Review
Engineering, Electrical & Electronic
Ashiqur Rahaman, Byungki Kim
Summary: This paper reviews recent biomimetic sound source localization approaches, discusses the necessity of biomimetic SSL, and evaluates the merits and demerits of each technique. The future perspective is also presented for designing next-generation microscale devices for biomimetic SSL.
JOURNAL OF MICROELECTROMECHANICAL SYSTEMS
(2022)
Review
Chemistry, Analytical
Haijian Zhang, Yanxiu Peng, Nuohan Zhang, Jian Yang, Yongtian Wang, He Ding
Summary: Thin-film microscale LEDs with their efficient performance and biocompatibility offer promising applications in biomedical research and clinical diagnosis and therapy. The innovations in design, fabrication techniques, and wireless power supply enable remote control and minimally invasive implantation of these LEDs, providing new possibilities for implantable probes.
Article
Ecology
Shifra Steinberg, Maor Grinberg, Michael Beitelman, Julianna Peixoto, Tomer Orevi, Nadav Kashtan
Summary: This study found that interactions between immigrant bacteria and resident microbiota affect the microscale spatial organization of leaf microbiota, especially due to the preferential attachment of microbiota cells near newly formed P. fluorescens aggregates.
Article
Chemistry, Physical
Jinjin Li, Yue Zhang, Xufeng Li, Chunyan Chen, Haihan Zou, Peng Yi, Xiaofang Liu, Ronghai Yu
Summary: In this study, smart electromagnetic functional devices were prepared based on electromagnetic wave responsive materials, showing potential applications in electromagnetic wave control systems and intelligent electromagnetic protection systems. By assembling polydimethylsiloxane films filled with magnetic liquid metal droplets, a tunable electromagnetic interference shielding material was obtained, and strain and magnetic sensors were successfully assembled for precise pressure and magnetic field sensing.
Article
Engineering, Electrical & Electronic
Jie Li, Ruiyang Qin, Jingjing Sun, Daniel Costinett
Summary: This article describes the systematic design of a 100-W multiload wireless charging station with positional flexibility for receivers, limited cross-channel disturbance, and high efficiency. The design uses transmitter coil design approach and an immittance network to achieve these features. A holistic system-level modeling and design method is proposed for maximum efficiency.
IEEE TRANSACTIONS ON POWER ELECTRONICS
(2022)
Article
Physics, Applied
Oliver J. Trojak, Sean Gorsky, Connor Murray, Fabrizio Sgrignuoli, Felipe A. Pinheiro, Luca Dal Negro, Luca Sapienza
Summary: Enhancing light-matter interactions on a chip using aperiodic structures allows for efficient visible light confinement and higher quality factors for optical resonances. This approach shows potential applications in active nanophotonic devices, improving the understanding of fundamental physical properties of light-emitting systems.
APPLIED PHYSICS LETTERS
(2021)
Article
Multidisciplinary Sciences
Peng Ji, Yue Gong, Ming-Liang Jin, Huai-Liang Wu, Lin-Wei Guo, Yu-Chen Pei, Wen-Jun Chai, Yi-Zhou Jiang, Yin Liu, Xiao-Yan Ma, Gen-Hong Di, Xin Hu, Zhi-Ming Shao
Summary: The response rates of immune checkpoint inhibitors in TNBC patients are limited, indicating the presence of additional immune escape mechanisms. By using customized in vivo CRISPR screens and transcriptomic analysis, Lgals2 was identified as a potential regulator involved in immune escape in TNBC. Mechanistic studies showed that Lgals2 induced the polarization and proliferation of tumor-associated macrophages through the CSF1/CSF1R axis, resulting in the immunosuppressive microenvironment of TNBC. Blockade of LGALS2 using an inhibitory antibody effectively halted tumor growth and reversed immune suppression.
Article
Biochemistry & Molecular Biology
Songbai Zhang, Vega Lloveras, Silvia Lope-Piedrafita, Pilar Calero-Perez, Shuang Wu, Silvia Lope-Piedrafita, Ana Paula Candiota, Jose Vidal-Gancedo
Summary: MRI is a highly required imaging approach for the early diagnosis and follow-up of tumors, especially brain cancer. Organic radicals anchored on a dendrimer macromolecule surface show promising potential as alternatives to traditional Gd-based contrast agents, with similar contrast enhancement effects, lower toxicity, and longer biological stability.
Article
Biology
Weirui Ma, Gang Zheng, Wei Xie, Christine Mayr
Summary: Liquid-like condensates in cells are not necessarily sphere-like, as various condensates with filamentous morphology have been observed. One example is the TIS granule network, which shares a large surface area with the rough endoplasmic reticulum and plays a crucial role in membrane protein trafficking. Reconstitution experiments have shown that a multivalent RNA-binding protein and RNAs with large unstructured regions can form a pervasive intermolecular interaction network that acts as a condensate skeleton.
Article
Chemistry, Multidisciplinary
Roberto Maria-Hormigos, Carmen C. Mayorga-Martinez, Martin Pumera
Summary: The cost of insect pests to human society is significant, and the use of pesticides is necessary. This study explores the use of hydrogel chitosan magnetic microrobots as chemical carriers to efficiently kill mealworm larvae.
Article
Nanoscience & Nanotechnology
Shi-Hui Chen, Lu-Yao Huang, Biao Huang, Mingxi Zhang, Hao Li, Dai-Wen Pang, Zhi-Ling Zhang, Ran Cui
Summary: This study synthesizes ultrasmall MnSe nanoparticles and demonstrates their potential as T-1-MRI contrast agents for clinical tumor imaging. The nanoparticles exhibit high relaxivity and a long MRI acquisition window, while also showing no appreciable toxicity to cells and organisms.
ACS APPLIED MATERIALS & INTERFACES
(2022)
Article
Chemistry, Analytical
Ion Stiharu, Sergey Andronenko, Almaz Zinnatullin, Farit Vagizov
Summary: Polymer-derived SiCNFe ceramics have potential as soft magnets in MEMS magnetic applications. The composition of SiCNFe ceramics is crucial for the microfabrication of magnetic MEMS devices. Mossbauer spectrum analysis reveals the formation of various Fe-containing magnetic nanoparticles in SiCNFe ceramics, indicating the incomplete pyrolysis process and the complex composition of the ceramic composite.
Article
Multidisciplinary Sciences
Masahiro Kato, Hayato Yoshizawa, Masato Nakaya, Yasutaka Kitagawa, Koichi Okamoto, Tomoaki Yamada, Masahito Yoshino, Kentaro Tanaka, Jun Onoe
Summary: This study reveals that not only the monoclinic phase but also the amorphous and triclinic phases of lead phthalocyanine (PbPc) can absorb visible light. The exciton dynamics in the PbPc film are explored through static and time-resolved photoluminescence analysis. By comparing PbPc-based organic solar cells (OSCs) with zinc phthalocyanine (ZnPc)-based OSCs, the reasons behind PbPc's effectiveness as a near-infrared (NIR) light absorber for sensitive devices are uncovered.
SCIENTIFIC REPORTS
(2022)
Article
Engineering, Biomedical
Cagatay M. M. Oral, Martina Ussia, Mario Urso, Jiri Salat, Adam Novobilsky, Michal Stefanik, Daniel Ruzek, Martin Pumera
Summary: Magnetic nanorobots with radiopaque features and microCT technology enable precise navigation and in vivo imaging in hard-to-reach areas of the human body. The nanorobots can be controlled by rotating magnetic fields and their internal structures can be revealed through X-ray contrast. In vivo experiments demonstrate the localization capability of the nanorobots in the gastrointestinal tract.
ADVANCED HEALTHCARE MATERIALS
(2022)
Review
Chemistry, Physical
Tahta Amrillah, Angga Hermawan, Yeremia Budi Cristian, Agustina Oktafiani, Diva Meisya Maulina Dewi, Ilma Amalina, Darminto, Jenh-Yih Juang
Summary: The search for materials for next-generation spintronic applications has experienced a surge in interest due to the discovery of numerous two-dimensional (2D) materials in the past decade. MXenes have emerged as potential candidates for various applications due to their unique tunability and properties. Their combination of conductivity and highly charged surfaces make them suitable for electronic applications, and their ease of modification allows for possible spintronic device applications. This article provides an overview of the potential applications of MXenes in spintronic devices, discussing fundamental aspects, fabrication, strategies, and future challenges.
PHYSICAL CHEMISTRY CHEMICAL PHYSICS
(2023)
Article
Chemistry, Multidisciplinary
Marjorie T. Buss, Pradeep Ramesh, Max Atticus English, Audrey Lee-Gosselin, Mikhail G. Shapiro
Summary: The use of a composite biomagnetic material with microscale magnetic particles and probiotic bacteria, along with an externally applied magnetic field, allows for better localization and retention of probiotic bacteria in the GI tract of mice. This technology enhances the ability of GI-targeted probiotics to accumulate at specific locations and stably colonize without the need for antibiotic treatment, providing external physical control to an important class of microbial theranostics.
ADVANCED MATERIALS
(2021)
Article
Engineering, Electrical & Electronic
Arian Hashemi Talkhooncheh, You Yu, Abhinav Agarwal, William Wei-Ting Kuo, Kuan-Chang Chen, Minwo Wang, Gudrun Hoskuldsdottir, Wei Gao, Azita Emami
Summary: This article introduces an efficient cold-starting energy harvester system, which operates at low voltages and can start up and continue operating at minimum input voltages. The system achieves high power efficiency across a wide range of loading powers.
IEEE JOURNAL OF SOLID-STATE CIRCUITS
(2021)
Article
Engineering, Electrical & Electronic
Kuan-Chang Chen, William Wei-Ting Kuo, Azita Emami
Summary: This article introduces a 4-level PAM4 receiver for wireline communication, incorporating CTLEs and a 2-tap DFE, with a proposed CMOS track-and-regenerate slicer for improving clock delay and signal swing. The direct DFE enabled by the proposed slicer eliminates the need for area/power intensive loop-unrolling and inductor-based bandwidth enhancement techniques at high data rates. The PAM4 receiver achieves a BER better than 1E-12 and energy efficiency of 1.1 pJ/b at 60 Gb/s in 28-nm CMOS technology.
IEEE JOURNAL OF SOLID-STATE CIRCUITS
(2021)
Review
Chemistry, Physical
Arash Farhadi, Felix Sigmund, Gil Gregor Westmeyer, Mikhail G. Shapiro
Summary: Advancements in research have allowed for the visualization of specific cell and molecular functions in non-invasive biological imaging using genetically encoded protein contrast agents, providing new forms of biomolecular and cellular contrast.
Article
Biochemistry & Molecular Biology
Przemyslaw Dutka, Dina Malounda, Lauren Ann Metskas, Songye Chen, Robert C. Hurt, George J. Lu, Grant J. Jensen, Mikhail G. Shapiro
Summary: Gas vesicles are protein nanostructures filled with air, used for flotation by various microorganisms and gaining interest in biotechnology applications. The diameter of gas vesicles is crucial for their mechanical stability, buoyancy function, and imaging properties. Discrepancies in reported diameters of gas vesicles can be explained by the method used for assessment, and electron microscopy techniques can provide accurate measurements of their dimensions.
Article
Physics, Applied
Claire Rabut, Di Wu, Bill Ling, Zhiyang Jin, Dina Malounda, Mikhail G. Shapiro
Summary: Ultrasound is increasingly used in molecular and cellular imaging with the help of new micro- and nanoscale contrast agents and reporter genes. Existing ultrasound techniques face limitations in terms of scan speed and field of view, but a new ultrafast nonlinear imaging modality has been introduced to address these issues, achieving higher sensitivity and faster imaging while allowing for simultaneous monitoring of phenomena that require ultrafast frame rates.
APPLIED PHYSICS LETTERS
(2021)
Article
Computer Science, Interdisciplinary Applications
Saransh Sharma, Aditya Telikicherla, Grace Ding, Fatemeh Aghlmand, Arian Hashemi Talkhooncheh, Mikhail G. Shapiro, Azita Emami
Summary: This paper presents a high-resolution 3D navigation and tracking system using magnetic field gradients for precise surgeries, replacing X-Ray fluoroscopy. The system utilizes monotonically varying magnetic fields in X, Y and Z directions to encode each spatial point uniquely and features miniaturized, wireless and battery-less devices for sensing the gradient field. A prototype device is designed with high localization accuracy demonstrated in vitro, achieving >= 90% utilization of coil-span for X and Y FOV.
IEEE TRANSACTIONS ON MEDICAL IMAGING
(2021)
Article
Multidisciplinary Sciences
Sangjin Yoo, David R. Mittelstein, Robert Hurt, Jerome Lacroix, Mikhail G. Shapiro
Summary: Focused ultrasound excites neurons through mechanosensitive ion channels, resulting in calcium accumulation and burst firing response. This non-invasive method provides high spatial precision and does not require chemical or genetic modification, making it an important tool for neuroscience research.
NATURE COMMUNICATIONS
(2022)
Article
Engineering, Mechanical
Hossein Salahshoor, Hongsun Guo, Mikhail G. Shapiro, Michael Ortiz
Summary: Ultrasound neuromodulation (UNM) is a promising technique for excitation or inhibition of neural activity, but its off-target sensory effects and their dependence on stimulation frequency are still unclear. Research shows that the brain is largely insulated by the skull, and shear waves are carried away from the skull by the vertebral column, forming a frequency-dependent waveguide mechanism that may contribute to the frequency dependence of UNM effects.
EXTREME MECHANICS LETTERS
(2022)
Article
Engineering, Electrical & Electronic
Arda Uran, Kerim Ture, Cosimo Aprile, Alix Trouillet, Florian Fallegger, Emilie C. M. Revol, Azita Emami, Stephanie P. Lacour, Catherine Dehollain, Yusuf Leblebici, Volkan Cevher
Summary: This article presents a neural recording system-on-chip that achieves high resource and wireless bandwidth efficiency. The chip is able to compress and reduce the data rate of raw neural signals while maintaining good classification performance, enabling simultaneous recording from a large number of channels.
IEEE JOURNAL OF SOLID-STATE CIRCUITS
(2022)
Article
Engineering, Electrical & Electronic
Manjunath Machnoor, Pragya Kosta, Manuel Monge, Gianluca Lazzi
Summary: This paper proposes a new rectifier design for low/medium coupling inductive wireless power transfer systems used in wireless biomedical implants, aiming to increase power transfer efficiency and reduce harmonics. The design decreases diode turn-on impedance and provides separate paths for RF and rectification signals, improving the efficiency and output performance of the rectifier.
IEEE JOURNAL OF ELECTROMAGNETICS RF AND MICROWAVES IN MEDICINE AND BIOLOGY
(2022)
Article
Computer Science, Hardware & Architecture
Angsagan Abdigazy, Manuel Monge
Summary: This letter presents a novel low-power, mm-scale transceiver for insertable smart pills. The transmitter incorporates an on-chip antenna and achieves a data rate of 33 Mb/s with low power consumption. The receiver uses a magnetic sensor and achieves a data rate of 0.02 kb/s.
IEEE SOLID-STATE CIRCUITS LETTERS
(2022)
Proceedings Paper
Engineering, Electrical & Electronic
Arda Uran, Kerim Ture, Cosimo Aprile, Alix Trouillet, Florian Fallegger, Azita Emami, Stephanie P. Lacour, Catherine Dehollain, Yusuf Leblebici, Volkan Cevher
2021 IEEE CUSTOM INTEGRATED CIRCUITS CONFERENCE (CICC)
(2021)
Article
Biophysics
Yuxing Yao, Zhiyang Jin, Bill Ling, Dina Malounda, Mikhail G. Shapiro
Summary: Research has shown that the ordered assembly of gas vesicles can be achieved by screening their mutual electrostatic repulsion with electrolytes and creating a crowding force with dissolved macromolecules. The study provides insight into how physically driven interactions affect the formation of protein superstructures, offering guidance for manipulating nanoparticle assembly in cellular environments. These findings inform research on the biotechnological applications of genetically encoded protein nanoparticles.
BIOPHYSICAL JOURNAL
(2021)
Proceedings Paper
Engineering, Electrical & Electronic
Fatemeh Aghlmand, Saransh Sharma, Azita Emami
Summary: This paper presents a fully integrated high-bandwidth receiver for RF-over-free-space optics, supporting high data rate optical communication in a high-loss atmospheric channel. The receiver chip uses adaptive control loops to compensate for atmospheric effects and achieves 58dB of gain and 18GHz of bandwidth, demonstrating its performance in adverse conditions.
2020 15TH EUROPEAN MICROWAVE INTEGRATED CIRCUITS CONFERENCE (EUMIC)
(2021)