期刊
MOLECULAR CATALYSIS
卷 435, 期 -, 页码 76-81出版社
ELSEVIER SCIENCE BV
DOI: 10.1016/j.mcat.2017.03.017
关键词
Henry reaction; Asymmetric catalysis; Copper; chiral N-aryl-diamine ligands; 2-Nitro-l-phenylethanol
资金
- CMIRA (Cooperations et Mobilites Internationales Rhone-Alpes)
- Lebanese University
Asymmetric Henry reaction between benzaldehyde derivatives and nitomethane leading to 2-nitro-1-aryl ethanol has been developed. It was found that N,N'-diarylated diamine ligands and N-aryl diamine induce enantioselectivity when(or when they are) combined to copper (II). The presence of triethylamine is crucial in case of N,N'-binaphthalene diamine at only low temperature (-20 degrees C), however in case of N-naphthalene diamine ligand there is no need of adding an external base. Good enantioselectivities (up to 83%) with good isolated yield were obtained using a catalytic loading of 10% mol at room temperature. (c) 2017 Elsevier B.V. All rights reserved.
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