Review
Oncology
Taojian Tu, Mario M. Alba, Aditi A. Datta, Handan Hong, Brittney Hua, Yunyi Jia, Jared Khan, Phillip Nguyen, Xiatoeng Niu, Pranav Pammidimukkala, Ielyzaveta Slarve, Qi Tang, Chenxi Xu, Yiren Zhou, Bangyan L. Stiles
Summary: Obesity is independently associated with an increased risk of carcinogenesis, particularly liver cancer. Liver lipid dysfunction and inflammation, as well as the involvement of liver macrophages, play crucial roles in driving the progression of liver cancer. Specific inflammatory mediators and molecular signals related to lipid metabolism are also involved in the activation and reprogramming of liver macrophages, contributing to the development of liver cancer.
FRONTIERS IN ONCOLOGY
(2022)
Review
Cell Biology
Nazli Alizadeh-Tabrizi, Stefan Hall, Christian Lehmann
Summary: Intravital microscopy is a unique imaging method that provides real-time insights into cellular functions without the need for tissue extraction. Despite specific challenges in lung imaging, advancements in surgical and optical techniques have enabled researchers to uncover mechanisms of leukocyte recruitment and function in models of pulmonary inflammation and infection.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Pharmacology & Pharmacy
Aoife B. Kilgallen, Frederieke van den Akker, Dries A. M. Feyen, Sandra Crnko, Christian J. B. Snijders Blok, Hendrik Gremmels, Bastiaan C. du Pre, Robin Reijers, Pieter A. Doevendans, Saskia C. A. de Jager, Joost P. G. Sluijter, Vasco Sampaio-Pinto, Linda W. van Laake
Summary: Circadian rhythms play a crucial role in the hyperacute immune response after a myocardial infarction (MI). The levels of immune cells and cardiac damage vary throughout the day, indicating the circadian influence on the immune response. These findings align with the clinical observation that patients who experience an MI early in the morning have worse outcomes.
FRONTIERS IN PHARMACOLOGY
(2022)
Review
Immunology
Huayu Guan, Xiang Zhang, Ming Kuang, Jun Yu
Summary: The gut-liver axis plays a crucial role in host-microbiota communications and immune homeostasis. In diseases such as hepatic cirrhosis, gut dysbiosis and impaired intestinal barrier lead to immune alterations in the liver and other organs. This review discusses the immune changes in the gut-liver axis and how microbiota-derived immune remodeling contributes to the progression of hepatic cirrhosis.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Gastroenterology & Hepatology
Hamza O. Yazdani, Christof Kaltenmeier, Kristin Morder, Juik Moon, Madelyn Traczek, Patricia Loughran, Ruben Zamora, Yoram Vodovotz, Feng Li, James H-C. Wang, David A. Geller, Richard L. Simmons, Samer Tohme
Summary: Exercise training preconditioning mitigates the inflammatory response to liver ischemia/reperfusion injury, protecting the liver from injury and metastases. By reducing neutrophil infiltration and NET formation, exercise training alters the complexity of hepatic inflammatory mediator networks and promotes an increase in tumor-suppressing T cells within the tumor microenvironment.
Review
Cell Biology
Xiaodong Du, Mingqian Li, Chen Huan, Guoyue Lv
Summary: This review discusses the origin, maturation, migration, and pathological effects of dendritic cell subsets in liver transplantation, as well as their roles in transplant rejection and tolerance. The latest progress in dendritic cell-based treatment regimens is also outlined.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2023)
Article
Cell Biology
Yongdae Yoon, Seong Chan Gong, Moon Young Kim, Soon Koo Baik, Ju-Eun Hong, Ki-Jong Rhee, Hoon Ryu, Young Woo Eom
Summary: Liver organoids generated using cell lines Huh-7, macrophages, LX-2 hepatic stellate cells, and primary liver sinusoidal endothelial cells were found to have increased expression of hepatocyte, LSEC, macrophage, and HSC-related genes compared to 2D-cultured cells. TAA treatment induced fibrotic and inflammatory responses in the liver organoids, which could be suppressed by N-acetyl-L-cysteine or tumor-necrosis-factor-stimulated gene 6 protein treatment.
Article
Multidisciplinary Sciences
A. M. Livernois, B. A. Mallard, S. L. Cartwright, A. Canovas
Summary: Heat stress negatively impacts cow health and production. Research on cellular response to heat stress may uncover protective molecular mechanisms that lead to superior resilience, aiding in selection for more resilient cattle. Analysis of genome-wide DNA methylation in response to heat stress revealed differentially methylated promoter regions associated with immune function, stress response, and other biological processes, highlighting pathways related to cellular protection.
SCIENTIFIC REPORTS
(2021)
Article
Microbiology
Carlos J. Ramirez-Flores, Billy Joel Erazo Flores, Andres M. Tibabuzo Perdomo, Katie L. Barnes, Sarah K. Wilson, Carolina Mendoza Cavazos, Laura J. Knoll, Melissa Bruckner Lodoen
Summary: Linoleic acid signals sexual development in the feline host, and TgLOXL1 plays a role in the IFN-gamma signaling cascade and changes localization in response to host immune activation.
Review
Microbiology
Natalia Vacani-Martins, Marcelo Meuser-Batista, Carina de Lima Pereira dos Santos, Alejandro Marcel Hasslocher-Moreno, Andrea Henriques-Pons
Summary: Chagas disease, caused by the protozoan Trypanosoma cruzi, was described over a century ago by Dr. Carlos Chagas in Brazil. Liver involvement, particularly hepatomegaly, is a common clinical sign and is more pronounced in cases of oral infection found in the Amazon region. Despite efforts to understand the mechanisms leading to cardiac and digestive manifestations in chronic patients, the importance of liver involvement and hepatic immune response in disease progression has not received much attention.
Article
Immunology
Sarah Boukezzi, Sara Costi, Lisa M. Shin, Seunghee Kim-Schulze, Flurin Cathomas, Abigail Collins, Scott J. Russo, Laurel S. Morris, James W. Murrough
Summary: This study found that patients with depression showed heightened neural response to threat, and it was correlated with inflammatory response and anxious arousal. The findings suggest that inflammation and amygdala activation may partially mediate the effect of stress on anxious arousal.
BRAIN BEHAVIOR AND IMMUNITY
(2022)
Article
Chemistry, Analytical
Hyungkook Jeon, Maoyu Wei, Xiwei Huang, Jiangfan Yao, Wentao Han, Renjie Wang, Xuefeng Xu, Jin Chen, Lingling Sun, Jongyoon Han
Summary: This study demonstrates a fully automated and label-free sample-to-answer platform for rapid immune state monitoring using white blood cells (WBCs). The platform integrates WBC separation and image processing to classify WBCs into their subtypes and detect activation-induced morphological changes for functional immune assessment, potentially enabling early detection of diseases.
ANALYTICAL CHEMISTRY
(2022)
Article
Immunology
Ruijie Xie, Mengde Xiao, Lihong Li, Nengqian Ma, Mingjiang Liu, Xiongjie Huang, Qianlong Liu, Ya Zhang
Summary: This study investigated the relationship between the systemic immune-inflammation index (SII) and hepatic steatosis and fibrosis. The results showed that increased SII levels are associated with hepatic steatosis but not with liver fibrosis. More large-scale prospective studies are needed to confirm these findings.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Multidisciplinary Sciences
Johanna Beil, Juliane Perner, Lena Pfaller, Marie-Apolline Gerard, Alessandro Piaia, Arno Doelemeyer, Adi Wasserkrug Naor, Lori Martin, Aline Piequet, Valerie Dubost, Salah-Dine Chibout, Jonathan Moggs, Remi Terranova
Summary: The possibility of adaptive inherited effects in mammals due to ancestral environmental exposure has long been debated. This study comprehensively investigates the transgenerational effects of exposure to a hepatotoxicant in rats and finds no morphological replication of enhanced wound healing response. However, transcriptional effects suggest transmission at the molecular level, although the functional relevance remains unclear.
NATURE COMMUNICATIONS
(2023)
Review
Cell Biology
Toshihiro Mitaka, Norihisa Ichinohe, Naoki Tanimizu
Summary: Mature hepatocytes in the liver can be categorized into three subpopulations based on their proliferative capability: type I, type II, and type III cells. Small hepatocytes (SHs) are unique cells that appear in the liver and may play a role in liver regeneration. They can be derived from hepatocytic progenitors and are involved in the liver's development and growth.
Article
Gastroenterology & Hepatology
Brenda Naemi Nakagaki, Kassiana Mafra, Erika de Carvalho, Mateus Eustaquio Lopes, Raquel Carvalho-Gontijo, Hortencia Maciel de Castro-Oliveira, Gabriel Henrique Campolina-Silva, Camila Dutra Moreira de Miranda, Maisa Mota Antunes, Ana Carolina Carvalho Silva, Ariane Barros Diniz, Debora Moreira Alvarenga, Maria Alice Freitas Lopes, Viviane Aparecida de Souza Lacerda, Matheus Silverio Mattos, Alan Moreira Araujo, Paula Vieira Teixeira Vidigal, Cristiano Xavier Lima, German A. B. Mahecha, Mila Fernandes Moreira Madeira, Gabriel Rocha Fernandes, Raquel Ferraz Nogueira, Thais Garcias Moreira, Bruna Araujo David, Rafael Machado Rezende, Gustavo Batista Menezes
JOURNAL OF HEPATOLOGY
(2018)
Article
Cell Biology
Alan Moreira de Araujo, Maisa Mota Antunes, Matheus Silverio Mattos, Ariane Barros Diniz, Debora Moreira Alvarenga, Brenda Naemi Nakagaki, Erika de Carvalho, Viviane Aparecida Souza Lacerda, Raquel Carvalho-Gontijo, Jorge Goulart, Kassiana Mafra, Maria Alice Freitas-Lopes, Hortencia Maciel de Castro Oliveira, Camila Miranda Dutra, Bruna Araujo David, Aristobolo Mendes Silva, Valerie Quesniaux, Bernhard Ryffel, Sergio Costa Oliveira, Glen N. Barber, Daniel Santos Mansur, Thiago Mattar Cunha, Rafael Machado Rezende, Andre Gustavo Oliveira, Gustavo Batista Menezes
Article
Cell Biology
Debora Moreira Alvarenga, Matheus Silverio Mattos, Mateus Eustaquio Lopes, Sarah Cozzer Marchesi, Alan Moreira Araujo, Brenda Naemi Nakagaki, Monica Morais Santos, Bruna Araujo David, Viviane Aparecida De Souza, Erika Carvalho, Rafaela Vaz Sousa Pereira, Pedro Elias Marques, Kassiana Mafra, Hortencia Maciel De Castro Oliveira, Camila Dutra Moreira De Miranda, Ariane Barros Diniz, Thiago Henrique Caldeira De Oliveira, Mauro Martins Teixeira, Rafael Machado Rezende, Maisa Mota Antunes, Gustavo Batista Menezes
Review
Cell Biology
Kassiana Mafra, Brenda Naemi Nakagaki, Hortencia Maciel Castro Oliveira, Rafael Machado Rezende, Maisa Mota Antunes, Gustavo Batista Menezes
JOURNAL OF LEUKOCYTE BIOLOGY
(2019)
Article
Cell Biology
Matheus Silverio Mattos, Mateus Eustaquio Lopes, Alan Moreira de Araujo, Debora Moreira Alvarenga, Brenda Naemi Nakagaki, Kassiana Mafra, Camila Dutra Moreira de Miranda, Ariane Barros Diniz, Maisa Mota Antunes, Maria Alice Freitas Lopes, Rafael Machado Rezende, Gustavo Batista Menezes
JOURNAL OF LEUKOCYTE BIOLOGY
(2020)
Article
Nutrition & Dietetics
Maisa Mota Antunes, Ariane Barros Diniz, Hortencia Maciel Castro-Oliveira, Gabriel Alvim Machado Mendes, Maria Alice Freitas-Lopes, Karen Marques de Oliveira Costa, Kassiana Mafra Bicalho, Brenda Naemi Lanza Nakagaki, Matheus Silverio Mattos, Camila Dutra Moreira de Miranda, Mateus Eustaquio Lopes, Alesandra Corte Reis Melao, Raquel Carvalho-Gontijo, Sridhar Radhakrishnnan, Matthew Ricci, Rafael Machado Rezende, Gustavo Batista Menezes
Summary: This study investigated the impact of using different fat sources on the development of nonalcoholic fatty liver disease in mice. Results showed that different high-fat dietary sources have varying immune and metabolic effects on the liver.
Article
Immunology
Maria Luiza Mundim Porto-Pedrosa, Camila Dutra Moreira de Miranda, Mateus Eustaquio Lopes, Brenda Naemi Nakagaki, Kassiana Mafra, Cristina Maria Pinto de Paula, Ariane Barros Diniz, Karen Marques de Oliveira Costa, Maisa Mota Antunes, Andre Gustavo Oliveira, Robert Balderas, Rodrigo Pestana Lopes, Gustavo Batista Menezes
Summary: This study used novel imaging techniques to describe the dynamic changes in immune development within the spleen for the first time. Adult and infant spleens had similar numbers and arrangement of lymphoid cells, while the immune environment in newborns was significantly different. In addition, the study showed how infections can alter the immune profile in the spleen, which may help in understanding the severity of infections.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Gastroenterology & Hepatology
Ariane Barros Diniz, Maisa Mota Antunes, Viviane Aparecida de Souza Lacerda, Brenda Naemi Nakagaki, Maria Alice Freitas Lopes, Hortencia Maciel de Castro-Oliveira, Matheus Silverio Mattos, Kassiana Mafra, Camila Dutra Moreira de Miranda, Karen Marques de Oliveira Costa, Mateus Eustaquio Lopes, Debora Moreira Alvarenga, Raquel Carvalho-Gontijo, Sarah Cozzer Marchesi, Debora Romualdo Lacerda, Alan Moreira de Araujo, Erika de Carvalho, Bruna Araujo David, Monica Morais Santos, Cristiano Xavier Lima, Juliana Assis Silva Gomes, Tereza Cristina Minto Fontes Cal, Bruna Roque de Souza, Claudia Alves Couto, Luciana Costa Faria, Paula Vieira Teixeira Vidigal, Adaliene Versiane Matos Ferreira, Sridhar Radhakrishnnan, Matthew Ricci, Andre Gustavo Oliveira, Rafael Machado Rezende, Gustavo Batista Menezes