Article
Chemistry, Analytical
Sean Toffessi Siewe, Samuel Calle, Francois Vander Meulen, Damien Valente, Jean-Marc Gregoire, Aline Banquart, Stephanie Chevalliot, Arnaud Capri, Franck Levassort
Summary: Tailored backings with high acoustic impedance and strong attenuation are needed for miniaturized high-frequency transducer design. The use of multiphasic metallic backings in this study has shown promising results in terms of sensitivity and bandwidth for imaging applications.
Article
Multidisciplinary Sciences
Di Wu, Diego Baresch, Colin Cook, Zhichao Ma, Mengtong Duan, Dina Malounda, David Maresca, Maria P. Abundo, Justin Lee, Shirin Shivaei, David R. Mittelstein, Tian Qiu, Peer Fischer, Mikhail G. Shapiro
Summary: Ultrasound can manipulate cells with high precision through acoustic radiation force (ARF), but this ability is disconnected from cellular genetic programs due to the similar acoustic properties of most cells. Gas vesicles (GVs), a unique class of gas-filled protein nanostructures, can serve as genetically encodable actuators for selective acoustic manipulation. GVs experience strong ARF with opposite polarity to most other materials due to their lower density and higher compressibility relative to water. When expressed inside cells, GVs invert the cells' acoustic contrast and amplify their ARF, enabling selective manipulation of cells based on their genotype. GVs provide a direct link between gene expression and acoustomechanical actuation, opening up a paradigm for selective cellular control in a broad range of contexts.
Article
Physics, Applied
Shifu Pu, Gepu Guo, Xiasheng Guo, Chenchen Zhou, Yuzhi Li, Qingyu Ma, Juan Tu, Dong Zhang
Summary: Auto-focusing acoustic-vortex (A-FAV) tweezers developed in this work use Half-Bessel beams to self-bend around obstacles, enabling stable object manipulation with improved resolution. The non-diffracting self-bending of HB beams allows for creation of obstacle-circumvention cavities, showing promise in various applications such as ultrasound imaging and object manipulation.
JOURNAL OF APPLIED PHYSICS
(2021)
Article
Acoustics
Tianquan Tang, Lixi Huang
Summary: This study examines the acoustic forces exerted on large particles by time-harmonic waves, taking into account the scattering effects of multiple sources and particles. The results show that the contribution of scattering waves becomes significant when the size parameter is greater than 2, and increases quadratically with the amplitude parameter of the transducers. The theoretical predictions are validated through finite element simulations and applied to more complex scenarios involving multiple particles manipulated by multiple transducers.
JOURNAL OF SOUND AND VIBRATION
(2021)
Article
Chemistry, Analytical
Hayong Jung, K. Kirk Shung, Hae Gyun Lim
Summary: Ultrasound imaging is a valuable tool in imaging human tissues, but conventional transducers face limitations in resolution for cellular applications. By using ultrahigh frequency (UHF) transducers, we achieved high-resolution cell imaging and acoustic tweezers. The results showed successful imaging of single cells and manipulation of cells and beads using the UHF transducers.
Article
Physics, Applied
Jie Huang, Qinxin Zhou, Xuemei Ren, Zheng Xu, Xiaojun Liu
Summary: Non-diffracting Bessel acoustic beams with self-healing, self-bending, and self-acceleration properties have potential applications for directional transportation of microbubbles. By adjusting the acoustic frequency, the maximum point of acoustic intensity on the beam mainlobe can be changed, and the curved trajectory and adjustable destination of microbubble transportation have been experimentally proven. The proposed method utilizes the conservative part of the radiation force to control the trajectory of microbubbles, making it suitable for in vivo applications.
APPLIED PHYSICS LETTERS
(2021)
Article
Neurosciences
Xu Qi, Jiayu Sun, Jiayu Zhu, Dechen Kong, Neil Roberts, Yijing Dong, Xiaoqi Huang, Qiang He, Haoyang Xing, Qiyong Gong
Summary: Neuromodulation technology offers novel therapeutic approaches for neural circuit dysfunction-related diseases. Transcranial focused ultrasound (FU) is an emerging approach with noninvasiveness and sharp focus, even in deep brain regions. It has advantages in precision and safety for neuromodulation of the peripheral and central nervous systems. Rating: 8/10
FRONTIERS IN HUMAN NEUROSCIENCE
(2023)
Article
Chemistry, Analytical
Hee Su Lee, Eun Young Jeong, Jin Ho Sung, Bo Eun Choi, Jong Seob Jeong
Summary: A novel technique for measuring the intraocular pressure (IOP) based on acoustic radiation force was proposed and experimentally demonstrated in the study. The experimental results show a close relationship between the ocular displacement induced by the acoustic radiation force and the IOP obtained by a commercial tonometer, indicating the potential of the proposed technique for measuring the IOP.
Article
Acoustics
Guilherme A. Braz, Andre L. Baggio, Paulo M. Agnollitto, Felipe W. Grillo, Theo Z. Pavan, Francisco J. A. Paula, Marcello H. Nogueira-Barbosa, George C. Cardoso, Antonio A. O. Carneiro
Summary: This study proposed a new method using bursts of megahertz-frequency acoustic radiation to observe kilohertz-frequency mechanical responses in biological tissues. The correlation between spectral maps of the acquired signals and mu CT data was found to be strong. The novel technique showed good image contrast in measuring soft tissue stiffness.
ULTRASOUND IN MEDICINE AND BIOLOGY
(2021)
Article
Engineering, Electrical & Electronic
Eun Young Jeong, Jin Ho Sung, Jong Seob Jeong
Summary: The study introduces a split-focused ultrasound technique based on phase inversion to reduce echo decorrelation artifacts, achieving higher peak contrast-to-noise ratio and improved accuracy of measured displacement in experiments. By utilizing a cross-segmented transducer to generate four independent focal lobes, the proposed method effectively reduces jitter and enhances ARFI imaging resolution.
IEEE SENSORS JOURNAL
(2021)
Article
Acoustics
Jie Huang, Xuemei Ren, Qinxin Zhou, Junhe Zhou, Zheng Xu
Summary: This paper introduces a new method that combines surface acoustic waves (SAWs) with microfluidics technology to efficiently manipulate substances on the surface of a substrate. By designing appropriate acoustic lenses, nonplanar SAWs can be generated, and directional particle transport can be achieved. This method has the potential for flexible cell manipulation in microfluidics and biomedical applications.
Article
Acoustics
Idowu Adeyemi, Mahmoud Meribout, Lyes Khezzar, Nabil Kharoua, Khalid Alhammadi, Varun Tiwari
Summary: Focused high frequency ultrasound emulsification provides significant benefits in terms of stability, droplet size, pressure, power usage, surfactant usage and dispersion. This study investigates the emulsification of oil droplets in water using high frequency focused ultrasound through experiments and numerical modeling. The effects of transducer power, frequency, oil viscosity, interfacial tension and initial droplet radius on the emulsification process were assessed. The experiments show that the acoustic pressure and Weber number increase with power. The numerical model gives reasonable predictions of the experimental data. Smaller droplets can be achieved at higher frequency excitation. The viscosity and droplet radius also influence the emulsification process.
ULTRASONICS SONOCHEMISTRY
(2023)
Article
Physics, Applied
Erika Numahata, Shin Yoshizawa, Shin-ichiro Umemura, Takuro Ishii, Yoshifumi Saijo
Summary: High-intensity focused ultrasound (HIFU) therapy is a noninvasive treatment for cancer. Acoustic radiation force (ARF) imaging can be used to estimate the heat distribution caused by HIFU. This study investigated the effect of shielding on the estimated heat distribution and proposed a correction method using ARF imaging to achieve tissue coagulation equivalent to that without shielding.
JAPANESE JOURNAL OF APPLIED PHYSICS
(2023)
Article
Physics, Applied
Yan-Chun Luo, Xin-Rui Li, Da-Jian Wu, Jie Yao, Xing-Feng Zhu, Liang-Fen Du, Xiao-Jun Liu
Summary: This study proposes a method for capturing and manipulating large Mie particles in three dimensions using acoustic manipulation technology, based on a hybrid acoustic artificial plate to generate a hybrid acoustic focused petal beam. By adjusting the topological charge of the beam, the zero-intensity zone in the beam can be adjusted, enabling stable trapping and manipulation of large Mie particles.
PHYSICAL REVIEW APPLIED
(2022)
Article
Physics, Multidisciplinary
Yuzhi Li, Peixia Li, Ning Ding, Gepu Guo, Qingyu Ma, Juan Tu, Dong Zhang
Summary: The weak-focused acoustic vortex (WFAV) is constructed by introducing an elevation angle to the planar transducers, allowing for manipulation of large-scale objects.