期刊
JOURNAL OF THE PEDIATRIC INFECTIOUS DISEASES SOCIETY
卷 6, 期 -, 页码 S32-S44出版社
OXFORD UNIV PRESS
DOI: 10.1093/jpids/pix054
关键词
beta-D-glucan; galactomannan; invasive fungal disease; mannan; polymerase chain reaction
资金
- National Institutes of Health [1R01 AI03315-A1, 1R01 HD081044-01]
- Henry Schueler Foundation
- Save Our Sick Children Foundation
- Medical College of Wisconsin Department of Pediatrics
- Children's Hospital of Wisconsin Research Institute
Invasive fungal diseases are important clinical problems that are often complicated by severe illness and therefore the inability to use invasive measures to definitively diagnose the disease. Tests for a range of fungal biomarkers that do not require an invasive sample-collection procedure have been incorporated into adult clinical practice, but pediatric data and pediatric-specific recommendations for some of these diagnostic tools are lacking. In this review, we summarize the published literature and contemporary strategies for using the biomarkers galactomannan, (1 -> 3)-beta-D-glucan, Candida mannan antigen and anti-mannan antibody, and fungal polymerase chain reaction for diagnosing invasive fungal disease in children. Data on biomarker use in neonates and children with cancer, history of hematopoietic stem cell transplant, or primary immunodeficiency are included. Fungal biomarker tests performed on blood, other body fluids, or tissue specimens represent promising adjuncts to the diagnostic armamentarium in populations with a high prevalence of invasive fungal disease, but substantial gaps exist in the correct use and interpretation of these diagnostic tools in pediatric patients.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据