期刊
CHEMISTRYSELECT
卷 2, 期 31, 页码 9999-10003出版社
WILEY-V C H VERLAG GMBH
DOI: 10.1002/slct.201702404
关键词
Benzoylation; C(sp2)-H Functionalization; Metal-free; 1,4-Naphthoquinone; Suzuki-Cross Coupling
资金
- Department of Science and Technology, New Delhi [SR/FT/CS-036/2014]
- Department of Science and Technology, New Delhi (CSIRNE-IST project) [GPP 293]
- DST, New Delhi, India
A synthetic strategy has been developed for the synthesis of 2,3-disubstituted-1,4-naphthoquinones. This synthetic protocol consists of metal-free tert-Butyl hydroperoxide (TBHP)-mediated oxidative benzoylation followed by Pd-catalyzed Suzukicross coupling reactions. Benzaldehyde, benzylalcohol and toluene were efficiently used as benzoyl radical source for the benzoylation of 1,4-naphthoquinones. By this protocol, a wide range of 1,4-naphthoquinones with different substitution patterns were efficiently prepared in a sequential way with good to excellent yields.
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