Evolutionary adaptations of biofilms infecting cystic fibrosis lungs promote mechanical toughness by adjusting polysaccharide production

Pel is a cationic exopolysaccharide that cross-links extracellular DNA in thePseudomonas aeruginosabiofilm matrix

(2015) Laura K. Jennings et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Polymorphonuclear Leukocytes Restrict Growth of Pseudomonas aeruginosa in the Lungs of Cystic Fibrosis Patients

(2014) Kasper N. Kragh et al.   INFECTION AND IMMUNITY

Single-Cell Control of Initial Spatial Structure in Biofilm Development Using Laser Trapping

(2014) Jaime B. Hutchison et al.   LANGMUIR

Oxygen Limitation within a Bacterial Aggregate

(2014) A. K. Wessel et al.   mBio

Dynamic Remodeling of Microbial Biofilms by Functionally Distinct Exopolysaccharides

(2014) S. C. Chew et al.   mBio

Pseudomonas aeruginosa Enhances Production of a Non-Alginate Exopolysaccharide during Long-Term Colonization of the Cystic Fibrosis Lung

(2013) Holly K. Huse et al.   PLoS One

Molecular basis for pH-dependent mucosal dehydration in cystic fibrosis airways

(2013) A. L. Garland et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The extracellular polysaccharide Pel makes the attachment of P. aeruginosa to surfaces symmetric and short-ranged

(2013) Benjamin J. Cooley et al.   Soft Matter

The Extracellular Matrix Component Psl Provides Fast-Acting Antibiotic Defense in Pseudomonas aeruginosa Biofilms

(2013) Nicole Billings et al.   PLoS Pathogens

Biophysics of biofilm infection

(2013) Philip S. Stewart   Pathogens and Disease

Mapping of Bacterial Biofilm Local Mechanics by Magnetic Microparticle Actuation

(2012) Olivier Galy et al.   BIOPHYSICAL JOURNAL

Super tough double network hydrogels and their application as biomaterials

(2012) Md. Anamul Haque et al.   POLYMER

Chemical and antimicrobial treatments change the viscoelastic properties of bacterial biofilms

(2011) Warren L. Jones et al.   BIOFOULING

Pseudomonas aeruginosa Psl polysaccharide reduces neutrophil phagocytosis and the oxidative response by limiting complement-mediated opsonization

(2011) Meenu Mishra et al.   CELLULAR MICROBIOLOGY

The Role of Biofilms: Are We Hitting the Right Target?

(2011) Randall Wolcott et al.   PLASTIC AND RECONSTRUCTIVE SURGERY

Phenotypes of Non-Attached Pseudomonas aeruginosa Aggregates Resemble Surface Attached Biofilm

(2011) Morten Alhede et al.   PLoS One

Mechanical robustness of Pseudomonasaeruginosa biofilms

(2011) Oliver Lieleg et al.   Soft Matter

Biosynthesis of the Pseudomonas aeruginosa Extracellular Polysaccharides, Alginate, Pel, and Psl

(2011) Michael J. Franklin et al.   Frontiers in Microbiology

Pseudomonas aeruginosabiofilms in cystic fibrosis

(2010) Niels Høiby et al.   Future Microbiology

Pseudomonas aeruginosauses a cyclic-di-GMP-regulated adhesin to reinforce the biofilm extracellular matrix

(2010) Bradley R. Borlee et al.   MOLECULAR MICROBIOLOGY

Why are double network hydrogels so tough?

(2010) Jian Ping Gong   Soft Matter

Parallel Evolution in Pseudomonas aeruginosa over 39,000 Generations In Vivo

(2010) H. K. Huse et al.   mBio

Absolute Quantitation of Bacterial Biofilm Adhesion and Viscoelasticity by Microbead Force Spectroscopy

(2009) Peter C.Y. Lau et al.   BIOPHYSICAL JOURNAL

Detection of Bacteria by Fluorescence in Situ Hybridization in Culture-Negative Soft Tissue Filler Lesions

(2009) THOMAS BJARNSHOLT et al.   DERMATOLOGIC SURGERY

Pseudomonas aeruginosa Rugose Small-Colony Variants Have Adaptations That Likely Promote Persistence in the Cystic Fibrosis Lung

(2009) M. Starkey et al.   JOURNAL OF BACTERIOLOGY

Genetic and biochemical analyses of thePseudomonas aeruginosaPsl exopolysaccharide reveal overlapping roles for polysaccharide synthesis enzymes in Psl and LPS production

(2009) Matthew S. Byrd et al.   MOLECULAR MICROBIOLOGY

Pseudomonas aeruginosabiofilms in the respiratory tract of cystic fibrosis patients

(2009) Thomas Bjarnsholt et al.   PEDIATRIC PULMONOLOGY

Assembly and Development of the Pseudomonas aeruginosa Biofilm Matrix

(2009) Luyan Ma et al.   PLoS Pathogens

Pseudomonas aeruginosain Chronic Obstructive Pulmonary Disease

(2008) Timothy F. Murphy et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Distribution, Organization, and Ecology of Bacteria in Chronic Wounds

(2008) K. Kirketerp-Moller et al.   JOURNAL OF CLINICAL MICROBIOLOGY

Localized Yielding Around Crack Tips of Double-Network Gels

(2008) Yoshimi Tanaka et al.   MACROMOLECULAR RAPID COMMUNICATIONS

Why chronic wounds will not heal: a novel hypothesis

(2007) Thomas Bjarnsholt et al.   WOUND REPAIR AND REGENERATION