Article
Engineering, Biomedical
Fawad Ur Rehman, Yang Liu, Meng Zheng, Bingyang Shi
Summary: Exosome application is a promising nanotechnology discipline for disease therapy and diagnosis. Due to their natural properties, such as efficient drug delivery and blood-brain barrier traversing ability, exosomes have gained attention in clinical translation for brain diseases treatment.
Review
Cell Biology
Zhongci Hang, Liping Zhou, Cencan Xing, Yongqiang Wen, Hongwu Du
Summary: The blood-brain barrier (BBB), as a critical barrier separating the circulating blood from the brain, plays a key role in the onset and treatment of neurodegenerative diseases (NDs). Improving BBB dysfunction and exploring efficient drug delivery methods are crucial for the treatment of NDs. This review summarizes methods to improve BBB dysfunction in NDs, discusses advances in BBB penetration techniques, and reviews various in vivo and in vitro BBB models and research methods related to NDs.
AGEING RESEARCH REVIEWS
(2023)
Review
Chemistry, Multidisciplinary
Jia Li, Meng Zheng, Olga Shimoni, William A. Banks, Ashley I. Bush, Jennifer R. Gamble, Bingyang Shi
Summary: The blood-brain barrier is a crucial neurovascular unit that prevents harmful substances from entering the brain and maintains normal neuronal function. Disruption of BBB in diseases can contribute to disease progression, while restoration of BBB integrity is a biomarker for better clinical outcomes. The BBB also plays a role in facilitating communication between neuronal and circulatory systems, showing promising results for brain-targeted drug delivery.
Review
Pharmacology & Pharmacy
Yuan Gao, Rui Wang, Lixia Zhao, Anchang Liu
Summary: Malignant glioma is a crucial part among all central nervous diseases, with high fatality and disability rates. Various therapeutic strategies, especially related to chemotherapy, are hindered by the blood-brain barrier. By studying ways to bypass the barrier and utilizing natural polymeric materials for drug delivery, advancements in treating malignant glioma are promising.
JOURNAL OF DRUG TARGETING
(2021)
Article
Chemistry, Physical
Yo Han Song, Ranjit De, Kang Taek Lee
Summary: Blood-brain barrier (BBB) is a crucial interface between the central nervous system (CNS) and its surroundings, allowing selective permeation of essential substances while restricting the entry of potentially harmful materials. The development of polymeric nanocarriers has shown promise in facilitating BBB permeation for the treatment of neurodegenerative diseases and brain cancers. However, the challenge of transporting drug-loaded nanomaterials across the BBB remains formidable. This concise analysis explores strategies for designing polymeric nanocarriers and discusses the impact of size, shape, surface charge, and ligand modification on BBB permeation. The review also highlights future directions for designing smart polymeric nanocarriers to enhance BBB permeation.
ADVANCES IN COLLOID AND INTERFACE SCIENCE
(2023)
Article
Food Science & Technology
Wen-Xia Sun, Chuan-tao Zhang, Xi-Na Yu, Jia-bin Guo, Hao Ma, Ke Liu, Pei Luo, Jing Ren
Summary: This study developed lactoferrin modified long-circulating liposomes for brain-targeted delivery of diosmetin, showing potential implications in Alzheimer's disease treatment.
JOURNAL OF FUNCTIONAL FOODS
(2022)
Review
Cell Biology
Miguel Pinto, Vera Silva, Sandra Barreiro, Renata Silva, Fernando Remiao, Fernanda Borges, Carlos Fernandes
Summary: Effective drugs for the treatment of neurodegenerative disorders remain a challenge, but the advancement of nanotechnology and nanomedicine offers potential solutions. Polymeric nanoparticles, particularly based on PLGA, have shown success in treating cancer and other diseases, but further research is needed for neurodegenerative disorders.
AGEING RESEARCH REVIEWS
(2022)
Article
Chemistry, Multidisciplinary
Masoud Farshbaf, Solmaz Mojarad-Jabali, Salar Hemmati, Ahmad Yari Khosroushahi, Hamidreza Motasadizadeh, Amir Zarebkohan, Hadi Valizadeh
Summary: This study developed a targeted delivery system based on nanostructured lipid carriers, which can effectively overcome the blood-brain barrier and blood-brain tumor barrier, and deliver therapeutics to glioma cells with high selectivity. It represents a promising treatment for brain cancer.
JOURNAL OF CONTROLLED RELEASE
(2022)
Review
Chemistry, Multidisciplinary
Santosh Bashyal, Chhitij Thapa, Sangkil Lee
Summary: This article provides an overview of recent exosome-based drug delivery nanoplatforms and discusses the potential of using exosomes as drug delivery vehicles for treating brain diseases. Exosomes possess advantages such as barrier penetration, targeting capability, and stability, but also face challenges that need to be addressed through future research efforts.
JOURNAL OF CONTROLLED RELEASE
(2022)
Review
Pharmacology & Pharmacy
Jovita Kanoujia, Ankita Kishore, Poonam Parashar
Summary: Polymeric micelles offer new possibilities for improving drug delivery to the brain due to their small size, long circulation time, stability, and targetability. Despite their benefits and potential applications for brain conditions, micelles are currently underutilized. This review explores the role of micellar delivery systems in treating brain diseases, including their administration routes and outcomes. It also discusses the current state of patents and clinical trials in relevant fields, as well as potential future applications.
CURRENT PHARMACEUTICAL DESIGN
(2023)
Review
Nanoscience & Nanotechnology
Zhiren Wang, Karina Marie Gonzalez, Leyla Estrella Cordova, Jianqin Lu
Summary: Neurodegenerative diseases are prevalent among aging populations in the 21st century, resulting in the progressive loss of neuronal function and related complications. However, effective therapeutical strategies remain a challenge due to limited drug delivery to the central nervous system. Nanotechnology-enabled drug delivery systems offer a potential solution, providing targeted and efficient treatment with minimal side effects. This review outlines the current applications and progress in enhancing therapeutic efficacy for neurodegenerative diseases.
WILEY INTERDISCIPLINARY REVIEWS-NANOMEDICINE AND NANOBIOTECHNOLOGY
(2023)
Review
Immunology
Yicun Wang, Jiyao Sheng, Jin Chai, Cuilin Zhu, Xin Li, Wei Yang, Ranji Cui, Tongtong Ge
Summary: Glioma is a life-threatening malignant tumor with challenges in traditional treatments and drug delivery. Crossing the blood-brain barrier poses difficulties for drug vectors, but phage-based drugs offer advantages such as thermodynamic stability, biocompatibility, and low toxicity. Tumor-targeting peptides from phage library and phages displaying targeting peptides are ideal drug delivery agents for personalized treatment of glioma.
FRONTIERS IN IMMUNOLOGY
(2021)
Review
Pharmacology & Pharmacy
Alaa Raad Al Jayoush, Hatem A. F. M. Hassan, Hawraa Asiri, Maryam Jafar, Reem Saeed, Rania Harati, Mohamed Haider
Summary: Neurodegenerative diseases have a significant impact on morbidity and mortality worldwide. The effectiveness of current therapeutic approaches for these diseases is limited due to poor drug delivery to the brain. Intranasal delivery has been proposed as a non-invasive strategy for delivering drugs to the brain, and niosomes, a type of nano-sized carrier, show promise for drug delivery to the brain.
JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY
(2023)
Review
Biochemistry & Molecular Biology
Ying-Chieh Wu, Tuuli-Maria Sonninen, Sanni Peltonen, Jari Koistinaho, Sarka Lehtonen
Summary: The blood-brain barrier plays a crucial role in regulating the delivery of substances to the brain and removing harmful metabolites. Malfunction of the BBB is associated with neurological diseases such as Alzheimer's disease and Parkinson's disease. Recent research focuses on using stem cell technology to model the BBB and explore potential treatments for neurological disorders.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Engineering, Biomedical
Smrithi Padmakumar, Gregory Jones, Olga Khorkova, Jane Hsiao, Jonghan Kim, Benjamin S. Bleier, Mansoor M. Amiji
Summary: This study demonstrates the successful application of a novel 'Minimally Invasive Nasal Depot' (MIND) delivery method for direct administration of therapeutics to the CNS in rodent models, resulting in sustained delivery and significant therapeutic effects, highlighting the potential for translational application in treating chronic age-related neurodegenerative diseases.