期刊
COMPUTATIONAL AND STRUCTURAL BIOTECHNOLOGY JOURNAL
卷 15, 期 -, 页码 366-371出版社
ELSEVIER SCIENCE BV
DOI: 10.1016/j.csbj.2017.06.001
关键词
Biosensor; Gene expression; HucR; Ligand binding; Lignin catabolism
资金
- National Science Foundation [MCB-1515349]
- National Institutes of Health [1R15GM107825]
- Emerging Frontiers
- Direct For Biological Sciences [1515349] Funding Source: National Science Foundation
Bacteria have evolved sophisticated mechanisms for regulation of metabolic pathways. Such regulatory circuits ensure that anabolic pathways remain repressed unless final products are in short supply and that catabolic enzymes are not produced in absence of their substrates. The precisely tuned gene activity underlying such circuits is in the purview of transcription factors that may bind pathway intermediates, which in turn modulate transcription factor function and therefore gene expression. This review focuses on the role of ligand-responsive MarR family transcription factors in controlling expression of genes encoding metabolic enzymes and the mechanisms by which such control is exerted. Prospects for exploiting these transcription factors for optimization of gene expression for metabolic engineering and for the development of biosensors are considered. (C) 2017 The Author. Published by Elsevier B.V. on behalf of Research Network of Computational and Structural Biotechnology.
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