Review
Biotechnology & Applied Microbiology
Renlun Huang, Lang Guo, Menghan Gao, Jing Li, Songtao Xiang
Summary: Prostate cancer (PCa) is the most common cancer of urologic neoplasms, and the CCL5/CCR5 axis plays a significant role in its development, but challenges remain in precision oncology.
ONCOTARGETS AND THERAPY
(2021)
Article
Oncology
Wilfredo Alejandro Gonzalez-Arriagada, Ricardo D. Coletta, Carlo Lozano-Burgos, Cynthia Garcia, Jaime Maripillan, Francisca Alcayaga-Miranda, Bastian Godinez-Pacheco, Sebastian Oyarce-Pezoa, Rene Martinez-Flores, Isaac E. Garcia
Summary: The CCR5/CCL5 axis plays an important role in the behavior of oral cancer, with CCR5 expression associated with clinical stage and metastasis, and CCL5 associated with overall survival. The CCR5 antagonist Maraviroc can inhibit cell proliferation, increase apoptosis, and modify cytoskeletal organization. In vivo studies show that Maraviroc can reduce neck metastasis.
JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY
(2023)
Article
Oncology
Karen J. Dunbar, Tatiana A. Karakasheva, Qiaosi Tang, Gizem Efe, Eric W. Lin, Michael Harris, Varun Sahu, Uma M. Sachdeva, Jianhua Hu, Andres J. Klein-Szanto, Brian Henick, Hiroshi Nakagawa, Anil K. Rustgi, J. Alan Diehl
Summary: Cancer-associated fibroblasts (CAF) play a role in promoting tumor growth, metastasis, and therapeutic resistance, and their communication with esophageal squamous cell carcinoma (ESCC) tumor cells is mediated by the secreted factor CC motif chemokine ligand 5 (CCL5). Loss of tumor-derived CCL5 reduces ESCC cell proliferation and the recruitment of CAFs to xenograft tumors, and CCR5 inhibition with Maraviroc mimics these effects. High CCL5 or CCR5 expression is associated with worse prognosis in low-grade esophageal carcinomas.
MOLECULAR CANCER RESEARCH
(2023)
Article
Immunology
Lin-Nan Shao, Shi-Hang Zhou, Ni Wang, Shu-Ting Zhang, Ming Liu
Summary: The study revealed that rs1024610 and the ATGC haplotype in CCL2 could be reasonable markers of liver abnormalities, while rs2280788 and the TGCT haplotype in CCL5 are likely to play a significant role in liver fibrosis during chronic HCV infection.
IMMUNOLOGICAL INVESTIGATIONS
(2022)
Review
Cardiac & Cardiovascular Systems
Yongyan Song, Shujin Li, Chuan He
Summary: Activated by ligands, PPAR gamma plays a role in enhancing insulin sensitivity, promoting adipocyte differentiation, and possessing anti-atherosclerosis, anti-inflammation, and anti-oxidation properties. Polymorphisms in the PPARG gene have been associated with coronary artery disease, possibly through affecting PPARG gene expression and PPAR gamma protein function, leading to metabolic disorders and increased susceptibility to CAD.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2022)
Article
Cardiac & Cardiovascular Systems
Zi Wang, Limin Xia, Xiaoye Li, Jinqiang Shen, Qing Xu, Qiuyi Ji, Qianzhou Lv
Summary: The study showed that patients carrying the ABCB1 3435 wild-type genotype (CC) had a higher risk of severe perioperative bleeding compared with patients carrying the variant genotype (CT or TT). Low baseline hemoglobin level, low baseline estimated glomerular filtration rate, discontinuing clopidogrel 5 days or less before surgery, and the ABCB1 wild-type genotype (CC) were independent risk factors for severe perioperative bleeding.
ANNALS OF THORACIC SURGERY
(2021)
Article
Biology
Pandian Sokkar, Mirja Harms, Christina Stuerzel, Andrea Gilg, Goenuel Kizilsavas, Martina Raasholm, Nico Preising, Manfred Wagner, Frank Kirchhoff, Ludger Staendker, Gilbert Weidinger, Benjamin Mayer, Jan Muench, Elsa Sanchez-Garcia
Summary: The research identified the key interaction motifs of EPI-X4 with CXCR4, explaining its receptor antagonization. Subsequently, shortened derivatives of EPI-X4 with optimized receptor antagonizing properties were developed as new leads for CXCR4 inhibitors.
COMMUNICATIONS BIOLOGY
(2021)
Article
Biology
Fanny Momboisse, Giacomo Nardi, Philippe Colin, Melanie Hery, Nelia Cordeiro, Simon Blachier, Olivier Schwartz, Fernando Arenzana-Seisdedos, Nathalie Sauvonnet, Jean-Christophe Olivio-Marin, Bernard Lagane, Thibault Lagache, Anne Brelot
Summary: This study investigated the impact of different states on the biological function and therapeutic targeting of CC chemokine receptor 5 (CCR5). The researchers used microscopy and statistical methods to track and classify the motion of different receptor subpopulations. The results showed that CCR5 exists in various ligand-free forms, stabilized by different ligands. Agonist stimulation restricted the mobility of CCR5 and led to its clustering, while inverse agonist stimulation had the opposite effect. The study also demonstrated the importance of CCR5 dimerization in its coupling to G proteins, immobilization and clustering upon activation, and receptor endocytosis.
Review
Immunology
Hanli Xu, Shuye Lin, Ziyun Zhou, Duoduo Li, Xiting Zhang, Muhan Yu, Ruoyi Zhao, Yiheng Wang, Junru Qian, Xinyi Li, Bohan Li, Chuhan Wei, Keqiang Chen, Teizo Yoshimura, Ji Ming Wang, Jiaqiang Huang
Summary: Over the past thirty years, the importance of chemokines and their receptors has been recognized in various immune processes and disease pathogenesis. The genetic and nongenetic regulation of chemokines and receptors leads to functional heterogeneity and their imbalances contribute to various diseases. Understanding the molecular basis and interactions of chemokines and receptors will advance the application of precision medicine.
CELLULAR & MOLECULAR IMMUNOLOGY
(2023)
Article
Cardiac & Cardiovascular Systems
Marco Antonutti, Federica Baldan, Corrado Lanera, Leonardo Spedicato, Davide Zanuttini, Teodoro Bisceglia, Enrico Favaretto, Stefano Poli, Chiara Tioni, Dario Sut, Dario Gregori, Giuseppe Damante, Alessandro Proclemer
Summary: The use of hormone therapy and the presence of malignant ventricular arrhythmias at onset are prognostic factors for recurrent SCAD and MACE. Proximal SCAD site and the presence of ventricular arrhythmias at onset are prognostic factors for MACE. Molecular genetics analysis appears to be a promising tool for additional role it could play in predicting MACE.
INTERNATIONAL JOURNAL OF CARDIOLOGY
(2021)
Article
Medicine, Research & Experimental
Jie Lin, Ya Xu, Peiwen Guo, Yu-Jie Chen, Jiru Zhou, Min Xia, Binbin Tan, Xin Liu, Hua Feng, Yujie Chen
Summary: Due to metabolic disequilibrium and immune suppression, intracerebral hemorrhage patients are prone to infections. The intrinsic mechanisms underlying the effects of infection-related peripheral inflammation after ICH remain unclear.
JOURNAL OF TRANSLATIONAL MEDICINE
(2023)
Article
Pharmacology & Pharmacy
Lin Fang, Weiping Tian, Chen Zhang, Xueyan Wang, Wanjing Li, Qi Zhang, Yuxin Zhang, Junnian Zheng
Summary: This study combined chimeric antigen receptor T-cell (CAR-T) therapy and oncolytic virus (OVs) as a potential treatment for solid tumors. The results showed that this combination therapy increased CAR-T cell infiltration and anti-tumor effects, demonstrating the potential and prospects of CAR-T in solid tumor treatment.
PHARMACOLOGICAL RESEARCH
(2023)
Article
Chemistry, Multidisciplinary
Qing-lin Wu, Li-yuan Cui, Wen-yu Ma, Sha-sha Wang, Zhao Zhang, Zhong-ping Feng, Hong-shuo Sun, Shi-feng Chu, Wen-bin He, Nai-hong Chen
Summary: This study characterized the therapeutic potential of a novel CCR5 antagonist A14 in treating ischemic stroke mice. A14 dose-dependently inhibited the CCR5 activity and exerted protective effects against neuronal ischemic injury in vitro and in vivo. Compared to maraviroc, A14 had better BBB permeability and showed sustained protective effects against motor impairment.
ACTA PHARMACOLOGICA SINICA
(2023)
Article
Health Care Sciences & Services
In-Jai Kim, Jeong-Yong Lee, Hyeon-Woo Park, Han-Sung Park, Eun-Ju Ko, Jung-Hoon Sung, Nam-Keun Kim
Summary: The study suggests that HOTAIR gene polymorphisms may serve as novel biomarkers for diagnosing coronary artery disease (CAD) and are closely associated with CAD susceptibility. Variations in genetic polymorphisms, genotype combinations, and haplotype analysis of HOTAIR are linked to disease occurrence and clinical factors contributing to disease susceptibility.
JOURNAL OF PERSONALIZED MEDICINE
(2021)
Review
Genetics & Heredity
Damian Malinowski, Oliwia Bochniak, Katarzyna Luterek-Puszynska, Michal Puszynski, Andrzej Pawlik
Summary: Coronary artery disease (CAD) is a leading cause of mortality worldwide and has a heritable component. Recent research has made progress in uncovering the genetic factors involved, offering potential for prevention, diagnosis, and treatment. Numerous genes related to lipid and carbohydrate metabolism, endothelial and smooth muscle function, coagulation, and the immune system have been identified as playing a role in CAD. Inflammation, mediated in part by TGF beta 1, is important in the development of CAD.
Article
Medicine, General & Internal
Lih-Ju Chen, Ping-Ju Chen, Shun-Fa Yang, Jia-Yuh Chen
Summary: This study found that Escherichia coli is the most common causative organism in jaundiced infants with significant bacteriuria. Current recommended antibiotic treatment for neonatal urinary tract infection with E. coli shows low sensitivity to ampicillin but high sensitivity to gentamicin. It is suggested to modify the empiric antibiotic treatment for Gram-negative bacterial infections in neonates by changing gentamicin to amikacin.
JOURNAL OF THE CHINESE MEDICAL ASSOCIATION
(2022)
Article
Biochemistry & Molecular Biology
Chen-Yi Liao, Ting-Chien Wu, Shun-Fa Yang, Jinghua Tsai Chang
Summary: N-acetylcysteine (NAC) can act as both an antioxidant and a pro-oxidant. The effect of NAC on cell proliferation varies depending on the antioxidant activity of the cells. The sensitivity of cells to NAC is determined by their intracellular ROS levels.
Article
Ophthalmology
Chia-Yi Lee, Hung-Chi Chen, Jing-Yang Huang, Chi-Chun Lai, Shun-Fa Yang, Wei-Chi Wu
Summary: This study used the National Health Insurance Research Database in Taiwan to investigate the risk of mood disorders in patients who experienced retinal detachment. The results showed that patients with recurrent RD and multiple surgeries, as well as females with RD who needed surgical treatment, were at greater risk for developing major depressive disorder.
Article
Ophthalmology
Chia-Chen Lin, Chia-Yi Lee, Jing-Yang Huang, Sheng-Min Hsu, Jia-Horung Hung, Shun-Fa Yang
Summary: This study provides an in-depth analysis of the trends in DR, DME, and related comorbidities in patients with T2DM. It shows that the prevalence and incidence of DR and PDR decreased over time, while the prevalence and incidence of DME increased. Additionally, the percentage of patients with hyperlipidaemia increased in all forms of DR, while the percentage of patients with ESRD increased only in DME.
BRITISH JOURNAL OF OPHTHALMOLOGY
(2023)
Article
Genetics & Heredity
Chee-Ming Lee, Yi-Sun Yang, Edy Kornelius, Chien-Ning Huang, Min-Yen Hsu, Chia-Yi Lee, Shu-Yen Peng, Shun-Fa Yang
Summary: The SNP rs145204276 Del/Del variant of the GAS5 gene is associated with an increased susceptibility to diabetic retinopathy (DR) in diabetes mellitus (DM) patients, particularly in those with non-proliferative diabetic retinopathy (NPDR).
Article
Genetics & Heredity
Chih-Chun Chuang, Yi-Sun Yang, Edy Kornelius, Chien-Ning Huang, Min-Yen Hsu, Chia-Yi Lee, Shun-Fa Yang
Summary: The T allele of LINC00673 SNP rs11655237 is associated with a higher risk of developing NPDR. Patients with the LINC00673 SNP rs11655237 CT + TT variant have a shorter duration of diabetes mellitus.
FRONTIERS IN GENETICS
(2022)
Article
Genetics & Heredity
Kuan-Chun Hsueh, Oswald Ndi Nfor, Shu-Yi Hsu, Shun-Fa Yang, Yung-Po Liaw
Summary: In Taiwan, T2D and PNPLA3 rs738409 polymorphism are associated with the development of liver cirrhosis. This study found a significant association between T2D, rs738409 GG genotype, and liver cirrhosis.
FRONTIERS IN GENETICS
(2022)
Article
Pharmacology & Pharmacy
Peace Wun-Ang Lu, Chia-Hsuan Chou, Jia-Sin Yang, Yi-Hsien Hsieh, Meng-Ying Tsai, Ko-Hsiu Lu, Shun-Fa Yang
Summary: HO-3867 induces apoptosis in human osteosarcoma cells through the JNK signaling pathway.
Article
Medicine, General & Internal
Hsien-Cheng Huang, Bei-Hao Shiu, Shih-Chi Su, Chi-Chou Huang, Wen-Chien Ting, Lun-Ching Chang, Shun-Fa Yang, Ying-Erh Chou
Summary: The study suggests that MMP-11 gene polymorphisms may influence the clinicopathological characteristics of colorectal cancer patients, providing potential biomarkers for disease progression evaluation and shedding light on sex differences in CRC development and prognosis.
Article
Health Care Sciences & Services
Kuo-Hsun Hung, Shao-Lun Tsao, Shun-Fa Yang, Bo-Yuan Wang, Jing-Yang Huang, Wen-Tyng Li, Liang-Tsai Yeh, Cheng-Hung Lin, Yin-Yang Chen, Chao-Bin Yeh
Summary: This study investigated the association between anesthesia methods (general anesthesia and neuraxial anesthesia) during cesarean section and the risk of postpartum depression. The results showed that women who underwent general anesthesia had a higher risk of depressive disorders and a higher need for antidepressants to address sleep problems.
JOURNAL OF PERSONALIZED MEDICINE
(2022)
Article
Environmental Sciences
Chung-Yuan Lee, Yung-Chuan Ho, Chiao-Wen Lin, Min-Chieh Hsin, Po-Hui Wang, Ya-Cheng Tang, Shun-Fa Yang, Yi-Hsuan Hsiao
Summary: The synthetic curcumin analog, EF-24, has been shown to have enhanced bioavailability and stronger anti-inflammatory and anti-cancer activity compared to curcumin. This study investigated the effects of EF-24 on TPA-induced cellular migration of cervical cancer and found that EF-24 significantly reduced cellular migration and invasion. Further analysis revealed that EF-24 modulated MMP-9 expression by inhibiting the phosphorylation of the p38 signaling pathway. These findings suggest that EF-24 may have potential as a chemopreventive agent for cervical cancer.
ENVIRONMENTAL TOXICOLOGY
(2023)
Article
Ophthalmology
Hsiang-Wen Chien, Chia-Yi Lee, Jing-Yang Huang, Hung-Chi Chen, Kai Wang, Shun-Fa Yang
Summary: This study, using the National Health Insurance Research Database of Taiwan, found a relationship between congenital cytomegalovirus (CMV) infection and late-onset keratitis. Severe congenital CMV infection was found to be significantly correlated with late-onset keratitis in individuals with congenital CMV infection.
EUROPEAN JOURNAL OF OPHTHALMOLOGY
(2023)
Article
Cell Biology
Yi-Fang Ding, Yung-Wei Lin, Wen-Kuan Chiu, Chiao-Wen Lin, Yi-Chieh Yang, Lun-Ching Chang, Jungshan Chang, Shun-Fa Yang, Ming-Hsien Chien
Summary: This study investigated the association between genetic variants of HRH1 and OSCC susceptibility and clinicopathologic variables. The results showed that certain genotypes of HRH1 were associated with a lower risk of developing larger tumor sizes, especially in patients with a betelquid-chewing habit. Furthermore, HRH1 expression levels were upregulated in OSCC tissues and correlated with tumor sizes and prognoses.
Article
Cell Biology
Hsueh-Ju Lu, Chun-Yi Chuang, Mu-Kuan Chen, Chun-Wen Su, Wei-En Yang, Chia-Ming Yeh, Kuan-Ming Lai, Chih-Hsin Tang, Chiao-Wen Lin, Shun-Fa Yang
Summary: ALDH7A1 polymorphisms and expression levels are associated with oral cancer development and prognosis, affecting pathological features, cell migration, and patient outcomes.
Article
Integrative & Complementary Medicine
Shih-Chi Su, Yi-Tzu Chen, Yi-Hsien Hsieh, Wei-En Yang, Chun-Wen Su, Wen-Yu Chiu, Shun-Fa Yang, Chiao-Wen Lin
Summary: Gambogic acid can inhibit cell proliferation and induce apoptosis in oral squamous cell carcinoma by activating the p38-dependent apoptotic pathway. These findings provide potential directions for the development of new treatments for oral cancer.
AMERICAN JOURNAL OF CHINESE MEDICINE
(2022)
