期刊
JOURNAL FOR IMMUNOTHERAPY OF CANCER
卷 5, 期 -, 页码 -出版社
BMC
DOI: 10.1186/s40425-017-0217-6
关键词
FAK; Immunotherapy; Checkpoint blockade; Pancreatic cancer
资金
- Cancer Research UK [20850, 22011] Funding Source: researchfish
Immunotherapy has had remarkable success in the treatment of some cancer types. However, pancreatic cancer has remained largely refractory to immunotherapy, including immune checkpoint inhibitors. Recently, Jiang and colleagues identified a key role for FAK in regulating the composition of the fibrotic and immuno-suppressive pancreatic tumour niche, and showed that FAK inhibitors can be used in combination with immune checkpoint blockade and gemcitabine chemotherapy to significantly delay pancreatic tumour progression. This study further supports the use of FAK inhibitors in combination with immunotherapy.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据