期刊
MOLECULAR IMAGING
卷 16, 期 -, 页码 -出版社
HINDAWI LTD
DOI: 10.1177/1536012117709384
关键词
clinical translation of novel oncologic radiotracers; cancer detection imaging; cancer imaging; immunohistochemistry; integrin
资金
- Deutsche Forschungsgemeinschaft [NO822/4-1]
beta(6)-integrin immunohistochemistry analysis of a large number of pancreatic ductal adenocarcinoma (PDAC, 383 primary tumors, 7 lymph node, and 8 distant metastases) and 34 pancreatic intraepithelial neoplasia (PanIN) specimens revealed a high prevalence of alpha(v)ss(6)-integrin expression in PDAC primaries (88%) and in almost all metastases, as well as in PanIN (57%). These findings underscore the high potential of a novel alpha(v)ss(6)-integrin targeting positron emission tomography (PET) radiopharmaceutical, Ga-68-Avebehexin, for early diagnosis of pancreatic cancer.
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