期刊
JOURNAL OF CLINICAL MEDICINE
卷 6, 期 3, 页码 -出版社
MDPI
DOI: 10.3390/jcm6030024
关键词
Jmjd3; H3K27me3; osteoblast differentiation; bone formation; osteoblast apoptosis
资金
- National Natural Science Foundation of China [81500843]
- scientific activities foundation for overseas students, Ministry of Human Resources and Social Security of the People's Republic of China [2016-176]
Posttranslational modifications including histone methylation regulate gene transcription through directly affecting the structure of chromatin. Trimethylation of histone 3 lysine 27 (H3K27me3) is observed at the promoters of a wide variety of important genes, especially for mammalian development, and contributes to gene silencing. Demethylase Jumonji domain-containing 3 (Jmjd3) catalyzes the transition of H3K27me3 to H3K27me1, therefore from a repressive to an active status of gene expression. Jmjd3 plays important roles in cell differentiation, inflammation, and tumorigenesis by targeting distinct transcription factors. In this review, we summarize the pivotal roles of Jmjd3 in maintaining skeletal homeostasis through regulating osteoblast differentiation, maturation, and apoptosis.
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