Serine/Threonine Kinase 3-Phosphoinositide-Dependent Protein Kinase-1 (PDK1) as a Key Regulator of Cell Migration and Cancer Dissemination

PDK1-SGK1 Signaling Sustains AKT-Independent mTORC1 Activation and Confers Resistance to PI3Kα Inhibition

(2016) Pau Castel et al.   CANCER CELL

MiR-128b is down-regulated in gastric cancer and negatively regulates tumour cell viability by targeting PDK1/Akt/NF-κB axis

(2016) Ling Zhang et al.   JOURNAL OF BIOSCIENCES

PDK1–Akt pathway regulates radial neuronal migration and microtubules in the developing mouse neocortex

(2016) Yasuhiro Itoh et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

PDK1 Is a Regulator of Epidermal Differentiation that Activates and Organizes Asymmetric Cell Division

(2016) Teruki Dainichi et al.   Cell Reports

A Small Molecule Inhibitor of PDK1/PLCγ1 Interaction Blocks Breast and Melanoma Cancer Cell Invasion

(2016) Claudio Raimondi et al.   Scientific Reports

PDK1: A signaling hub for cell migration and tumor invasion

(2015) Paolo Armando Gagliardi et al.   BIOCHIMICA ET BIOPHYSICA ACTA-REVIEWS ON CANCER

PDK1 and SGK3 Contribute to the Growth of BRAF-Mutant Melanomas and Are Potential Therapeutic Targets

(2015) M. Scortegagna et al.   CANCER RESEARCH

PDK1 regulates focal adhesion disassembly by modulating endocytosis of  v 3 integrin

(2015) L. di Blasio et al.   JOURNAL OF CELL SCIENCE

The PDK1–Rsk Signaling Pathway Controls Langerhans Cell Proliferation and Patterning

(2015) Rossana Zaru et al.   JOURNAL OF IMMUNOLOGY

Conditional PDK1 Ablation Promotes Epidermal and T-Cell-Mediated Dysfunctions Leading to Inflammatory Skin Disease

(2015) Minjun Yu et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

PDK1 induces JunB, EMT, cell migration and invasion in human gallbladder cancer

(2015) Shixian Lian et al.   Oncotarget

COL11A1 confers chemoresistance on ovarian cancer cells through the activation of Akt/c/EBPβ pathway and PDK1 stabilization

(2015) Yi-Hui Wu et al.   Oncotarget

Deletion of PDK1 Causes Cardiac Sodium Current Reduction in Mice

(2015) Zhonglin Han et al.   PLoS One

3-Phosphoinositide-Dependent Kinase 1 Controls Breast Tumor Growth in a Kinase-Dependent but Akt-Independent Manner

(2015) Paolo Armando Gagliardi et al.   NEOPLASIA

PI3K/AKT signaling pathway and cancer: an updated review

(2014) Miriam Martini et al.   ANNALS OF MEDICINE

PDK1-mediated activation of MRCKα regulates directional cell migration and lamellipodia retraction

(2014) Paolo Armando Gagliardi et al.   JOURNAL OF CELL BIOLOGY

Upregulation of PDK1 associates with poor prognosis in esophageal squamous cell carcinoma with facilitating tumorigenicity in vitro

(2014) Zhonglu Yang et al.   MEDICAL ONCOLOGY

Invadopodia Are Required for Cancer Cell Extravasation and Are a Therapeutic Target for Metastasis

(2014) Hon S. Leong et al.   Cell Reports

Selective Requirement of PI3K/PDK1 Signaling for Kras Oncogene-Driven Pancreatic Cell Plasticity and Cancer

(2013) Stefan Eser et al.   CANCER CELL

PDK1 regulates VDJ recombination, cell-cycle exit and survival during B-cell development

(2013) Ram K C Venigalla et al.   EMBO JOURNAL

The PDK1 master kinase is over-expressed in acute myeloid leukemia and promotes PKC-mediated survival of leukemic blasts

(2013) J. Zabkiewicz et al.   HAEMATOLOGICA

Genetic inactivation or pharmacological inhibition of Pdk1 delays development and inhibits metastasis of Braf V600E ::Pten –/– melanoma

(2013) M Scortegagna et al.   ONCOGENE

The Kinase PDK1 Is Essential for B-Cell Receptor Mediated Survival Signaling

(2013) Sung-Gyoo Park et al.   PLoS One

PDK1 Signaling Toward PLK1-MYC Activation Confers Oncogenic Transformation, Tumor-Initiating Cell Activation, and Resistance to mTOR-Targeted Therapy

(2013) J. Tan et al.   Cancer Discovery

PDK1 regulates the generation of oligodendrocyte precursor cells at an early stage of mouse telencephalic development

(2012) Kenji Watatani et al.   GENES TO CELLS

A novel regulatory mechanism links PLCγ1 to PDK1

(2012) Claudio Raimondi et al.   JOURNAL OF CELL SCIENCE

PI3K signalling: the path to discovery and understanding

(2012) Bart Vanhaesebroeck et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Targeting PDK1 in Cancer

(2011) C. Raimondi et al.   CURRENT MEDICINAL CHEMISTRY

Phosphoinositide 3-kinase signaling pathway mediated by p110α regulates invadopodia formation

(2011) Hideki Yamaguchi et al.   JOURNAL OF CELL BIOLOGY

B55β-Associated PP2A Complex Controls PDK1-Directed Myc Signaling and Modulates Rapamycin Sensitivity in Colorectal Cancer

(2010) Jing Tan et al.   CANCER CELL

Drugging the PI3 Kinome: From Chemical Tools to Drugs in the Clinic

(2010) P. Workman et al.   CANCER RESEARCH

Mechanism of Phosphorylation-induced Activation of Phospholipase C-γ Isozymes

(2010) Aurelie Gresset et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Temporal Differences in the Dependency on Phosphoinositide-Dependent Kinase 1 Distinguish the Development of Invariant V 14 NKT Cells and Conventional T Cells

(2010) D. K. Finlay et al.   JOURNAL OF IMMUNOLOGY

PDK1 Regulates Vascular Remodeling and Promotes Epithelial-Mesenchymal Transition in Cardiac Development

(2010) Q. Feng et al.   MOLECULAR AND CELLULAR BIOLOGY

Genetic inactivation of AKT1, AKT2, and PDPK1 in human colorectal cancer cells clarifies their roles in tumor growth regulation

(2010) K. Ericson et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A Reduction in Pten Tumor Suppressor Activity Promotes ErbB-2-Induced Mouse Prostate Adenocarcinoma Formation through the Activation of Signaling Cascades Downstream of PDK1

(2009) Olga C. Rodriguez et al.   AMERICAN JOURNAL OF PATHOLOGY

AKT-Independent Signaling Downstream of Oncogenic PIK3CA Mutations in Human Cancer

(2009) Krishna M. Vasudevan et al.   CANCER CELL

3-Phosphoinositide-Dependent Kinase 1 Potentiates Upstream Lesions on the Phosphatidylinositol 3-Kinase Pathway in Breast Carcinoma

(2009) M. Maurer et al.   CANCER RESEARCH

Targeting the PI3K signaling pathway in cancer

(2009) Kwok-Kin Wong et al.   CURRENT OPINION IN GENETICS & DEVELOPMENT

Pdk1 activity controls proliferation, survival, and growth of developing pancreatic cells

(2009) Joby J. Westmoreland et al.   DEVELOPMENTAL BIOLOGY

Focal adhesion disassembly requires clathrin-dependent endocytosis of integrins

(2009) Wei-Ting Chao et al.   FEBS LETTERS

Plasticity of cell migration: a multiscale tuning model

(2009) Peter Friedl et al.   JOURNAL OF CELL BIOLOGY

Clathrin mediates integrin endocytosis for focal adhesion disassembly in migrating cells

(2009) Ellen J. Ezratty et al.   JOURNAL OF CELL BIOLOGY

Phosphoinositide (3,4,5)-Triphosphate Binding to Phosphoinositide-Dependent Kinase 1 Regulates a Protein Kinase B/Akt Signaling Threshold That Dictates T-Cell Migration, Not Proliferation

(2009) C. Waugh et al.   MOLECULAR AND CELLULAR BIOLOGY

Down-Regulation of 3-Phosphoinositide-Dependent Protein Kinase-1 Levels Inhibits Migration and Experimental Metastasis of Human Breast Cancer Cells

(2009) Y. Liu et al.   MOLECULAR CANCER RESEARCH

The kinase PDK1 integrates T cell antigen receptor and CD28 coreceptor signaling to induce NF-κB and activate T cells

(2009) Sung-Gyoo Park et al.   NATURE IMMUNOLOGY

The nuts and bolts of AGC protein kinases

(2009) Laura R. Pearce et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

PDK1 coordinates survival pathways and  -adrenergic response in the heart

(2009) K. Ito et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Phosphoinositide 3-kinases in cell migration

(2008) Robert J. Cain et al.   BIOLOGY OF THE CELL

Asymmetric focal adhesion disassembly in motile cells

(2008) Joshua A Broussard et al.   CURRENT OPINION IN CELL BIOLOGY

PDK1 regulates cancer cell motility by antagonising inhibition of ROCK1 by RhoE

(2008) Sophie Pinner et al.   NATURE CELL BIOLOGY