期刊
AMERICAN JOURNAL OF CHINESE MEDICINE
卷 43, 期 3, 页码 529-542出版社
WORLD SCIENTIFIC PUBL CO PTE LTD
DOI: 10.1142/S0192415X15500330
关键词
FM1-43; Neurotrophic Factor; Neurotransmitter Receptor; Presynaptic Plasticity; Synaptogenesis; Spinogenesis; Undaria pinnatifida
资金
- MKE (the Ministry of Knowledge Economy), Korea , under the RIS (Regional Innovation System) support Program [R0002920]
- Ministry of Trade, Industry & Energy (MOTIE), Republic of Korea [R0002920] Funding Source: Korea Institute of Science & Technology Information (KISTI), National Science & Technology Information Service (NTIS)
Reductions in neurotrophic factors are implicated in synaptic dysfunction in the central nervous system, but exogenous neurotrophic factors with potential effects on neuritic regeneration and synaptic reconstruction could offer therapeutic and preventive strategies for treating memory-related neurological disorders. In an earlier effort to identify natural neurotrophic agents, we found that the ethanol extract of the edible marine alga Undaria pinnatifida (UPE) had promising effects on the neuritogenesis of cultured hippocampal neurons. Here, we further investigated the ability of UPE to promote spinogenesis and synaptogenesis in primary cultures of hippocampal neurons. It was found that UPE triggered significant increase in numbers of dendritic filopodia and spines, promoted the formation of excitatory and inhibitory synapses, and potentiated synaptic transmission by increasing the sizes of reserve vesicle pools at presynaptic terminals. These findings indicate a substantial role for UPE in the morphological and functional maturation of neurons and suggest that UPE is a possible therapeutic preventative measure and treatment for neurodegenerative diseases, such as those involving cognitive disorders and memory impairments.
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