Article
Chemistry, Multidisciplinary
Dan Li, Danyang Wang, Yulu Yang, Pengfei Gao, Wuzhe Fan, Xianhui Zhang, Yu Tang, Weihu Yang, Kaiyong Cai
Summary: In this study, the genomic characteristics of osteonecrosis of the femoral head (ONFH) were analyzed, and differentially expressed genes (DEGs) related to autophagy were identified. A modified titanium substrate was designed to upregulate HIF-1 alpha expression in mesenchymal stem cells (MSCs) and human umbilical vein endothelial cells (HUVECs) through receptors of TGF-beta and TNFR. The upregulated HIF-1 alpha in MSCs promoted autophagy and regulated MSCs proliferation and osteogenic differentiation, while in HUVECs, it accelerated angiogenesis by increasing VEGF expression. The modified titanium substrate enhanced the integration effect of the implant and reta\rded the deterioration of ONFH.
ADVANCED FUNCTIONAL MATERIALS
(2023)
Article
Engineering, Biomedical
Peifang Xu, Cao Jing, Xue Feng, Qi Gao, Sang Yeul Lee, Juan Ye
Summary: A porous silicone scaffold with desired microstructure and mechanical properties was developed for orbital implantation. The scaffold showed no cytotoxicity and promoted adhesion and proliferation of vascular endothelial cells in vitro. Implantation of the scaffold in rabbit anophthalmic sockets provided satisfactory volume replacement and induced extensive fibro-vascularization, demonstrating promising orbital reconstruction effects.
JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART B-APPLIED BIOMATERIALS
(2021)
Article
Engineering, Biomedical
Patrick T. Hall, Samantha Z. Bratcher, Caleb Stubbs, Rebecca E. Rifkin, Remi M. Grzeskowiak, Bryce J. Burton, Cheryl B. Greenacre, Stacy M. Stephenson, David E. Anderson, Dustin L. Crouch
Summary: The study confirmed the importance of successful skin healing and postoperative care in implanting endoprostheses in a rabbit model of hindlimb amputation. Adjusting the surgical incision to preserve vasculature, increasing the radii size on the endoprostheses to reduce skin stress, and collecting radiographs pre-surgery to match the bone pin size were all key factors contributing to successful outcomes.
ANNALS OF BIOMEDICAL ENGINEERING
(2021)
Article
Engineering, Biomedical
Xiaoyu Huang, Yang Ge, Bina Yang, Qi Han, Wen Zhou, Jingou Liang, Mingyun Li, Xian Peng, Biao Ren, Bangcheng Yang, Michael D. Weir, Qiang Guo, Haohao Wang, Xinxuan Zhou, Xugang Lu, Thomas W. Oates, Hockin H. K. Xu, Dongmei Deng, Xuedong Zhou, Lei Cheng
Summary: Peri-implantitis is a major problem causing implant failure, with early anti-infection and osseointegration promotion being key factors to address this issue. A novel compound PD, combined with MAO treatment, shows potential in inhibiting severe peri-implantitis by exhibiting anti-infection and osteogenic properties.
BIOACTIVE MATERIALS
(2021)
Article
Engineering, Mechanical
Chunyan Yao, Dongdong Chen, Zhongli Zheng, Qiangsheng Wang, Kaijie Fu
Summary: The study showed that as the porosity of porous-surfaced implants increased, the neck stress increased and strength decreased. In animal experiments, the ratio of BV to TV of the implants ranged from 55.38% to 79.86%, with the highest value at a porosity of 16%. Porous-surfaced implants with hydroxyapatite coating had higher bone formation content internally and around the implants compared to those without coating.
RAPID PROTOTYPING JOURNAL
(2021)
Article
Multidisciplinary Sciences
Shuyi Wu, Jianmeng Xu, Leiyan Zou, Shulu Luo, Run Yao, Bingna Zheng, Guobin Liang, Dingcai Wu, Yan Li
Summary: Ti implantation infection is a major threat to the success of dental implants, with coatings on Ti surfaces losing their antibacterial efficacy rapidly. The N-halamine polymeric coating presented in this study demonstrates long-lasting renewable antibacterial efficacy, providing a promising solution for prevention and treatment of peri-implant infection.
NATURE COMMUNICATIONS
(2021)
Article
Biochemistry & Molecular Biology
Imen Hammami, Silvia Rodrigues Gavinho, Ana Sofia Padua, Isabel Sa-Nogueira, Jorge Carvalho Silva, Joao Paulo Borges, Manuel Almeida Valente, Manuel Pedro Fernandes Graca
Summary: Implantology is important for oral rehabilitation, and this study aimed to address challenges by developing a biomaterial for dental implant coating based on zirconium-modified 45S5 Bioglass. The incorporation of zirconium enhanced conductivity and showed antibacterial effects, without cytotoxicity, making it a potential coating material for dental implants.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Medicine, General & Internal
Li-Ching Chang
Summary: Photofunctionalization can enhance osseointegration and soft tissue seal, but does not address the challenge of oral cancer cases. More clinical trials focused on complex implant cases and non-dental fields are needed in the future.
JOURNAL OF CLINICAL MEDICINE
(2022)
Review
Biochemistry & Molecular Biology
Ming Yi, Ying Yin, Jiwei Sun, Zeying Wang, Qingming Tang, Cheng Yang
Summary: This review comprehensively summarizes the application and mechanisms of hormones in implant osseointegration, and discusses their effects on the prognosis of implants. The results show that systemic hormones can regulate the osseointegration of oral implants through endogenous or exogenous drug-delivery methods.
FRONTIERS IN MOLECULAR BIOSCIENCES
(2022)
Article
Engineering, Multidisciplinary
Min-Chun Pan, Shih-Yao Wang, Chin-Sung Chen
Summary: A noncontact handheld assessment device based on resonance frequency analysis was developed to quantify dental implant stability. The device employed vibro-acoustic technique and outperformed the traditional magnetic sensing technique. In vitro and in vivo tests were conducted to verify device performance and observe osseointegration in live bodies.
Article
Orthopedics
Adele Changoor, R. Peter Suderman, Ibrahim Alshaygy, Ariel Fuhrmann, Margarete K. Akens, Oleg Safir, Marc D. Grynpas, Paul R. T. Kuzyk
Summary: Two commercially available porous coatings, Gription and Porocoat, were compared for the first time in a challenging intra-articular, weight-bearing, ovine model. The study found that Gription coating provided superior fixation strength and bone ingrowth compared to Porocoat.
JOURNAL OF ORTHOPAEDIC RESEARCH
(2022)
Article
Engineering, Biomedical
Ana Civantos, Andrea Mesa-Restrepo, Yadir Torres, Akshath R. Shetty, Ming Kit Cheng, Camilo Jaramillo-Correa, Teresa Aditya, Jean Paul Allain
Summary: Chemical and physical surface modification methods, such as direct irradiation synthesis (DIS), have been successfully used to address stress shielding and osseointegration challenges in bone regeneration. DIS generates self-organized nanopatterns on the surface of materials, enhancing their mechanical properties and topography for better osseointegration. By adjusting the volume percentage of spacer NaCl particles, the porosity and morphology of the material can be controlled. These nanoscale features are biocompatible and promote cell differentiation and mineralization, making them promising for bone tissue engineering.
JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART A
(2023)
Review
Biochemistry & Molecular Biology
Nicolas Blanc-Sylvestre, Philippe Bouchard, Catherine Chaussain, Claire Bardet
Summary: Biomedical research relies on animal models to bridge the gap between laboratory experiments and clinical applications, with current trends emphasizing the replacement, reduction, and refinement of animal use. New development strategies are gradually shifting towards in vitro or biomaterial approaches, highlighting the importance of thoughtful selection of animal models based on research objectives.
Article
Dentistry, Oral Surgery & Medicine
Danny Hadaya, Joan Pi-Anfruns, Benjamin Bellon, Benjamin E. Pippenger, Tara L. Aghaloo
Summary: In this short-term study, immediately loaded fully tapered implants obtained high survival with similar osseointegration ability as apically tapered implants when placed in healed sites and fresh extraction sockets.
CLINICAL ORAL IMPLANTS RESEARCH
(2022)
Review
Medicine, General & Internal
Xinrui Lang, Bo Qiao, Ziyu Ge, Jiahui Yan, Yanzhen Zhang
Summary: Photofunctionalization has a positive effect on implant stability and osseointegration speed, leading to improved stability and faster healing time. However, its effect on marginal bone loss remains unclear.
JOURNAL OF CLINICAL MEDICINE
(2022)