期刊
SCIENCE ADVANCES
卷 3, 期 8, 页码 -出版社
AMER ASSOC ADVANCEMENT SCIENCE
DOI: 10.1126/sciadv.1700826
关键词
-
资金
- Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases, the Tsinghua-Peking Center for Life Sciences
- 1000 Talents Recruitment Program
Although azides have been widely used in nitrene transfer reactions, in situ generation of N-H imines fromazides for downstream transformations has rarely been explored. We report copper- mediated formation of N-unsubstituted aliphatic imines from easily available aliphatic azides using a customized phenanthroline-based ligand (L-1*). Through trapping in situ-generated N-H imines, multisubstituted pyridines or indoles were readily synthesized. C-13-labeled azide was used as part of an isotope labeling study, which suggests that the construction of pyridine derivatives involves a three-component dehydrogenative condensation. The construction of 2,3,5-triaryl pyridines using this method provided evidence supporting a proposed pathway involving both imine formation and abnormal Chichibabin pyridine synthesis. The generation of N-unsubstituted imine intermediates was also confirmed by formation of indole derivatives from alkyl azides.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据