Review
Oncology
Allan Relecom, Maysaloun Merhi, Varghese Inchakalody, Shahab Uddin, Darawan Rinchai, Davide Bedognetti, Said Dermime
Summary: Immune checkpoint inhibitors have shown therapeutic benefits in solid cancers and some hematological malignancies, but predicting treatment response remains challenging. Studies on the dynamics of the immune system and tumor under immune checkpoint blockade have revealed mechanisms of action and adaptive resistance to these therapeutic agents.
JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH
(2021)
Review
Oncology
Shuang Huang, Gang Zheng, Kai Yang
Summary: This systematic review and meta-analysis evaluated the efficacy and safety of neoadjuvant PD-1/PD-L1 inhibitors combined with CTLA-4 inhibitors in malignant solid tumors. The results showed that the addition of CTLA-4 inhibitors did not significantly improve overall response rate and survival outcomes. However, there was an increased risk of grade 3-4 adverse events with the combination therapy. More large-scale and multicenter randomized controlled trials are needed to obtain more reliable results.
WORLD JOURNAL OF SURGICAL ONCOLOGY
(2023)
Review
Immunology
Meng Chen, Chenyan Li, Mingjun Sun, Yiling Li, Xuren Sun
Summary: This review summarizes the challenges in the treatment of gastroesophageal cancers (GECs) and the use of immune checkpoint inhibitors as a new therapeutic approach. Ongoing clinical trials with PD-1/PD-L1 pathway blockers in GEC are discussed, and further research is needed to apply them in the clinical care of patients. The review provides insights into the efficacy of PD-1/PD-L1 antibodies as a first-line treatment and in second-line or more treatment for GEC.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Oncology
Joe Yeong, Huey Yew Jeffrey Lum, Chong Boon Teo, Benjamin Kye Jyn Tan, Yiong Huak Chan, Ryan Yong Kiat Tay, Joan Rou-En Choo, Anand D. Jeyasekharan, Qing Hao Miow, Lit-Hsin Loo, Wei Peng Yong, Raghav Sundar
Summary: Our study showed that PD-L1 CPS scores and positivity rates are higher with the 28-8 assay compared to the 22C3 and other assays in GC PD-L1 IHC. Therefore, caution should be exercised in considering these assays as equivalent until stronger evidence of inter-assay concordance is established.
Review
Oncology
M. Kossai, N. Radosevic-Robin, F. Penault-Llorca
Summary: Immunotherapy for breast cancer still faces challenges in patient selection and biomarker identification, with only PD-L1 expression and mismatch repair deficiency status approved for PD-1/PD-L1 inhibitors. Ongoing research is focusing on finding additional predictive biomarkers, including immune gene signatures and tumor-infiltrating lymphocytes, to improve treatment efficacy. Dynamic assessment of treatment response through biomarkers like circulating PD-L1 and immune cell quantity, as well as consideration of host factors like microbiome and lifestyle, are important for integrating immunomodulating therapies into breast cancer management.
Article
Biochemistry & Molecular Biology
Navid Sobhani, Victoria Bouche, Giovanni Aldegheri, Andrea Rocca, Alberto D'Angelo, Fabiola Giudici, Cristina Bottin, Carmine Antonio Donofrio, Maurizio Pinamonti, Benvenuto Ferrari, Stefano Panni, Marika Cominetti, Jahard Aliaga, Marco Ungari, Antonio Fioravanti, Fabrizio Zanconati, Daniele Generali
Summary: With the introduction of immunotherapies, there is new hope for cancer therapy, especially for cancers with poor prognoses like glioblastoma multiforme (GBM). However, these therapies are only effective in a small percentage of patients, highlighting the need for accurate predictors of response. In our study, we found that while TILs and PD-L1 expression are detectable in the majority of GBM samples, they do not significantly correlate with overall survival.
Article
Chemistry, Multidisciplinary
Yoshihide Suzuki, Keisuke Ichinohe, Akihiro Sugawara, Shinya Kida, Shinya Murase, Jing Zhang, Osamu Yamada, Toshio Hattori, Yoshiteru Oshima, Haruhisa Kikuchi
Summary: In this study, novel immune checkpoint inhibitors with enhanced potency were developed through modifications of an existing unnatural pentacyclic compound. These inhibitors showed the ability to suppress both CTLA-4 and PD-L1 gene expression and protein expression, making them the first reported dual small-molecule inhibitors of CTLA-4 and PD-L1.
FRONTIERS IN CHEMISTRY
(2021)
Review
Chemistry, Analytical
Pei Wang, Longfei Tang, Bohui Zhou, Liangfen Cheng, Robert Chunhua Zhao, Juan Zhang
Summary: Immune checkpoints are a series of molecules that regulate the degree of immune activation, including PD-1/PD-L1, CTLA-4, LAG-3, and others. Immune checkpoint therapy is considered to be a safer and more effective treatment for tumor immunotherapy compared to conventional therapy. The analysis of immune checkpoints is crucial for immunotherapy medication, treatment, and prognosis evaluation.
TRAC-TRENDS IN ANALYTICAL CHEMISTRY
(2022)
Article
Agriculture, Dairy & Animal Science
Ilaria Porcellato, Samanta Mecocci, Chiara Brachelente, Katia Cappelli, Federico Armando, Alessia Tognoloni, Elisabetta Chiaradia, Valentina Stefanetti, Luca Mechelli, Marco Pepe, Rodolfo Gialletti, Benedetta Passeri, Alessandro Ghelardi, Elisabetta Razzuoli
Summary: The study investigated the expression of PD-L1 and CTLA-4 in penile tumors of horses, particularly in malignant squamous cell carcinomas. Results showed that these molecules are not frequently expressed in equine penile tumors, suggesting limited efficacy of ICI in treating these tumors.
Review
Oncology
Mattia Garutti, Serena Bonin, Silvia Buriolla, Elisa Bertoli, Maria Antonietta Pizzichetta, Iris Zalaudek, Fabio Puglisi
Summary: Immunotherapy has revolutionized the treatment of melanoma, but the lack of clinically validated predictive biomarkers contributes to its unpredictable efficacy. Predictive biomarkers could aid in patient stratification, drug selection, and treatment adjustment, yet their difficulty in obtaining reflects the complexity of tumor biology. Biomarkers play a crucial role in guiding clinicians through the decision-making process for checkpoint inhibition in melanoma.
Article
Medicine, Research & Experimental
Youliang Zhao, Changfu Hao, Meng Li, Yaqian Qu, Yonghua Guo, Xuedan Deng, Huifang Si, Wu Yao
Summary: This study demonstrates the potential value of immune checkpoint inhibitors, particularly PD-1/PD-L1 inhibitors, in the treatment of silica-induced pulmonary fibrosis. The findings suggest that these inhibitors can modulate immune system disruption caused by silica exposure and provide new ideas for the treatment of fibrosis-related diseases.
BIOMEDICINE & PHARMACOTHERAPY
(2022)
Article
Biochemistry & Molecular Biology
Ana Erman, Marija Ignjatovic, Katja Leskovsek, Simona Miceska, Ursa Lampreht Tratar, Masa Bosnjak, Veronika Kloboves Prevodnik, Maja Cemazar, Lidija Kandolf Sekulovic, Gorazd Avgustin, Janja Ocvirk, Tanja Mesti
Summary: The study aims to investigate whether the human gastrointestinal microbiome and exosomal mRNA expression of PD-L1 and IFN? can predict the response to immune checkpoint inhibitor treatment and its association with adverse events. It is conducted in metastatic melanoma patients to determine the relevance of these biomarkers in treatment outcomes.
Article
Oncology
Akhilesh Mishra, Kuldeep Gupta, Dhiraj Kumar, Gabriela Lofland, Ajay Kumar Sharma, Lilja B. Solnes, Steven P. Rowe, Patrick M. Forde, Martin G. Pomper, Edward W. Gabrielson, Sridhar Nimmagadda
Summary: This study investigated the relationship between PD-L1 expression and therapy-induced changes in cancer using a peptide-based PD-L1 imaging agent, [F-18]DK222, in humanized mouse models. The results showed that [F-18]DK222-PET has potential as a non-invasive tool for monitoring the effects of immunotherapy on tumors, detecting variable PD-L1 expression, quantifying therapy-induced changes, and differentiating the impact of different therapies on tumors.
JOURNAL FOR IMMUNOTHERAPY OF CANCER
(2023)
Review
Oncology
Hao Zhang, Ziyu Dai, Wantao Wu, Zeyu Wang, Nan Zhang, Liyang Zhang, Wen-Jing Zeng, Zhixiong Liu, Quan Cheng
Summary: The regulatory mechanisms of PD-L1 and CTLA-4 play a crucial role in immunotherapy, and understanding their interactions can help improve patients' treatment responses and clinical care.
JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH
(2021)
Article
Oncology
Zhaodan Xin, Liting You, Feifei Na, Jin Li, Min Chen, Jiajia Song, Ling Bai, Jie Chen, Juan Zhou, Binwu Ying
Summary: In this study, the researchers identified several immunogenetic variants associated with immune-related adverse events (irAEs) and irAEs-free survival in patients treated with PD-1/PD-L1 inhibitors, which could serve as potential predictive biomarkers.
EUROPEAN JOURNAL OF CANCER
(2023)
Review
Cardiac & Cardiovascular Systems
Sjoerd M. Verwijs, Yigal M. Pinto, Diederik W. D. Kuster, Jolanda van der Velden, Jacqueline Limpens, Juliette C. van Hattum, Saskia N. van der Crabben, Ronald H. Lekanne Deprez, Arthur A. M. Wilde, Harald T. Jorstad
Summary: Studies have shown that genetic variants associated with cardiomyopathies may be related to improved physical performance. This may explain the prevalence of such variants in athletes and the general population.
Review
Dermatology
Sanne E. Uitentuis, Caroline Bambach, Yannick S. Elshot, Jacqueline Limpens, Alexander C. J. van Akkooi, Marcel W. Bekkenk
Summary: Synthesis of available data indicates no significant differences in recurrence and survival rates between different clinical excision margins and MMS in treating MCC.
DERMATOLOGIC SURGERY
(2022)
Article
Pediatrics
Anouk Pels, Wes Onland, Rolf M. F. Berger, Arno F. J. van Heijst, Enrico Lopriore, Irwin K. M. Reiss, Jacqueline Limpens, Sanne J. Gordijn, Wessel Ganzevoort
Summary: This study reflects on the unexpected finding of pulmonary hypertension in infants born within the Dutch STRIDER trial and discusses its definition and possible pathophysiological mechanisms. It was found that infants of mothers allocated to antenatal sildenafil had a higher rate of pulmonary hypertension compared to those in the placebo group.
EUROPEAN JOURNAL OF PEDIATRICS
(2022)
Review
Cardiac & Cardiovascular Systems
Frank Meijerink, Samme M. de Witte, Jacqueline Limpens, Robbert J. de Winter, Berto J. Bouma, Jan Baan
Summary: This study aimed to determine the prognostic value of pulmonary hypertension (PH), right ventricular (RV) dysfunction, and tricuspid regurgitation (TR) on mortality after transcatheter mitral valve repair (TMVR). The results showed that patients with significant mitral regurgitation (MR) and concomitant PH, RV dysfunction, or TR had worse prognosis after TMVR. Careful assessment of these parameters should be done before making clinical decisions for TMVR.
HEART LUNG AND CIRCULATION
(2022)
Review
Urology & Nephrology
Eva V. Vodegel, Arnoud W. Kastelein, Charlotte H. J. R. Jansen, Jacqueline Limpens, Sandra E. Zwolsman, Jan-Paul W. R. Roovers, Carlijn R. Hooijmans, Zeliha Guler
Summary: The study showed that estrogen therapy has a positive effect on vaginal wound healing, improving neovascularisation, wound closure, collagen synthesis, tissue strength, granulation, and inflammatory response. Future research should determine the potential of estrogen therapy to improve surgical outcomes.
NEUROUROLOGY AND URODYNAMICS
(2022)
Review
Obstetrics & Gynecology
Kelly Nijsten, Larissa A. W. Jansen, Jacqueline Limpens, Martijn J. J. Finken, Marjette H. Koot, Iris J. Grooten, Tessa J. Roseboom, Rebecca C. Painter
Summary: This systematic review evaluated the effects of maternal hyperemesis gravidarum on offspring health. The results suggest that hyperemesis gravidarum is associated with increased risk of anxiety disorder, sleep problems, attention deficit (hyperactivity) disorder, and autism spectrum disorder in offspring.
AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY
(2022)
Article
Oncology
Julien A. M. Vos, Laura A. M. Duineveld, Vera E. van Miltenburg, Inge Henselmans, Henk C. P. M. van Weert, Kristel M. van Asselt
Summary: This study aims to describe the needs of colon cancer patients and how healthcare providers respond to these needs during routine follow-up consultations in hospital. The findings indicate that patients' questions and concerns mainly revolve around the health system and information domain, and healthcare providers respond to different types of needs in a similar fashion. Overall, patients are satisfied with the information and communication they receive.
SUPPORTIVE CARE IN CANCER
(2022)
Review
Acoustics
B. B. Bet, J. M. De Vries, J. Limpens, M. Van Wely, E. Van Leeuwen, S. A. Clur, E. Pajkrt
Summary: A systematic review and meta-analysis found that fetuses with premature atrial contractions (PAC) have a 4-5 times higher risk of congenital heart defects (CHD) compared to the general population. The incidence of CHD was higher in the high-risk population. Advanced ultrasound examination is recommended for accurate diagnosis of PAC and exclusion of CHD, and weekly fetal heart-rate monitoring is advised to detect arrhythmia early and prevent cardiac failure.
ULTRASOUND IN OBSTETRICS & GYNECOLOGY
(2022)
Review
Obstetrics & Gynecology
Charlotte E. van Dijk, Sofie H. Breuking, Sophie Jansen, Jacqueline C. E. J. M. Limpens, Brenda M. Kazemier, Eva Pajkrt
Summary: The objective of this study was to compare indications for cervical cerclage and their associated complications in singleton pregnancies. The study found that ultrasound-indicated and history-indicated cerclage had fewer complications compared to physical examination-indicated cerclage. There is a need for standardized reporting of complications in studies on cervical cerclage.
AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY
(2023)
Article
Primary Health Care
Julien A. M. Vos, Vera E. van Miltenburg, Frederique H. Beverdam, Henk C. P. M. van Weert, Kristel M. van Asselt
Summary: This study explored patients' experiences of GP-led versus surgeon-led care in colon cancer survivorship. Overall, patients were satisfied with both types of care. However, expectations differed when it came to GP involvement.
BRITISH JOURNAL OF GENERAL PRACTICE
(2022)
Review
Dermatology
Y. S. Elshot, D. C. K. S. Tio, A. S. E. van Haersma-de With, W. Ouwerkerk, B. Zupan-Kajcovski, M. B. Crijns, C. E. J. M. Limpens, W. M. C. Klop, M. W. Bekkenk, A. J. M. Balm, M. A. de Rie
Summary: This study aimed to evaluate the effect of different surgical techniques and reflectance confocal microscopy (RCM) on local recurrence and survival outcomes of lentigo maligna (melanoma) (LM/LMM). The results showed that microscopically controlled surgical techniques were more effective in reducing the rate of local recurrence compared to wide local excision.
JOURNAL OF THE EUROPEAN ACADEMY OF DERMATOLOGY AND VENEREOLOGY
(2023)
Article
Oncology
Julien A. M. Vos, Edanur Sert, Wim B. Busschers, Laura A. M. Duineveld, Thijs Wieldraaijer, Jan Wind, Sandra C. Donkervoort, Marc J. P. M. Govaert, Frederique H. Beverdam, Anke B. Smits, Willem A. Bemelman, Gijsbert Heuff, Henk C. P. M. van Weert, Kristel M. van Asselt, I CARE Study Grp
Summary: In this study, the detection of recurrences and the effect of transferring care from a surgeon to a general practitioner on time to detection were compared in colon cancer patients. The results showed that there were no significant differences in recurrence rates and mortality between patients who received follow-up care from a general practitioner versus a surgeon.
JNCI-JOURNAL OF THE NATIONAL CANCER INSTITUTE
(2023)
Review
Behavioral Sciences
A. Boots, A. M. Wiegersma, Y. Vali, M. van den Hof, M. W. Langendam, J. Limpens, E. V. Backhouse, S. D. Shenkin, J. M. Wardlaw, T. J. Roseboom, S. R. de Rooij
Summary: Environmental exposures during pregnancy can negatively impact brain development and increase the risk of Alzheimer's disease. This systematic review examines the evidence linking prenatal exposures to brain biomarkers associated with AD. The review identified 79 studies reporting on prenatal exposures such as alcohol, smoking, illicit drugs, and nutritional deficiencies, which were associated with smaller brain volumes. The findings highlight the importance of the prenatal environment in shaping the risk of neurodegenerative diseases in later life.
NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS
(2023)
Review
Psychiatry
Aline Marileen Wiegersma, Amber Boots, Miranda w W. Langendam, Jacqueline Limpens, Susan D. D. Shenkin, Aniko Korosi, Tessa J. J. Roseboom, Susanne R. de Rooij
Summary: This systematic review examined the association between prenatal factors and later risk for dementia, finding that prenatal factors related to a suboptimal prenatal environment are associated with an increased risk of dementia.
SOCIAL PSYCHIATRY AND PSYCHIATRIC EPIDEMIOLOGY
(2023)
Article
Primary Health Care
Julien A. M. Vos, Robin de Best, Laura A. M. Duineveld, Henk C. P. M. van Weert, Kristel M. van Asselt
Summary: The opinions of general practitioners (GPs) about the transfer of survivorship care from specialist to primary care vary. While they recognize the potential benefits, there is no consensus about permanently transferring survivorship care to primary care. Barriers and facilitators to implementation highlight the importance of both personal and system level factors.
