☆ 4.4 Article

Autoantibodies to Granulocyte-Macrophage Colony-Stimulating Factor Associated With Severe and Unusual Manifestations of Cryptococcus gattii Infections

OPEN FORUM INFECTIOUS DISEASES (2017)

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OPEN FORUM INFECTIOUS DISEASES

卷 4, 期 4, 页码 -

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OXFORD UNIV PRESS INC

DOI: 10.1093/ofid/ofx211

关键词

cryptococcus; GM-CSF autoantibodies; immune deficits; spinal epidural abscess

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Immunology Infectious Diseases Microbiology

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Cryptococcus gattii infections, especially including those with severe clinical manifestations, may be related to underlying host immunologic factors. We present 2 cases with autoantibodies to granulocyte-macrophage colony-stimulating factor (GM-CSF), a key cytokine in macrophage function. Immunologic evaluation for anti-GM-CSF antibodies may be important to inform management and counseling.

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