Review
Health Care Sciences & Services
Catarina Ramos Pereira, Jorge Machado, Jorge Rodrigues, Natalia M. de Oliveira, Maria Begona Criado, Henri J. Greten
Summary: This systematic review aimed to evaluate the effectiveness of acupuncture treatments in relieving Parkinson's disease symptoms. The study found positive effects of acupuncture in improving motor and non-motor symptoms, but the discrepancies in study design and methodology make it difficult to compare the results.
Review
Medicine, Research & Experimental
Jing-Qi Fan, Wei-Jing Lu, Wei-Qiang Tan, Wei-Cheng Feng, Li-Xing Zhuang
Summary: This article summarizes the similarities and differences in treatment concepts and methods between Chinese and Western medicine for Parkinson's disease, as well as the latest evidence and prospective treatment options for acupuncture in Parkinson's disease.
BIOMEDICINE & PHARMACOTHERAPY
(2022)
Article
Clinical Neurology
Asako Kakimoto, Miki Kawazoe, Kanako Kurihara, Takayasu Mishima, Yoshio Tsuboi
Summary: Long-term levodopa treatment in patients with Parkinson's disease often causes motor fluctuations, which can affect their quality of life. This study found that Parkinson's disease patients with non-motor fluctuations had a lower quality of life compared to those with only motor fluctuations or no fluctuations.
FRONTIERS IN NEUROLOGY
(2023)
Article
Clinical Neurology
Michiel F. Dirkx, James M. Shine, Rick C. Helmich
Summary: Fluctuations in cerebral integration and arousal drive spontaneous fluctuations in PD rest tremor. Increasing cerebral integration and enhanced arousal amplify PD tremor activity. Attenuating enhanced cerebral integration may reduce tremor in PD.
MOVEMENT DISORDERS
(2023)
Review
Biochemistry & Molecular Biology
Karim E. Shalaby, Omar M. A. El-Agnaf
Summary: Gene therapy has the potential to replace current treatments for Parkinson's disease and has been shown to be safe and effective in current trials.
Review
Clinical Neurology
Jing Wu, Yi Wang, Xueyan Wang, Yujia Xie, Weihong Li
Summary: This systematic review and meta-analysis aimed to evaluate the efficacy and safety of acupuncture in treating dysphagia in Parkinson's disease (PD). The results showed that acupuncture combined with control treatment was more effective in improving dysphagia and clinical efficiency, and reducing complications compared to control treatment alone. However, due to the high risk of bias in the included studies, more high-quality evidence is needed to confirm the efficacy and safety of acupuncture for dysphagia in PD.
FRONTIERS IN NEUROLOGY
(2023)
Review
Biochemistry & Molecular Biology
Sri Jayanti, Rita Moretti, Claudio Tiribelli, Silvia Gazzin
Summary: With the increase in life expectancy, the prevalence of Parkinson's disease is expected to rise, but the diagnosis still relies on clinical symptoms. Current treatments mainly focus on alleviating symptoms without stopping or slowing down disease progression. Therefore, exploring the therapeutic potential of bilirubin in PD is crucial for the development of disease-modifying treatments.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Geriatrics & Gerontology
Xiaopeng Wen, Kunbin Li, Hao Wen, Qian Wang, Zhiyuan Wu, Xianli Yao, Bing Jiao, Pingge Sun, Shuqi Ge, Chenyang Wen, Liming Lu
Summary: This study suggests that acupuncture-related therapies combined with conventional medication may benefit individuals with Parkinson's disease, particularly in improving UPDRS, PDQ-39 scores, and Madopar dosage. Additional high-quality randomized trials are needed to further evaluate the efficacy of acupuncture-related therapies for Parkinson's disease.
FRONTIERS IN AGING NEUROSCIENCE
(2021)
Article
Medicine, General & Internal
Sangmin Park, Aeyung Kim, Gunhyuk Park, Ojin Kwon, Sangsoo Park, Horyong Yoo, Junghee Jang
Summary: This study investigated specific genes involved in the therapeutic response to acupuncture in patients with Parkinson's disease. The findings suggest ANKRD22 and SYN1 as potential biomarkers for predicting/monitoring therapeutic responses to acupuncture in PD patients, particularly those with gait disturbance. Further research is needed to validate these findings in a larger sample of PD patients.
Review
Integrative & Complementary Medicine
Jingyi Wen, Xi Chen, Yong Yang, Jianxin Liu, Enyin Li, Jiayou Liu, Ziwei Zhou, Weihua Wu, Kai He
Summary: Acupuncture, a traditional Chinese health care approach, is gaining attention and recognition globally; this review provides a comprehensive profile of its development, application, and mechanisms in treating major diseases, offering valuable information for investigators and acupuncturists.
AMERICAN JOURNAL OF CHINESE MEDICINE
(2021)
Article
Public, Environmental & Occupational Health
Hao Wen, Xiaojing Wei, Shuqi Ge, Jingchun Zeng, Wen Luo, Rouhao Chen, Yu Dong, Songhua Xiao, Yunfeng Lai, Liming Lu
Summary: Acupuncture as an adjunctive therapy for patients receiving methadone maintenance treatment shows significant clinical and economic benefits, including reducing methadone dosage, improving drug cravings, and alleviating insomnia, leading to an improved quality of life. However, the cost of acupuncture may exceed what society is willing to pay, indicating a need for further study.
FRONTIERS IN PUBLIC HEALTH
(2021)
Article
Oncology
Aisha Augustin, Adrien Le Guennec, Chianna Umamahesan, Aidan Kendler-Rhodes, Rosalind M. Tucker, Elena Chekmeneva, Panteleimon Takis, Matthew Lewis, Karthik Balasubramanian, Neville DeSouza, Benjamin H. Mullish, David Taylor, Suzanne Ryan, Kevin Whelan, Yun Ma, Mohammad A. A. Ibrahim, Ingvar Bjarnason, Bu' Hussain Hayee, Andre Charlett, Sylvia M. Dobbs, R. John Dobbs, Clive Weller
Summary: This study explores the involvement of the gut-brain axis in Parkinson's disease (PD) and finds that the gut health, intestinal inflammation, and systemic inflammatory response are related to the clinical phenotype of PD. The researchers also observe that prolonged colonic transit is associated with a lack of short-chain fatty acids, and deficits in specific metabolites, such as tryptophan, are linked to PD symptoms. In addition, PD patients have a faster pulse rate, which is associated with deficits in certain metabolites and increased serum CCL20 levels. The study highlights the importance of gut health and inflammation in PD pathophysiology.
CLINICAL AND TRANSLATIONAL MEDICINE
(2023)
Article
Biology
Amit Frishberg, Inge van den Munckhof, Rob Ter Horst, Kiki Schraa, Leo A. B. Joosten, Joost H. W. Rutten, Adrian C. Iancu, Ioana M. Dregoesc, Bogdan A. Tigu, Mihai G. Netea, Niels P. Riksen, Irit Gat-Viks
Summary: By mapping similarities among clinical parameters in normal physiological settings, a quantitative two-dimensional model representing the whole-body state has been identified, including both traditional metabolic syndrome and a novel non-classical metabolic syndrome. These findings offer new avenues for improved personalized diagnosis and treatment of diseases.
Article
Neurosciences
Moxuan Zhang, Wenjia Meng, Chong Liu, Huizhi Wang, Renpeng Li, Qiao Wang, Yuan Gao, Siyu Zhou, Tingting Du, Tianshuo Yuan, Lin Shi, Chunlei Han, Fangang Meng
Summary: This study analyzed the expression profile and immunity of cuproptosis-related genes (CRGs) in Parkinson's disease (PD) using multiple GEO datasets. Dysregulated CRGs and differential immune responses were identified in PD. A predictive model for the occurrence of PD based on core genes was established, and the core genes were found to be significantly correlated with tyrosine hydroxylase activity. This study provides new insights into the relationship between cuproptosis and PD and offers potential for PD treatment.
Review
Clinical Neurology
Sushma Kola, Indu Subramanian
Summary: Recent studies have shown that aerobic exercise and strength training can improve brain structure and function in Parkinson's disease patients, social prescribing and cognitive behavioral therapy can alleviate loneliness, Ayurvedic and traditional Chinese medicine practices such as yoga, tai chi and acupuncture can improve mobility, mood, and quality of life, while art therapy, music, and dance therapy can alleviate freezing of gait. The virtual use of these integrative therapies improves patient accessibility and participation.
CURRENT NEUROLOGY AND NEUROSCIENCE REPORTS
(2023)
Article
Integrative & Complementary Medicine
Tieh-Cheng Fu, Yi-Chung Lin, Ching-Mao Chang, Wei-Ling Chou, Pei-Hsun Yuan, Min-Hui Liu, Chao-Hung Wang, Juei-Chao Chen, Hen-Hong Chang, Tai-Long Pan
BMC COMPLEMENTARY AND ALTERNATIVE MEDICINE
(2016)
Article
Integrative & Complementary Medicine
Shu-Wen Weng, Bor-Chyuan Chen, Yu-Chiao Wang, Chun-Kai Liu, Mao-Feng Sun, Ching-Mao Chang, Jaung-Geng Lin, Hung-Rong Yen
EVIDENCE-BASED COMPLEMENTARY AND ALTERNATIVE MEDICINE
(2016)
Article
Multidisciplinary Sciences
Hen-Hong Chang, Shue-Fen Luo, Yin-Tzu Hsue, Ching-Mao Chang, Tzung-Yan Lee, Yu-Chuen Huang, Ming-Ling Hsu, Yu-Jen Chen
SCIENTIFIC REPORTS
(2016)
Article
Oncology
Tom Fleischer, Tung-Ti Chang, Jen-Huai Chiang, Ching-Mao Chang, Ching-Yun Hsieh, Hung-Rong Yen
Article
Plant Sciences
Fang-Pey Chen, Ching-Mao Chang, Ta-Peng Wu, Jen-Lin Yang, Yen-Ying Kung, Yi-Hsiang Huang, Chien-Wei Su, Keng-Hsin Lan, Shu-Chiung Chiang, Shinn-Jang Hwang
JOURNAL OF ETHNOPHARMACOLOGY
(2017)
Article
Plant Sciences
Ching-Mao Chang, Po-Chang Wu, Jen-Huai Chiang, Yau-Huei Wei, Fang-Pey Chen, Tzeng-Ji Chen, Tai-Long Pan, Hung-Rong Yen, Hen-Hong Chang
JOURNAL OF ETHNOPHARMACOLOGY
(2017)
Article
Integrative & Complementary Medicine
Pei-Wen Wu, Po-Hsuan Shih, Yen-Ying Kung, Fang-Pey Chen, Ching-Mao Chang
COMPLEMENTARY THERAPIES IN MEDICINE
(2018)
Article
Mathematical & Computational Biology
Tieh-Cheng Fu, Chaur-Chin Chen, Ching-Mao Chang, Hen-Hong Chang, Hsueh-Ting Chu
COMPUTATIONAL AND MATHEMATICAL METHODS IN MEDICINE
(2018)
Article
Environmental Sciences
Ta-Peng Wu, Cheng-Hung Tsai, Yu-Ting Su, Chu-Chiao Wang, Tzeng-Ji Chen, Ching-Mao Chang, Fang-Pey Chen
INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH
(2018)
Article
Plant Sciences
Ching-Mao Chang, Po-Hsuan Shih, Tzeng-Ji Chen, Wen-Chao Ho, Chun-Pai Yang
JOURNAL OF ETHNOPHARMACOLOGY
(2019)
Article
Medicine, General & Internal
Gilbert Aaron Lee, Ching-Mao Chang, Ying Chieh Wu, Ruo-yu Ma, Cheng-Yu Chen, Yin-Tzu Hsue, Nan-Shih Liao, Hen-Hong Chang
Summary: The study found that SS-1 can inhibit the activation of T cells and reduce the levels of different cytokines, which helps improve the symptoms of patients with SS.
JOURNAL OF THE FORMOSAN MEDICAL ASSOCIATION
(2021)
Article
Integrative & Complementary Medicine
Diem Ngoc Hong Tran, I-Hsuan Hwang, Fun-Jou Chen, Yuan-Pu Tseng, Ching-Mao Chang, Shih-Jen Tsai, Jen-Lin Yang, Ta-Peng Wu, Chung-Hua Hsu, Fang-Pey Chen, Yen-Ying Kung
Summary: This study investigated the core prescription pattern of Chinese herbal medicine among patients with depressive disorders in Taiwan, revealing common formulas and single herbs, with a core pattern consisting of a combination of multiple herbs. This core prescription pattern may be a potential candidate for future pharmacological or clinical trials targeting depressive disorders.
INTEGRATIVE MEDICINE RESEARCH
(2021)
Article
Medicine, General & Internal
Yun-Chain Yau, Chun-Pai Yang, Ching-Po Lin, I-Ju Tsai, Ching-Mao Chang, Cheng-Chia Yang, Po-Hsuan Shih, Yin-Yin Liao
Summary: This study explored the efficacy of oral steroids in treating carpal tunnel syndrome by analyzing ultrasound findings and potential mechanisms, showing significant improvements in AMP, CSA, GSS, and DML in the steroid group compared to the nicergoline group at 2 and 4 weeks.
Letter
Gastroenterology & Hepatology
Hong-Chun Lin, Chien-Ming Yen, Kuo-Feng Chen, Yen-Ying Kung, Yung-Hung Hsieh, Ching-Mao Chang
HEPATOLOGY INTERNATIONAL
(2022)
Letter
Immunology
Tieh-Cheng Fu, Juei-Chao Chen, Ching-Mao Chang
BRAIN BEHAVIOR AND IMMUNITY
(2024)