Article
Biochemistry & Molecular Biology
Rafael Jaen, Adrian Povo-Retana, Cesar Rosales-Mendoza, Patricia Capillas-Herrero, Sergio Sanchez-Garcia, Paloma Martin-Sanz, Marina Mojena, Patricia Prieto, Lisardo Bosca
Summary: Atherosclerosis is a cardiovascular disease characterized by the formation of plaques and chronic inflammation. Proprotein convertase subtilisin/kexin type 9 (PCSK9) is an important protein involved in atherosclerosis. Through LDLR, human macrophages can take up circulating PCSK9, which activates the TLR4 pathway and leads to increased reactive oxygen species production, reduced lipid metabolism and cholesterol efflux gene expression, and enhanced pro-inflammatory cytokine production. This ultimately compromises macrophage viability and contributes to the progression of atherosclerosis.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Chemistry, Multidisciplinary
Jiwei Li, Mengchi Sun, Linlin Liu, Weiguang Yang, Ao Sun, Jicheng Yu, Dongchun Liu, Wutong Zhao, Maosheng Cheng, Zhonggui He, Zhen Gu, Jin Sun
Summary: Inspired by the probiotic Escherichia coli strain Nissle 1917, probiotic-derived outer membrane vesicles (OMVs) serve as an effective platform for treating inflammatory bowel disease (IBD). Nanoprobiotics, encapsulating manganese dioxide nanozymes, adhere to inflamed colonic epithelium and eliminate excess reactive oxygen species, showing better therapeutic efficacy than commercial IBD chemotherapeutics.
Review
Chemistry, Multidisciplinary
Chenyang Zhang, Xin Wang, Jiangfeng Du, Zhanjun Gu, Yuliang Zhao
Summary: ROS play a vital role in physiological and pathological processes, and research on regulating ROS for disease treatments has gained wide attention. Advances in nanotechnology have led to the development of numerous nanomaterials with the ability to regulate ROS, aiming to find new and effective ROS-related nanotherapeutic modalities. Despite significant progress in ROS-based nanomedicines, there is a need to address fundamental principles for designing ROS-associated nanomedicines to minimize gaps in biomedical applications. This review summarizes current progress in ROS-associated nanomedicines in disease treatments and presents key principles for their design. Future perspectives in the development of ROS-associated nanomedicines are also discussed.
Review
Chemistry, Inorganic & Nuclear
Nahyun Kwon, Dayeh Kim, K. M. K. Swamy, Juyoung Yoon
Summary: Reactive oxygen species (ROS) and reactive nitrogen species (RNS) play crucial roles in human life, but overproduction can lead to cell damage and diseases. Researchers have developed fluorescent and luminescent probes based on metal-coordinated systems to detect and image these active species, providing valuable tools for studying their roles in signaling and pathology.
COORDINATION CHEMISTRY REVIEWS
(2021)
Review
Biotechnology & Applied Microbiology
Jiaxue Liu, Boyan Jia, Zhibo Li, Wenliang Li
Summary: Applying reactive polymer materials sensitive to biological stimuli has attracted extensive research interest. The application of reactive oxygen species (ROS)-responsive polymers as drug-delivery systems in organisms has received much attention due to the special physiological effects of ROS on tumors or inflammation. The research progress of ROS-responsive polymers and their application in recent years were summarized and analyzed in this paper. From the perspective of nanoparticle drug delivery systems, multi-responsive delivery systems, and ROS-responsive hydrogels, the future development trends in this field were discussed.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2023)
Article
Immunology
Yi-Chu Liao, Szu-Yu Wu, Ya-Fang Huang, Pei-Chi Lo, Tzu-Yi Chan, Chih-An Chen, Chun-Hsin Wu, Che-Chia Hsu, Chia-Liang Yen, Peng-Chieh Chen, Chi-Chang Shieh
Summary: The study reveals the critical role of NOX2-derived ROS in regulating the function and gene expression in arthritic neutrophils, suggesting it as a potential target for treatment of immune-mediated arthritis. Abnormal redox regulation can lead to the dual effects of strong pro-inflammatory and weakened anti-inflammatory functions of neutrophils, highlighting the importance of targeting these pathways for therapeutic interventions in arthritis.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Developmental Biology
Karina Geurtzen, Alejandra Cristina Lopez-Delgado, Ankita Duseja, Anastasia Kurzyukova, Franziska Knopf
Summary: In zebrafish, a model organism, immune cell behavior during bone repair after osteoblast loss has been studied. Osteoblast loss triggers recruitment of neutrophils and macrophages, which leads to the generation of osteoclasts. Glucocorticoid signaling inhibits macrophage recruitment and changes their phenotype. Although osteoblast loss can be compensated for by committed osteoblasts, macrophages continue to populate the region.
Review
Chemistry, Multidisciplinary
Gabriel T. Huynh, Vidhishri Kesarwani, Julia A. Walker, Jessica E. Frith, Laurence Meagher, Simon R. Corrie
Summary: The combination of nanomaterials and fluorescent detection offers new opportunities for monitoring oxygen and ROS in biological systems, improving optical properties and interactions with cells and media, and providing ratiometric sensing robust to environmental drift.
FRONTIERS IN CHEMISTRY
(2021)
Article
Chemistry, Physical
Patryk Szymaszek, Patrycja Sroda, Malgorzata Tyszka-Czochara, Anna Chachaj-Brekiesz, Tomasz Swiergosz, Joanna Ortyl
Summary: Here we report the synthesis of a novel fluorescent probe P182 for quantitative measurement of H2O2. This fluorometric probe displays a fluorescence turn-on response in the presence of H2O2. It offers good performances in terms of sensitivity and response time, and shows non-toxic activity for in vivo studies. This study provides research on molecular fluorescence probe for the detection of H2O2.
JOURNAL OF MOLECULAR LIQUIDS
(2023)
Review
Chemistry, Physical
Xin Hu, Pengxuan Zhao, Yongping Lu, Yani Liu
Summary: Atherosclerosis is the leading cause of death in western developed countries, and early prevention and effective treatment are crucial. Nanoparticles with unique characteristics offer new options for AS treatment, especially through ROS-based NPs for targeted therapy, prolonged effects, and reduced side effects.
Review
Biochemistry & Molecular Biology
Aikaterini Berdiaki, Monica Neagu, Ioanna Spyridaki, Andrey Kuskov, Serge Perez, Dragana Nikitovic
Summary: Hyaluronan (HA) is a natural compound that is found on the cell surface and tissue extracellular matrix. It is synthesized by enzymes and degraded by other substances. HA has different effects on the body depending on its molecular weight, with high molecular weight HA being anti-inflammatory and low molecular weight HA being pro-inflammatory. Reactive oxygen species (ROS) can degrade HA and affect vascular integrity, while HA can also play a role in wound healing. Understanding the interactions between ROS and HA is an important research topic.
Article
Chemistry, Multidisciplinary
Xiaoluan Lu, Zhongshan He, Xiao Xiao, Xuelian Wei, Xiangrong Song, Shiyong Zhang
Summary: A new natural antioxidant-based nanodrug (VC@cLAVs) has been developed to treat atherosclerosis (AS) by loading antioxidants vitamin C (VC) into lipoic acid (LA)-constructed vesicles. This nanodrug not only increases the blood half-life of natural antioxidants but also enhances the antioxidation capacity through the mutual recycling of two redox pairs LA/DHLA and VC/DHA. In vivo results show that VC@cLAVs significantly reduces plaque area in mice compared to free VC and LA. This natural antioxidant-based nanodrug holds great potential for clinical applications.
Article
Biochemistry & Molecular Biology
Chih-Hsing Hung, Yi-Ching Lin, Yi-Giien Tsai, Yu-Chih Lin, Chia-Hong Kuo, Mei-Lan Tsai, Chao-Hung Kuo, Wei-Ting Liao
Summary: Acrylamide promoted mitochondria-specific ROS generation, increased gene expression of mitochondrial respiratory chain complex II SDHA, induced histone modifications and upregulated PINK1 expression, leading to a macrophage M2 polarization shift in THP-1 cells.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Chemistry, Multidisciplinary
Hong-Gui Xu, Margot Schikora, Miroslav Sisa, Steffen Daum, Insa Klemt, Christina Janko, Christoph Alexiou, Galyna Bila, Rostyslav Bilyy, Wenjie Gong, Michael Schmitt, Leopold Sellner, Andriy Mokhir
Summary: Novel ER-targeted prodrugs have been developed with activation only in cancer cells, demonstrating anticancer efficacy and cancer cell specificity. These prodrugs induce ER stress, attenuate mitochondrial membrane potential, and generate mitochondrial ROS leading to cell death via necrosis. Activation of the new prodrugs has also been demonstrated in the Nemeth-Kellner lymphoma murine model.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2021)
Review
Chemistry, Multidisciplinary
Yi Chen, Mingju Shui, Qin Yuan, Chi Teng Vong, Zhengming Yang, Zhejie Chen, Shengpeng Wang
Summary: The etiology of inflammatory bowel disease (IBD) is complex and involves an excessive immune response leading to the release of reactive oxygen species (ROS) and chronic inflammation. Targeting excess ROS for inflammatory suppression has been recognized as a feasible strategy for treating IBD. Additionally, overexpression of ROS can trigger drug release from novel drug delivery systems to alleviate IBD symptoms.
JOURNAL OF CONTROLLED RELEASE
(2023)
Article
Biochemical Research Methods
Yazan Ranneh, Ayman M. Mahmoud, Abdulmannan Fadel, Mohammed Albujja, Abdah Md Akim, Hasiah Ab Hamid, Huzwah Khazaai
Summary: The study demonstrated the potential of Stingless Bee Honey in suppressing systemic acute inflammation induced by lipopolysaccharide in rats. It works by preventing tissue injury, ameliorating pro-inflammatory cytokines, and reducing oxidative stress. This suggests that Stingless Bee Honey may be an effective anti-inflammatory nutraceutical deserving further mechanistic studies.
COMBINATORIAL CHEMISTRY & HIGH THROUGHPUT SCREENING
(2021)
Article
Integrative & Complementary Medicine
Muhammad Murtala Mainasara, Mohd Fadzelly Abu Bakar, Abdah Md Akim, Alona C. Linatoc, Fazleen Izzany Abu Bakar, Yazan K. H. Ranneh
Summary: This study aimed to explore the secondary metabolites, antioxidant, and antiproliferative activities of Dioscorea bulbifera leaf from Johor, Malaysia. Results showed that the extract exhibited promising anticancer and natural antioxidant properties, indicating potential for further research and validation in vivo.
EVIDENCE-BASED COMPLEMENTARY AND ALTERNATIVE MEDICINE
(2021)
Review
Urology & Nephrology
Mohammed H. Albujja, Ramachandran Vasudevan, Saleh Alghamdi, Chong P. Pei, Khairul A. Bin Mohd Ghani, Yazan Ranneh, Patimah B. Ismail
PROSTATE INTERNATIONAL
(2020)
Review
Biochemistry & Molecular Biology
Harinash Rao, Sulin Choo, Sri Raja Rajeswari Mahalingam, Diajeng Sekar Adisuri, Priya Madhavan, Abdah Md. Akim, Pei Pei Chong
Summary: Biofilms play a crucial role in antimicrobial resistance, with their unique physiological state and cell density contributing to increased resistance compared to planktonic counterparts, particularly in fungal biofilms which are less studied. Various biofilm mitigation therapies have been reported, including antimicrobial photodynamic therapy and antimicrobial lock therapy.
Article
Biology
Yazan Ranneh, Mohd Fadzelly Abu Bakar, Nur Amalina Ismail, Faridah Kormin, Maryati Mohamed, Abdah Md Akim, Azizul Isha
Summary: The study investigated the antioxidant and anti-aging enzyme activities of traditional medicinal plants, with the single extracts of Cnestis palala and Urceola micrantha showing high antioxidant activities and good inhibitions against certain enzymes. This research provides a promising baseline for exploring novel anti-aging agents from natural resources.
SAUDI JOURNAL OF BIOLOGICAL SCIENCES
(2021)
Review
Education & Educational Research
Abdull Assyaqireen Abdull Mutalib, Abdah Md Akim, Mohamad Hasif Jaafar
Summary: This study conducted a systematic review to analyze the effectiveness of distance learning among undergraduate health sciences students during the COVID-19 pandemic. The results showed that online learning performed better than expected, with improved academic performance and skill development reported. However, challenges such as internet issues and low interaction between learners and instructors were identified.
BMC MEDICAL EDUCATION
(2022)
Review
Chemistry, Multidisciplinary
Norfarina Bahari, Norhashila Hashim, Abdah Md Akim, Bernard Maringgal
Summary: Impaired healing wounds require a deeper understanding of the biochemical processes involved, and the integration of nanotechnology and honey offers new possibilities for wound treatment. The use of honey in wound dressings is becoming a major trend due to its multiple beneficial properties and diverse fabrication methods.
Review
Chemistry, Multidisciplinary
Norfarina Bahari, Norhashila Hashim, Khalina Abdan, Abdah Md Akim, Bernard Maringgal, Laith Al-Shdifat
Summary: The use of natural reducing and capping agents in environmentally sustainable synthesis of nanoparticles (NPs) has gained importance. Honey has emerged as a promising agent in the synthesis of metal and metal oxide NPs, serving as both a stabilizing and reducing agent. This review focuses on honey-mediated synthesis of silver NPs (Ag-NPs) and zinc oxide NPs (ZnO-NPs), highlighting its role as a reducing and capping agent, and provides a comprehensive examination of bio-based reducing and capping/stabilizing agents. The review also discusses environmentally friendly methods for NP synthesis.
Review
Pharmacology & Pharmacy
Gul-E-Saba Chaudhry, Rehmat Jan, Abdah Akim, Muhammad Naveed Zafar, Yeong Yik Sung, Tengku Sifzizul Tengku Muhammad
Summary: Research on natural plant extracts and isolated compounds, along with their mechanism of action, has shown potential for the development of new therapeutic agents for future drug development. These phytochemicals can target multiple signals effectively, inducing apoptosis, modulating cell cycle arrest, inhibiting invasion and metastasis, and affecting other prosurvival signaling pathways.
ADVANCED PHARMACEUTICAL BULLETIN
(2021)
Review
Pharmacology & Pharmacy
Gul-e-Saba Chaudhry, Abdah Akim, Muhammad Naveed Zafar, Naila Safdar, Yeong Yik Sung, Tengku Sifzizul Tengku Muhammad
Summary: Cancer progression involves the pivotal roles of HA and CD44, their interaction regulating survival signaling pathways affecting cell proliferation and metastasis. Targeting HA, CD44, and their binding may offer promising strategies for cancer therapeutics.
ADVANCED PHARMACEUTICAL BULLETIN
(2021)
Review
Integrative & Complementary Medicine
Yazan Ranneh, Abdah Md Akim, Hasiah Ab. Hamid, Huzwah Khazaai, Abdulmannan Fadel, Zainul Amiruddin Zakaria, Mohammed Albujja, Mohd Fadzelly Abu Bakar
Summary: Inflammation plays a key role in chronic diseases and there is a growing interest in natural functional foods with therapeutic and preventive actions. Honey, produced by honeybees and stingless bees, has unique phenolic and flavonoid compounds that show potential against inflammation-related diseases. Studies focus on the bioavailability and bioaccessibility of honey polyphenols and their roles in targeting inflammatory pathways in various diseases.
BMC COMPLEMENTARY MEDICINE AND THERAPIES
(2021)
