期刊
CELLS
卷 6, 期 3, 页码 -出版社
MDPI
DOI: 10.3390/cells6030021
关键词
autophagy; zebrafish; GFP-Lc3; confocal microscopy; mitophagy; aggrephagy; xenophagy
类别
资金
- Research Council of Norway [221831]
- Netherlands Technology Foundation STW [13259]
- Smartmix program of the Netherlands Ministry of Economic Affairs
- Ministry of Education, Culture and Science [NWOA_6QY9BM]
- Horizon COST action TRANSAUTOPHAGY [CA15138]
- Norwegian Centennial Chair Program
Autophagy is an evolutionarily conserved catabolic process which allows lysosomal degradation of complex cytoplasmic components into basic biomolecules that are recycled for further cellular use. Autophagy is critical for cellular homeostasis and for degradation of misfolded proteins and damaged organelles as well as intracellular pathogens. The role of autophagy in protection against age-related diseases and a plethora of other diseases is now coming to light; assisted by several divergent eukaryotic model systems ranging from yeast to mice. We here give an overview of different methods used to analyse autophagy in zebrafish-a relatively new model for studying autophagy-and briefly discuss what has been done so far and possible future directions.
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