Review
Pharmacology & Pharmacy
Nicole B. Day, William C. Wixson, C. Wyatt Shields
Summary: Immunotherapy is a rapidly developing area in cancer treatment, with magnetic systems offering advantages in improving performance by increasing spatiotemporal control, reducing off-target effects, and enhancing efficacy. These systems enable various methods for programming immune responses, including magnetic hyperthermia, targeted delivery of drug carriers, structual changes in biomaterials driven by magnets, and interactions with cellular receptors using magnetic particles for promoting antitumor activity.
ACTA PHARMACEUTICA SINICA B
(2021)
Review
Chemistry, Multidisciplinary
Bahareh Rezaei, Parsa Yari, Sean M. Sanders, Haotong Wang, Vinit Kumar Chugh, Shuang Liang, Shahriar Mostufa, Kanglin Xu, Jian-Ping Wang, Jenifer Gomez-Pastora, Kai Wu
Summary: Magnetic nanoparticles (MNPs) have been widely used in various fields, especially in biomedical applications. Their ability to be remotely controlled and used in magnetic biosensing and imaging, as well as for targeted drug delivery and cancer treatment, has attracted great interest. The material and morphological structure design of MNPs is an important focus of research.
Review
Oncology
Zhi Wei Tay, Prashant Chandrasekharan, Benjamin D. Fellows, Irati Rodrigo Arrizabalaga, Elaine Yu, Malini Olivo, Steven M. Conolly
Summary: Magnetic Particle Imaging (MPI) is an emerging imaging technique that provides direct imaging of superparamagnetic iron oxide nanoparticles, showing great potential in cancer diagnosis and therapy monitoring. Different from MRI, MPI offers ideal image contrast with zero background tissue signal, enabling clear visualization of cancer. MPI enhances therapeutic precision and accuracy through magnetic means, contributing to the advancement of cancer imaging and guided therapy.
Article
Chemistry, Physical
Bijaideep Dutta, Swati Checker, K. C. Barick, H. G. Salunke, Vikram Gota, P. A. Hassan
Summary: By grafting malic acid onto the surface of Fe3O4, we designed highly water-dispersible Fe3O4 magnetic nanoparticles with good aqueous colloidal stability, pH-dependent surface charge characteristics, and superparamagnetic behavior. The optimized electrostatic conjugation of drug onto MMNCs surface achieved a maximum loading efficiency of 72%, resulting in pH-dependent controlled release characteristics and dose-dependent cellular uptake of DOX-MMNCs, showing considerable toxicity towards breast cancer cells. Additionally, our magnetic hyperthermia studies demonstrated the excellent heating efficiency of the MMNCs for safe application in hyperthermia therapy.
JOURNAL OF ALLOYS AND COMPOUNDS
(2021)
Article
Pharmacology & Pharmacy
Michal Zuk, Weronika Gaweda, Agnieszka Majkowska-Pilip, Magdalena Osial, Marcin Wolski, Aleksander Bilewicz, Pawel Krysinski
Summary: This study successfully synthesized multifunctional nanoparticle conjugates with magnetic and anticancer properties, showing high potential for effective in vivo applications.
Article
Nanoscience & Nanotechnology
Wenwen Jia, Yiyao Qi, Zhenrong Hu, Zuquan Xiong, Zhenyi Luo, Zhen Xiang, Jingzhou Hu, Wei Lu
Summary: This study successfully developed a multifunctional cancer theranostic nanoplatform with high efficiency in magneto-triggered hyperthermia, magnetic-responsive controlled drug delivery, enhanced MRI signal, and good biocompatibility.
ADVANCED COMPOSITES AND HYBRID MATERIALS
(2021)
Article
Polymer Science
Dalal A. Alromi, Seyed Yazdan Madani, Alexander Seifalian
Summary: Nanoparticles, particularly magnetic nanoparticles, are considered promising tools for cancer treatment due to their unique properties such as magnetic control in an external magnetic field.
Article
Materials Science, Multidisciplinary
Mitra Rafizadeh-Sourki, S. A. Hassanzadeh-Tabrizi
Summary: Zn0.5Ni0.5Fe2O4/C nanocomposite with magnetic properties and drug absorption capacity shows controlled drug release, efficient antibacterial characteristics, and significant hyperthermal ability.
DIAMOND AND RELATED MATERIALS
(2022)
Article
Oncology
Nuria Lafuente-Gomez, Paula Milan-Rois, David Garcia-Soriano, Yurena Luengo, Marco Cordani, Hernan Alarcon-Iniesta, Gorka Salas, Alvaro Somoza
Summary: The study introduced a smart gemcitabine delivery system based on magnetic nanoparticles, enabling selective release in pancreatic cancer cells via disulfide bonds. The modified nanoparticles showed promising potential for biomedical applications by reducing drug toxicity in non-cancerous cells, enhancing internalization, and synergistic cytotoxic effects when combined with magnetic hyperthermia.
Article
Pharmacology & Pharmacy
Bijaideep Dutta, Sandeep. B. Shelar, Vasumathy Rajan, Swati Checker, B. N. Pandey, Sanjay Kumar, P. A. Hassan, Divya, K. C. Barick
Summary: The study demonstrates a simplified technique for developing gelatin grafted Fe3O4 magnetic nanoparticles (Gel-MNPs) and investigates their potential applications in drug delivery and hyperthermia therapy. The Gel-MNPs show good stability and pH dependent surface properties, and exhibit dose dependent cytotoxicity towards lung and breast cancer cells with curcumin as a model drug.
JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY
(2022)
Article
Chemistry, Physical
Mahnaz Amiri, Payam Khazaeli, Ali Salehabadi, Masoud Salavati-Niasari
Summary: Hydrogels are widely used in drug delivery due to their biocompatibility and related properties. Continuous drug release to target areas can be achieved by activating/modifying hydrogels with magnetic or fluorescent materials. Developing new crosslinked polymers with biocompatibility and biodegradability is essential for novel drug delivery platforms.
ADVANCES IN COLLOID AND INTERFACE SCIENCE
(2021)
Review
Instruments & Instrumentation
Bhavana Joshi, Abhijeet Joshi
Summary: The study highlights the potential of using magnetic nanoparticles for targeted brain therapy to overcome the limitations of the blood-brain barrier. Combining drug delivery with contrast imaging functionality can lead to more effective drug delivery and imaging.
DRUG DELIVERY AND TRANSLATIONAL RESEARCH
(2022)
Article
Pharmacology & Pharmacy
Ishdeep Kaur, Terence Tieu, Veerasikku G. Deepagan, Muhammad A. Ali, Fahad Alsunaydih, David Rudd, Maliheh A. Moghaddam, Laure Bourgeois, Timothy E. Adams, Kristofer J. Thurecht, Mehmet Yuce, Anna Cifuentes-Rius, Nicolas H. Voelcker
Summary: Despite the clinical benefits of chemotherapeutics, drug resistance remains a major challenge in breast cancer treatment. Nanomedicines, such as porous silicon nanoparticles (pSiNPs), offer a targeted and effective approach by delivering multiple therapeutics and minimizing drug resistance. In this study, breast cancer-targeted pSiNPs co-loaded with an anticancer drug and gold nanoclusters (AuNCs) were engineered. The combination of hyperthermia and chemotherapy using targeted pSiNPs showed higher cell-killing efficacy compared to monotherapy and a nontargeted system with combined therapeutics. These findings highlight the potential of targeted pSiNPs as a versatile platform for personalized medicine.
Article
Biochemistry & Molecular Biology
Morteza Eskandani, Hossein Derakhshankhah, Soheila Zare, Rana Jahanban-Esfahlan, Mehdi Jaymand
Summary: A pH-responsive magnetic hydrogel-based drug delivery system was designed and developed using a novel strategy based on horseradish peroxidase-mediated crosslinking. It showed promising synergistic effects for in vitro chemo/hyperthermia therapy of human breast cancer cells.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2023)
Review
Polymer Science
Al Mamun, Lilia Sabantina
Summary: The number of cancer patients is increasing rapidly worldwide, making it one of the leading causes of human death. Despite the development of new cancer treatment procedures, their efficiency is limited and they come with high toxicity. In contrast, magnetic hyperthermia, a field rooted in the use of magnetic nanomaterials, offers a potential solution for cancer treatment.
Article
Chemistry, Multidisciplinary
Hyunsik Hong, Sunhong Min, Sagang Koo, Yunjung Lee, Jinho Yoon, Woo Young Jang, Nayeon Kang, Ramar Thangam, Hyojun Choi, Hee Joon Jung, Seong-Beom Han, Qiang Wei, Seung-Ho Yu, Dong-Hwee Kim, Ramasamy Paulmurugan, Woong Kyo Jeong, Ki-Bum Lee, Taeghwan Hyeon, Dokyoon Kim, Heemin Kang
Summary: This study investigates the modulation of stem cell differentiation in the microenvironment using nanoassembly-based magnetic screens. Different sizes of screens can affect the adhesion, mechanotransduction, and differentiation of stem cells by adjusting nanogaps. This regulation mechanism is shown to be effective in vivo, demonstrating the potential for diverse modalities of unscreening RGDs to modulate stem cell differentiation for tissue repair.
ADVANCED MATERIALS
(2022)
Review
Chemistry, Multidisciplinary
Letao Yang, Kapil D. Patel, Christopher Rathnam, Ramar Thangam, Yannan Hou, Heemin Kang, Ki-Bum Lee
Summary: Extracellular vesicles (e.g., exosomes) carrying various biomolecules have great potential in biomedical applications, but their heterogeneity and inefficient uptake by recipient cells are critical barriers. Multifunctional nanomaterials, such as magnetic nanomaterials, can play crucial roles in addressing these issues and enhancing the applications of extracellular vesicles.
Article
Chemistry, Multidisciplinary
Joohyung Son, Soo Jeong Park, Taehyeong Ha, Sang-Nam Lee, Hyeon-Yeol Cho, Jeong-Woo Choi
Summary: By combining human brain organoids and motor neuron spheroids, we have developed an engineered brain-spinal cord assembloid system that can mimic signal transmission from the brain to the whole body. Using caffeine as a neurochemical model, we successfully demonstrated neural stimulation signals transferring from the brain organoids to the motor neuron spheroids. This research has important implications for studying neural signal transmission and controlling muscle actuators.
Article
Chemistry, Physical
Joungpyo Lim, Jinho Yoon, Minkyu Shin, Ki-Bum Lee, Jeong-Woo Choi
Summary: The study introduces a novel cell differentiation biomolecular electron controller, achieving successful spatiotemporal control of SH-SY5Y cell differentiation, providing a promising strategy for regenerative medicine and cell therapy.
Article
Chemistry, Multidisciplinary
Letao Yang, Brian M. Conley, Christopher Rathnam, Hyeon-Yeol Cho, Thanapat Pongkulapa, Brandon Conklin, Ki-Bum Lee
Summary: This study reports the development of a dynamic laser interference lithography (DIL) technique to generate large-scale combinatorial biophysical cue (CBC) arrays with diverse micro/nanostructures for investigating the role of biophysical cues in direct cell reprogramming. Through this approach, unconventional nanopatterns that induce the direct reprogramming of human fibroblasts into neurons were rapidly identified.
Article
Multidisciplinary Sciences
Markus Hackl, Edward V. Contrada, Jonathan E. Ash, Atharv Kulkarni, Jinho Yoon, Hyeon-Yeol Cho, Ki-Bum Lee, John M. Yarbrough, Cesar A. Lopez, Sandrasegaram Gnanakaran, Shishir P. S. Chundawat
Summary: Protein adsorption to solid carbohydrate interfaces is crucial in biological processes such as biomass deconstruction. This study focuses on understanding the interactions between carbohydrate-binding modules (CBMs) and polysaccharides to improve enzymatic efficiency in biomass deconstruction. The research presents a method using single-molecule force spectroscopy to study the unbinding behavior of CBMs from polysaccharide surfaces. The results reveal distinct CBM binding conformations and provide insights into the structural mechanisms through molecular dynamics simulations.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2022)
Article
Chemistry, Multidisciplinary
Letao Yang, Christopher Rathnam, Takuya Hidaka, Yannan Hou, Brandon Conklin, Ganesh N. Pandian, Hiroshi Sugiyama, Ki-Bum Lee
Summary: The study highlights the development of a nanoparticle-based synthetic mitochondrial transcription regulator (MitoScript) for controlling mitochondrial DNA transcription. MitoScript demonstrates great colloidal stability, biocompatibility, efficient cell uptake, and selective mitochondria targeting. It effectively downregulated the expression of the ND6 gene, which impacted the cell's redox status, resulting in increased ROS generation. This technology could contribute to understanding mitochondrial disorders and developing treatments for mitochondrial diseases.
Article
Chemistry, Multidisciplinary
Brian M. Conley, Letao Yang, Basanta Bhujel, Jeffrey Luo, Inbo Han, Ki-Bum Lee
Summary: We developed a dynamic and multifunctional nanohybrid peptide hydrogel that can overcome the heterogeneous pro-inflammatory and inhibitory extracellular matrix microenvironment, enabling robust repair of severely wounded fibrocartilaginous tissues.
Article
Chemistry, Multidisciplinary
Letao Yang, Basanta Bhujel, Yannan Hou, Jeffrey Luo, Seong Bae An, Inbo Han, Ki-Bum Lee
Summary: Degeneration of fibrocartilaginous tissues is often associated with complex pro-inflammatory factors, including reactive oxygen species (ROS), cell-free nucleic acids (cf-NAs), and epigenetic changes in immune cells. A self-therapeutic and epigenetic modulator-encapsulated hybrid protein nanoscaffold shows promise for restoring dysregulated inflammatory signaling and treating degenerative fibrocartilaginous diseases, such as disc injuries. The nanoscaffold exhibits inflammatory stimuli-responsive drug release, disc-mimetic stiffness, and excellent biodegradability, along with the ability to scavenge ROS and cf-NAs, reducing inflammation and promoting tissue regeneration.
ADVANCED MATERIALS
(2023)
Review
Chemistry, Multidisciplinary
Sarah Nevins, Callan D. McLoughlin, Alfredo Oliveros, Joshua B. Stein, Mohammad Abdur Rashid, Yannan Hou, Mi-Hyeon Jang, Ki-Bum Lee
Summary: Nanotechnology offers a promising approach for targeted drug delivery, improving the effectiveness and safety of therapeutics. Nanomaterials developed for selective targeting of cancers can potentially treat off-target effects caused by chemotherapy. Chemotherapy-induced neurotoxicity, neuropathy, and cardiomyopathy are common side effects that impact the quality of life for breast and ovarian cancer survivors. Nanoparticles have the potential to enhance therapeutic efficacy and reduce side effects, but more research is needed to develop interventions for women cancer survivors.
Article
Engineering, Biomedical
Jeffrey Luo, Anjani Darai, Thanapat Pongkulapa, Brian Conley, Letao Yang, Inbo Han, Ki-Bum Lee
Summary: Intervertebral disc degeneration is a common cause of back pain and can lead to more serious conditions such as disc herniation and spinal stenosis. Traditional growth factor therapies have limited effectiveness in completely regenerating degenerated discs, thus there is a need for bioscaffolds. A new injectable bioorthogonal hydrogel, called BIOGEL, was developed using tetrazine-norbornene bioorthogonal ligation combined with gelatin. This BIOGEL showed promising results in promoting tissue repair and functional recovery in rat models of IVD degeneration.
BIOACTIVE MATERIALS
(2023)
Editorial Material
Clinical Neurology
Jeffrey Luo, Joshua B. Stein, Ki-Bum Lee
Review
Chemistry, Physical
Sara Shakibania, Mehrdad Khakbiz, Cemile Kilic Bektas, Lida Ghazanfari, Milad Tavakoli Banizi, Ki-Bum Lee
Summary: Early diagnosis of diseases is crucial in selecting appropriate treatments, preventing problems, and stopping the spread of diseases. Additive manufacturing (AM) or 3D printing technology has been widely used in biomedical applications, providing highly precise and economical diagnostic tools with complex geometries.
MOLECULAR SYSTEMS DESIGN & ENGINEERING
(2022)
Article
Chemistry, Physical
Ali Akbar Ashkarran, Atiyeh Hosseini, Reza Loloee, George Perry, Ki-Bum Lee, Mikael Lund, Mohammad Reza Ejtehadi, Morteza Mahmoudi
Summary: We investigated the charge transport characteristics of self-assembled monolayers (SAMs) of short tau peptides using electron tunneling rates and quantum mechanical simulation. Our findings showed that the conformation and phosphorylation of short peptides can significantly affect their electron tunneling current and energy levels.
JOURNAL OF COLLOID AND INTERFACE SCIENCE
(2022)