Steering chemical reactions with force

Mechanical forces regulate the reactivity of a thioester bond in a bacterial adhesin

(2017) Daniel J. Echelman et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Altering Product Selectivity by Mechanochemistry

(2017) José G. Hernández et al.   JOURNAL OF ORGANIC CHEMISTRY

Reversible Unfolding and Folding of the Metalloprotein Ferredoxin Revealed by Single-Molecule Atomic Force Microscopy

(2017) Hai Lei et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Mechanobiology: A measure of molecular muscle

(2017) Michael Eisenstein   NATURE

Synthesis and characterization of triangulene

(2017) Niko Pavliček et al.   Nature Nanotechnology

Mechanochemical unzipping of insulating polyladderene to semiconducting polyacetylene

(2017) Zhixing Chen et al.   SCIENCE

Binding of Myomesin to Obscurin-Like-1 at the Muscle M-Band Provides a Strategy for Isoform-Specific Mechanical Protection

(2017) Stefano Pernigo et al.   STRUCTURE

Tailoring protein nanomechanics with chemical reactivity

(2017) Amy E. M. Beedle et al.   Nature Communications

Translation: The proof is in the protein

(2017) David Schilter   Nature Reviews Chemistry

Single Molecule Study of Force-Induced Rotation of Carbon–Carbon Double Bonds in Polymers

(2016) Wenmao Huang et al.   ACS Nano

Advances in Quantum Mechanochemistry: Electronic Structure Methods and Force Analysis

(2016) Tim Stauch et al.   CHEMICAL REVIEWS

Single-Molecule Observation of a Mechanically Activated Cis-to-Trans Cyclopropane Isomerization

(2016) Junpeng Wang et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

A HaloTag Anchored Ruler for Week-Long Studies of Protein Dynamics

(2016) Ionel Popa et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Defining Single Molecular Forces Required for Notch Activation Using Nano Yoyo

(2016) Farhan Chowdhury et al.   NANO LETTERS

Force-induced tautomerization in a single molecule

(2016) Janina N. Ladenthin et al.   Nature Chemistry

Unexpected mechanochemical complexity in the mechanistic scenarios of disulfide bond reduction in alkaline solution

(2016) Przemyslaw Dopieralski et al.   Nature Chemistry

Reversible Bergman cyclization by atomic manipulation

(2016) Bruno Schuler et al.   Nature Chemistry

The physics of pulling polyproteins: a review of single molecule force spectroscopy using the AFM to study protein unfolding

(2016) Megan L Hughes et al.   REPORTS ON PROGRESS IN PHYSICS

Protein S-sulfenylation is a fleeting molecular switch that regulates non-enzymatic oxidative folding

(2016) Amy E. M. Beedle et al.   Nature Communications

Polymer Mechanochemistry: From Destructive to Productive

(2015) Jun Li et al.   ACCOUNTS OF CHEMICAL RESEARCH

Force-Induced Reversal of β-Eliminations: Stressed Disulfide Bonds in Alkaline Solution

(2015) Przemyslaw Dopieralski et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Monitoring Oxidative Folding of a Single Protein Catalyzed by the Disulfide Oxidoreductase DsbA

(2015) Thomas B. Kahn et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Catch and Release: Orbital Symmetry Guided Reaction Dynamics from a Freed “Tension Trapped Transition State”

(2015) Junpeng Wang et al.   JOURNAL OF ORGANIC CHEMISTRY

The Mechanochemistry of a Structural Zinc Finger

(2015) Judit Perales-Calvo et al.   Journal of Physical Chemistry Letters

Reactivity and Mechanism of a Mechanically Activated anti-Woodward–Hoffmann–DePuy Reaction

(2015) Junpeng Wang et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Structural Insights and the Surprisingly Low Mechanical Stability of the Au–S Bond in the Gold-Specific Protein GolB

(2015) Wei Wei et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Force-Rate Characterization of Two Spiropyran-Based Molecular Force Probes

(2015) Gregory R. Gossweiler et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Relative Mechanical Strengths of Weak Bonds in Sonochemical Polymer Mechanochemistry

(2015) Bobin Lee et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Mapping Mechanical Force Propagation through Biomolecular Complexes

(2015) Constantin Schoeler et al.   NANO LETTERS

Extracellular rigidity sensing by talin isoform-specific mechanical linkages

(2015) Katharina Austen et al.   NATURE CELL BIOLOGY

Inducing and quantifying forbidden reactivity with single-molecule polymer mechanochemistry

(2015) Junpeng Wang et al.   Nature Chemistry

Force-induced chemical reactions on the metal centre in a single metalloprotein molecule

(2015) Peng Zheng et al.   Nature Communications

The mechanochemistry of copper reports on the directionality of unfolding in model cupredoxin proteins

(2015) Amy E. M. Beedle et al.   Nature Communications

Reversible Unfolding-Refolding of Rubredoxin: A Single-Molecule Force Spectroscopy Study

(2014) Peng Zheng et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

S-Glutathionylation of Cryptic Cysteines Enhances Titin Elasticity by Blocking Protein Folding

(2014) Jorge Alegre-Cebollada et al.   CELL

Metalloproteins Containing Cytochrome, Iron–Sulfur, or Copper Redox Centers

(2014) Jing Liu et al.   CHEMICAL REVIEWS

Isolated nuclei adapt to force and reveal a mechanotransduction pathway in the nucleus

(2014) Christophe Guilluy et al.   NATURE CELL BIOLOGY

Direct correlation of single-molecule properties with bulk mechanical performance for the biomimetic design of polymers

(2014) Jaeyoon Chung et al.   NATURE MATERIALS

Force-dependent isomerization kinetics of a highly conserved proline switch modulates the mechanosensing region of filamin

(2014) L. Rognoni et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Mechanical activation of vinculin binding to talin locks talin in an unfolded conformation

(2014) Mingxi Yao et al.   Scientific Reports

Homolytic Cleavage of FeS Bonds in Rubredoxin under Mechanical Stress

(2013) Guilherme M. Arantes et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Sulfenic acid chemistry, detection and cellular lifetime

(2013) Vinayak Gupta et al.   BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS

Polymer mechanochemistry: techniques to generate molecular force via elongational flows

(2013) Preston A. May et al.   CHEMICAL SOCIETY REVIEWS

Nanomechanics of HaloTag Tethers

(2013) Ionel Popa et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Single Molecule Force Spectroscopy Reveals the Molecular Mechanical Anisotropy of the FeS4 Metal Center in Rubredoxin

(2013) Peng Zheng et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

The Janus-faced role of external forces in mechanochemical disulfide bond cleavage

(2013) Przemyslaw Dopieralski et al.   Nature Chemistry

Nuclear Lamin-A Scales with Tissue Stiffness and Enhances Matrix-Directed Differentiation

(2013) J. Swift et al.   SCIENCE

Single-Molecule Mechanoenzymatics

(2012) Elias M. Puchner et al.   Annual Review of Biophysics

Kinetics and Mechanisms of Thiol–Disulfide Exchange Covering Direct Substitution and Thiol Oxidation-Mediated Pathways

(2012) Péter Nagy   ANTIOXIDANTS & REDOX SIGNALING

Force-Clamp Analysis Techniques Give Highest Rank to Stretched Exponential Unfolding Kinetics in Ubiquitin

(2012) Herbert Lannon et al.   BIOPHYSICAL JOURNAL

Mechanical Force Can Fine-Tune Redox Potentials of Disulfide Bonds

(2012) Ilona B. Baldus et al.   BIOPHYSICAL JOURNAL

Protein Folding Drives Disulfide Formation

(2012) Pallav Kosuri et al.   CELL

Covalent Mechanochemistry: Theoretical Concepts and Computational Tools with Applications to Molecular Nanomechanics

(2012) Jordi Ribas-Arino et al.   CHEMICAL REVIEWS

Stretching single polysaccharides and proteins using atomic force microscopy

(2012) Piotr E. Marszalek et al.   CHEMICAL SOCIETY REVIEWS

Hydrogen Bond Strength Modulates the Mechanical Strength of Ferric-Thiolate Bonds in Rubredoxin

(2012) Peng Zheng et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Tension Trapping of Carbonyl Ylides Facilitated by a Change in Polymer Backbone

(2012) Hope M. Klukovich et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Rate limit of protein elastic response is tether dependent

(2012) R. Berkovich et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Direct observation of a force-induced switch in the anisotropic mechanical unfolding pathway of a protein

(2012) B. Jagannathan et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

PicoNewton-Millisecond Force Steps Reveal the Transition Kinetics and Mechanism of the Double-Stranded DNA Elongation

(2011) Pasquale Bianco et al.   BIOPHYSICAL JOURNAL

Direct Measurements of the Mechanical Stability of Zinc-Thiolate Bonds in Rubredoxin by Single-Molecule Atomic Force Microscopy

(2011) Peng Zheng et al.   BIOPHYSICAL JOURNAL

Chemomechanics: chemical kinetics for multiscale phenomena

(2011) Zhen Huang et al.   CHEMICAL SOCIETY REVIEWS

Direct Quantification of the Attempt Frequency Determining the Mechanical Unfolding of Ubiquitin Protein

(2011) Ionel Popa et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Influence of External Force on Properties and Reactivity of Disulfide Bonds

(2011) Maria Francesca Iozzi et al.   JOURNAL OF PHYSICAL CHEMISTRY A

Contrasting the Individual Reactive Pathways in Protein Unfolding and Disulfide Bond Reduction Observed within a Single Protein

(2011) Sergi Garcia-Manyes et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Kinetic Measurements on Single-Molecule Disulfide Bond Cleavage

(2011) Jian Liang et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Highly Covalent Ferric−Thiolate Bonds Exhibit Surprisingly Low Mechanical Stability

(2011) Peng Zheng et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Mechanics and Chemistry: Single Molecule Bond Rupture Forces Correlate with Molecular Backbone Structure

(2011) Michael Frei et al.   NANO LETTERS

Direct observation of disulfide isomerization in a single protein

(2011) Jorge Alegre-Cebollada et al.   Nature Chemistry

Disulfide Bond Cleavage: A Redox Reaction Without Electron Transfer

(2010) Florian Hofbauer et al.   CHEMISTRY-A EUROPEAN JOURNAL

Molecular Stress Relief through a Force-Induced Irreversible Extension in Polymer Contour Length

(2010) Dong Wu et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Atomistic Evidence of How Force Dynamically Regulates Thiol/Disulfide Exchange

(2010) Wenjin Li et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Mechanochemical Transduction of Externally Applied Forces to Mechanophores

(2010) Jordi Ribas-Arino et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

A mechanically stabilized receptor–ligand flex-bond important in the vasculature

(2010) Jongseong Kim et al.   NATURE

Probing static disorder in Arrhenius kinetics by single-molecule force spectroscopy

(2010) T.-L. Kuo et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Structural insight into M-band assembly and mechanics from the titin-obscurin-like-1 complex

(2010) S. Pernigo et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Trapping a Diradical Transition State by Mechanochemical Polymer Extension

(2010) J. M. Lenhardt et al.   SCIENCE

Mechanochemistry: One Bond at a Time

(2009) Jian Liang et al.   ACS Nano

Kinetics of Thiol/Disulfide Exchange Correlate Weakly with the Restoring Force in the Disulfide Moiety

(2009) Timothy J. Kucharski et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Understanding Covalent Mechanochemistry

(2009) Jordi Ribas-Arino et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Mechanically-Induced Chemical Changes in Polymeric Materials

(2009) Mary M. Caruso et al.   CHEMICAL REVIEWS

How far can a rubber molecule stretch before breaking? Ab initio study of tensile elasticity and failure in single-molecule polyisoprene and polybutadiene

(2009) David E. Hanson et al.   JOURNAL OF CHEMICAL PHYSICS

First Principles Dynamics and Minimum Energy Pathways for Mechanochemical Ring Opening of Cyclobutene

(2009) Mitchell T. Ong et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

gem-Dichlorocyclopropanes as Abundant and Efficient Mechanophores in Polybutadiene Copolymers under Mechanical Stress

(2009) Jeremy M. Lenhardt et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Force-induced activation of covalent bonds in mechanoresponsive polymeric materials

(2009) Douglas A. Davis et al.   NATURE

Force-activated reactivity switch in a bimolecular chemical reaction

(2009) Sergi Garcia-Manyes et al.   Nature Chemistry

Diversity of chemical mechanisms in thioredoxin catalysis revealed by single-molecule force spectroscopy

(2009) Raul Perez-Jimenez et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Osmolyte-induced separation of the mechanical folding phases of ubiquitin

(2009) S. Garcia-Manyes et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Direct observation of an ensemble of stable collapsed states in the mechanical folding of ubiquitin

(2009) S. Garcia-Manyes et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

On the remarkable mechanostability of scaffoldins and the mechanical clamp motif

(2009) A. Valbuena et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Stretching Single Talin Rod Molecules Activates Vinculin Binding

(2009) A. del Rio et al.   SCIENCE

Mechanoenzymatic Cleavage of the Ultralarge Vascular Protein von Willebrand Factor

(2009) X. Zhang et al.   SCIENCE

Mechanical Network in Titin Immunoglobulin from Force Distribution Analysis

(2009) Wolfram Stacklies et al.   PLoS Computational Biology

Single-Molecule Force Spectroscopy Measurements of Bond Elongation during a Bimolecular Reaction

(2008) Sri Rama Koti Ainavarapu et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Single-molecule force spectroscopy: optical tweezers, magnetic tweezers and atomic force microscopy

(2008) Keir C Neuman et al.   NATURE METHODS

Mechanoenzymatics of titin kinase

(2008) E. M. Puchner et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Theory, analysis, and interpretation of single-molecule force spectroscopy experiments

(2008) O. K. Dudko et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Mechanism of Thiolate−Disulfide Interchange Reactions in Biochemistry

(2007) Robert D. Bach et al.   JOURNAL OF ORGANIC CHEMISTRY

A Single-Molecule Assay to Directly Identify Solvent-Accessible Disulfide Bonds and Probe Their Effect on Protein Folding

(2007) Sri Rama Koti Ainavarapu et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY