期刊
NATURE BIOMEDICAL ENGINEERING
卷 1, 期 9, 页码 697-713出版社
NATURE PUBLISHING GROUP
DOI: 10.1038/s41551-017-0131-8
关键词
-
资金
- Cancer Research UK
- UK Medical Research Council
- National Institutes of Health
- Commonwealth Foundation for Cancer Research
- Center for Experimental Therapeutics of Memorial Sloan Kettering Cancer Center
- Cancer Research UK [16584] Funding Source: researchfish
Complex molecular and metabolic phenotypes depict cancers as a constellation of different diseases with common themes. Precision imaging of such phenotypes requires flexible and tunable modalities capable of identifying phenotypic fingerprints by using a restricted number of parameters while ensuring sensitivity to dynamic biological regulation. Common phenotypes can be detected by in vivo imaging technologies, and effectively define the emerging standards for disease classification and patient stratification in radiology. However, for the imaging data to accurately represent a complex fingerprint, the individual imaging parameters need to be measured and analysed in relation to their wider spatial and molecular context. In this respect, targeted palettes of molecular imaging probes facilitate the detection of heterogeneity in oncogene-driven alterations and their response to treatment, and lead to the expansion of rational-design elements for the combination of imaging experiments. In this Review, we evaluate criteria for conducting multiplexed imaging, and discuss its opportunities for improving patient diagnosis and the monitoring of therapy.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据