Article
Biochemistry & Molecular Biology
Indu Yadav, Shiv Dutt Purohit, Hemant Singh, Neeladri Singha Das, Chandrachur Ghosh, Partha Roy, Narayan Chandra Mishra
Summary: Developing an ideal vitreous substitute/implant is a challenge, as there is a high risk of bacterial infection associated with implants. In this study, a bacterial resistant vitreous implant was developed by incorporating the antibiotic meropenem into a hydrogel. The hydrogel showed desired biocompatibility, transparency, water content, and viscoelasticity, making it suitable for vitreous substitute.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2023)
Article
Biochemistry & Molecular Biology
Hou Liu, Yubin Feng, Songtian Che, Lin Guan, Xinting Yang, Yue Zhao, Linan Fang, Andrei V. Zvyagin, Quan Lin
Summary: This study explored a method of promoting spinal cord injury repair by injecting neural stem cells into the injury site using a biodegradable conductive hydrogel scaffold. Results showed that the conductive hydrogel facilitated the differentiation of stem cells into neurons and inhibited the formation of glial cells and scars. The study provides a new approach for treating spinal cord injuries.
Article
Biophysics
Salvatore Federico, Giovanna Pitarresi, Fabio S. Palumbo, Calogero Fiorica, Fang Yang, Gaetano Giammona
Summary: This study aimed to investigate the effects of chemical derivatization of hyaluronic acid on osteoinductive potential for guided bone regeneration. The results showed that the electrospun membranes with alkyl pendant grafts and crosslinking process demonstrated tunable resistance and enhanced drug release properties, as well as good cytocompatibility and cell proliferation. Osteogenic differentiation and mineralization were observed after 35 days, indicating the potential for application in bone regeneration.
COLLOIDS AND SURFACES B-BIOINTERFACES
(2021)
Article
Biochemistry & Molecular Biology
Kristine Salma-Ancane, Artemijs Sceglovs, Eliza Tracuma, Jacek K. Wychowaniec, Kristine Aunina, Anna Ramata-Stunda, Vizma Nikolajeva, Dagnija Loca
Summary: Hydrogels based on hyaluronic acid and ε-polylysine with antibacterial and cell attractive properties were designed using physical and chemical crosslinking methods. Both types of crosslinked hydrogels showed fast swelling behavior and long-term stability, with physically crosslinked hydrogels demonstrating better inhibition of Gram-negative E. coli.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2022)
Article
Chemistry, Applied
Min Li, Weibin Jia, Xiuli Zhang, Hongjuan Weng, Guofeng Gu, Zonggang Chen
Summary: In this study, a biomimetic hyaluronic acid oligosaccharides (oHAs)-based composite scaffold was developed for bone tissue engineering applications to stimulate osteogenesis and endothelialization. The results demonstrated that the oHAs-based scaffolds promoted endothelial cell attachment, facilitated osteogenic differentiation, and exhibited ideal biocompatibility and tissue regenerative capacity.
CARBOHYDRATE POLYMERS
(2021)
Article
Nanoscience & Nanotechnology
Claudio Ivan Serra-Aguado, Mar Llorens-Gamez, Pablo Vercet-Llopis, Virginia Martinez-Chicote, Sanjukta Deb, Angel Serrano-Aroca
Summary: This study reports on the development of PLA scaffolds infused with sodium alginate cross-linked with calcium and zinc divalent cations, which exhibit antibacterial and osteoinductive properties. They have the potential to be used for bone tissue regeneration.
ACS APPLIED MATERIALS & INTERFACES
(2022)
Review
Engineering, Biomedical
Fernanda Zamboni, Chun Kwok Wong, Maurice N. Collins
Summary: This article discusses the interaction between hyaluronic acid and pathogenic microorganisms, as well as the antimicrobial activity of different molecular weights of hyaluronic acid in biomedical and pharmaceutical applications. These studies are crucial for the development of next generation antimicrobial therapeutic strategies.
BIOACTIVE MATERIALS
(2023)
Article
Engineering, Biomedical
Yihao Liu, Haoyi Niu, Chengwei Wang, Xiaoxiao Yang, Wentao Li, Yuxin Zhang, Xiaojun Ma, Yuanjing Xu, Pengfei Zheng, Jinwu Wang, Kerong Dai
Summary: This study developed a new hydrogel material with biocompatibility, easy degradation, and wound healing properties using physical electrostatic cross-linking and freeze-drying. The material showed excellent antibacterial and pro-coagulation abilities, promoting hemostasis and reducing blood loss in both in vitro and in vivo experiments. Additionally, it exhibited superior cytocompatibility and biodegradability. Therefore, this material has great potential for clinical application as a hemostatic and wound healing material.
BIOACTIVE MATERIALS
(2022)
Article
Biochemistry & Molecular Biology
Sara E. Maloney, Kyle McGrath, Mona Jasmine R. Ahonen, Daniel S. Soliman, Evan S. Feura, Hannah R. Hall, Shannon M. Wallet, Robert Maile, Mark H. Schoenfisch
Summary: The combination of hyaluronic acid (HA) and nitric oxide (NO) created a single-agent wound therapeutic with broad-spectrum bactericidal activity and accelerated wound closure. The HA derivatives with NO-releasing properties showed diverse release kinetics and did not inhibit endogenous biodegradation pathways.
Article
Biophysics
Rongzhi He, Junhao Sui, Guangchao Wang, Yang Wang, Kaihang Xu, Sheng Qin, Shuogui Xu, Fang Ji, Hao Zhang
Summary: In this study, researchers improved the drug release control of titanium nanotubes by immobilizing dopamine and hyaluronic acid on the surface of the drug-loaded nanotubes. The results demonstrated that the modified nanotubes exhibited improved drug loading and release control, as well as enhanced antibacterial and osteogenic abilities.
COLLOIDS AND SURFACES B-BIOINTERFACES
(2022)
Article
Biochemistry & Molecular Biology
Ning Zhang, Rongjin Shi, Man Zhou, Ping Wang, Yuanyuan Yu, Qiang Wang
Summary: Textiles with efficient and long-lasting antibacterial properties have been achieved through the application of lysozyme as a stabilizer and ultrasonic assisted functional modification of molybdenum disulfide nanosheets. The amyloid-like phase-transited lysozyme (PTL) formed by lysozyme in the presence of reducing agents self-assembles on the fabric and reduces AgNPs in situ, leading to continuous antibacterial activity even in the absence of sunlight. The combined approach resulted in high bactericidal rates for S.aureus and E.coli, and the inactivation rates remained high even after multiple washing cycles.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2023)
Article
Biochemistry & Molecular Biology
Zhen Wang, Kaiyue Li, Qianru Xu, Guoliang Fu, Haiying Li, Wenzhi Yang
Summary: A novel wound dressing that possesses antibacterial properties and accelerates skin wound repair was developed. The dressing has a three-dimensional cavity structure, good swelling and moisturizing ability, no cytotoxicity, and certain antibacterial capability. In rat skin wound healing, the dressing can reduce inflammation and accelerate wound closure.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2022)
Article
Biochemistry & Molecular Biology
Jun Zan, Yang Shuai, Jun Zhang, Jiachi Zhao, Bingxin Sun, Liuyimei Yang
Summary: In this study, a slow-controlled bifunctional nano-structure was developed by encapsulating hyaluronic acid (HA) on the surface of silver-metal organic framework (Ag-MOF) and then loaded in a poly lactic-co-glycolic acid scaffold to prevent intrauterine adhesion (IUA). The scaffold exhibited long-term antibacterial property and good biocompatibility, inhibited inflammation, promoted the release of anti-inflammatory cytokines, and effectively inhibited fibroblast growth.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2023)
Review
Biotechnology & Applied Microbiology
Reza Alipoor, Mohammad Ayan, Michael R. Hamblin, Reza Ranjbar, Somaye Rashki
Summary: Bacterial contamination of medical devices is a significant concern for public health and hospital-acquired infections. Hyaluronic acid (HA) has bactericidal effects and nanotechnology has been used to improve its clinical utility. Combining HA with other bactericidal molecules can enhance the antibacterial effects and improve the management of hard-to-heal wound infections.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2022)
Article
Chemistry, Physical
Irfan Hussain, Sana Fatima, Shahbaz Ahmed, Mohammad Tabish
Summary: The binding mechanism between human lysozyme (Lyz) and beta-resorcylic acid (BR) was systematically examined using various biophysical and computational techniques. Experimental results confirmed the formation of a static complex with a calculated average binding distance. The forces driving the complex formation were determined to be van der Waals and hydrogen bonding.
JOURNAL OF MOLECULAR LIQUIDS
(2022)
Review
Food Science & Technology
Peter Myintzaw, Amit K. Jaiswal, Swarna Jaiswal
Summary: This article discusses the global epidemiology of Campylobacteriosis, the importance of official control, and the relevance of food handlers and food safety. Consumers' food handling practices are the main risk factors for exposure to this foodborne illness.
FOOD REVIEWS INTERNATIONAL
(2023)
Review
Food Science & Technology
Shubham Sharma, Amit K. Jaiswal, Brendan Duffy, Swarna Jaiswal
Summary: This review article focuses on the challenges faced by the food processing industry regarding food contact surfaces, discussing relevant regulations provided by the European framework and exploring new approaches to tackle these challenges.
FOOD REVIEWS INTERNATIONAL
(2023)
Article
Chemistry, Applied
Shubham Sharma, Megan Byrne, Kalpani Y. Perera, Brendan Duffy, Amit K. Jaiswal, Swarna Jaiswal
Summary: This study prepared PLA/PBAT composite blend films infused with TiO2 and different concentrations of cinnamon essential oil for cheese packaging. The films were evaluated for their optical, mechanical, chemical, thermal stability, water contact angle, and antibacterial properties, as well as their performance on cheese. The results showed that the thickness of the films increased with the concentration of cinnamon oil, as did the water contact angle and UV barrier properties. The PLA-PBAT-TiO2-7%Cinn film exhibited the most effective antibacterial activity against both S. aureus and E. coli. Additionally, the cheese packed in the PLA-PBAT-TiO2-7%Cinn film showed the least weight loss and enhanced antibacterial activity against E. coli during a 12-day storage period.
Review
Food Science & Technology
Dileswar Pradhan, Amit K. Jaiswal, Swarna Jaiswal
Summary: The food industry currently relies on non-biodegradable synthetic plastics for packaging, causing significant environmental pollution. Biodegradable nanocomposites using nanocellulose as a reinforcing material show promising potential for sustainable primary food packaging. Nanocellulose-based materials improve the mechanical and thermal properties of biopolymer matrices, resulting in better barrier and preservation properties for fruits, vegetables, and meat products. However, the lack of regulatory standards and legislation poses challenges for the commercial utilization of nanocellulose-based materials in food packaging.
FOOD REVIEWS INTERNATIONAL
(2023)
Article
Multidisciplinary Sciences
Nidal S. Khatib, James Monsen, Saima Ahmed, Yuming Huang, David A. Hoey, Niamh C. Nowlan
Summary: This study investigates the role of TRPV4 in mechanical regulation of cartilage and bone formation. The researchers found that mechanical stimulation of mouse embryo hindlimbs induces knee cartilage growth and expression of TRPV4. They also demonstrated that TRPV4 activity is necessary for loading-driven joint cartilage growth and shape, and this is mediated by control of cell proliferation and matrix biosynthesis.
Review
Food Science & Technology
Nur Alim Bahmid, Shahida Anusha Siddiqui, Hermawan Dwi Arianto, Kirana Sanggrami Sasmitaloka, Nikheel Bhoraj Rathod, Satriyo Krido Wahono, Swarna Jaiswal, Gulden Goksen, Anastasia Wheni Indrianingsih
Summary: This article reviews cellulose-based coating materials, synthesis and functional properties of cellulose-based coatings, incorporation of active agents into coating material, and the effects of coatings on tropical fruit quality. Choosing the appropriate coating materials is crucial for preserving the quality of tropical fruits.
FOOD REVIEWS INTERNATIONAL
(2023)
Review
Biochemistry & Molecular Biology
Buliyaminu Adegbemiro Alimi, Shivani Pathania, Jude Wilson, Brendan Duffy, Jesus Maria Celayeta Frias
Summary: This article summarizes the importance of chitin and chitosan extracted from different fruiting parts of mushrooms, as well as the different methods used to quantify extracted chitin and the physicochemical properties of chitin and chitosan from some mushroom species.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2023)
Article
Multidisciplinary Sciences
Janith Wanigasekara, Lara F. Carroll, Patrick Cullen, Brijesh Tiwari, James Curtin
Summary: Three-dimensional (3D) cell culture models can effectively simulate the natural in vivo environment, shape, tissue stiffness, stressors, gradients, and cellular response, bridging the gap between in vitro cell cultures and in vivo responses, without the associated costs and ethical concerns of animal models.
Review
Biochemistry & Molecular Biology
Laura E. Healy, Xianglu Zhu, Milica Pojic, Carl Sullivan, Uma Tiwari, James Curtin, Brijesh K. Tiwari
Summary: Seaweed is gaining attention as a potential sustainable source of nutrition for humans due to its rich nutritional profile and ability to produce functional ingredients. The extraction of compounds such as alginate, agar, and carrageenan from seaweed is well-established, and innovative processing methods are being explored. A wide range of products can be developed using seaweed, including bread, noodles, and yogurt, as well as enhancing the nutritional profile of meat products. This review paper explores the unique properties of seaweed as a food source, the processes involved in seaweed aquaculture, and the challenges facing the industry.
Article
Biophysics
Brid Murphy, Carolina Martins, Mimma Maggio, Mick A. Morris, David A. Hoey
Summary: In this study, a novel method of surface doping using a block copolymer-based surface chemistry was developed to create a pattern of gallium oxide nanodots on the surface. The low gallium content in this pattern enhanced osteointegration, as proven by comprehensive bioassays.
COLLOIDS AND SURFACES B-BIOINTERFACES
(2023)
Article
Food Science & Technology
Eduarda M. Cabral, Xianglu Zhu, Marco Garcia-Vaquero, Sara Perez-Vila, Jiafei Tang, Laura G. Gomez-Mascaraque, Mahesha M. Poojary, James Curtin, Brijesh K. Tiwari
Summary: This study aimed to valorize hemp waste from oil extraction as a source of protein by analyzing the effect of high-pressure processing (HPP) pre-treatments combined with conventional or ultrasound-assisted extraction (UAE) methods. The results showed that UAE had advantages over conventional extraction methods in protein recovery, and the HPP pre-treatments had an impact on protein recovery and purity. These findings indicate the potential of using UAE for protein recovery in the food industry and the importance of further research for optimization and cost estimation.
Review
Chemistry, Multidisciplinary
Kalpani Y. Y. Perera, Maille Hopkins, Amit K. K. Jaiswal, Swarna Jaiswal
Summary: Food packaging is of great importance for consumer satisfaction and prolonging the shelf life of food products. The emergence of novel food packaging materials, such as nanoclays, has gained attention due to the environmental pollution caused by plastic packaging and the need to reduce food waste. Nanoclays, including montmorillonite, halloysite, bentonite, Cloisite, and organically modified nanoclays, have been used to enhance the mechanical and barrier properties of food packaging materials and promote biodegradation. This article examines the development of nanoclay-based food packaging materials, focusing on bio-based polymers with nanoclay and analyzing their mechanical, barrier, and antibacterial characteristics. Additionally, it discusses the migration of nanoclays, toxicity levels, and relevant legislation.
JOURNAL OF NANOSTRUCTURE IN CHEMISTRY
(2023)
Article
Food Science & Technology
Kalpani Y. Perera, Amit K. Jaiswal, Swarna Jaiswal
Summary: Eco-friendly antimicrobial food packaging materials are crucial for extending the shelf life of food, reducing waste, and maintaining quality. A newly developed packaging material for cheese incorporates nanoclay and clove essential oil into a matrix of sodium alginate and gelatin, providing controlled moisture, enhanced antimicrobial properties, and maintained quality. The material exhibited favorable chemical, physical, and biological properties, with increased antimicrobial activity and biodegradability within 45 days. Application trials showed that the packaging film effectively extended the shelf life of cheese while preserving its weight, pH, appearance, and inhibiting microbial growth.
Article
Marine & Freshwater Biology
Erica Terese Krueger, Janina V. Buescher, David A. Hoey, David Taylor, Peter J. O'Reilly, Quentin G. Crowley
Summary: Ocean acidification may have negative impacts on the formation and structural stability of coral skeletons.
OCEANS-SWITZERLAND
(2023)
