Article
Genetics & Heredity
Milad Norouzi, Mohammad Reza Bakhtiarizadeh, Abdolreza Salehi
Summary: Diet not only provides essential nutrients but also contains xenomiRs, which can enter the body through dietary intake and regulate gene expression. However, there are discrepancies in the research on the transfer of xenomiRs, possibly due to experimental artifacts, small sample size, and inefficient bioinformatics pipeline. While xenomiRs were absent in most samples, they were found in colostrum and may modulate infants' immune systems.
FRONTIERS IN GENETICS
(2022)
Review
Microbiology
Brice Felden, Yoann Augagneur
Summary: Bacterial gene expression is controlled by a complex system of molecules, with small regulatory RNAs (sRNAs) emerging as key players alongside transcription factors. sRNAs influence various biological processes and can act intracellularly or even in extracellular vesicles, impacting host cell interactions. Studies suggest that sRNA-mediated mechanisms are more diverse than previously thought, beyond traditional classifications.
FRONTIERS IN MICROBIOLOGY
(2021)
Article
Health Care Sciences & Services
Rebecca D. Russell, Lucinda J. Black, Andrea Begley
Summary: This study explored the experiences of adults with MS in navigating dietary advice, their attitudes towards making dietary decisions, and their needs for dietary resources and education. The findings indicated that people with MS are highly motivated to make dietary changes and improve their health. The self-determination theory was used to explain why individuals with MS make dietary modifications and their varying levels of motivation.
HEALTH EXPECTATIONS
(2021)
Review
Oncology
Leila Erfanparast, Mohammad Taghizadieh, Ali Akbar Shekarchi
Summary: Oral cancer is a significant public health concern with a negative impact on society. Despite advancements in treatment, the survival rate for oral cancer remains low, and the underlying molecular mechanisms of OSCC carcinogenesis are not fully understood. Noncoding RNAs, such as microRNAs and long ncRNAs, play important roles in cancer cell development. Understanding the relationship between ncRNAs and different types of cell death is essential. Manipulating ncRNA expression offers potential for controlling the occurrence and development of oral cancer. This review aims to explore the impact of ncRNAs on cell death and identify potential targets for oral cancer therapy.
FRONTIERS IN ONCOLOGY
(2022)
Article
Pharmacology & Pharmacy
Ru Chen, Juan Wu, Chang Lu, Ting Yan, Yu Qian, Huiqing Shen, Yujing Zhao, Jianzhen Wang, Pengzhou Kong, Xinri Zhang
Summary: CA extracted from cinnamon has shown antiviral and anti-tumor effects, including inhibiting proliferation, invasion, and migration, inducing apoptosis, and suppressing tumor growth in NSCLC. Through the ceRNA network, key genes SOCS1, BTG2, and BTK were identified as playing essential roles in CA against NSCLC.
FRONTIERS IN PHARMACOLOGY
(2021)
Review
Endocrinology & Metabolism
Cecile Jacovetti, Mustafa Bilal Bayazit, Romano Regazzi
Summary: ncRNAs play crucial roles in gene regulation, with various types having different regulatory functions. piRNAs, snoRNAs, and tRFs have potential therapeutic implications in metabolic disorders.
FRONTIERS IN ENDOCRINOLOGY
(2021)
Article
Microbiology
Manuel Brenes-Alvarez, Agustin Vioque, Alicia M. Muro-Pastor
Summary: Heterocysts are specialized nitrogen-fixing cells in filamentous cyanobacteria, and NsiR1 is a noncoding RNA that regulates the expression of hetF and alr3234 genes to participate in heterocyst differentiation and commitment.
MICROBIOLOGY SPECTRUM
(2022)
Article
Chemistry, Multidisciplinary
Guoping Li, Aidan C. Manning, Alex Bagi, Xinyu Yang, Priyanka Gokulnath, Michail Spanos, Jonathan Howard, Patricia P. Chan, Thadryan Sweeney, Robert Kitchen, Haobo Li, Brice D. Laurent, Sary F. Aranki, Maria Kontaridis, Louise C. Laurent, Kendall Van Keuren-Jensen, Jochen Muehlschlegel, Todd M. Lowe, Saumya Das
Summary: The study highlights the crucial role of transfer RNA-derived small RNAs in different stress responses and introduces a new sequencing technique for generating a comprehensive abundance landscape of cellular and extracellular tDRs. It also reveals that extracellular tDRs have distinct fragmentation signatures which are better indicators of different stress responses than miRNAs.
Review
Evolutionary Biology
Yiqian Li, Jerome H. L. Hui
Summary: Small RNA molecules are essential regulators of gene expression and genome stability in eukaryotes. Cnidarians, as early-branching animals, provide crucial insights into the evolution of small RNA pathways. However, the knowledge of small RNA regulation in cnidarians is limited. This review aims to enhance our understanding of small RNA pathway development in early-branch animals by presenting the current-known small RNA information in cnidarians.
EVOLUTIONARY APPLICATIONS
(2023)
Article
Biology
Lei Liu, Xiaolin Wang, Wenfang Zhao, Qiqi Li, Jingxin Li, He Chen, Ge Shan
Summary: This study used CRISPR/Cas9 technology to generate in situ knockin (KI) strains of all C. elegans Argonautes. Through RNA immunoprecipitation and high-throughput sequencing, the sRNA profiles of individual Argonautes were obtained, and their sRNA partners were analyzed. The study revealed how different Argonautes bind to different types of sRNAs and demonstrated their regulatory roles in transgenerational epigenetic inheritance and managing levels of long transcripts. The findings provide a comprehensive view of the regulatory network formed by C. elegans Argonautes and sRNAs.
SCIENCE CHINA-LIFE SCIENCES
(2023)
Review
Biochemistry & Molecular Biology
Mei Yang, Yongzhen Mo, Daixi Ren, Shun Liu, Zhaoyang Zeng, Wei Xiong
Summary: Transfer RNAs (tRNAs), responsible for amino acid translocation during protein synthesis, can be sheared into small non-coding RNA fragments known as tRNA-derived small RNAs (tDRs). With the advancements in sequencing technologies and bioinformatics, more tDRs have been identified, showing their essential role in transcription, translation, and various cellular processes. Aberrant expression of tDRs is associated with human diseases, particularly tumorigenesis and tumor progression. tDRs regulate the tumor microenvironment by influencing cancer stem cells, immunity, energy metabolism, and extracellular matrix remodeling, highlighting their clinical application prospects.
Article
Biochemical Research Methods
Zena Cai, Ping Fu, Ye Qiu, Aiping Wu, Gaihua Zhang, Yirong Wang, Taijiao Jiang, Xing-Yi Ge, Haizhen Zhu, Yousong Peng
Summary: vsRNAfinder is a de novo method for identifying high-confidence vsRNAs from sRNA-Seq data, which outperforms widely used methods in identifying viral miRNAs and shows similar performance in animal and plant sRNAs identification. It greatly facilitates the effective identification of vsRNAs from sRNA-Seq data.
BRIEFINGS IN BIOINFORMATICS
(2022)
Article
Plant Sciences
Chengjie Chen, Jiawei Li, Junting Feng, Bo Liu, Lei Feng, Xiaoling Yu, Guanliang Li, Jixian Zhai, Blake C. Meyers, Rui Xia
Summary: This study comprehensively annotated small RNAs in 143 plant species with fully sequenced genomes and publicly available sRNA data, providing a valuable resource for genomic and genetic research on plant small RNAs. The sRNAanno database offers more complete and reliable miRNA annotations compared to other public plant sRNA databases, as well as genomic information on PHAS loci and hc-siRNA loci from these plant species.
HORTICULTURE RESEARCH
(2021)
Review
Biochemistry & Molecular Biology
Mohammad Aslam, Beenish Fakher, Yuan Qin
Summary: In living organisms, sexual reproduction relies on the successful development of gametes, with flowering plants producing gametes in specialized organs of the flower, the gametophytes. Recent evidence suggests that small RNA-mediated pathways play important roles in the development and specification of the female gametophyte. Numerous protein complexes, molecular, and genetic mechanisms are involved in tightly regulating the development of the female gametophyte, known as the embryo sac, in plants.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Biochemistry & Molecular Biology
Nikolay K. Shakhpazyan, Liudmila M. Mikhaleva, Arcady L. Bedzhanyan, Nikolay K. Sadykhov, Konstantin Y. Midiber, Alexandra K. Konyukova, Andrey S. Kontorschikov, Ksenia S. Maslenkina, Alexander N. Orekhov
Summary: This comprehensive review explores the intricate roles of long non-coding RNAs (lncRNAs) within the microenvironment of colorectal cancer (CRC), particularly in relation to immunity, intercellular communication, and therapeutic potential. The review highlights the significance of lncRNAs in influencing inflammation, immune evasion, and treatment response in CRC, and proposes them as potential candidates for novel therapeutic strategies and biomarkers. The review also examines the complex interplay of lncRNAs with CRC tumor subtypes, their impact on immunity and inflammation within the tumor stroma, and their transportation through extracellular vesicles, specifically exosomes. Additionally, the review delves into the intricate relationship between lncRNAs and other non-coding RNAs, such as microRNAs and circular RNAs, in mediating cell-to-cell communication within the CRC microenvironment. Finally, potential strategies to manipulate lncRNAs to enhance anti-tumor immunity are proposed, highlighting the importance of lncRNAs in innovative therapeutic interventions in CRC.