Article
Nutrition & Dietetics
Valentina De Cosmi, Alessandra Mazzocchi, Veronica D'Oria, Alessandro Re, Giulia Carla Immacolata Spolidoro, Gregorio P. Milani, Cristiana Berti, Silvia Scaglioni, Claudia Giavoli, Silvia Bergamaschi, Giulia Rodari, Eriselda Profka, Roberto Colombo, Carlo Agostoni
Summary: This study investigated the effect of vitamin D and DHA co-supplementation on vitamin D status, body composition, and metabolic markers of obese children with vitamin D deficiency. The study found that more than 50% of the children improved their vitamin D status at the end of the study, but co-supplementation was not more effective than vitamin D plus wheat germ oil.
Article
Urology & Nephrology
Corrado Vitale, Martino Marangella, Francesca Bermond, Laura Fabbrini, Alberto Tricerri
Summary: The study found that cholecalciferol supplementation may increase calcium excretion or reveal an underlying condition of absorptive hypercalciuria, potentially leading to an increase in urine supersaturation with calcium salts and a higher risk of stone formation.
WORLD JOURNAL OF UROLOGY
(2021)
Article
Endocrinology & Metabolism
Fei-Long Wei, Tian Li, Quan-You Gao, Yuli Huang, Cheng-Pei Zhou, Wen Wang, Ji-Xian Qian
Summary: This study concluded that daily doses of 700 IU to 2000 IU of supplemental vitamin D were associated with a lower risk of falls among ambulatory and institutionalized older adults. High-dose vitamin D was effective in preventing falls, while low-dose vitamin D showed no significant effect. The preventive effect of vitamin D on falls was influenced by supplemental calcium, concentration, and frequency.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Public, Environmental & Occupational Health
Seyed Vahid Jasemi, Zhale Zandieh, Narges Zandieh, Mohsen Rezaei Hemami, Ali Darvishi, Zahra Abdollahi, Ramin Heshmat
Summary: This study aimed to assess the cost-effectiveness of the vitamin D supplementation program in reducing adolescent depressive symptoms in Iranian adolescents. The results showed that the program is a cost-effective and dominant strategy in preventing depression through cost-saving and QALYs increment.
Review
Nutrition & Dietetics
Ricardo Usategui-Martin, Daniel-Antonio De Luis-Roman, Jose Maria Fernandez-Gomez, Marta Ruiz-Mambrilla, Jose-Luis Perez-Castrillon
Summary: This study evaluated the impact of polymorphisms in the vitamin D receptor gene on the response to vitamin D supplementation through a systematic review and meta-analysis. The results suggest that the TaqI and FokI polymorphisms may play a role in modulating the response to vitamin D supplementation.
Article
Biochemistry & Molecular Biology
Ting Hu, Lulu Ren, Han Li, Zhuoling An
Summary: Vitamin D plays important roles in calcium-phosphate homeostasis and bone health. Recent studies have shown its non-skeletal functions in regulating endogenous metabolism. This study examined the effects of vitamin D supplementation or deficiency on metabolic phenotypes in mice using targeted metabolomics analysis. The results showed that vitamin D deficiency caused fat deposition in the liver, while supplementation improved fat accumulation. Metabolic perturbations related to vitamin D regulation were observed in various metabolic pathways.
JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY
(2023)
Review
Nutrition & Dietetics
Emilia Gospodarska, Ranjini Ghosh Dastidar, Carsten Carlberg
Summary: Vitamin D intervention studies aim to evaluate the effects of vitamin D-3 on health and disease. However, recent large-scale randomized controlled trials did not yield statistically significant results. We propose an alternative approach that involves segregating study participants into different groups based on their responsiveness to vitamin D-3 supplementation and measuring a larger set of genome-wide parameters over time.
Article
Cell Biology
Rai-Hua Lai, Chih-Cheng Hsu, Ben-Hui Yu, Yu-Ru Lo, Yueh-Ying Hsu, Mei-Hsin Chen, Jyh-Lyh Juang
Summary: Vitamin D deficiency may not be the cause but a consequence of AD. Supplementation of vitamin D in AD mice and humans exacerbates AD and enhances the non-genomic VDR/p53 complex in the brain. Long-term use of vitamin D-3 supplements may increase the risk of dementia and mortality.
Article
Nutrition & Dietetics
Christian Mingiano, Tommaso Picchioni, Guido Cavati, Filippo Pirrotta, Marco Calabrese, Ranuccio Nuti, Stefano Gonnelli, Alberto Fortini, Bruno Frediani, Luigi Gennari, Daniela Merlotti
Summary: This study aimed to evaluate the relationship between 25-OH vitamin D (25OHD) levels and prognosis, mortality, mechanical ventilation, and orotracheal intubation in hospitalized COVID-19 patients. The study found a positive correlation between 25OHD levels and oxygenation levels, and significantly lower levels in patients requiring mechanical ventilation and intubation. Patients with severe 25OHD deficiency had longer hospital stays and higher mortality rates. Additionally, supplementation with calcifediol reduced hospitalization duration and mortality rates.
Review
Nutrition & Dietetics
Manuel Rupprecht, Stefan Wagenpfeil, Jakob Schoepe, Reinhold Vieth, Thomas Vogt, Joerg Reichrath
Summary: A meta-analysis was conducted to investigate the impact of oral vitamin D supplementation on serum 25-hydroxyvitamin D levels in healthy adults in Europe. The findings suggest that vitamin D supplementation can significantly increase serum 25(OH)D levels, with the effect influenced by dosage and baseline serum levels.
Review
Food Science & Technology
Malgorzata Starek, Justyna Mierzwa, Pawel Gumulka, Monika Dabrowska
Summary: Vitamin D has gained widespread interest in the fields of science, medicine, analytics, and nutrition. Understanding the physicochemical properties, demand, deficiency, supplementation, interactions, and analysis methods of vitamin D can lead to a deeper comprehension of its role in the development of diseases.
CRITICAL REVIEWS IN FOOD SCIENCE AND NUTRITION
(2022)
Article
Pediatrics
Hao Gou, Ya Wang, Yan Liu, Cai Peng, Weijia He, Xiangjuan Sun
Summary: The prevalence of overweight and obesity in children and adolescents is increasing globally. Vitamin D deficiency has been partially associated with child and adolescent overweight/obesity. This systematic review and meta-analysis assesses the effectiveness of vitamin D supplementation on child and adolescent overweight/obesity. Overall, high-dose vitamin D supplementation may reduce cardiometabolic risk and improve insulin resistance.
EUROPEAN JOURNAL OF PEDIATRICS
(2023)
Review
Food Science & Technology
Amin Gasmi, Geir Bjorklund, Massimiliano Peana, Pavan Kumar Mujawdiya, Lyudmila Pivina, Adrien Ongenae, Salva Piscopo, Beatrice Severin
Summary: Calcium is essential for bone health and nerve signaling, while phosphorus is a key component of ATP and helps regulate metabolic energy. Vitamins D and K are crucial for the absorption and excretion of calcium and phosphorus, with vitamin D playing a regulatory role in various bodily functions.
CRITICAL REVIEWS IN FOOD SCIENCE AND NUTRITION
(2022)
Article
Medicine, General & Internal
Weronika Galus, Anna Walawska-Hrycek, Michalina Rzepka, Ewa Krzystanek
Summary: This study assessed the vitamin D status and practices among MS patients and professionals in the clinical setting. Results showed that while most patients confirmed vitamin D supplementation, only a small percentage achieved optimal vitamin D levels. Lack of doctor's recommendation was the most common reason for the absence of supplementation.
JOURNAL OF CLINICAL MEDICINE
(2022)
Review
Pharmacology & Pharmacy
Kai-Jie Qi, Zhong-Tao Zhao, Wen Zhang, Fang Yang
Summary: Vitamin D supplementation may benefit adults with metabolic syndrome by reducing insulin resistance and hypertension. However, its effects on blood lipid profile and HbA1c remain inconclusive.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Cell Biology
Sima Seifi, Farzaneh Pouya, Mahsa Rahmani, Mehrane Mehramiz, Azam Rastgar-Moghadam, Masoumeh Gharib, Farzad Rahmani, Soodabeh Shahidsales, Seyed Mahdi Hassanian, Majid Khazaei, Parisa Dadjoo, Seyede Sara Parvin, Yeganeh Yazdinezhad, Seyed Mohammad Reza Parizadeh, Gordon A. Ferns, Mehdi Fathi, Amir Avan
JOURNAL OF CELLULAR PHYSIOLOGY
(2020)
Review
Cell Biology
Farzad Rahmani, Aghigh Ziaeemehr, Soodabeh Shahidsales, Masoumeh Gharib, Majid Khazaei, Gordon A. Ferns, Mikhail Ryzhikov, Amir Avan, Seyed M. Hassanian
JOURNAL OF CELLULAR PHYSIOLOGY
(2020)
Article
Environmental Sciences
Samaneh Karbalaei, Abolfazl Golieskardi, Dorothy Uning Watt, Mathieu Boiret, Parichehr Hanachi, Tony R. Walker, Ali Karami
MARINE POLLUTION BULLETIN
(2020)
Article
Engineering, Environmental
Samaneh Karbalaei, Parichehr Hanachi, Gholamreza Rafiee, Parvaneh Seifori, Tony R. Walker
Summary: The study found that exposure to mixtures of chlorpyrifos (CPF) and polystyrene (PS) microplastics (MPs) had significant effects on histopathological and histomorphometric biomarkers in rainbow trout, particularly in the gills and gut. Exposure to CPF and PS-MPs individually or combined led to significant changes in histomorphometric biomarkers in fish tissues.
JOURNAL OF HAZARDOUS MATERIALS
(2021)
Article
Environmental Sciences
Parichehr Hanachi, Samaneh Karbalaei, Sujuan Yu
Summary: Individual polystyrene microplastics had minimal effects on the nutritional parameters of fish muscle, but in combination with chlorpyrifos insecticide, significant alterations were observed. This study suggests that polystyrene microplastics can increase the toxicity and adverse effects of chlorpyrifos on fish muscle, leading to low nutritional value in fish from contaminated areas.
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
(2021)
Article
Public, Environmental & Occupational Health
Afsane Bahrami, Zahra Farjami, Gordon A. Ferns, Parichehr Hanachi, Majid Ghayour Mobarhan
Summary: The study found that female adolescents in northeastern Iran have limited knowledge about the biological functions, causes of deficiency, and sources of Vitamin D. Some participants did not use sunscreen during the day, and those who did had significantly lower serum Vitamin D levels. However, there was no significant association between knowledge about Vitamin D and serum levels or dietary intake.
Article
Environmental Sciences
Mehdi Khoshnamvand, Parichehr Hanachi, Saeed Ashtiani, Tony R. Walker
Summary: The presence of nanoplastics in aquatic media raises concerns about their adverse effects on aquatic organisms. This study found that amino-functionalized polystyrene nanoplastics of smaller sizes exhibited greater toxicity on green microalgae compared to larger nanoplastics. Additionally, high concentrations of nanoplastics can affect the morphology and shape of algae, potentially limiting material transport, gas exchange, and energy transfer.
Article
Marine & Freshwater Biology
Parichehr Hanachi, Mehdi Khoshnamvand, Tony R. Walker, Amir Hossein Hamidian
Summary: The presence of natural organic matter (NOM), modeled by humic acid (HA), can mitigate the acute toxicity of amino-functionalized polystyrene nanoplastics (PS-NH2) to green microalga Chlorella vulgaris, reducing cellular aggregation and cell size reduction. Higher concentrations of HA are more effective in reducing the toxicity of PS-NH2. The formation of cellular aggregates under the influence of PS-NH2 is likely related to the electrostatic attraction between the positively charged surfaces of the particles and the negatively charged polysaccharide walls of C. vulgaris.
AQUATIC TOXICOLOGY
(2022)
Article
Biochemical Research Methods
Zahra Gharari, Parichehr Hanachi, Tony R. Walker
Summary: Scutellaria multicaulis stem extract was used to synthesize silver nanoparticles (Sm-AgNPs) which exhibited optimal shape, size, and stability for drug use. These Sm-AgNPs showed higher antioxidant activity and effective anticancer properties against MDA-MB231 cells, indicating their potential as new antitumor agents for breast cancer treatment.
ANALYTICAL BIOCHEMISTRY
(2022)
Article
Pharmacology & Pharmacy
Zahra Gharari, Parichehr Hanachi, Hanie Sadeghinia, Tony R. Walker
Summary: This study synthesized silver nanoparticles using C. intybus leaf-derived callus extract and evaluated their antibacterial, antioxidant, and anticancer activities. The results showed that these silver nanoparticles exhibited significant cytotoxicity against breast cancer cells and inhibitory effects on cell proliferation. Additionally, they demonstrated strong antibacterial and antioxidant activities.
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2022)
Article
Chemistry, Physical
Parichehr Hanachi, Zahra Gharari, Hanie Sadeghinia, Tony R. Walker
Summary: In this study, silver nanoparticles (Hp-AgNPs) were synthesized using stem extract of Persian hogweed and their phytochemical contents, antioxidant, and anti-proliferative activities were evaluated. The biosynthesized Hp-AgNPs showed high antioxidant activity and inhibited the growth of human breast cancer cells.
JOURNAL OF MOLECULAR STRUCTURE
(2022)
Article
Oncology
Parichehr Hanachi, Fariba Rezaei Fakhrnezhad, Roshanak Zarringhalami, Ilkay Erdogan Orhan
Summary: The study found that Impatiens walleriana and Ocimum basilicum contain a significant amount of anthocyanins and carotenoid compounds, showing cytotoxic effects on human gastric adenocarcinoma and ovarian carcinoma cell lines. Impatiens walleriana exhibited the strongest cytotoxicity on AGS cancer cells, while Ocimum basilicum had slightly higher cytotoxicity on SKOV3 cancer cells. Further research and trials are needed to fully explore the potential of these extracts.
INTERNATIONAL JOURNAL OF CANCER MANAGEMENT
(2021)
Article
Nutrition & Dietetics
Elahe Allahyari, Parichehr Hanachi, Seyed Jamal Mirmoosavi, Gordon A. Ferns, Afsane Bahrami, Majid Ghayour-Mobarhan
Summary: This study investigated the association between cardiometabolic risk factors and the response to vitamin D supplementation using artificial neural networks. Results showed that baseline serum vitamin D level, waist to hip ratio, BMI, systolic blood pressure, heart rate, and waist circumference were important factors in predicting the response to vitamin D levels.
Article
Environmental Sciences
Mehdi Khoshnamvand, Zhineng Hao, Oluniyi O. Fadare, Parichehr Hanachi, Yongsheng Chen, Jingfu Liu
Article
Oncology
Roshanak Zarringhalami, Parichehr Hanachi, Ertugrul Kaya, Aydan Fulden Agan, Kagan Agan, Mert Donmez
INTERNATIONAL JOURNAL OF CANCER MANAGEMENT
(2020)