Article
Health Care Sciences & Services
Umile Giuseppe Longo, Arianna Carnevale, Carlo Massaroni, Daniela Lo Presti, Alessandra Berton, Vincenzo Candela, Emiliano Schena, Vincenzo Denaro
Summary: The study proposes a personalized, predictive, participatory, precision, and preventive (P5) medicine model, highlighting the potential for tailoring diagnosis and therapy for patients with RC diseases by defining genetic predispositions and assessing lifestyle and environmental factors.
JOURNAL OF PERSONALIZED MEDICINE
(2021)
Article
Medicine, General & Internal
Hao-Wen Chen, Rui Zhou, Bi-Fei Cao, Kuan Liu, Qi Zhong, Yi-Ning Huang, Hua-Min Liu, Jin-Qing Zhao, Xian-Bo Wu
Summary: This study explores the relationship between specific gut microbiota and insomnia, and their mediating effects of inflammation. Targeting these specific gut microbiota alterations could potentially lead to personalized treatment strategies for managing insomnia.
Review
Cardiac & Cardiovascular Systems
E. Reijnders, A. van der Laarse, J. W. Jukema, C. M. Cobbaert
Summary: By analyzing research papers, we explored strategies for minimizing residual cardiovascular disease risk and identified new risk factors. Personalized treatment based on individual risk factors, including lipid abnormalities, is crucial.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2023)
Article
Medicine, General & Internal
Cancan Cui, Te Zhang, Yitian Qi, Jiaqi Chu, Haikun Xu, Chen Sun, Zhenming Zhang, Xingang Wang, Siqi Yue, Xiaoping Kang, Ling Fang
Summary: This study found that individuals with diabetes have an increased risk of arterial stiffness, but adherence to good glycemic control can mitigate this risk.
Article
Medicine, General & Internal
Si Chen, Nan Wang, Siqi Xiong, Xiaobo Xia
Summary: This bioinformatic study identifies NFKB1, IL18, KITLG, TLR9, FKBP2, and HDAC4 as key genes for POAG and GM regulation. Immune response modulated by macrophages plays an important role in POAG and may be potential targets for future predictive, preventive, and personalized diagnosis and treatment.
Article
Medicine, General & Internal
Karen Otte, Tobias Ellermeyer, Masahide Suzuki, Hanna M. Rohling, Ryota Kuroiwa, Graham Cooper, Sebastian Mansow-Model, Masahiro Mori, Hanna Zimmermann, Alexander U. Brandt, Friedemann Paul, Shigeki Hirano, Satoshi Kuwabara, Tanja Schmitz-Hubsch
Summary: This study found performance differences in a short set of six motor tests between healthy German and Japanese adults, particularly in body posture. Body height was identified as a significant factor affecting performance in short comfortable and maximum speed walks. Japanese adults demonstrated higher amplitude of body movement and faster transition speed compared to German adults.
Article
Medicine, General & Internal
Bo Ram Kim, Tae Keun Yoo, Hong Kyu Kim, Ik Hee Ryu, Jin Kuk Kim, In Sik Lee, Jung Soo Kim, Dong-Hyeok Shin, Young-Sang Kim, Bom Taeck Kim
Summary: This study used eye examinations to predict sarcopenia and help identify individuals at high risk early on. Factors such as decreased levator function, cataracts, and age-related macular degeneration were associated with increased risk of sarcopenia in men, while blepharoptosis and cataracts were associated with increased risk in women. The XGBoost technique showed promising results with AUCs of 0.746 and 0.762 in men and women, respectively.
Review
Microbiology
Matus Dohal, Igor Porvaznik, Ivan Solovic, Juraj Mokry
Summary: Tuberculosis is a global health issue with drug-resistant strains posing a significant challenge to treatment. Treatment ineffectiveness in some individuals with pulmonary tuberculosis has hindered global tuberculosis control efforts. Approaches such as artificial intelligence, genetic screening, and whole genome sequencing can help identify the causes of treatment failure and adjust treatment accordingly.
FRONTIERS IN MICROBIOLOGY
(2023)
Article
Medicine, General & Internal
Xiaoni Meng, Fei Wang, Xiangyang Gao, Biyan Wang, Xizhu Xu, Youxin Wang, Wei Wang, Qiang Zeng
Summary: This study aims to explore the relationship between suboptimal health status (SHS) and type 2 diabetes mellitus (T2DM) by examining the characteristics of IgG N-glycans. The study found significant associations between IgG N-glycan traits and T2DM. Combining IgG N-glycans with clinical features, a combined model was developed that could better differentiate between T2DM patients and healthy individuals. The findings suggest that early detection of T2DM risk individuals and personalized prevention and treatment can be achieved through the detection of IgG N-glycans.
Article
Medicine, General & Internal
Xiaoni Meng, Biyan Wang, Xizhu Xu, Manshu Song, Haifeng Hou, Wei Wang, Youxin Wang
Summary: This study found that suboptimal health status (SHS) is associated with changes in immunoglobulin G (IgG) N-glycan profiles. IgG N-glycan profiles may serve as potential biomarkers for early detection of SHS. The logistic regression model including IgG N-glycans showed moderate performance in predicting SHS, providing an opportunity for SHS management and advanced treatment of non-communicable diseases (NCDs).
Editorial Material
Obstetrics & Gynecology
Malak El Sabeh, Mostafa A. Borahay
Summary: Uterine fibroids are the most common tumors of the female reproductive tract, but current treatment options are standardized and lack individualized consideration.
REPRODUCTIVE SCIENCES
(2021)
Review
Hematology
Mikael Benson
Summary: Digital twins are computational models designed to optimize and understand complex systems more effectively. They can be translated into individual patients to computationally treat diseases and select the most suitable drugs for curing them. However, the challenge lies in the inadequate response of many patients to drug treatment, highlighting the gap between disease complexity and clinical practice.
ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY
(2023)
Article
Medicine, General & Internal
Zhike Zhou, Jun Bai, Shanshan Zhong, Rongwei Zhang, Kexin Kang, Xiaoqian Zhang, Ying Xu, Chuansheng Zhao, Mei Zhao
Summary: This study found that PPP3R1 is involved in the pathogenesis of AD by regulating axon guidance, glutamatergic synapse, LTP, and MAPK signaling pathways, with low levels of PPP3R1 accurately predicting the onset of AD.
Article
Medicine, General & Internal
Xu Qin, Jianglin Zhou, Zizhuo Wang, Chenzhao Feng, Junpeng Fan, Jia Huang, Dianxing Hu, Babak Baban, Shengqi Wang, Ding Ma, Chaoyang Sun, Zhe Zhou, Gang Chen
Summary: This study investigated the specific changes in the genital microbiota caused by ovarian cancer and their potential clinical value. The study found that ovarian cancer can alter the genital microbiota, but bacteria were still the dominant microorganisms in all samples. The study also suggested the application of microbiota in a predictive, preventive, and personalized medicine (PPPM) model for ovarian cancer treatment.
Review
Medicine, General & Internal
Lenka Koklesova, Alena Mazurakova, Marek Samec, Erik Kudela, Kamil Biringer, Peter Kubatka, Olga Golubnitschaja
Summary: Mitochondria play a crucial role in cellular functions and their damage can compromise overall organ functionality. The outcomes of mitochondrial stress vary significantly among individuals, leading to a wide range of associated pathologies. Distinguishing disease predisposition and progression in the context of compromised mitochondrial health is a challenging task in the paradigm shift towards personalized medicine. Robust quantification of mitochondrial health is essential for the successful implementation of personalized medicine concepts. The Mitochondrial Health Index (MHI) and Bioenergetic Health Index (BHI) hold potential as quantification systems to assess mitochondrial health and its relevance to disease development and severity.
Review
Pharmacology & Pharmacy
Dimitri Poddighe, Micol Romano, Facundo Garcia-Bournissen, Erkan Demirkaya
Summary: Familial Mediterranean fever (FMF) is commonly diagnosed in childhood and is treated predominantly with colchicine, but in cases of intolerance or resistance, the use of biologics, especially interleukin-1 antagonists, should be considered.
BRITISH JOURNAL OF CLINICAL PHARMACOLOGY
(2022)
Review
Medicine, General & Internal
Dimitri Poddighe, Micol Romano, Kuanysh Dossybayeva, Diyora Abdukhakimova, Dinara Galiyeva, Erkan Demirkaya
Summary: This article reviews and analyzes clinical studies on celiac disease (CD) among children with juvenile idiopathic arthritis (JIA). The findings suggest a high prevalence of CD in JIA patients, particularly in those who are asymptomatic. However, there is no evidence supporting periodic CD screening for children with other pediatric rheumatic diseases.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Biology
Sezgin Sahin, Micol Romano, Ferhat Guzel, David Piskin, Dimitri Poddighe, Siren Sezer, Ozgur Kasapcopur, C. Thomas Appleton, Ilker Yilmaz, Erkan Demirkaya
Summary: This study finds that FMF-AA patients with a homozygous M694V mutation have a higher risk of cardiovascular disease compared to patients with other genotypes. They also have higher levels of fibroblast growth factor 23 (FGF23), carotid intima-media thickness (cIMT), and pentraxin-3 (PTX3).
Review
Medicine, General & Internal
Dimitri Poddighe, Erkan Demirkaya, Vitaliy Sazonov, Micol Romano
Summary: Mycoplasma pneumoniae is a common cause of community-acquired pneumonia in children and can also lead to extrapulmonary diseases. Children with primary immunodeficiencies, especially those with humoral immune deficiencies, may experience persistent or severe infections caused by M. pneumoniae. Actively searching for M. pneumoniae infection may be beneficial, particularly in children with humoral immune deficiencies.
INTERNATIONAL JOURNAL OF CLINICAL PRACTICE
(2022)
Article
Medicine, General & Internal
Kuanysh Dossybayeva, Yergali Bexeitov, Zaure Mukusheva, Zhaina Almukhamedova, Maykesh Assylbekova, Diyora Abdukhakimova, Marzhan Rakhimzhanova, Dimitri Poddighe
Summary: This study aimed to assess circulating basophils in children with pediatric SLE. The results showed a significant reduction in peripherally circulating basophils in children with pSLE compared to the other two groups of patients.
Article
Biology
Micol Romano, Facundo Garcia-Bournissen, David Piskin, Ulkumen Rodoplu, Lizzy Piskin, Abdelbaset A. Elzagallaai, Tunc Tuncer, Siren Sezer, Didar Ucuncuoglu, Tevfik Honca, Dimitri Poddighe, Izzet Yavuz, Peter Stenvinkel, Mahmut Ilker Yilmaz, Erkan Demirkaya
Summary: This study aimed to evaluate the impact of a combination of natural products on inflammation, endothelial dysfunction, and oxidative stress in patients with familial Mediterranean fever (FMF) and Serum Amyloid A amyloidosis. The results showed that the combination therapy significantly reduced inflammatory markers, improved endothelial function, and reduced oxidative stress.
Review
Nutrition & Dietetics
Dimitri Poddighe, Kuanysh Dossybayeva, Diyora Abdukhakimova, Lyudmila Akhmaltdinova, Aigul Ibrayeva
Summary: This review analyzes the pathophysiological aspects and clinical evidence of gallbladder dysfunction in CD patients, highlighting the potential medical complications and research gaps. CD patients may develop gallbladder dysmotility, leading to impaired emptying during digestion. Although CD patients do not seem to be more susceptible to gallbladder complications, further clinical studies are needed to fully understand the clinical implications of gallbladder alterations in CD patients.
Editorial Material
Pediatrics
Dimitri Poddighe, Vahid Ziaee, Ozgur Kasapcopur
FRONTIERS IN PEDIATRICS
(2022)
Review
Oncology
Akzhol Karim, Kundyz Shaikhyzada, Assel Suleimenova, Bakytkali Ibraimov, Dair Nurgaliev, Dimitri Poddighe
Summary: Atypical teratoid/rhabdoid tumor (AT/RT) is a rare and highly malignant embryonal neoplasm that occurs mainly in infants and young children. It is characterized by rapid growth and poor prognosis. The diagnosis of this tumor is based on immunohistochemical staining for loss of nuclear integrase interactor 1 (INI1) expression. There is currently no validated treatment protocol, and multimodality treatment is commonly used.
FRONTIERS IN ONCOLOGY
(2022)
Review
Biochemistry & Molecular Biology
Diana Talipova, Aiganym Smagulova, Dimitri Poddighe
Summary: This review discusses the potential role of Toll-like receptors (TLRs) in the immunopathogenesis of CD. Although evidence from basic research is limited, differences in TLR expression and activation have been observed between active CD patients and controls or treated CD patients in some clinical studies. Therefore, TLRs may be part of the non-HLA-related genetic factors implicated in CD pathogenesis, considering their potential role in the interaction between the host immune system and environmental factors.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Green & Sustainable Science & Technology
Dimitri Poddighe, Massimo Pignatelli
Summary: This article presents the first experience of implementing an ACGME-oriented Pediatric Residency Program in Central Asia. The vision, general project, main organizational aspects, and challenges of this program are described and discussed in this article.
Review
Oncology
Akzhol Karim, Kundyz Shaikhyzada, Nazgul Abulkhanova, Akzhunis Altyn, Bakytkali Ibraimov, Dair Nurgaliyev, Dimitri Poddighe
Summary: Wilms tumor (WT) is a rare form of cancer that typically affects children and is usually confined to the kidneys. Extra-renal Wilms tumor (ERWT) is even rarer and develops in other areas of the body, such as the retroperitoneum and inguinal regions, and occasionally at the level of the spinal cord. Our research emphasizes the importance of timely diagnosis and treatment and, possibly, standardized medical approach, in order to improve the outcome of these very rare pediatric malignancies, whose clinical management is even more problematic in developing countries.
Article
Medicine, General & Internal
Altinoy T. Kamilova, Gulnoza K. Azizova, Dimitri Poddighe, Zulkhumar E. Umarnazarova, Dilrabo A. Abdullaeva, Svetlana I. Geller, Noiba D. Azimova
Summary: This study investigates the prevalence and clinical characteristics of Celiac Disease (CD) in symptomatic children in Uzbekistan. Among the 206 children studied, 5.3% were diagnosed with CD. Watery diarrhea was more frequently observed in CD patients. A full diagnostic work-up for CD in the local clinical setting is recommended.
Article
Respiratory System
Makhabbat Bekbossynova, Lyudmila Akhmaltdinova, Kuanysh Dossybayeva, Ainur Tauekelova, Zauresh Smagulova, Tatyana Tsechoeva, Gulsimzhan Turebayeva, Aliya Sailybayeva, Zhanar Kalila, Tahmina Mirashirova, Timur Muratov, Dimitri Poddighe
Summary: Memory T cell imbalance is observed in patients with COVID-19, with an increase in central memory T cells and a decrease in effector memory T cells. Additional research is needed to confirm these findings as potential biological markers for interstitial lung involvement in viral respiratory infections.
RESPIRATORY RESEARCH
(2022)
Letter
Psychiatry
Dimitri Poddighe
JOURNAL OF THE ACADEMY OF CONSULTATION-LIAISON PSYCHIATRY
(2022)
