Article
Agriculture, Dairy & Animal Science
Beatriz Fuentes-Romero, Alberto Munoz-Prieto, Jose J. Ceron, Maria Martin-Cuervo, Manuel Iglesias-Garcia, Escolastico Aguilera-Tejero, Elisa Diez-Castro
Summary: Obesity and its associated complications are increasing problems in humans and horses. This study found that plasma resistin concentrations in horses are predominantly related to inflammatory conditions and not to insulin dysregulation, similar to humans.
Article
Critical Care Medicine
Shinya Onishi, Hiroshi Matsuura, Akinori Osuka, Hisatake Matsumoto, Takeshi Ebihara, Hiroshi Ogura
Summary: The study aimed to investigate the relationship between changes in adipokines and the clinical course of severely burned patients. The results showed that resistin, an adipokine, was associated with other pro-inflammatory cytokines and was related to the severity and prognosis of major burns.
Article
Pharmacology & Pharmacy
Stella Trompet, Iris Postmus, Helen R. Warren, Raymond Noordam, Roelof A. J. Smit, Elizabeth Theusch, Xiaohui Li, Benoit Arsenault, Daniel I. Chasman, Graham A. Hitman, Patricia B. Munroe, Jerome I. Rotter, Bruce M. Psaty, Mark J. Caulfield, Ron M. Krauss, Adrienne L. Cupples, Wouter J. Jukema
Summary: The pharmacogenetic effect of genetic variation on cardiovascular disease risk reduction in response to statin treatment was investigated through a genome-wide association study (GWAS). The results showed that genetic variation did not significantly affect the response of statins on cardiovascular risk reduction. This suggests that genetic testing for predicting the effects of statins on clinical events may not be a useful tool in clinical practice.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Medicine, General & Internal
Rosemary Brown, Jim Lewsey, Sarah Wild, Jennifer Logue, Paul Welsh
Summary: This study found that non-achievement of lipid and statin adherence targets in myocardial infarction survivors is associated with increased risks of all-cause and cardiovascular disease mortality, but not with recurrent myocardial infarctions. Further research is needed to optimize their use in clinical practice to improve outcomes.
Review
Pharmacology & Pharmacy
Junteng Zhou, Zhichao Zhou, Xiaojing Liu, Hai-Yan Yin, Yong Tang, Xin Cao
Summary: Activation of the P2X7 receptor mediates inflammatory responses and pyroptosis in cardiovascular diseases, leading to the release of pro-inflammatory cytokines and worsening cardiac phenotypes. Inhibition of the P2X7 receptor has shown promise in attenuating these pathological mechanisms and improving cardiovascular outcomes.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Cardiac & Cardiovascular Systems
Ihsan Gadi, Sameen Fatima, Ahmed Elwakiel, Sumra Nazir, Moh'd Mohanad Al-Dabet, Rajiv Rana, Fabian Bock, Jayakumar Manoharan, Dheerendra Gupta, Ronald Biemann, Bernhard Nieswandt, Ruediger Braun-Dullaeus, Christian Besler, Markus Scholz, Robert Geffers, John H. Griffin, Charles T. Esmon, Shrey Kohli, Berend Isermann, Khurrum Shahzad
Summary: In this study, specific inhibition of coagulation using direct oral anticoagulants had varying effects on gene expression and inflammation, despite comparable anticoagulant outcomes and infarct sizes. The inhibition of fXa led to reduced sterile inflammation and myocardial fibrosis compared to the inhibition of fIIa. These findings suggest that targeting individual coagulation proteases can elicit specific cellular responses independent of their anticoagulant effects.
CIRCULATION RESEARCH
(2021)
Article
Cardiac & Cardiovascular Systems
Lotta Ulander, Heli Tolppanen, Otto Hartman, Tuomas T. Rissanen, Riitta Paakkanen, Jouni Kuusisto, Olli Anttonen, Tuomo Nieminen, Jaana Yrjola, Ransu Ryysy, Teemu Drews, Seppo Utriainen, Pasi Karjalainen, Ismo Anttila, Katariina Nurmi, Kristiina Silventoinen, Miika Koskinen, Petri T. Kovanen, Jukka Lehtonen, Kari K. Eklund, Juha Sinisalo
Summary: Hydroxychloroquine significantly reduces IL-6 levels in myocardial infarction patients without causing clinically significant adverse events. Larger randomized clinical trials are needed to confirm the potential impact on cardiovascular endpoints after myocardial infarction.
INTERNATIONAL JOURNAL OF CARDIOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Ingmar Soren Meyer, Xue Li, Carina Meyer, Oksana Voloshanenko, Susann Pohl, Michael Boutros, Hugo Albert Katus, Norbert Frey, Florian Leuschner
Summary: This study tested the therapeutic potential of the Wnt secretion inhibitor LGK-974 in a model of ischemia/reperfusion injury and found that LGK-974 can attenuate inflammatory response, improve heart function, and potentially be used for immunomodulatory approaches to improve cardiac remodeling after myocardial infarction.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Mohamed Abo-Aly, Elica Shokri, Lakshman Chelvarajan, Wadea M. Tarhuni, Himi Tripathi, Ahmed Abdel-Latif
Summary: Circulating monocytes have different subsets and play different roles in cardiovascular physiology and disease progression. This study found that CD14+CD16++ monocytes and their subsets expressing CCR2, CD42, and CD11b may be important predictors of clinical outcomes in patients with ST-elevation myocardial infarction (STEMI). Further studies are needed to confirm these findings.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Medicine, General & Internal
Yong Hoon Kim, Ae-Young Her, Myung Ho Jeong, Byeong-Keuk Kim, Sung-Jin Hong, Seunghwan Kim, Chul-Min Ahn, Jung-Sun Kim, Young-Guk Ko, Donghoon Choi, Myeong-Ki Hong, Yangsoo Jang
Summary: In patients with AMI undergoing DES implantation, the efficacy of statin treatment varied according to baseline renal function. Although statin treatment was effective in reducing mortality, this beneficial effect was diminished with worsening baseline renal function.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Pharmacology & Pharmacy
Nasrin Maleki Dizaji, Alireza Garjani, Samin Mousavi, Mahdieh Mohammadi, Haleh Vaez
Summary: The study suggests that Infliximab may partially improve hemodynamic depression in the early stages following MI, but could worsen heart function later on, potentially exacerbating tissue damage.
EUROPEAN JOURNAL OF PHARMACOLOGY
(2021)
Article
Cardiac & Cardiovascular Systems
Brittany Weber, David W. Biery, Avinainder Singh, Sanjay Divakaran, Adam N. Berman, Wanda Y. Wu, Jenifer M. Brown, Jon Hainer, Khurram Nasir, Katherine Liao, Deepak L. Bhatt, Marcelo F. Di Carli, Ron Blankstein
Summary: This study aimed to investigate the prevalence and prognosis of autoimmune systemic inflammatory diseases (SID) among young adults who experienced myocardial infarction (MI). The findings showed that approximately 2.5% of young MI patients had SID, and these individuals had a higher risk of long-term mortality.
EUROPEAN JOURNAL OF PREVENTIVE CARDIOLOGY
(2022)
Review
Cardiac & Cardiovascular Systems
Sreejit Gopalkrishna, Jillian Johnson, Robert M. Jaggers, Albert Dahdah, Andrew J. Murphy, Nordin M. J. Hanssen, Prabhakara R. Nagareddy
Summary: Neutrophils play a dual role in inflammation and wound healing, causing tissue damage while also facilitating healing. Recent studies have revealed their transcriptional activity and ability to influence other cells through cargo release. They have emerged as important regulators in cardiovascular diseases and could be potential targets for therapeutic strategies.
CARDIOVASCULAR RESEARCH
(2022)
Article
Cardiac & Cardiovascular Systems
Ville Kyto, Paivi Rautava, Aleksi Tornio
Summary: Initiating high-dose statin therapy after myocardial infarction is associated with better long-term cardiovascular outcomes.
EUROPEAN HEART JOURNAL-CARDIOVASCULAR PHARMACOTHERAPY
(2023)
Article
Cardiac & Cardiovascular Systems
Chandini Raina MacIntyre, Abrar Ahmad Chughtai, Arpita Das, Bayzidur Rahman, Aye M. Moa, Chieh H. Gan, Timothy C. Tan
Summary: The study found a significantly higher rate of laboratory-confirmed influenza among statin users who were not vaccinated. However, there was no significant difference in influenza vaccine effectiveness between statin users and non-users after vaccination. Statin users had a significantly higher risk of influenza, suggesting that they should be vaccinated against influenza.
INTERNATIONAL JOURNAL OF CARDIOLOGY
(2021)
Review
Endocrinology & Metabolism
Olga Gruzdeva, Daria Borodkina, Evgenya Uchasova, Yulia Dyleva, Olga Barbarash
DIABETES METABOLIC SYNDROME AND OBESITY-TARGETS AND THERAPY
(2019)
Article
Multidisciplinary Sciences
Olga Gruzdeva, Evgenya Uchasova, Yulia Dyleva, Daria Borodkina, Olga Akbasheva, Viktoria Karetnikova, Natalia Brel, Kokov Alexander, Olga Barbarash
Article
Biochemistry & Molecular Biology
Maxim Yu Sinitsky, Yulia A. Dyleva, Evgenya G. Uchasova, Ekaterina Belik, Arseniy E. Yuzhalin, Olga Gruzdeva, Vera G. Matveeva, Anastasia Ponasenko
Summary: This study compared the gene expression levels of adipocytes in different adipose tissues of coronary artery disease patients. It was found that DPP4 and APLN mRNA were higher expressed in epicardial adipose tissue, while ITLN1 gene was overexpressed in this tissue. Additionally, APLN and DPP4 mRNA expression were correlated with blood lipid levels.
ARCHIVES OF PHYSIOLOGY AND BIOCHEMISTRY
(2022)
Article
Hematology
Christoph Male, Anthonie W. A. Lensing, Joseph S. Palumbo, Riten Kumar, Ildar Nurmeev, Kerry Hege, Damien Bonnet, Philip Connor, Helene L. Hooimeijer, Marcela Torres, Anthony K. C. Chan, Gili Kenet, Susanne Holzhauer, Amparo Santamaria, Pascal Amedro, Elizabeth Chalmers, Paolo Simioni, Rukhmi V. Bhat, Donald L. Yee, Olga Lvova, Jan Beyer-Westendorf, Tina T. Biss, Ida Martinelli, Paola Saracco, Marjolein Peters, Krisztian Kallay, Cynthia A. Gauger, M. Patricia Massicotte, Guy Young, Akos F. Pap, Madhurima Majumder, William T. Smith, Jurgen F. Heubach, Scott D. Berkowitz, Kirstin Thelen, Dagmar Kubitza, Mark Crowther, Martin H. Prins, Paul Monagle
LANCET HAEMATOLOGY
(2020)
Article
Medicine, General & Internal
Tamara Pecherina, Anton Kutikhin, Vasily Kashtalap, Victoria Karetnikova, Olga Gruzdeva, Oksana Hryachkova, Olga Barbarash
Article
Cardiac & Cardiovascular Systems
A. A. Khorlampenko, V. N. Karetnikova, A. M. Kochergina, J. S. Ignatova, J. A. Dyleva, O. Gruzdeva, O. L. Barbarash
Article
Medicine, General & Internal
E. Belik, O. Gruzdeva, O. F. Akbasheva, Yu A. DYleva, D. A. Borodkina, M. Yu Sinitsky, A. Sotnikov, K. A. Kozyrin, N. K. Brel, D. Yu Naumov, A. A. Shilov, E. E. Bychkova, V. N. Karetnikova, O. L. Barbarash
TERAPEVTICHESKII ARKHIV
(2020)
Article
Medicine, General & Internal
Natalia K. Brel, Olga Gruzdeva, Alexander N. Kokov, Vladislava L. Masenko, Yulia A. Dyleva, Ekaterina Belik, Olga L. Barbarash
Summary: This study assessed the relationship between visceral obesity (VO) prevalence and coronary calcification (CC) severity in patients with verified CAD. The study found that the VAT/SAT index had a direct correlation with CC, indicating that VAT morphology could be an important diagnostic sign of massive CC in CAD patients, affecting treatment and prognosis.
TERAPEVTICHESKII ARKHIV
(2021)
Article
Health Care Sciences & Services
Olga V. Gruzdeva, Yulia A. Dyleva, Ekaterina V. Belik, Maxim Y. Sinitsky, Aleksandr N. Stasev, Aleksandr N. Kokov, Natalia K. Brel, Evgenia O. Krivkina, Evgenia E. Bychkova, Roman S. Tarasov, Olga L. Barbarash
Summary: This study assessed the expression and secretion of adipocytokine genes in the adipose tissue of patients with coronary artery disease (CAD) and patients with aortic or mitral valve replacement. The results showed that epicardial fat depots in CAD patients exhibited more pronounced changes and increased pro-inflammatory activity compared to the group with heart defects.
JOURNAL OF PERSONALIZED MEDICINE
(2022)
Review
Medicine, General & Internal
E. G. Uchasova, O. Gruzdeva, E. Belik, Yu A. Dyleva
BYULLETEN SIBIRSKOY MEDITSINY
(2020)
Article
Transplantation
A. A. Shilov, A. Bezdenezhnykh, V. Ganyukov, R. S. Tarasov, E. G. Uchasova, O. L. Barbarash, L. S. Barbarash
VESTNIK TRANSPLANTOLOGII I ISKUSSTVENNYH ORGANOV
(2019)
Article
Medicine, General & Internal
Yu. S. Ignatova, V. N. Karetnikova, A. A. Horlampenko, O. V. Gruzdeva, Yu. A. Dyleva, O. L. Barbarash
TERAPEVTICHESKII ARKHIV
(2019)