Article
Surgery
Robert Cubas, Robert Andres, Shravan Chintalapani, Estefania Roldan, Andrea Marcadis, Valerie Wu Chao Ying, Robert Bowles, Jose Martinez
Summary: The study reviewed one surgeon's experience with esophageal dilations after transhiatal esophagectomy, showing that early aggressive endoscopic management of esophageal anastomotic strictures after THE can be safely performed.
SURGICAL ENDOSCOPY AND OTHER INTERVENTIONAL TECHNIQUES
(2021)
Article
Surgery
Shinichiro Kobayashi, Kengo Kanetaka, Akira Yoneda, Naoyuki Yamaguchi, Kazuma Kobayashi, Yasuhiro Nagata, Yasuhiro Maruya, Shun Yamaguchi, Masaaki Hidaka, Susumu Eguchi
Summary: This study aimed to evaluate the safety and efficacy of endoscopic examinations of the anastomotic region in the acute period after esophagectomy. It found that the endoscopic mucosal ischemic index can effectively predict the occurrence of anastomotic complications after surgery.
LANGENBECKS ARCHIVES OF SURGERY
(2023)
Article
Gastroenterology & Hepatology
Matias E. Czerwonko, Farhood Farjah, Brant K. Oelschlager
Summary: The routine use of LapTHE for DE and GEJ cancers, along with the inclusion of six operative principles, results in a low rate of anastomotic complications compared to national benchmarks. The median number of lymph nodes procured was 19, and negative margins were achieved in all cases. Major complication rate was 24%, 90-day mortality was 2.0%, and reoperation rate was 5.4%.
JOURNAL OF GASTROINTESTINAL SURGERY
(2023)
Article
Pediatrics
Ali Kamran, Charles J. Smithers, Shawn N. Izadi, Steven J. Staffa, David Zurakowski, Farokh R. Demehri, Somala Mohammed, Hester F. Shieh, Peter D. Ngo, Jessica Yasuda, Michael A. Manfredi, Thomas E. Hamilton, Russell W. Jennings, Benjamin Zendejas
Summary: Anastomotic strictures (AS) after esophageal atresia (EA) repair are common complications. While most can be controlled with endoscopic therapy, some require surgical intervention. This study retrospectively reviewed data from two institutions and found that surgery for refractory AS is associated with low morbidity and high rates of esophageal preservation.
JOURNAL OF PEDIATRIC SURGERY
(2023)
Article
Gastroenterology & Hepatology
Osama Baghdadi, Jessica Yasuda, Steven Staffa, Peter Ngo, Benjamin Zendejas, Thomas Hamilton, Russell Jennings, Michael Manfredi
Summary: Esophageal stenting can be successful in preventing anastomotic strictures following surgical repair in pediatric patients with esophageal atresia. The change in luminal diameter after stenting is the most significant predictor of stent success.
JOURNAL OF PEDIATRIC GASTROENTEROLOGY AND NUTRITION
(2022)
Article
Gastroenterology & Hepatology
Daisuke Motegi, Hiroshi Ichikawa, Takeo Bamba, Yusuke Muneoka, Yosuke Kano, Kenji Usui, Takaaki Hanyu, Takashi Ishikawa, Yuki Hirose, Kohei Miura, Yosuke Tajima, Yoshifumi Shimada, Jun Sakata, Satoru Nakagawa, Shin-ichi Kosugi, Toshifumi Wakai
Summary: This study aimed to identify risk factors for anastomotic leakage (AL) after esophagectomy for esophageal cancer. The results showed that peptic or endoscopic submucosal dissection (ESD) ulcer scars were independently associated with AL, in addition to diabetes mellitus. The scars in the anterior/posterior gastric wall were more frequent in patients with AL, and the gastric conduit with scars had significantly lower flow velocity evaluated by indocyanine green (ICG) fluorescence imaging. Therefore, preventive interventions and careful postoperative management should be provided to minimize the risk and severity of AL in patients with these risk factors.
JOURNAL OF GASTROINTESTINAL SURGERY
(2023)
Review
Surgery
Lisanne M. D. Pattynama, Wietse J. Eshuis, Mark van Berge I. Henegouwen, Jacques J. G. H. M. Bergman, Roos E. Pouw
Summary: This study describes the use of a new treatment modality called "vacuum-stent" for the management of transmural defects in the upper GI tract. The results show that this treatment method successfully closed the defects without any major adverse events.
FRONTIERS IN SURGERY
(2023)
Article
Surgery
Oscar Akesson, Isak Heyman, Jan Johansson, Pehr Rissler, Dan Falkenback
Summary: This study used early endoscopic assessment and a novel endoscopy score system to predict anastomotic complications after esophagectomy, with the results showing that the combined endoscopy score was the only predictor and an accurate tool for predicting anastomotic complications.
SURGICAL ENDOSCOPY AND OTHER INTERVENTIONAL TECHNIQUES
(2022)
Article
Surgery
Elvira L. Vos, Masaya Nakauchi, Marinela Capanu, Bernard J. Park, Daniel G. Coit, Daniela Molena, Samuel S. Yoon, David R. Jones, Vivian E. Strong
Summary: Reinforcing the anastomosis with a biologic, degradable extracellular matrix (ECM) after total gastrectomy or esophagectomy was mostly feasible and safe, but did not significantly decrease the occurrence of anastomotic leak.
JOURNAL OF THE AMERICAN COLLEGE OF SURGEONS
(2022)
Article
Medical Informatics
Ziran Zhao, Xi Cheng, Xiao Sun, Shanrui Ma, Hao Feng, Liang Zhao
Summary: The study developed and validated a risk prediction model using machine learning techniques to accurately predict the risk of anastomotic leakage in patients who underwent esophagectomies. The model demonstrated high accuracy in prediction, offering assistance in the prevention and treatment of anastomotic leakage.
JMIR MEDICAL INFORMATICS
(2021)
Article
Oncology
Makoto Sohda, Tatsuya Miyazaki, Takayoshi Watanabe, Nobuhiro Nakazawa, Yasunari Ubukata, Kengo Kuriyama, Keigo Hara, Makoto Sakai, Akihiko Sano, Takehiko Yokobori, Hiroomi Ogawa
Summary: The study found a significant inverse correlation between the temperature of the planned site of gastric conduit anastomosis and anastomotic leakage, with a cutoff point temperature of 27.6 degrees Celsius for predicting anastomotic leakage. Keeping the planned gastric tube anastomosis line at 27.6 degrees Celsius or higher is recommended to reduce the occurrence of anastomotic leakage.
ANTICANCER RESEARCH
(2021)
Article
Respiratory System
Wen-Quan Yu, Hui-Jiang Gao, Guo-Dong Shi, Jia-Yu Tang, Hua-Feng Wang, Shi-Yu Hu, Yu-Cheng Wei
Summary: This study aimed to identify variables associated with anastomotic leakage after esophagectomy and established a prediction tool. The established nomogram showed good discrimination ability and might benefit treatment results and clinical decision-making.
JOURNAL OF THORACIC DISEASE
(2021)
Article
Oncology
Sander Ubels, Eric Matthee, Moniek Verstegen, Bastiaan Klarenbeek, Stefan Bouwense, Mark I. van Berge Henegouwen, Freek Daams, Jan Willem T. Dekker, Marc J. van Det, Stijn van Esser, Ewen A. Griffiths, Jan Willem Haveman, Grard Nieuwenhuijzen, Peter D. Siersema, Bas Wijnhoven, Gerjon Hannink, Frans van Workum, Camiel Rosman, Joos Heisterkamp, Fatih Polat, Jeroen Schouten, Pritam Singh
Summary: This study aimed to assess the differences in failure to rescue (FTR) after anastomotic leak (AL) between different centers. The results showed that high-volume centers had lower FTR, which could be explained by lower leak severity, lower secondary ICU readmission rate, and higher availability of therapeutic modalities.
Article
Surgery
Junya Kitadani, Toshiyasu Ojima, Keiji Hayata, Taro Goda, Akihiro Takeuchi, Shinta Tominaga, Naoki Fukuda, Tomoki Nakai, Shotaro Nagano, Manabu Kawai
Summary: Comparing whole stomach reconstruction with narrow gastric tube reconstruction after esophagectomy for esophageal cancer, the former is considered to be safe and effective in preventing anastomotic leakage, and it also leads to shorter postoperative hospital stays.
LANGENBECKS ARCHIVES OF SURGERY
(2023)
Article
Emergency Medicine
Anthony DeVivo, Alexander Y. Sheng, Alex Koyfman, Brit Long
Summary: Esophageal perforation is a serious and rare condition that requires a multidisciplinary team approach for diagnosis and management. Classic signs and symptoms are not enough to rule out this condition, and advanced imaging is needed for diagnosis and evaluation.
AMERICAN JOURNAL OF EMERGENCY MEDICINE
(2022)
Article
Surgery
Eivind Gottlieb-Vedi, Joonas H. H. Kauppila, Fredrik Mattsson, Mats Lindblad, Magnus Nilsson, Pernilla Lagergren, Ioannis Rouvelas, Jesper Lagergren, FINEGO Grp
Summary: This study suggests that minimally invasive esophagectomy (MIE) is associated with higher 5-year survival compared to open esophagectomy (OE) in patients with esophageal cancer, especially total MIE.
Article
Surgery
Linda Claassen, Gerjon Hannink, Misha D. P. Luyer, Alan P. Ainsworth, Mark I. van Berge Henegouwen, Edward Cheong, Freek Daams, Marc J. van Det, Peter van Duijvendijk, Suzanne S. Gisbertz, Christian A. Gutschow, Joos Heisterkamp, Juha T. Kauppi, Bastiaan R. Klarenbeek, Ewout A. Kouwenhoven, Barbara S. Langenhoff, Michael H. Larsen, Ingrid S. Martijnse, Ernst Jan van Nieuwenhoven, Donald L. van der Peet, Jean-Pierre E. N. Pierie, Robert E. G. J. M. Pierik, Fatih Polat, Jari V. Rusanen, Ioannis Rouvelas, Meindert N. Sosef, Eelco B. Wassenaar, Frits J. H. van den Wildenberg, Edwin S. van der Zaag, Magnus Nilsson, Grard A. P. Nieuwenhuijzen, Frans van Workum, Camiel Rosman
Summary: This study investigated the pooled learning curves of Ivor Lewis totally minimally invasive esophagectomy (TMIE) in European hospitals. It found that centers with higher annual volume had more efficient learning curves, while visiting expert clinics, completing fellowships, or implementing under proctor supervision were not associated with more efficient learning.
Editorial Material
Oncology
Masaru Hayami, Nelson Ndegwa, Mats Lindblad, Gustav Linder, Jakob Hedberg, David Edholm, Jan Johansson, Jesper Lagergren, Lars Lundell, Magnus Nilsson, Ioannis Rouvelas
ANNALS OF SURGICAL ONCOLOGY
(2022)
Article
Oncology
Masaru Hayami, Nelson Ndegwa, Mats Lindblad, Gustav Linder, Jakob Hedberg, David Edholm, Jan Johansson, Jesper Lagergren, Lars Lundell, Magnus Nilsson, Ioannis Rouvelas
Summary: The study demonstrates that MIE offers better survival and improved short-term postoperative outcomes compared with OE in patients with esophageal and GEJ cancers, including shorter operation time, less intraoperative bleeding, higher number of resected lymph nodes, shorter hospital stay, and fewer complications.
ANNALS OF SURGICAL ONCOLOGY
(2022)
Review
Oncology
Stepan M. Esagian, Ioannis A. Ziogas, Konstantinos Skarentzos, Ioannis Katsaros, Georgios Tsoulfas, Daniela Molena, Michalis V. Karamouzis, Ioannis Rouvelas, Magnus Nilsson, Dimitrios Schizas
Summary: Robot-assisted minimally invasive esophagectomy (RAMIE) is a safe and feasible procedure that can reduce cardiopulmonary complications, wound infections, blood loss, and hospital stays compared to open esophagectomy.
Article
Oncology
Martin Graversen, I. Rouvelas, A. P. Ainsworth, A. P. Bjarnesen, S. Detlefsen, S. B. Ellebaek, C. W. Fristrup, M. G. Liljefors, L. Lundell, M. Nilsson, P. Pfeiffer, L. S. Tarpgaard, A. Tsekrekos, M. B. Mortensen
Summary: This study evaluated the feasibility and safety of laparoscopic D2 gastrectomy in combination with pressurized intraperitoneal aerosol chemotherapy (PIPAC) in gastric adenocarcinoma patients. The results showed that this combination treatment is feasible and safe.
ANNALS OF SURGICAL ONCOLOGY
(2023)
Editorial Material
Oncology
M. Graversen, I. Rouvelas, A. P. Ainsworth, A. P. Bjarnesen, S. Detlefsen, S. B. Ellebaek, C. W. Fristrup, M. G. Liljefors, L. Lundell, M. Nilsson, P. Pfeiffer, L. S. Tarpgaard, A. Tsekrekos, M. B. Mortensen
ANNALS OF SURGICAL ONCOLOGY
(2023)
Article
Oncology
Andrianos Tsekrekos, Laura E. Vossen, Lars Lundell, Martin Jeremiasen, Erik Johnsson, Jakob Hedberg, David Edholm, Fredrik Klevebro, Magnus Nilsson, Ioannis Rouvelas
Summary: This study compared the short-term postoperative, oncological, and survival outcomes of laparoscopic gastrectomy and open gastrectomy for locally advanced gastric cancer. The results showed that laparoscopic surgery had similar rates of postoperative complications but lower 90-day mortality. Laparoscopic surgery also resulted in more lymph node resections and better overall survival.
Article
Oncology
K. Nilsson, F. Klevebro, B. Sunde, I. Rouvelas, M. Lindblad, E. Szabo, I. Halldestam, U. Smedh, B. Wallner, J. Johansson, G. Johnsen, E. K. Aahlin, H. -o. Johannessen, G. Alexandersson von Doebeln, G. O. Hjortland, N. Wang, Y. Shang, D. Borg, A. Quaas, I. Bartella, C. Bruns, W. Schroeder, M. Nilsson
Summary: Prolonged time to surgery after neoadjuvant chemoradiotherapy for oesophageal cancer did not improve histological response or other pathological endpoints, while there was a trend towards worse survival. Therefore, caution is needed in routinely delaying surgery for more than 6 weeks after neoadjuvant chemoradiotherapy.
ANNALS OF ONCOLOGY
(2023)
Article
Oncology
Andrianos Tsekrekos, David Borg, Victor Johansson, Magnus Nilsson, Fredrik Klevebro, Lars Lundell, Maria Gustafsson-Liljefors, Ioannis Rouvelas
Summary: This study aimed to investigate whether laparoscopic gastrectomy (LG) had a positive impact on compliance with adjuvant chemotherapy compared with open gastrectomy (OG) in patients with gastric cancer. The results showed no significant difference between LG and OG in terms of initiation of adjuvant chemotherapy, modification of chemotherapy, and time interval from surgery to start of treatment. However, major complications had a significant negative impact on both outcomes.
ANNALS OF SURGICAL ONCOLOGY
(2023)
Editorial Material
Oncology
Andrianos Tsekrekos, David Borg, Victor Johansson, Magnus Nilsson, Fredrik Klevebro, Lars Lundell, Maria Gustafsson-Liljefors, Ioannis Rouvelas
ANNALS OF SURGICAL ONCOLOGY
(2023)
Editorial Material
Oncology
Andrianos Tsekrekos, David Borg, Victor Johansson, Magnus Nilsson, Fredrik Klevebro, Lars Lundell, Maria Gustafsson-Liljefors, Ioannis Rouvelas
ANNALS OF SURGICAL ONCOLOGY
(2023)
Article
Oncology
Anders Holmen, William Jebril, Satoshi Ida, Thorhallur Agustsson, Maria Lampi, Ioannis Rouvelas, Berit Sunde, Fredrik Klevebro
Summary: Neoadjuvant therapy is associated with symptom reduction and improved health-related quality of life in patients with gastroesophageal cancer.
Article
Gastroenterology & Hepatology
Fahad Murad, Fredrik Klevebro, Gert Henriksson, Ioannis Rouvelas, Mats Lindblad, Magnus Nilsson
Summary: Aerodigestive fistula (ADF) is a pathological connection between the upper digestive tract and the airway, associated with high mortality and complex treatment. This study assessed 61 patients with three types of ADF and found that temporary fistula sealing and definitive surgical repair were effective treatment methods.
DISEASES OF THE ESOPHAGUS
(2023)
Article
Surgery
Motonari Ri, Antonios Tzortzakakis, Ira Sotirova, Andrianos Tsekrekos, Fredrik Klevebro, Mats Lindblad, Magnus Nilsson, Ioannis Rouvelas
Summary: The study aimed to determine the relationship between postoperative C-reactive protein (CRP) and anastomotic leakage (AL) in patients with esophageal cancer. Through a review of patient data from the Karolinska University Hospital between 2006 and 2022, it was found that early changes in postoperative CRP levels may help in the early detection of anastomotic leakage.
LANGENBECKS ARCHIVES OF SURGERY
(2023)