Article
Public, Environmental & Occupational Health
Joshua Kuan Tan, Gek Hsiang Lim, Nur Nasyitah Mohamed Salim, Sing Yi Chia, Julian Thumboo, Yong Mong Bee
Summary: The study investigates the association between mean HbA1c, HbA1c variability, and all-cause mortality and diabetes-related macrovascular complications in patients with diabetes. The results show that both low (<6%) and high (>=8%) levels of HbA1c are associated with increased risk of all-cause mortality and diabetes-related macrovascular complications. Patients with stable HbA1c levels of 6-8% have the lowest risk.
CLINICAL EPIDEMIOLOGY
(2023)
Article
Endocrinology & Metabolism
Christine Y. K. Lau, Alice P. S. Kong, Joseph T. F. Lau, Virginia Chan, Phoenix K. H. Mo
Summary: This study explored the mediating role of diabetes distress in the relationship between coping and glycaemic control, and found that insulin treatment moderated this mediation. The results indicated that interventions aimed at boosting confidence and autonomy in individuals with diabetes could help reduce diabetes distress.
ACTA DIABETOLOGICA
(2021)
Article
Medicine, General & Internal
Roberta Zupo, Fabio Castellana, Francesco Panza, Marco Castellana, Luisa Lampignano, Raffaele Ivan Cincione, Vincenzo Triggiani, Gianluigi Giannelli, Vittorio Dibello, Rodolfo Sardone, Giovanni De Pergola
Summary: Screening for NAFLD is crucial for managing fatty liver, and glucose metabolism plays a significant role in monitoring the risk of NAFLD in overweight subjects without diabetes.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Public, Environmental & Occupational Health
Feifei Liu, Ke Zhang, Gongbo Chen, Jie He, Mengnan Pan, Feng Zhou, Xiangxiang Wang, Jiahui Tong, Yuming Guo, Shanshan Li, Hao Xiang
Summary: This study found that exposure to PM10, PM2.5, and NO2 was associated with elevated blood sugar levels and increased incidence of diabetes in elderly Chinese populations. With the rising prevalence and incidence of diabetes in China, urgent measures to improve air quality are needed.
INTERNATIONAL JOURNAL OF EPIDEMIOLOGY
(2022)
Article
Anesthesiology
S. Lam, B. Kumar, Y. K. Loke, S. E. Orme, K. Dhatariya
Summary: The study aims to clarify the association between glycated haemoglobin (HbA(1c)) and postoperative outcomes in people without diabetes. The researchers found that individuals without diabetes but with a HbA(1c)>= 42 mmol.mol(-1) had increased odds of postoperative complications, but this association is likely influenced by comorbidity.
Review
Anesthesiology
Daniel J. Drayton, Rebecca J. Birch, Carlota D'Souza-Ferrer, Michael Ayres, Simon J. Howell, Ramzi A. Ajjan
Summary: This study conducted a scoping review to examine the association between diabetes mellitus (DM) and adverse perioperative outcomes. The results showed that the definition of DM in the published literature is inconsistent, limiting the potential for pooled analysis. The study findings suggest that DM is associated with adverse outcomes such as mortality, complications, and infections.
BRITISH JOURNAL OF ANAESTHESIA
(2022)
Article
Biochemistry & Molecular Biology
Xue-Qing Feng, Yi Ju, Wei-Tao Dou, Qing Li, Zhong-Gan Jin, Xiao-Peng He, Tony D. James, Bang-Ce Ye
Summary: This study presents an aptamer-based sensor for the rapid and selective electrochemical detection of HbA(1c). The modified aptamers coated onto screen printed electrodes exhibited electroactivity, allowing for the concentration-dependent reduction of current intensity in the sensor system when haemoglobin was added. Electrochemical impedance spectroscopy also confirmed the selective binding of analytes to the aptamer-coated electrode, showing promise in the development of portable electrochemical sensors for HbA(1c) detection.
Article
Endocrinology & Metabolism
Jea Young Min, Nicholas Williams, Will Simmons, Samprit Banerjee, Fei Wang, Yongkang Zhang, April B. Reese, Alvin Mushlin, James H. Flory
Summary: This study examined the association between baseline glucose control and the risk of COVID-19 hospitalization and in-hospital death among patients with diabetes. The results showed that diabetes patients with poor glucose control have a higher risk of COVID-19 hospitalization, although the association with in-hospital death is less consistent.
Article
Medicine, General & Internal
Archana Sharma, Ingrid Nermoen, Elisabeth Qvigstad, Anh T. Tran, Christine Sommer, Naveed Sattar, Jason M. R. Gill, Hanne L. Gulseth, Stina T. Sollid, Kare Birkeland
Summary: This study revealed significant ethnic differences in actionable ADA-HbA(1c) levels between South Asian and Nordic women with previous GDM, with important risk factors including South Asian ethnicity, GDM history, use of glucose-lowering drugs during pregnancy, older age, and higher fasting glucose levels during pregnancy.
Review
Medical Laboratory Technology
Claire L. Meek
Summary: Despite advances in care, women with diabetes in pregnancy are at increased risk of complications, and offspring exposed to hyperglycaemia may experience long-term effects. Monitoring glycaemic control in pregnancy is vital, but there is no consensus on the best method. Continuous glucose monitoring devices offer new opportunities for assessment of glycaemia.
ANNALS OF CLINICAL BIOCHEMISTRY
(2022)
Review
Medicine, General & Internal
Samuel J. Westall, Ram Prakash Narayanan, Simon Watmough, Greg Irving, Niall Furlong, Sid McNulty, Sumudu Bujawansa, Kevin Hardy
Summary: Evidence and guidelines support the individualised approach to care for people with type 2 diabetes and individualisation of glycaemic targets in response to patient factors. Factors such as cardiovascular disease, hypoglycaemia unawareness, advanced age, and patient preference should be considered when setting glycaemic targets. Personalised care and treatment targets should involve shared decision-making between physician and patient.
Review
Endocrinology & Metabolism
Eric Pasqualotto, Janine Midori Figueiredo Watanabe, Douglas Mesadri Gewehr, Raphaela da Silva Maintinguer, Simone van de Sande-Lee, Gustavo Neves de Araujo, Fidel Silveira Leal, Carlos Eduardo Andrade Pinheiro
Summary: This study found that bexagliflozin can effectively reduce HbA1c levels, blood pressure, and body weight in patients with T2DM, with similar side effects compared to placebo.
DIABETES OBESITY & METABOLISM
(2023)
Article
Endocrinology & Metabolism
Adam H. Dyer, Robert Briggs, Eamon Laird, Leane Hoey, Catherine F. Hughes, Helene McNulty, Mary Ward, J. J. Strain, Anne M. Molloy, Conal Cunningham, Kevin McCarroll
Summary: In older adults, both high HbA(1c) levels and the presence of diabetes are associated with poorer cognitive performance and specific domain-specific neuropsychological performance. This suggests that focusing on HbA(1c) levels, not just diabetes status, may be important for promoting optimal brain health in older adults.
Article
Critical Care Medicine
Julien Bohe, Hassane Abidi, Vincent Brunot, Amna Klich, Kada Klouche, Nicholas Sedillot, Xavier Tchenio, Jean-Pierre Quenot, Jean-Baptiste Roudaut, Nicolas Mottard, Fabrice Thiolliere, Jean Dellamonica, Florent Wallet, Bertrand Souweine, Alexandre Lautrette, Jean-Charles Preiser, Jean-Francois Timsit, Charles-Herve Vacheron, Ali Ait Hssain, Delphine Maucort-Boulch
Summary: This study aimed to compare individualized glucose control with conventional glucose control among ICU patients. While there were significant differences in glycemic control between the groups, the 90-day survival probability did not show significant differences. However, non-diabetic patients in the IC group had a higher risk of 90-day mortality compared to the CC group.
INTENSIVE CARE MEDICINE
(2021)
Review
Endocrinology & Metabolism
Amir Reza Moravejolahkami, Mehdi Shakibaei, Andrea Mary Fairley, Manoj Sharma
Summary: Dysbiosis in the gut has been linked to T1DM, and this review analyzed the effects of probiotics, prebiotics, and synbiotics on T1DM patients. After evaluating 258 entries, five trials were included, showing that probiotic supplementation decreased fasting blood glucose but had no significant effect on HbA1c, C-peptide, and insulin requirements. Probiotics may serve as a complementary therapeutic strategy for T1DM, but more trials are needed.
DIABETES-METABOLISM RESEARCH AND REVIEWS
(2023)
Article
Pharmacology & Pharmacy
James M. G. Curneen, Louise Rabbitt, Darragh Browne, Darragh F. O'Donoghue, Yousef Alansari, Brendan Harhen, Ailbhe Ni Ghriofa, John Ferguson, John William McEvoy, David Lappin, David P. Finn, Paula M. O'Shea, Michael Conall Dennedy
Summary: This study aimed to compare patient-reported adherence to antihypertensive medications with objective evidence. By using mass spectrometry spot urinalysis, the research found that combining spot urine mass spectrometry and self-reporting can identify higher rates of nonadherence in patients attending a tertiary hypertension clinic.
BRITISH JOURNAL OF CLINICAL PHARMACOLOGY
(2023)
Review
Pharmacology & Pharmacy
James Bernard Walsh, Daniel M. McCartney, Eamon Laird, Kevin McCarroll, Declan G. Byrne, Martin Healy, Paula M. O'Shea, Rose Anne Kenny, John L. Faul
Summary: This review examines the association between vitamin D, SARS-CoV-2 infection, and COVID-19 severity. The authors conclude that there is a causal relationship between low vitamin D status and increased risk of infection and severe COVID-19. They suggest that vitamin D supplementation may be beneficial for improving immunity against SARS-CoV-2, especially in vulnerable populations. The study highlights the prevalence of low vitamin D status among Irish adults.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Nutrition & Dietetics
Mohammed Faraz Rafey, Razk Abdalgwad, Paula Mary O'Shea, Siobhan Foy, Brid Claffey, Colin Davenport, Derek Timothy O'Keeffe, Francis Martin Finucane
Summary: This study found that completion of a low energy liquid diet led to a reduction in insulin resistance and cardiovascular risk in patients with severe obesity, proportional to weight loss.
FRONTIERS IN NUTRITION
(2022)
Article
Endocrinology & Metabolism
Delia Bogdanet, Michelle Toth Castillo, Helen Doheny, Louise Dervan, Miguel Angel Luque-Fernandez, Jose Halperin, Paula M. O'Shea, Fidelma P. Dunne
Summary: This study evaluated the predictive ability of first trimester plasma glycated CD59 (pGCD59) for gestational diabetes mellitus (GDM). The results showed that pGCD59 may be a good predictor for GDM in women with a high BMI and a fair predictor for GDM diagnosed by an elevated fasting plasma glucose (FPG) independent of BMI.
DIABETES RESEARCH AND CLINICAL PRACTICE
(2022)
Article
Endocrinology & Metabolism
Wendy N. Groenendijk, Tomas P. Griffin, Md N. Islam, Liam Blake, Deirdre Wall, Marcia Bell, Paula M. O'Shea
Summary: The clinical performance and user acceptance of remote capillary blood samples prepared using the MiniCollect(R) capillary blood collection device as an alternative to venepuncture for glycated haemoglobin analysis were assessed. The results showed good agreement between HbA(1c) results from capillary and venous collection, and the participants found the MiniCollect device easy to use.
Article
Endocrinology & Metabolism
Kate M. Warde, Yi Jan Lim, Eduardo Ribes Martinez, Felix Beuschlein, Paula O'Shea, Constanze Hantel, Michael Conall Dennedy
Summary: This study demonstrates that mitotane-induced cytotoxicity in adrenocortical carcinoma (ACC) may be mediated through enhanced breakdown of lipid droplets and activation of lipolysis. Understanding the role of cholesterol and lipids in ACC could provide potential novel therapeutic options, particularly in mitotane-resistant disease.
Article
Endocrinology & Metabolism
Delia Bogdanet, Michelle T. Castillo, Helen Doheny, Louise Dervan, Miguel A. Luque-Fernandez, Jose Halperin, Paula M. O'Shea, Fidelma P. Dunne
Summary: The aim of this study was to assess the ability of postpartum glycated CD59 (pGCD59) to predict the development of glucose intolerance in women with gestational diabetes. The results showed that women with higher levels of PP pGCD59 were more likely to develop glucose intolerance. However, fasting plasma glucose was found to be a better diagnostic test for identifying postpartum glucose intolerance.
Article
Medicine, General & Internal
Andrew Smyth, ConorJudge Judge, Claire Kerins, Suzanne McDermott, Aoife Niland, Colette Corcoran, Roisin Dineen, Alberto Alvarez-Iglesias, Aoife Nolan, Andrew Mente, Matthew D. Griffin, Paula O'Shea, Michelle Canavan, Salim Yusuf, Martin O'Donnell
Summary: Intensive dietary counseling can lead to short-term reductions in sodium intake and blood pressure, but it does not have a significant effect on sodium intake, blood pressure, or cardiorenal biomarkers at two years in individuals with moderate sodium intake.
Review
Endocrinology & Metabolism
Nathan Mullen, James Curneen, Padraig T. Donlon, Punit Prakash, Irina Bancos, Mark Gurnell, Michael C. Dennedy
Summary: Primary aldosteronism is a common cause of secondary hypertension with increased morbidity and mortality. The current limitations in patient care include delayed recognition, limited access to diagnostic procedures, and lack of a definitive therapy option for some patients. However, recent advances in machine learning algorithms, noninvasive diagnostics, and selective therapies have the potential to improve care for patients with primary aldosteronism.
Article
Medicine, General & Internal
Maria O'Sullivan, Caoimhe Moran, Tomas P. Griffin, Helen Doheny, Daniel M. A. McCartney, Paula M. O'Shea
Summary: The study reveals that the vitamin D levels of individuals in the west of Ireland have increased during the COVID-19 lockdown restrictions, leading to a decrease in deficiency. This could be attributed to changes in diet and/or supplementation, or increased sun exposure.
IRISH JOURNAL OF MEDICAL SCIENCE
(2023)
Article
Medicine, General & Internal
Fidelma Dunne, Christine Newman, Alberto Alvarez-Iglesias, John Ferguson, Andrew Smyth, Marie Browne, Paula O'Shea, Declan Devane, Paddy Gillespie, Delia Bogdanet, Oratile Kgosidialwa, Aoife Egan, Yvonne Finn, Geraldine Gaffney, Aftab Khattak, Derek O'Keeffe, Aaron Liew, Martin O'Donnell
Summary: Early initiation of metformin is not superior to placebo for the primary outcome of gestational diabetes. Further investigation of metformin in larger clinical trials is supported by the prespecified secondary outcome data.
JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION
(2023)
Article
Medical Laboratory Technology
Md Nahidul Islam, Claire Lyons, Tomas P. Griffin, Siobhan Hamon, Fidelma P. Dunne, Paula M. O'Shea
Summary: The study assessed the stability of glucose in two different blood collection tubes and found that the FC-Mix tube stored at 4 degrees Celsius showed the best agreement with the WHO specifications. The findings suggest the introduction of FC-Mix tubes into routine clinical practice.
ANNALS OF CLINICAL BIOCHEMISTRY
(2023)
Article
Endocrinology & Metabolism
Nathan Mullen, Padraig T. Donlon, Jan Sebek, Katen Duffy, Grazia Cappiello, Sarah Feely, Kate M. Warde, Brendan Harhen, David P. Finn, Paula M. O'Shea, Punit Prakash, Martin O'Halloran, Michael C. Dennedy
Summary: Primary aldosteronism is the most common cause of secondary hypertension. Adrenalectomy is the first-line treatment, but only suitable for unilateral disease. Thermal ablation is an emerging approach to target aldosterone-producing tumors while preserving normal adrenal cortex. Sublethal hyperthermia in vitro can temporarily inhibit cortisol steroidogenesis in adrenocortical cells.
Article
Endocrinology & Metabolism
Delia Bogdanet, Michelle Toth Castillo, Helen Doheny, Louise Dervan, Miguel Angel Luque-Fernandez, Jose A. Halperin, Paula M. O'Shea, Fidelma P. Dunne
Summary: The study shows that pGCD59 has the potential to predict adverse pregnancy outcomes, with first and second trimester levels correlating with macrosomic infants, polyhydramnios, pregnancy-induced hypertension, and neonatal hypoglycemia. Prospective studies with a larger number of cases are needed to further validate this emerging biomarker's predictive ability in adverse pregnancy outcomes.
ACTA DIABETOLOGICA
(2023)
