Genomic Signature of the Natural Oncolytic Herpes Simplex Virus HF10 and Its Therapeutic Role in Preclinical and Clinical Trials

Ratification vote on taxonomic proposals to the International Committee on Taxonomy of Viruses (2015)

(2015) M. J. Adams et al.   ARCHIVES OF VIROLOGY

Talimogene Laherparepvec: First Global Approval

(2015) Sarah L. Greig   DRUGS

Oncolytic viruses: a new class of immunotherapy drugs

(2015) Howard L. Kaufman et al.   NATURE REVIEWS DRUG DISCOVERY

Designing herpes viruses as oncolytics

(2015) Cole Peters et al.   Molecular Therapy-Oncolytics

Frontline treatment with gemcitabine, oxaliplatin and erlotinib for the treatment of advanced or metastatic pancreatic cancer: a multicenter phase II study of the Hellenic Oncology Research Group (HORG)

(2014) O. Katopodis et al.   CANCER CHEMOTHERAPY AND PHARMACOLOGY

Combination therapy of oncolytic herpes simplex virus HF10 and bevacizumab against experimental model of human breast carcinoma xenograft

(2014) Gewen Tan et al.   INTERNATIONAL JOURNAL OF CANCER

How Taxol/paclitaxel kills cancer cells

(2014) Beth A. Weaver   MOLECULAR BIOLOGY OF THE CELL

Evaluation of the Safety and Biodistribution of M032, an Attenuated Herpes Simplex Virus Type 1 Expressing hIL-12, After Intracerebral Administration to Aotus Nonhuman Primates

(2014) Justin C. Roth et al.   Human Gene Therapy Clinical Development

Combination Treatment of Human Pancreatic Cancer Xenograft Models with the Epidermal Growth Factor Receptor Tyrosine Kinase Inhibitor Erlotinib and Oncolytic Herpes Simplex Virus HF10

(2013) Kazuo Yamamura et al.   ANNALS OF SURGICAL ONCOLOGY

New viruses for cancer therapy: meeting clinical needs

(2013) Tanner S. Miest et al.   NATURE REVIEWS MICROBIOLOGY

Enhanced antitumoral activity of oncolytic herpes simplex virus with gemcitabine using colorectal tumor models

(2012) Shinichi Esaki et al.   INTERNATIONAL JOURNAL OF CANCER

A First in Human Phase 1 Study of CG0070, a GM-CSF Expressing Oncolytic Adenovirus, for the Treatment of Nonmuscle Invasive Bladder Cancer

(2012) James M. Burke et al.   JOURNAL OF UROLOGY

An oncolytic adenovirus defective in pRb-binding (dl922–947) can efficiently eliminate pancreatic cancer cells and tumors in vivo in combination with 5-FU or gemcitabine

(2011) M Bhattacharyya et al.   CANCER GENE THERAPY

The oncolytic adenovirus AdΔΔ enhances selective cancer cell killing in combination with DNA-damaging drugs in pancreatic cancer models

(2011) G Cherubini et al.   GENE THERAPY

Combination of the Tumor Angiogenesis Inhibitor Bevacizumab and Intratumoral Oncolytic Herpes Virus Injections as a Treatment Strategy for Human Gastric Cancers

(2011) Tomohiro Deguchi et al.   HEPATO-GASTROENTEROLOGY

Effects of capsid-modified oncolytic adenoviruses and their combinations with gemcitabine or silica gel on pancreatic cancer

(2011) Lotta Kangasniemi et al.   INTERNATIONAL JOURNAL OF CANCER

A phase I dose-escalation clinical trial of intraoperative direct intratumoral injection of HF10 oncolytic virus in non-resectable patients with advanced pancreatic cancer

(2010) A Nakao et al.   CANCER GENE THERAPY

Combination with low-dose gemcitabine and hTERT-promoter-dependent conditionally replicative adenovirus enhances cytotoxicity through their crosstalk mechanisms in pancreatic cancer

(2010) Manabu Onimaru et al.   CANCER LETTERS

Impact of tumor microenvironment on oncolytic viral therapy

(2010) Jeffrey Wojton et al.   CYTOKINE & GROWTH FACTOR REVIEWS

Antiangiogenic cancer therapy combined with oncolytic virotherapy leads to regression of established tumors in mice

(2010) Timothy Kottke et al.   JOURNAL OF CLINICAL INVESTIGATION

Oncolytic Adenoviral Mutants with E1B19K Gene Deletions Enhance Gemcitabine-induced Apoptosis in Pancreatic Carcinoma Cells and Anti-Tumor Efficacy In vivo

(2009) S. Leitner et al.   CLINICAL CANCER RESEARCH

Gemcitabine directly inhibits myeloid derived suppressor cells in BALB/c mice bearing 4T1 mammary carcinoma and augments expansion of T cells from tumor-bearing mice

(2009) Hanh K. Le et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

Synergistic antitumor activity of oncolytic reovirus and chemotherapeutic agents in non-small cell lung cancer cells

(2009) Shizuko Sei et al.   Molecular Cancer

Preclinical evaluation of synergistic effect of telomerase-specific oncolytic virotherapy and gemcitabine for human lung cancer

(2009) D. Liu et al.   MOLECULAR CANCER THERAPEUTICS

Anti-VEGF single-chain antibody GLAF-1 encoded by oncolytic vaccinia virus significantly enhances antitumor therapy

(2009) A. Frentzen et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Bevacizumab Increases Viral Distribution in Human Anaplastic Thyroid Carcinoma Xenografts and Enhances the Effects of E1A-Defective Adenovirus dl922-947

(2008) S. Libertini et al.   CLINICAL CANCER RESEARCH

Oncolytic virotherapy for malignant melanoma with herpes simplex virus type 1 mutant HF10

(2008) Daisuke Watanabe et al.   JOURNAL OF DERMATOLOGICAL SCIENCE

Oncolytic HSV-1 Infection of Tumors Induces Angiogenesis and Upregulates CYR61

(2008) Kazuhiko Kurozumi et al.   MOLECULAR THERAPY

Oncolytic herpes virus with defective ICP6 specifically replicates in quiescent cells with homozygous genetic mutations in p16

(2008) M Aghi et al.   ONCOGENE