Article
Nutrition & Dietetics
Nicholas A. Hulett, Rebecca L. Scalzo, Jane E. B. Reusch
Summary: This review examines the physiological mechanisms of glucose uptake in healthy individuals and individuals with type 2 diabetes, highlighting insulin resistance as a key factor. The review also emphasizes the importance of exercise in enhancing glucose uptake.
Article
Endocrinology & Metabolism
Paola A. Ramos, Kelli A. Lytle, Danae Delivanis, Soren Nielsen, Nathan K. LeBrasseur, Michael D. Jensen
Summary: The study found that there were no defects in insulin receptor signaling at the Akt/AS160 level in the muscles of obese individuals, indicating uncertainties in the mechanism of muscle insulin resistance in obesity.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2021)
Article
Endocrinology & Metabolism
Kohei Kido, Tatsuro Egawa, Shinya Watanabe, Kentaro Kawanaka, Jonas T. Treebak, Tatsuya Hayashi
Summary: This study demonstrated the synergistic enhancement of insulin-stimulated TBC1D4 phosphorylation and glucose uptake by fasting and prior muscle contraction, which is associated with augmented AMPK pathway activation.
AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM
(2022)
Article
Food Science & Technology
Camila Donoso-Barraza, Juan Carlos Borquez, Carlos Sepulveda, Francisco Diaz-Castro, Claudia Sepulveda-Quinenao, Juan Manuel Rodriguez, Omar Porras, Rodrigo Troncoso
Summary: This study investigates the role of hydrogen sulfide (H2S) in insulin signaling and glucose uptake. The results show that glucose restriction increases endogenous production of H2S and H2S disrupts insulin-induced glucose uptake, which may help maintain plasma glucose levels.
FOOD AND CHEMICAL TOXICOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Ching-Chia Wang, Huang-Jen Chen, Ding-Cheng Chan, Chen-Yuan Chiu, Shing-Hwa Liu, Kuo-Cheng Lan
Summary: The study found that acrolein exposure led to increased fasting blood glucose and impaired glucose tolerance in mice. It also showed that acrolein treatment decreased the expression of GLUT4 in both mouse soleus muscles and C2C12 myotubes, as well as suppressed phosphorylation of glucose metabolic signals. Additionally, over-expression of constitutive activation of Akt reversed the inhibitory effects of acrolein on GLUT4 protein expression and glucose uptake in myotubes.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Biochemistry & Molecular Biology
Stephanie N. Alu, Evan A. Los, George A. Ford, William L. Stone
Summary: Considerable evidence supports the role of oxidative stress in adult type 2 diabetes (T2D), and this will also affect more and more children. Understanding the factors contributing to oxidative stress and T2D risk may help develop optimal early intervention strategies. The combination of systems medicine and redoxomics holds promise in optimizing future healthcare strategies for T2D patients.
Review
Endocrinology & Metabolism
Jinhee Hwang, Debbie C. Thurmond
Summary: The impaired GLUT4 translocation and defects in SNARE proteins and their regulators are closely related to the pathogenesis of diabetes. Novel functions of SNARE proteins in pathways not typically associated with SNAREs may provide new therapeutic targets for combating insulin resistance and diabetes.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Chemistry, Medicinal
Yanhong Yao, Xinzhou Yang, Jinhua Shen, Ping Zhao
Summary: In this study, the researchers investigated the mechanism of Estradiol Dipropionate (EDP) on glucose uptake in L6 skeletal muscle cells. They found that EDP promoted glucose uptake and GLUT4 expression by activating AMPK and PKC signaling pathways. The findings suggest that EDP may be a potential drug for the treatment of type 2 diabetes.
Article
Biochemistry & Molecular Biology
Jongsoo Mok, Tae Sub Park, Sunhong Kim, Daehoon Kim, Cheol Soo Choi, Joonghoon Park
Summary: The study found that Prokr1 plays an important role in skeletal muscle, improving insulin sensitivity and being a potential therapeutic target for ameliorating insulin resistance in skeletal muscle.
Article
Food Science & Technology
William T. Moore, Jing Luo, Dongmin Liu
Summary: Insulin resistance is a major risk factor for developing type-2 diabetes, and skeletal muscle is the main tissue involved in insulin-mediated glucose disposal. Kaempferol, a flavonol present in many foods, has been shown to improve insulin sensitivity in obese mice. This study demonstrates that kaempferol directly stimulates glucose uptake and prevents lipotoxicity-induced impairment of glucose uptake in human skeletal muscle cells through the AMPK/Akt pathway, suggesting its potential as a therapeutic agent for insulin resistance.
FOOD SCIENCE AND HUMAN WELLNESS
(2023)
Review
Biochemistry & Molecular Biology
Sander A. J. Verbrugge, Julia A. Alhusen, Shimon Kempin, Nicolas J. Pillon, Jan Rozman, Henning Wackerhage, Maximilian Kleinert
Summary: Exercise is a cornerstone treatment for type 2 diabetes mellitus by improving insulin sensitivity of glucose uptake in skeletal muscle. A systematic review identified 176 genes related to muscle glucose uptake, with over 50% of them being regulated by exercise. Endurance and resistance exercise show both common and unique changes in gene expression and phosphorylation related to glucose uptake.
JOURNAL OF CELLULAR BIOCHEMISTRY
(2022)
Article
Biochemistry & Molecular Biology
Tomomi Minemura, Atsunori Fukuhara, Michio Otsuki, Iichiro Shimomura
Summary: The study reveals that LDHA regulates Glut1 expression and basal glucose uptake in adipocytes. Knockout or inhibition of LDHA leads to decreased Glut1 protein levels and reduced glucose uptake.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2022)
Review
Physiology
David H. Wasserman
Summary: Research conducted over the last 50 years has provided insights into the mechanisms of insulin-stimulated glucose transport in skeletal muscle cells, highlighting the importance of glucose phosphorylation by hexokinases for glucose uptake. However, the regulation of insulin-regulated hexokinase II remains poorly understood.
Article
Biochemistry & Molecular Biology
Ayumi Goto, Yuki Endo, Hitoshi Yamashita
Summary: The study investigates the role of CREG1 in skeletal muscle regeneration and glucose uptake. Results show that CREG1 stimulates glucose uptake in skeletal muscles partially through AMPK activation. This suggests that CREG1 plays an essential role in muscle regeneration by affecting glucose metabolism in skeletal muscles.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2023)
Article
Medicine, Research & Experimental
Soumyalekshmi Nair, Dominic Guanzon, Nanthini Jayabalan, Andrew Lai, Katherin Scholz-Romero, Priyakshi Kalita de Croft, Valeska Ormazabal, Carlos Palma, Emilio Diaz, Elizabeth A. McCarthy, Alexis Shub, Jezid Miranda, Eduard Gratacos, Fatima Crispi, Gregory Duncombe, Martha Lappas, H. David McIntyre, Gregory Rice, Carlos Salomon
Summary: Gestational diabetes mellitus (GDM) poses a significant public health concern, affecting 9-15% of pregnancies worldwide. This study found that EV-associated miRNAs in GDM patients undergo significant changes during gestation and can be effectively used for classification. A set of proteins associated with JAK-STAT signaling in skeletal muscle biopsies from GDM patients was identified, which may be targeted by the miRNA-92a-3p carried by circulating EVs. Overexpression of miRNA-92a-3p was shown to increase insulin sensitivity in primary skeletal muscle cells.
JOURNAL OF TRANSLATIONAL MEDICINE
(2021)
Article
Endocrinology & Metabolism
Rajakrishnan Veluthakal, Ragadeepthi Tunduguru, Daleep Kumar Arora, Vaibhav Sidarala, Khadija Syeda, Cornelis P. Vlaar, Debbie C. Thurmond, Anjaneyulu Kowluru
Article
Endocrinology & Metabolism
Miwon Ahn, Stephanie M. Yoder, Zhanxiang Wang, Eunjin Oh, Latha Ramalingam, Ragadeepthi Tunduguru, Debbie C. Thurmond
Article
Biochemistry & Molecular Biology
Ragadeepthi Tunduguru, Jing Zhang, Arianne Aslamy, Vishal A. Salunkhe, Joseph T. Brozinick, Jeffrey S. Elmendorf, Debbie C. Thurmond
JOURNAL OF BIOLOGICAL CHEMISTRY
(2017)
Article
Endocrinology & Metabolism
Arianne Aslamy, Eunjin Oh, Erika M. Olson, Jing Zhang, Miwon Ahn, Abu Saleh Md Moin, Ragadeepthi Tunduguru, Vishal A. Salunkhe, Rajakrishnan Veluthakal, Debbie C. Thurmond
Article
Microbiology
V. Balasubramanian, S. Solapure, H. Iyer, A. Ghosh, S. Sharma, P. Kaur, R. Deepthi, V. Subbulakshmi, V. Ramya, V. Ramachandran, M. Balganesh, L. Wright, D. Melnick, S. L. Butler, V. K. Sambandamurthy
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
(2014)
Article
Microbiology
B. K. Kishore Reddy, Sudhir Landge, Sudha Ravishankar, Vikas Patil, Vikas Shinde, Subramanyam Tantry, Manoj Kale, Anandkumar Raichurkar, Sreenivasaiah Menasinakai, Naina Vinay Mudugal, Anisha Ambady, Anirban Ghosh, Ragadeepthi Tunduguru, Parvinder Kaur, Ragini Singh, Naveen Kumar, Sowmya Bharath, Aishwarya Sundaram, Jyothi Bhat, Vasan K. Sambandamurthy, Christofer Bjoerkelid, T. Alwyn Jones, Kaveri Das, Balachandra Bandodkar, Krishnan Malolanarasimhan, Kakoli Mukherjee, Vasanthi Ramachandran
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
(2014)
Article
Pharmacology & Pharmacy
Ragadeepthi Tunduguru, Tim T. Chiu, Latha Ramalingam, Jeffrey S. Elmendorf, Amira Klip, Debbie C. Thurmond
BIOCHEMICAL PHARMACOLOGY
(2014)
Article
Multidisciplinary Sciences
Sudha Ravishankar, Anisha Ambady, Haripriya Ramu, Naina Vinay Mudugal, Ragadeepthi Tunduguru, Anand Anbarasu, Umender K. Sharma, Vasan K. Sambandamurthy, Sudha Ramaiah
Article
Endocrinology & Metabolism
Jing Zhang, Eunjin Oh, Karla E. Merz, Arianne Aslamy, Rajakrishnan Veluthakal, Vishal A. Salunkhe, Miwon Ahn, Ragadeepthi Tunduguru, Debbie C. Thurmond