Multiplexed enrichment of rare DNA variants via sequence-selective and temperature-robust amplification

Diagnostics based on nucleic acid sequence variant profiling: PCR, hybridization, and NGS approaches

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Reversible acetylation on Lys501 regulates the activity of RNase II

(2016) Limin Song et al.   NUCLEIC ACIDS RESEARCH

Fragment Length of Circulating Tumor DNA

(2016) Hunter R. Underhill et al.   PLoS Genetics

Denoising DNA deep sequencing data—high-throughput sequencing errors and their correction

(2015) David Laehnemann et al.   BRIEFINGS IN BIOINFORMATICS

Simulation-guided DNA probe design for consistently ultraspecific hybridization

(2015) Juexiao Sherry Wang et al.   Nature Chemistry

High-throughput RNA profiling via up-front sample parallelization

(2015) Azeet Narayan et al.   NATURE METHODS

Continuously tunable nucleic acid hybridization probes

(2015) Lucia R Wu et al.   NATURE METHODS

PCR heads into the field

(2015) Vivien Marx   NATURE METHODS

Mutation tracking in circulating tumor DNA predicts relapse in early breast cancer

(2015) Isaac Garcia-Murillas et al.   Science Translational Medicine

Mutation profiling of tumor DNA from plasma and tumor tissue of colorectal cancer patients with a novel, high-sensitivity multiplexed mutation detection platform

(2015) Evelyn Kidess et al.   Oncotarget

Analytical and Clinical Validation of a Digital Sequencing Panel for Quantitative, Highly Accurate Evaluation of Cell-Free Circulating Tumor DNA

(2015) Richard B. Lanman et al.   PLoS One

Circulating Tumor DNA as a Liquid Biopsy for Cancer

(2014) E. Heitzer et al.   CLINICAL CHEMISTRY

An ultrasensitive method for quantitating circulating tumor DNA with broad patient coverage

(2014) Aaron M Newman et al.   NATURE MEDICINE

Multitarget Stool DNA Testing for Colorectal-Cancer Screening

(2014) Thomas F. Imperiale et al.   NEW ENGLAND JOURNAL OF MEDICINE

Detection of Circulating Tumor DNA in Early- and Late-Stage Human Malignancies

(2014) C. Bettegowda et al.   Science Translational Medicine

Single molecule molecular inversion probes for targeted, high-accuracy detection of low-frequency variation

(2013) J. B. Hiatt et al.   GENOME RESEARCH

Mycobacterium tuberculosis mutation rate estimates from different lineages predict substantial differences in the emergence of drug-resistant tuberculosis

(2013) Christopher B Ford et al.   NATURE GENETICS

The NHGRI GWAS Catalog, a curated resource of SNP-trait associations

(2013) Danielle Welter et al.   NUCLEIC ACIDS RESEARCH

A comparison of three methods for detecting KRAS mutations in formalin-fixed colorectal cancer specimens

(2012) D Gonzalez de Castro et al.   BRITISH JOURNAL OF CANCER

Ultrasensitive Measurement of Hotspot Mutations in Tumor DNA in Blood Using Error-Suppressed Multiplexed Deep Sequencing

(2012) A. Narayan et al.   CANCER RESEARCH

Competitive allele specific TaqMan PCR for KRAS, BRAF and EGFR mutation detection in clinical formalin fixed paraffin embedded samples

(2012) Audrey Didelot et al.   EXPERIMENTAL AND MOLECULAR PATHOLOGY

An integrated map of genetic variation from 1,092 human genomes

(2012)   NATURE

Optimizing the specificity of nucleic acid hybridization

(2012) David Yu Zhang et al.   Nature Chemistry

RNase H-dependent PCR (rhPCR): improved specificity and single nucleotide polymorphism detection using blocked cleavable primers

(2011) Joseph R Dobosy et al.   BMC BIOTECHNOLOGY

Detection of KRAS and BRAF Mutations in Colorectal Carcinoma

(2011) Maria Arcila et al.   JOURNAL OF MOLECULAR DIAGNOSTICS

High Fragmentation Characterizes Tumour-Derived Circulating DNA

(2011) Florent Mouliere et al.   PLoS One

Detection and quantification of rare mutations with massively parallel sequencing

(2011) I. Kinde et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Analyzing and minimizing PCR amplification bias in Illumina sequencing libraries

(2011) Daniel Aird et al.   GENOME BIOLOGY

COSMIC: mining complete cancer genomes in the Catalogue of Somatic Mutations in Cancer

(2010) S. A. Forbes et al.   NUCLEIC ACIDS RESEARCH

Dormancy contributes to the maintenance of microbial diversity

(2010) S. E. Jones et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Mutation Detection by Real-Time PCR: A Simple, Robust and Highly Selective Method

(2009) John Morlan et al.   PLoS One

Nonlinear electrophoretic response yields a unique parameter for separation of biomolecules

(2009) J. Pel et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Predicting Stability of DNA Duplexes in Solutions Containing Magnesium and Monovalent Cations

(2008) Richard Owczarzy et al.   BIOCHEMISTRY

Replacing PCR with COLD-PCR enriches variant DNA sequences and redefines the sensitivity of genetic testing

(2008) Jin Li et al.   NATURE MEDICINE