期刊
VIROLOGICA SINICA
卷 32, 期 1, 页码 89-96出版社
SPRINGER
DOI: 10.1007/s12250-017-3953-3
关键词
bunyavirus; severe fever with thrombocytopenia syndrome bunyavirus (SFTSV); isolation; phylogenetic analysis; genotype
类别
资金
- Science and Technology Basic Work Program [2013FY113500]
- National Key Research and Development Program from the Ministry of Science and Technology of China [2016YFE 0113500]
- European Union [653316]
Hubei Province is a major epidemic area of severe fever with thrombocytopenia syndrome bunyavirus (SFTSV) in China. However, to date, a few SFTSV strains have been isolated from Hubei Province, preventing effective studies of epidemic outbreaks. Here, we report three confirmed patients (2015-2016) with typical symptoms of severe fever with thrombocytopenia syndrome disease (SFTS) who were farmers resident in different regions in Hubei Province. Three new SFTSV strains were isolated from the serum samples of each patient. Characterization of viral growth properties showed that there were no significant differences in virus production. All strains were completely sequenced, and phylogenetic analysis showed that unlike the other strains from Hubei province, which belonged to the SFTSV C3 genotype, one of the three strains belonged to the SFTSV C2 genotype. These results suggested that multiple SFTSV genotypes have been circulating in Hubei Province, providing insights into SFTSV evolution and improving our understanding of SFTSV prevalence in Hubei Province.
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