Review
Chemistry, Medicinal
Xiaoning Sun, Bo Jia, Jingran Sun, Jianguo Lin, Bingjiu Lu, Jinlong Duan, Cheng Li, Qingqing Wang, Xin Zhang, Meng Tan, Dongsheng Zhong, Xiaoxiao Zhang, Ziyi Sun, Yan Zhang, Kuiwu Yao
Summary: Gastrodia elata Blume (Tianma) is a valuable herbal Traditional Chinese Medicine commonly used to treat various disorders. Modern pharmacological studies have shown that it possesses diverse pharmacological effects and can be beneficial in cardiovascular diseases.
Review
Pharmacology & Pharmacy
Changcheng Lu, Shuhui Qu, Zhangfeng Zhong, Hua Luo, Si San Lei, Hai-Jing Zhong, Huanxing Su, Yitao Wang, Cheong-Meng Chong
Summary: Parkinson's disease is an age-related neurodegenerative disease caused by the death and degeneration of dopaminergic neurons in the midbrain. Current drugs mainly aim to increase dopamine levels but cannot prevent or slow down the loss of dopaminergic neurons. Gastrodia elata Blume, a traditional medicinal herb, has shown potential as an add-on therapy for Parkinson's disease by reducing dopaminergic neuron death and pathological changes in various models.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Plant Sciences
Xu Zeng, Jiaxue Li, Tongyao Chen, Yuanyuan Li, Shunxing Guo
Summary: In this study, the metabolic profiles and chemical composition of different Gastrodia elata varieties were determined. The results showed that different varieties have diverse bioactive ingredients and exhibit various biological activities and healthcare value.
FRONTIERS IN PLANT SCIENCE
(2023)
Article
Food Science & Technology
Baiyu Zhang, Mengmeng Liu, Gang Liu, Dan Li, Benhong Zhou
Summary: This study elucidated the mechanisms of oral absorption of GEP polysaccharides through animal and Caco-2 cell models, demonstrating absorption through the small intestine, distribution in the liver and kidneys, and transport via endocytosis processes. The research provides guidance for clinical medicine administration and deepens the biological understanding of oral polysaccharides.
FOOD RESEARCH INTERNATIONAL
(2021)
Review
Plant Sciences
Meng-qi Gong, Fei-fan Lai, Jian-zhen Chen, Xiao-hong Li, Ya-jie Chen, Yu He
Summary: Gastrodia elata Blume has a long historical application in Asian countries and has been widely used in medicine and food. It contains various active components with neuroprotective, learning and memory improvement, cardioprotective, anti-depressant, anti-cancer effects, etc. However, research on its polysaccharide structure and non-medicinal parts is relatively limited.
JOURNAL OF ETHNOPHARMACOLOGY
(2024)
Article
Chemistry, Multidisciplinary
Ning Ji, Peng Liu, Ni Zhang, Shengyan Yang, Mingsheng Zhang
Summary: This study investigated the composition, physicochemical properties, in vitro biological activity, and hypoglycemic activity of polysaccharides from four varieties of G. elata. The polysaccharides had the same monosaccharide composition but different content in each variety. They also exhibited differences in in vitro antioxidant and hypoglycemic activity, molecular weight, yield, and chemical composition. GaE-R showed the best polysaccharide activity.
FRONTIERS IN CHEMISTRY
(2022)
Article
Pharmacology & Pharmacy
Lijun Cheng, Hui Wang, Kejian Ma, Yang Deng, Maoru Li, Ji Ma
Summary: In this study, a novel processing technology-alcohol steamed GE (AGE) was proposed as an alternative to traditional processing. Compared with fresh GE, AGE showed changes in the relative content of certain compounds, but both fresh and steamed GE demonstrated promising hypnotic and anti-anxiety effects. Furthermore, the anti-anxiety mechanism of GE was found to be related to the tryptophan metabolic pathway.
FRONTIERS IN PHARMACOLOGY
(2023)
Article
Biology
Yu-En Lin, Chin-Hsien Lin, En-Peng Ho, Yi-Ci Ke, Stavroula Petridi, Christopher J. H. Elliott, Lee-Yan Sheen, Cheng-Ting Chien
Summary: The water extracts of Gastrodia elata Blume (GE) show neuroprotective effects in G2019S-induced Parkinson's disease fruit flies and transgenic mice by improving motor abilities and protecting dopaminergic neurons. The mechanism involves the activation of the Nrf2 protein in glial cells, which inhibits degenerative signaling pathways in neurons, ultimately preventing neuronal loss and maintaining coordination.
Article
Pharmacology & Pharmacy
Hong Huang, Yiwen Zhang, Caihong Yao, Qinghu He, Fang Chen, Han Yu, Guanghua Lu, Ning Jiang, Xinmin Liu
Summary: This study evaluated the effects of Fresh Gastrodia elata Blume (FG) on cognitive deficits induced by chronic restraint stress (CRS) and found that FG improved learning and memory abilities by regulating mitochondrial apoptosis-related proteins and proinflammatory cytokines.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Pharmacology & Pharmacy
Yiwen Zhang, Hong Huang, Caihong Yao, Xinran Sun, Qinghu He, Muhammad Iqbal Choudharyc, Shanguang Chen, Xinmin Liu, Ning Jiang
Summary: The study found that fresh Gastrodia elata Blume has a positive effect on cognitive impairment caused by simulated weightlessness. It improves spatial memory and cognitive ability in mice, protects the nervous system by balancing oxidative stress and inflammation factors, regulates protein expression through the PI3K/AKT/mTOR pathway, and corrects abnormal changes in neurons.
FRONTIERS IN PHARMACOLOGY
(2023)
Article
Cell Biology
Hengtao Xie, Yingying Chen, Wei Wu, Xiaobo Feng, Kairong Du
Summary: The study found that GBP treatment enhanced paw withdrawal latency and threshold in rats, restored Vin-induced sciatic nerve damage, and attenuated the increase of proinflammatory cytokine levels. GBP also downregulated the mRNA levels of inflammatory cytokines in the nerves and enhanced SIRT1 activity. This suggests that GBP has a potential protective effect against chemotherapy-induced neuropathic pain through inhibition of neuroinflammation.
MEDIATORS OF INFLAMMATION
(2021)
Article
Chemistry, Medicinal
Tingyu Shan, Minzhen Yin, Junxian Wu, Hanwen Yu, Mengli Liu, Rui Xu, Jutao Wang, Huasheng Peng, Liangping Zha, Shuangying Gui
Summary: The Orchidaceae family, famous for its beautiful flowers, is diverse and widespread globally with high ornamental and medicinal value. Gastrodia elata Blume, a traditional Chinese medicinal herb, is a rootless and leafless achlorophyllous orchid known for its phenolic compounds with various bioactive properties. This study identified candidate genes involved in phenolic biosynthesis in G. elata through transcriptomic analysis and differential gene expression profiling. The results contribute to a better understanding of the biosynthesis of secondary metabolites in G. elata.
Article
Chemistry, Analytical
Pan-pan Yang, Zhong-da Zeng, Ying Hou, Ai-ming Chen, Juan Xu, Long-qing Zhao, Xiang-yi Liu
Summary: The rapid and accurate authentication of variants of plants with high chemical complexity is of great academic and practical significance. The combination of near infrared spectroscopy (NIR) and chemometrics, specifically partial least squares discrimination analysis (PLS-DA), proved to be an effective method for classification and prediction. Various preprocessing techniques and feature selection methods were compared to optimize the PLS-DA models, achieving high prediction accuracy.
JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS
(2023)
Article
Food Science & Technology
Chuanmao Zheng, Jieqing Li, Honggao Liu, Yuanzhong Wang
Summary: This study presents a fast and non-invasive method for the authentication of geographical indication (GI) of food or medicinal plants. Using infrared spectroscopy analysis and data fusion, accurate certification models were established, demonstrating that specific bands can serve as fingerprint regions for verifying the origin.
Article
Plant Sciences
Rongchun Wang, Qingyu Ren, Daili Gao, Yam Nath Paudel, Xia Li, Lizhen Wang, Pengyu Zhang, Baokun Wang, Xueliang Shang, Meng Jin
Summary: This study aimed to investigate the anti-depressant effect of Gastrodia elata (Tian Ma) and its molecular mechanism. The results showed that Gastrodia elata had a therapeutic effect on depression by acting on RTN4R and apoptosis-related targets, enhancing cell viability and inhibiting apoptosis. Moreover, Gastrodia elata alleviated depression-like symptoms in zebrafish by regulating related gene expressions.
JOURNAL OF ETHNOPHARMACOLOGY
(2022)
Article
Chemistry, Multidisciplinary
Nayeon Yang, Myungsoon Ko, Meejung Ahn, Taekyun Shin
Summary: This study found that Norgalanthamine has anti-inflammatory and anti-oxidative properties, which can mitigate the liver injury induced by carbon tetrachloride in mice. It restores antioxidant enzyme activities, reduces lipid accumulation and inflammation, and decreases fibrosis in the liver.
DRUG AND CHEMICAL TOXICOLOGY
(2023)
Article
Toxicology
Woong-Il Kim, Je-Oh Lim, So-Won Pak, Se-Jin Lee, In-Sik Shin, Changjong Moon, Jeong-Doo Heo, Jong-Choon Kim
Summary: This study investigated the potential effects of China dust exposure on cyclophosphamide-induced testicular toxicity in mice, and found that the exposure to China dust exacerbated the testicular toxicity induced by cyclophosphamide, possibly due to the induction of lipid peroxidation and reduced antioxidant activity.
TOXICOLOGICAL RESEARCH
(2023)
Article
Multidisciplinary Sciences
Ryo Muko, Tomoya Sunouchi, Shuntaro Urayama, Yuko Toishi, Kanichi Kusano, Hiroaki Sato, Masanori Muranaka, Taekyun Shin, Masa-aki Oikawa, Yoshinobu Ojima, Mohammad Ali, Yoshihiro Nomura, Hiroshi Matsuda, Akane Tanaka
Summary: In this study, DNA samples were extracted from 1700 Thoroughbred horses and analyzed for gene polymorphisms in the HRG gene. Two types of insertion/deletion polymorphisms (D1 and D2) were identified in the histidine-rich region of the HRG gene, with deletion lengths of 45 bp and 90 bp. These genetic polymorphisms in the HRG gene may be associated with athletic ability, productivity, and susceptibility to infectious diseases in Thoroughbred horses.
SCIENTIFIC REPORTS
(2023)
Article
Biology
Eunjin Cho, Xiangguo Che, Mary Jasmin Ang, Seongmin Cheon, Jinkyung Lee, Kwang Soo Kim, Chang Hoon Lee, Sang-Yeop Lee, Hee-Young Yang, Changjong Moon, Chungoo Park, Je-Yong Choi, Tae-Hoon Lee
Summary: Peroxiredoxin 5 (Prdx5) plays a significant role in regulating bone resorption and bone formation, and its deficiency leads to osteoporosis. Through immunoprecipitation and LC-MS/MS analysis, hnRNPK was identified as an interacting partner of Prdx5, and Prdx5 negatively regulates the expression of osteocalcin mediated by hnRNPK. Additionally, the loss of Prdx5 enhances the expression of osteoclast-related genes during the differentiation of bone marrow-derived macrophages into multinucleated osteoclasts. These findings suggest that Prdx5 plays an important role in maintaining bone homeostasis by regulating bone cell differentiation.
Correction
Biochemistry & Molecular Biology
Anji Song, Gwang-Won Cho, Changjong Moon, Ilyong Park, Chul Ho Jang
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Environmental Sciences
Sohi Kang, Yeonghoon Son, In-Sik Shin, Changjong Moon, Min Y. Lee, Kyung S. Lim, Su-Jin Park, Chang-Geun Lee, Wol S. Jo, Hae-June Lee, Joong S. Kim
Summary: Inflammatory bowel diseases can be diagnosed through diagnostic imaging, but radiation exposure in the intestine can worsen the progression of these diseases. To study the impact of radiation on bowel diseases, mice were induced with colitis and exposed to abdominal irradiation. The results showed that abdominal irradiation aggravated the effects of colitis, including decreased survival rate, body weight, and colon length, as well as increased inflammation levels and expression of inflammatory genes. This study provides valuable insights for patients with inflammatory bowel diseases.
RADIATION PROTECTION DOSIMETRY
(2023)
Article
Toxicology
Heung-Sik Seo, Jun-Ho Kim, Sang-Ho Kim, Myeong-Kyu Park, Nak-Won Seong, Geun-Hee Kang, Joong-Sun Kim, Sung-Ho Kim, Jong-Choon Kim, Changjong Moon
Summary: There were no treatment-related adverse effects observed in rats that received repeated oral doses of CPSS over 90 days. The CPSS showed no toxicity in terms of clinical signs, body weight, food consumption, detailed clinical observation, sensory reactivity, functional assessment, urinalysis, ophthalmic examination, gross pathology, hematology, serum biochemistry, hormone analysis, organ weight, and histopathology.
TOXICOLOGICAL RESEARCH
(2023)
Article
Cell Biology
Sungmoo Hong, Poornima D. E. Weerasinghe-Mudiyanselage, Sohi Kang, Changjong Moon, Taekyun Shin
Summary: This study used RNA-sequencing to analyze the transcriptomes of retinas in mice with EAE and identified differentially expressed genes (DEGs) related to EAE-induced visual impairment. Gene expression analysis showed that the upregulated genes in the retinas of mice with EAE were primarily associated with immune responses and immune-mediated inflammation. In addition, gene set enrichment analysis revealed a negative enrichment of gene sets related to the neuronal system and phototransduction cascade in EAE-affected retinas. This study provides novel molecular evidence for visual impairments in EAE and indicates directions for further research to elucidate the mechanisms of these visual impairments in MS.
ANIMAL CELLS AND SYSTEMS
(2023)
Review
Environmental Sciences
Jeongmin Lee, Poornima D. E. Weerasinghe-Mudiyanselage, Bohye Kim, Sohi Kang, Joong-Sun Kim, Changjong Moon
Summary: This article reviews the neurotoxicity of particulate matter (PM) and its impact on neurodegenerative diseases. Epidemiological and animal model studies have provided some mechanistic insights. The review highlights the effects of PM exposure on the central nervous system and identifies research gaps and future directions. The findings presented in this review are important for informing public health policies and the development of new treatments for neurodegenerative diseases.
ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY
(2023)
Article
Biochemistry & Molecular Biology
Jae Min Kim, Sam Seok Cho, Sohi Kang, Changjong Moon, Ji Hye Yang, Sung Hwan Ki
Summary: This study investigated the anti-inflammatory effects of the 70% ethanol extract of Castanopsis sieboldii (CSL3) leaf. The results showed that CSL3 inhibited NO release and iNOS expression in LPS-stimulated cells, and antagonized NF-κB and AP-1 activation through MAPK inhibition. CSL3 also decreased NLRP3 inflammasome activation and increased IL-1β expression. In addition, CSL3 protected against acute liver injury by inhibiting inflammasome formation and pyroptosis.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Pharmacology & Pharmacy
Sohi Kang, Hyun-Yong Kim, A. Yeong Lee, Hyo Seon Kim, Jun Hong Park, Byeong Cheol Moon, Hyeon Hwa Nam, Sung-Wook Chae, Bokyung Jung, Changjong Moon, In Sik Shin, Joong Sun Kim, Yun-Soo Seo
Summary: In this study, the effects of Camellia sinensis extract on ovalbumin-induced allergic asthma were evaluated. The results showed that the extract had anti-inflammatory and antioxidant activities, and could suppress the progression of asthma.
Article
Cell Biology
Bohye Kim, Joong-Sun Kim, Buhyun Youn, Changjong Moon
Summary: This study found that dopamine depletion in rats leads to increased plasticity-related signaling in the hippocampus. This may be a compensatory mechanism that promotes activity-independent neuroplasticity following dopamine depletion.
ANIMAL CELLS AND SYSTEMS
(2023)
Article
Biochemistry & Molecular Biology
Jeongmin Lee, Poornima D. E. Weerasinghe-Mudiyanselage, Bohye Kim, Sohi Kang, Joong-Sun Kim, Changjong Moon
MOLECULAR & CELLULAR TOXICOLOGY
(2023)
Article
Veterinary Sciences
Sungwoong Jang, Bohye Kim, Jeongmin Lee, Sohi Kang, Joong-Sun Kim, Jong-Choon Kim, Sung-Ho Kim, Taekyun Shin, Changjong Moon
Summary: This study examined the histological characteristics and glycoconjugate composition of the olfactory mucosa (OM) in Korean native cattle. The findings suggest that glycoconjugates may play a role in olfactory chemoreception, and their labeling properties may be closely related to OM development and maturity.
JOURNAL OF VETERINARY SCIENCE
(2022)
