei Wu, Zhitao Hu, Huahua Huang, Yongming Chen
Article
Oncology
Jing Guo, Yongming Chen, Zhimin Liu, Yuanxiang Guan, Wei Wang, Xiaowei Sun, Wei Li, Dazhi Xu
Article
Polymer Science
Houbo Zhou, Christopher M. Plummer, Huaan Li, Huahua Huang, Pengfei Ma, Le Li, Lixin Liu, Yongming Chen
Article
Oncology
Shuai Yang, Jingling Zhao, Shixin Huang, Bin Shu, Ronghua Yang, Lei Chen, Yingbin Xu, Julin Xie, Xusheng Liu, Ji Jia, Shaohai Qi
AMERICAN JOURNAL OF TRANSLATIONAL RESEARCH
(2020)
